scholarly journals Serum High Sensitive C-Reactive Protein in Obese Persons with Normal Glucose Tolerance & Impaired Fasting Glucose

2018 ◽  
Vol 4 (1) ◽  
pp. 21-24
Author(s):  
Soniya Fahmi ◽  
Sunjida Shahriah ◽  
Omma Hafsa Any ◽  
Mahbuba Akter ◽  
Samia Afrin
Keyword(s):  
Fasting Glucose ◽  
Normal Glucose Tolerance ◽  
Control Group ◽  
Case Group ◽  
Obese Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Normal Glucose ◽  
Obese Subjects ◽  
Hs Crp

Background: Obesity, characterized by increased fat mass and is currently regarded as a proinflammatory state and frequently associated with increased risk of cardiovascular diseases including Myocardial Infarction and also future risk for development of metabolic disorders such as T2DM. Highsensitivity C-reactive protein is a well-known inflammatory marker. Objective: In this study we aimed to determine the levels of serum high-sensitive C-reactive protein in obese parsons with normal glucose tolerance (NGT) and obese with impaired fasting glucose (IFG) individuals. Methodology: This was a case-control study which was conducted in the Department of Biochemistry, ZH Sikder Women’s Medical College, Dhaka during the period of July 2014 to June 2015. The age, sex and body mass index (BMI ≥ 30 kg / m²) matched 25 obese subjects with NGT were selected as control group and 25 obese patients with IFG were selected as case group. We measured levels of serum high sensitive Creactive protein in all groups. Subjects of both obese groups had significantly higher hs-CRP levels than the normal range. Results: A total number of 50 subjects were recruited for this study of which 25 obese subjects with NGT were selected as control group and 25 obese patients with IFG were selected as case group. The level of hs-CRP in obese with NGT and with IFG were found 2.91±1.56 mg/L & 3.42±1.72 mg/L, respectively. There are no significant difference between hs-CRP levels of obese subjects than the subjects with IFG (p>0.1). Conclusion: This study finding has concluded that obesity raises serum hsCRP level. IFG obese individuals are not at much higher cardiovascular and metabolic risk level than normal obese parsons. Bangladesh Journal of Infectious Diseases 2017;4(1):21-24

Correlation Between High Sensitivity C-Reactive Protein Level and Executive Function Disorders in Elderly Patients

2020 ◽  
Vol 17 (7) ◽  
pp. 3113-3116
Author(s):  
Dyah Anetta Afri Rukmi ◽  
Joseph Eko Wahono Rahardjo
Keyword(s):  
Executive Function ◽  
Elderly Patients ◽  
Complete Blood Count ◽  
High Sensitivity ◽  
High Serum ◽  
Control Group ◽  
Case Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

C-Reactive Protein is a marker of inflammation and vascular disease. The high serum of high-sensitivity C-Reactive Protein (hs-CRP) concentration was associated with interruption the integrity of the frontal-subcortical circuit. To determine the correlation between high serum concentration of hs-CRP and executive function disorder in elderly patients. Thirty six elderly patients was examined by using a case control study. The subjects were enrolled from the out-patient at Neurology Department Dr. Soetomo General Hospital, Surabaya, Indonesia. The time period was 4 months (April to July 2015). Executive function was measured with the Trail Making Test B (TMT B) and divided into two groups, case and control. Complete blood count and serum hs-CRP concentration were measured from nonfasting blood samples. Chi-square test was used for data analysis. Eighteen subjects were enrolled in the case group (3 men, 15 women) and the other 18 subjects were enrolled in the control group (4 men, 14 women). Executive function disorder was found in 17 (94,4%) subjects of case group and 11 (61,1%) subjects of control group. High levels of hs-CRP was not associated with executive function, with p = 0,149 and adjusted OR 5,629 (CI 95% 0, 538-58, 860). These data suggested that high levels of hs-CRP was not associated with executive function in elderly patients.

scholarly journals The metabolic effects of a commercially available chicken peri-peri (African bird’s eye chilli) meal in overweight individuals

2015 ◽  
Vol 117 (5) ◽  
pp. 635-644 ◽  
Author(s):  
Jacolene Kroff ◽  
David J. Hume ◽  
Paula Pienaar ◽  
Ross Tucker ◽  
Estelle V. Lambert ◽  
...  
Keyword(s):  
Core Body Temperature ◽  
Resting Energy Expenditure ◽  
High Sensitivity ◽  
Normal Glucose Tolerance ◽  
Metabolic Effects ◽  
Microvascular Reactivity ◽  
Reactive Protein ◽  
Metabolic Outcomes ◽  
Normal Glucose ◽  
Hs Crp

