Rate of visual field decay in glaucomatous eyes with acquired pits of the optic nerve

2020 ◽  
pp. bjophthalmol-2020-315980
Author(s):  
Golnoush Mahmoudinezhad ◽  
Mark Lin ◽  
Alessandro Rabiolo ◽  
Esteban Morales ◽  
Pradtana Hirunpatravong ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Visual Field ◽  
Open Angle Glaucoma ◽  
Rate Of Change ◽  
Control Group ◽  
Mean Deviation ◽  
Global Rate ◽  
Field Decay ◽  
Event Based ◽  
The Relationship

BackgroundTo evaluate the relationship between the presence of an acquired pit of the optic nerve (APON) and the rate of visual field (VF) decay in primary open-angle glaucoma (POAG).MethodsConsecutive patients with POAG were screened for APON by three glaucoma specialists. A control group of POAG eyes without APON were matched with the APON group for factors such as age, gender, baseline intraocular pressure and baseline mean deviation (MD). The pointwise rate of change (PRC) was used for pointwise comparisons between the two groups. MD rate, Visual Field Index (VFI) rate and Glaucoma Rate Index (GRI) were used for global rate comparisons. We compared the proportions of eyes progressing in the groups with event-based guided progression analysis (GPA), MD, VFI and GRI criteria.ResultsMean (SD) PRC was faster in the APON group −1.00 (±2.57) %/year compared with the control group −0.25 (±2.19) %/year; p<0.001. MD rate (−0.22 (±0.27) dB/year vs 0.03 (±0.41) dB/year; p=0.009), VFI rate (−0.81 (±0.86) %/year vs −0.05 (±1.0) %/year; p=0.04) and GRI (−12.27 (±16.27) vs -3.75 (±10.6); p=0.052) were all faster in the APON group compared with controls. The proportion of progressing eyes with GPA, MD, VFI and GRI was not significantly different between the two groups (p>0.1).ConclusionsThe presence of APON in patients with POAG is associated with focal, fast rates of VF decay. Identification of patients with APON should alert clinicians to the possibility of a fast rate of functional progression and to consider appropriately aggressive treatment of their glaucoma.

On the relationship between the level of ophthalmotonus, the state of the optic nerve head and the visual field in patients with open-angle glaucoma

1985 ◽  
Vol 66 (2) ◽  
pp. 158-158
Author(s):  
D. I. Sabitova ◽  
L. B. Galiaskarova
Keyword(s):  
Optic Nerve ◽  
Visual Field ◽  
Optic Nerve Head ◽  
Open Angle Glaucoma ◽  
The State ◽  
Open Angle ◽  
Kinetic Mode ◽  
The Relationship

In 115 patients (164 eyes) with open-angle glaucoma, the visual field was examined using the approximate static perimeter of Wurgaft and in the kinetic mode on the spherical perimeter.

The relationship between optic nerve head and peripapillary vascular densities and visual field analysis in open angle glaucoma

2021 ◽  
Vol 16 (2) ◽  
pp. 113
Author(s):  
Ahmet Kaderli ◽  
Sinem Karabulut ◽  
Sema Tamer Kaderli ◽  
Cansu Kaya ◽  
Aylin Karalezli
Keyword(s):  
Optic Nerve ◽  
Visual Field ◽  
Optic Nerve Head ◽  
Open Angle Glaucoma ◽  
Field Analysis ◽  
Open Angle ◽  
The Relationship

scholarly journals Macular choroidal thickness: evaluation of variability among measurements and assessment of predictive value of glaucomatous visual field damage

2021 ◽  
Author(s):  
Maria Marenco ◽  
Federico Rissotto ◽  
Andrea Palamini ◽  
Carlo Alberto Cutolo ◽  
Giulia Agosto ◽  
...  
Keyword(s):  
Visual Field ◽  
Predictive Value ◽  
Choroidal Thickness ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Mean Deviation ◽  
Choroidal Circulation ◽  
Visual Field Damage ◽  
Visual Field Indices ◽  
The Relationship