AbstractA growing body of evidence suggests that capsaicin ingestion may lead to desirable metabolic outcomes; however, the results in humans are equivocal. Whether or not benefits may be gained from ingestion of capsaicin via a commercially available meal has not been determined. The objectives of this randomised, cross-over intervention study were to compare the 2 h postprandial effects of a standard commercially prepared meal containing chilli (HOT, 5·82 mg total capsaicinoids) with a similar meal with no chilli (CON, <1·0 mg total capsaicinoids) on resting energy expenditure, plasma insulin, glucose, serum high sensitivity C-reactive protein (hs-CRP) concentrations, core body temperature and forearm microvascular reactivity responses in overweight individuals. A total of thirty-four apparently healthy individuals (sixteen men and eighteen women) between 18 and 50 years of age, with a BMI >25 kg/m2 and a waist circumference >94 cm (men) or 80 cm (women), were studied. Participants had normal glucose tolerance and were accustomed, but were not regular chilli eaters. A paired t test indicated that insulin AUC was smaller following the HOT meal (P=0·002). Similarly, there was a tendency for glucose AUC to be reduced following the HOT meal (P=0·056). No discernable effects of the HOT meal were observed on metabolic rate, core temperature, hs-CRP concentrations and endothelial-dependent microvascular reactivity. The results from this study indicate that a standard restaurant meal containing a relatively small dose of capsaicin delivered via African bird’s eye chilli, which is currently available to the public, results in lower postprandial insulin concentrations in overweight individuals, compared with the same meal without chilli.

scholarly journals ROLE OF CARDIAC MARKERS IN CHRONIC RENAL FAILURE PATIENTS.

2020 ◽  
pp. 81-82
Author(s):  
Ramesh Chandra Thanna ◽  
B K Agarwal ◽  
Rakesh Romday ◽  
Neha Sharma
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Positive Association ◽  
Morbidity And Mortality ◽  
Control Group ◽  
High Morbidity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

Introduction: Cardiovascular diseases (CVD) are known as important reasons of the increased morbidity and mortality observed in patients with chronic renal failure (CRF). The association of serum Interlukin-6 , homocysteine as well as other cardiovascular risk factors in relation to existence and cause of CVD were investigated. Method: In this study 200 CRF patients were recruited and further stratified into group with Male and Female as case groups. Those without renal failure were assigned as control group (n=200). Results: The patients with CRF showed a significant increase in plasma levels of Cpk-MB homocysteine and C-reactive protein (CRP) compared to control. The positive association were observed between homocysteine, Urea and Hs-CRP, IL_6 . It shows a significant Association of parameters in CRF . Conclusion: The results demonstrated elevation in plasma values IL-6 , homocysteine and HS-CRP in patients with CRF . However, these modifications may be lead to atherosclerosis and consequence CVD event. These parameters may be important with respect to the high morbidity and mortality of CVD found in patients with CRF.

Highly sensitive C-reactive protein levels in Iranian patients with pulmonary complication of sulfur mustard poisoning and its correlation with severity of airway diseases

2009 ◽  
Vol 28 (12) ◽  
pp. 739-745 ◽  
Author(s):  
Davood Attaran ◽  
Shahrzad M Lari ◽  
Mohammad Khajehdaluee ◽  
Hossein Ayatollahi ◽  
Mohammad Towhidi ◽  
...  
Keyword(s):  
Lung Function ◽  
Sulfur Mustard ◽  
Chronic Obstructive ◽  
Case Group ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Highly Sensitive ◽  
The Mean ◽  
Hs Crp

Background: Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due to SM poisoning. Methods: Fifty consecutive SM patients with stable COPD and a mean age 46.3 ± 9.18 years were enrolled in this cross sectional study. Thirty healthy men were selected as controls. Lung function parameters were evaluated. Serum hs-CRP by immunoturbidometry assay was measured in both the patients and controls. Results: In the case group, the mean forced expiratory volume in one second (FEV1) was 2.14 ± 0.76 L (58.98% ± 17.51% predicted). The mean serum hs-CRP was 9.4 ± 6.78 SD and 3.9 ± 1.92 SD mg/L in the cases and controls, respectively, with significant statistical differences (p < .001). There was negative correlation between the serum hs-CRP and FEV1 levels (p = .01). The serum hs-CRP levels were also correlated with Global Initiative for Chronic Obstructive Lung disease (GOLD) stages (r = .45, p < .001). Conclusions: Our findings suggest that the serum hs-CRP level is increased in SM patients with COPD and may have a direct correlation with disease severity. It may then be used as a marker for the severity of COPD in patients with SM poisoning.

scholarly journals Reduction in Serum High-Sensitivity C-Reactive Protein Favors Kidney Outcomes in Patients with Impaired Fasting Glucose or Diabetes

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Lili Liu ◽  
Bixia Gao ◽  
Jinwei Wang ◽  
Chao Yang ◽  
Shouling Wu ◽  
...  
Keyword(s):  
Kidney Function ◽  
Impaired Fasting Glucose ◽  
No Reduction ◽  
Cox Regression ◽  
Fasting Glucose ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Kidney Function Decline

Objective. We aimed to evaluate whether the reduction in serum high-sensitivity C-reactive protein (hs-CRP) favors kidney outcomes. Methods. This study was a subanalysis including patients with impaired fasting glucose or diabetes of the Kailuan cohort study. The predictor was based on two consecutive visits of hs-CRP levels in 2006 and 2008. A total of 3924 patients with hs-CRP≥3 mg/L in 2006 were divided into two groups according to whether the levels of hs-CRP were reduced in 2008: Group 1: no reduction: hs-CRP≥3 mg/L in 2008; Group 2: reduction: hs-CRP<3 mg/L in 2008. Kidney outcomes include kidney function decline and development and progression of proteinuria and were followed up until the end of 2015. Results. There were 3905, 2049, and 493 patients included into our analysis for the outcomes of kidney function decline and the development and progression of proteinuria, respectively. A total of 398, 297, and 47 events occurred after 5 years of follow-up, respectively. Cox regression revealed that patients with reduction in hs-CRP have lower risk of kidney function decline (HR 0.71, 95% CI 0.57-0.89, and P=0.002) and development of proteinuria (0.77, 0.61-0.99, and P=0.038) after controlling for potential confounders as compared to those with no reduction in hs-CRP levels. Conclusions. Reduction in serum hs-CRP levels favors kidney outcomes in patients with impaired fasting glucose or diabetes.

scholarly journals High Specific C-Reactive Protein in Prediction of the Early Outcome of Primary Intra Cerebral Hemorrhage

2021 ◽  
pp. 54-61
Author(s):  
Khaled Eltoukhy ◽  
Mohamed Gomaa ◽  
Yasmin Ibrahim ◽  
Mohamed Saad
Keyword(s):  
Cerebral Hemorrhage ◽  
Hemorrhagic Stroke ◽  
Multivariable Analysis ◽  
University Hospital ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Test Kit ◽  
Hs Crp ◽  
Ct Brain

Background: Primary intra cerebral hemorrhage (ICH) has high rate of disability and death. Many factors was supposed to be predictors of the outcome. The significance of measuring C-reactive protein (CRP) levels to predict the outcome is uncertain, and data have been controversial. The objective of our clinical study was to determine the relationship of hs-CRP levels with bad outcome. The authors tested if (independent of confounding factors) hs-CRP levels was elevated on admission (< 24 hours after ictus). Fifty patients with acute spontaneous hemorrhagic stroke, within 24 hours of onset confirmed by CT brain were admitted at neurology department, Mansoura University Hospital from June 2017 to September 2018. Age and sex cross-matched 50 healthy persons were studied as control group. Patient and control groups were subjected to full history, general and neurological examination, GCS on admission, National Institute of Health Stroke Scale (NIHSS) on admission, ICH score and Canadian scale on admission and after 30 days, Venous Blood samples were taken within 24 hours of onset and tested for routine laboratory investigations (liver function, serum creatinine, CBC and blood glucose) and High Sensitive C-Reactive Protein level using Enzyme Immunoassay Test Kit. Computed tomography (CT) brain was repeated 72 hours later. Multivariable regression analyses were used to evaluate associations of hs-CRP concentration and ICH outcome. Kaplan–Meier analysis was used for survival. Results: This study revealed that Hs-CRP is significantly higher in patient group (9.3 mg/l) when compared to control group (0.68 mg/dl) with p value < 0,001. There was statistically significant correlation between NIHSS and hs-CRP levels but there was no statistically significant correlation between hs-CRP levels and stroke outcome. Conclusion: Taking these covariates into multivariable analysis revealed that there is correlation between hs-CRP and hemorrhagic stroke but it cannot be used as a predictor of its outcome.

A hypertriglyceridemic state increases high sensitivity C-reactive protein of Japanese men with normal glucose tolerance

Endocrine ◽  
2011 ◽  
Vol 41 (1) ◽  
pp. 96-102 ◽  
Author(s):  
Kyoko Okada ◽  
Norihiro Furusyo ◽  
Masayuki Murata ◽  
Yasunori Sawayama ◽  
Mosaburo Kainuma ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
High Sensitivity ◽  
Normal Glucose Tolerance ◽  
C Reactive Protein ◽  
Japanese Men ◽  
Reactive Protein ◽  
Normal Glucose

Relation Between C-Reactive Protein and Impaired Fasting Glucose in Obese Subjects