Introduction: To investigate the relationship between the choroidal circulation and glaucoma, assessing macular choroidal thickness (MCT) as a predictive value of glaucomatous visual field damage. Methods: Twenty primary open-angle glaucoma patients were recruited. Patients underwent two SS-OCTs scans: one with DRI OCT (Topcon) and the other with PLEX Elite 9000 (Zeiss). Standard OCT parameters were acquired by DRI OCT, while MCT was manually measured in 5 points on Plex ELITE 9000 images. The relationship among MCT, standard OCT parameters and visual field indices were evaluated. Pearson’s r correlation was calculated to evaluate these relationships. Reproducibility of measurements was analyzed. Results: MCT measurements showed a good intra- and inter-observer repeatability. A negative correlation appeared between MCT and body mass index (BMI) (r = -0.518, p=0.023). Mean deviation showed a statistically significant correlation with MCT measured at sub-foveal and at 1000 µm nasally (r = 0.50, p=0.03 and r = 0.52, p=0.023). A correlation was found between the two MCT (Zeiss vs Topcon) measurements and between MCT and peripapillary choroidal thickness (r = 0.944 and r = 0.740, p<0.001, respectively). Conclusions: A good intra- and inter-observer reproducibility was found. MCT showed a weak predictive value of glaucomatous visual field damage. A significant correlation was found between MCT and BMI.

On the relationship between the level of ophthalmotonus, the state of the optic nerve head and the visual field in patients with open-angle glaucoma

1985 ◽  
Vol 66 (2) ◽  
pp. 91-93
Author(s):  
D. I. Sabitova ◽  
L. B. Galiaskarova
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Visual Field ◽  
Optic Nerve Head ◽  
Open Angle Glaucoma ◽  
The State ◽  
Open Angle ◽  
The Relationship

We studied the possibilities of using the approximate static perimeter proposed by MB Vurgaft to assess the state of the visual field in glaucoma and to clarify the relationship between the state of the optic nerve head, the visual field and intraocular pressure in patients with open-angle glaucoma.

scholarly journals Correlation between fundus autofluorescence and visual function in patients with cone-rod dystrophy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Satoru Kanda ◽  
Takumi Hara ◽  
Ryosuke Fujino ◽  
Keiko Azuma ◽  
Hirotsugu Soga ◽  
...  
Keyword(s):  
Visual Field ◽  
Significant Relationship ◽  
Fundus Autofluorescence ◽  
Univariate Analysis ◽  
Retrospective Chart Review ◽  
Mean Deviation ◽  
Wide Field ◽  
The Mean ◽  
The Relationship ◽  
Field Imaging

AbstractThis study aimed to investigate the relationship between autofluorescence (AF) signal measured with ultra-wide field imaging and visual functions in patients with cone-rod dystrophy (CORD). A retrospective chart review was performed for CORD patients. We performed the visual field test and fundus autofluorescence (FAF) measurement and visualized retinal structures with optical coherence tomography (OCT) on the same day. Using binarised FAF images, we identified a low FAF area ratio (LFAR: low FAF/30°). Relationships between age and logMAR visual acuity (VA), central retinal thickness (CRT), central choroidal thickness (CCT), mean deviation (MD) value, and LFAR were investigated. Thirty-seven eyes of 21 CORD patients (8 men and 13 women) were enrolled. The mean patient age was 49.8 years. LogMAR VA and MD were 0.52 ± 0.47 and − 17.91 ± 10.59 dB, respectively. There was a significant relationship between logMAR VA and MD (p = 0.001). LogMAR VA significantly correlated with CRT (p = 0.006) but not with other parameters. Conversely, univariate analysis suggested a significant relationship between MD and LFAR (p = 0.001). In the multivariate analysis, LFAR was significantly associated with MD (p = 0.002). In conclusion, it is useful to measure the low FAF area in patients with CORD. The AF measurement reflects the visual field deterioration but not VA in CORD.

scholarly journals Optic Disc Vascularization in Glaucoma: Value of Spectral-Domain Optical Coherence Tomography Angiography

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Pierre-Maxime Lévêque ◽  
Pierre Zéboulon ◽  
Emmanuelle Brasnu ◽  
Christophe Baudouin ◽  
Antoine Labbé
Keyword(s):  
Visual Field ◽  
Univariate Analysis ◽  
Normal Subjects ◽  
Vessel Density ◽  
Spectral Domain ◽  
Control Group ◽  
Mean Deviation ◽  
Ganglion Cell Complex ◽  
Fiber Layer ◽  
Spectral Domain Oct