Inflammation ◽  
2012 ◽  
Vol 35 (5) ◽  
pp. 1742-1746 ◽  
Author(s):  
Luis E. Simental-Mendía ◽  
Brissia Lazalde ◽  
Graciela Zambrano-Galván ◽  
Luis Simental-Saucedo ◽  
Elizabeth Rábago-Sánchez ◽  
...  
Keyword(s):  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Obese Subjects

scholarly journals Association of Mitral Annulus Calcification with High-Sensitivity C-Reactive Protein, Which Is a Marker of Inflammation

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Ertuğrul Kurtoğlu ◽  
Hasan Korkmaz ◽  
Erdal Aktürk ◽  
Mücahid Yılmaz ◽  
Yakup Altaş ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Systemic Inflammation ◽  
High Sensitivity ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Artery Disease ◽  
The Relationship

Objectives. There are limited clinical data revealing the relationship between mitral annular calcification (MAC) and systemic inflammation. The goal of the present study was to compare high-sensitivity C-reactive protein (hs-CRP) levels in patients with and without MAC and investigate the relationship between MAC and hs-CRP.Methods. One hundred patients with MAC who underwent transthoracic echocardiography (TTE) and 100 age-matched controls without MAC who underwent TTE were included in our study. Hs-CRP levels were compared between groups.Results. Prevalence of female gender, hypertension, and coronary artery disease were significantly higher in the MAC group than in the control group (64% versus 45%,P=0.007, 42% versus 28%,P=0.03and 37% versus 18%,P=0.003, resp.). On multivariate analysis, age, gender, and coronary artery disease were the only independent predictors of MAC. The levels of hs-CRP were higher in the MAC group than in the control group (2.02±0.35versus1.43±0.47 mg/dl,P<0.001). This increase in hs-CRP levels in the MAC group persisted in patients without hypertension, coronary artery disease, and in male patients when compared to the control group.Conclusions. Our study demonstrated that hs-CRP, which is a sensitive marker of systemic inflammation, increased in patients with MAC.

scholarly journals Analysis on the Clinical Characteristics of 36 Cases of Novel Coronavirus Pneumonia in Kunming

2020 ◽  
Author(s):  
Haiyan Fu ◽  
Hongjuan Li ◽  
Xiaoqing Tang ◽  
Xiang Li ◽  
Jie Shen ◽  
...  
Keyword(s):  
T Cells ◽  
Normal Control ◽  
Cd8 T Cells ◽  
Clinical Characteristics ◽  
Normal Control Group ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Novel Coronavirus

AbstractObjectiveTo analyze the clinical characteristics of patients with novel coronavirus pneumonia in Kunming City, and to study the correlation between nutritional status and immune function.MethodsClinical data of 36 patients with novel coronavirus pneumonia in isolation area of Kunming Third People’s Hospital from January 31 to February 15, 2020 were collected, and the basic situation, clinical characteristics, laboratory examination and CT imaging characteristics were analyzed. Serum albumin (ALB), prealbumin (PAB), hypersensitive c-reactive protein (hs-crp), CD3T cells, CD4T cells, CD8T cells and normal control group were analyzed. A simple linear regression analysis of the relationship between proalbumin and T cell subpopulation counts in the blood of patients.Results(1) The patients with new coronavirus pneumonia in Kunming were mainly of common type. (2) 50% of the patients’ first symptoms were fever and cough; (3) The total number of white blood cells in peripheral blood was normal or decreased in 23 cases (79%), and the lymphocyte count decreased in 5 cases (13.89%), without anemia. Hypersensitive c-reactive protein increased in 19 (52.78%) cases, and procalcitonin increased in 1 case. Albumin decreased in 5 cases (13.89%), proalbumin decreased in 15 cases (41.67%), alanine transaminase increased slightly in 4 cases (11.11%), alanine transaminase increased slightly in 4 cases (11.11%), total bilirubin increased slightly in 11 cases (30.56%), and renal function and blood coagulation were normal. Absolute value of CD3+T cells is with a decrease in 21 cases (58.3%), CD4+T in 28 cases (77.8%), CD8+T in 17 cases (47.2%), and CD4+/ CD8+ inverse in 6 cases (16.7%). (4) The prealbumin, CD3 T cells, CD4 T cells and CD8 T cells in the new coronavirus pneumonia group were significantly lower than those in the normal control group, and the hypersensitive c-reactive protein was higher than that in the normal control group. (5) The levels of PAB in the serum of the patients were linearly correlated with hs-crp, CD3 T cells, CD4 T cells and CD8 T cells, and the correlation coefficients were −0.474, 0.558, 0.467 and 0.613, respectively, showing statistical differences.ConclusionThe clinical characteristics of the novel coronavirus pneumonia in Kunming are different from those in Wuhan. The changes of serum proalbumin and T cell subsets are relatively obvious. Changes in serum proalbumin may contribute to the early warning of novel coronavirus pneumonia. The nutritional status of patients with common and mild pneumonia should be considered.

Sign in / Sign up

Export Citation Format

Share Document