Purpose. To detect changes in optic nerve head (ONH) vascularization in glaucoma patients using spectral-domain OCT angiography (OCT-A).Material and Method. Fifty glaucoma patients and 30 normal subjects were evaluated with OCT-A (AngioVue®, Optovue). The total ONH vessel density and temporal disc vessel density were measured. Clinical data, visual field (VF) parameters, and spectral-domain OCT evaluation (RNFL: retinal nerve fiber layer thickness, GCC: ganglion cell complex thickness, and rim area) were recorded for glaucoma patients. Correlations among total and temporal ONH vessel density and structural and VF parameters were analyzed.Results. In the glaucoma group, total and temporal ONH vessel density were reduced by 24.7% (0.412 versus 0.547;p<0.0001) and 22.88% (0.364 versus 0.472;p=0.001), respectively, as compared with the control group. Univariate analysis showed significant correlation between rim area (mm2) and temporal ONH vessel density (r=0.623;p<0.0001) and total ONH vessel density (r=0.609;p<0.0001). Significant correlations were found between temporal and total ONH vessel density and RNFL, GCC, VF mean deviation, and visual field index.Conclusion. In glaucoma patients OCT-A might detect reduced ONH blood vessel density that is associated with structural and functional glaucomatous damage. OCT-A might become a useful tool for the evaluation of ONH microcirculation changes in glaucoma.

Comparing the usefulness of a new algorithm to measure visual field using the variational Bayes linear regression in glaucoma patients, in comparison to the Swedish interactive thresholding algorithm

2021 ◽  
pp. bjophthalmol-2020-318304
Author(s):  
Hiroshi Murata ◽  
Ryo Asaoka ◽  
Yuri Fujino ◽  
Masato Matsuura ◽  
Kazunori Hirasawa ◽  
...  
Keyword(s):  
Visual Field ◽  
Linear Regression ◽  
Open Angle Glaucoma ◽  
Variational Bayes ◽  
Mean Deviation ◽  
Test Duration ◽  
Field Analyser ◽  
Measurement Duration ◽  
Measurement Algorithm ◽  
Thresholding Algorithm

Background/aimsWe previously reported that the visual field (VF) prediction model using the variational Bayes linear regression (VBLR) is useful for accurately predicting VF progression in glaucoma (Invest Ophthalmol Vis Sci. 2014, 2018). We constructed a VF measurement algorithm using VBLR, and the purpose of this study was to investigate its usefulness.Method122 eyes of 73 patients with open-angle glaucoma were included in the current study. VF measurement was performed using the currently proposed VBLR programme with AP-7700 perimetry (KOWA). VF measurements were also conducted using the Swedish interactive thresholding algorithm (SITA) standard programme with Humphrey field analyser. VF measurements were performed using the 24–2 test grid. Visual sensitivities, test–retest reproducibility and measurement duration were compared between the two algorithms.ResultMean mean deviation (MD) values with SITA standard were −7.9 and −8.7 dB (first and second measurements), whereas those with VBLR-VF were −8.2 and −8.0 dB, respectively. There were no significant differences across these values. The correlation coefficient of MD values between the 2 algorithms was 0.97 or 0.98. Test–retest reproducibility did not differ between the two algorithms. Mean measurement duration with SITA standard was 6 min and 02 s or 6 min and 00 s (first or second measurement), whereas a significantly shorter duration was associated with VBLR-VF (5 min and 23 s or 5 min and 30 s).ConclusionVBLR-VF reduced test duration while maintaining the same accuracy as the SITA-standard.

scholarly journals Comparison of Latanoprost/Timolol with Carbonic Anhydrase Inhibitor and Dorzolamide/Timolol with Prostaglandin Analog in the Treatment of Glaucoma

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Kenji Inoue ◽  
Shoichi Soeda ◽  
Goji Tomita
Keyword(s):  
Visual Field ◽  
Fixed Combination ◽  
Open Angle Glaucoma ◽  
Field Testing ◽  
Mean Deviation ◽  
Single Action ◽  
Before And After ◽  
Group 2 ◽  
Concomitant Medications ◽  
Medication Changes

Purpose.We retrospectively reviewed medical records of glaucoma patients to investigate how switching medications may affect intraocular pressure (IOP) management. Three concomitant medications were changed to two medications: one combination drop and one single-action drop. Associated adverse effects were also examined.Subjects and Methods.A total of 112 patients with primary open-angle glaucoma or ocular hypertension were examined. All patients were concomitantly using a prostaglandin (PG) analog, aβ-blocker, and a carbonic anhydrate inhibitor (CAI). Fifty-five patients began using latanoprost (PG analog)/timolol (β-blocker) fixed-combination (LTFC) drops and a CAI (group 1), and 57 patients began using dorzolamide (CAI)/timolol fixed-combination (DTFC) drops and a PG analog (group 2). The IOP was measured every 6 months for 2 years following medication changes. Changes in visual field mean deviation (MD) and medication discontinuations were also examined.Results.There were no significant differences in IOP or MD values before and after medication changes in either group. The proportion of medication discontinuations, uncontrolled IOP, and adverse reactions was similar in both groups.Conclusion.Switching patients from multiple single-action medications to combination medications was not associated with changes in IOP, visual field testing results, or adverse event frequency.

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