A novel approach to improve detection of glucocorticoid doping in sport with new guidance for physicians prescribing for athletes

2021 ◽  
pp. bjsports-2020-103512
Author(s):  
Rosa Ventura ◽  
Peter Daley-Yates ◽  
Irene Mazzoni ◽  
Katia Collomp ◽  
Martial Saugy ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Potential Risk ◽  
Performance Enhancement ◽  
Systemic Effect ◽  
High Potential ◽  
Routes Of Administration ◽  
Novel Approach ◽  
The World ◽  
World Anti Doping Agency ◽  
Pharmacological Potential

The systemic effect of glucocorticoids (GCs) following injectable routes of administration presents a potential risk to both improving performance and causing harm to health in athletes. This review evaluates the current GC antidoping regulations defined by the World Anti-Doping Agency and presents a novel approach for defining permitted and prohibited use of glucocorticoids in sport based on the pharmacological potential for performance enhancement (PE) and risk of adverse effects on health. Known performance-enhancing doses of glucocorticoids are expressed in terms of cortisol-equivalent doses and thereby the dose associated with a high potential for PE for any GC and route of administration can be derived. Consequently, revised and substance-specific laboratory reporting values are presented to better distinguish between prohibited and permitted use in sport. In addition, washout periods are presented to enable clinicians to prescribe glucocorticoids safely and to avoid the risk of athletes testing positive for a doping test.

WADA and Doping in World Sport

2017 ◽  
Author(s):  
Thomas M. Hunt
Keyword(s):  
Performance Enhancement ◽  
Governance Structure ◽  
Second World War ◽  
International Governance ◽  
The World ◽  
World Anti Doping Agency ◽  
The Subject ◽  
The 1960S ◽  
Regulatory Powers ◽  
Second World

Performance enhancement in sport has a long and controversial history. Although several organizations enacted prohibitions on the subject of doping prior to the Second World War, public scrutiny on the issue remained relatively light until the second half of the twentieth century. Beginning in the 1960s, officials passed a number of regulatory measures with the twin goals of protecting the health of athletes and ensuring the fairness of competitions. Due partially to the effects of Cold War political rivalries, the use of drugs by athletes nevertheless remained widespread in the world of sport. This policy situation changed dramatically with the end of the superpower conflict in 1991, however. The following decade was marked by increasingly vociferous calls for reform from outside the international governance structure for sport. In February of 1999, regulatory powers over the subject were centralized in a new organization called the World Anti-Doping Agency (WADA).

scholarly journals Unnatural Technology in a “Natural” Practice? Human Nature and Performance-Enhancing Technology in Sport

Philosophies ◽  
2019 ◽  
Vol 4 (3) ◽  
pp. 35
Author(s):  
Francisco Javier Lopez Frias
Keyword(s):  
Human Nature ◽  
Work Ethic ◽  
Performance Enhancement ◽  
Protestant Ethic ◽  
Critical Questions ◽  
The World ◽  
World Anti Doping Agency ◽  
And Performance ◽  
Spirit Of Sport ◽  
Do So

(1) Background: The World Anti-Doping Agency (WADA) utilizes three criteria to include a technology in the List of Banned Substances and Methods—performance enhancement, health, and the spirit of sport. The latter is arguably the most fundamental one, as WADA justifies the anti-doping mission by appealing to it. (2) Method: Given the interrelationship among the notions of “human nature,” “natural talent,” and “sport,” I investigate what view of human nature underpins the “spirit of sport” criterion. To do so, I focus on both WADA’s official documents and scholarly formulations of the spirit of sport (that align with that of WADA). (3) Results: I show that the value attributed to excellence and effort in WADA’s formulation of the “spirit of sport” criterion has its roots in the notion of human nature of the work ethic that resulted from the secularization of the Protestant ethic. (4) Conclusion: Drawing on my analysis of the “spirit of sport” criterion, I pose critical questions concerning the justification of WADA’s anti-doping campaign and a tentative solution to move forward in the debate.

scholarly journals Performance Enhancement and the Spirit of the Dance. Non Zero Sum

Philosophies ◽  
2020 ◽  
Vol 5 (4) ◽  
pp. 46
Author(s):  
Blanca Rodríguez López
Keyword(s):  
Performance Enhancement ◽  
The World ◽  
World Anti Doping Agency ◽  
Performance Enhancers ◽  
The Difference ◽  
Zero Sum ◽  
Special Case

The current anti-doping policy in sports has enormous costs in economic, social, and human terms. As these costs are likely to become even bigger with the advent of bioenhancing technologies, in this paper I analyze the reasons for this policy. In order to clarify this issue, I compare sports with dance, an activity that has many similarities with sports but where there are no bans on performance enhancers. Considering the World Anti-Doping Agency (WADA) criteria for banning a substance, we argue that two of them, the potential to enhance performance and the risk for health, are similar in dance and sports, thus I claim that the difference had to be in the so-called “spirit” of sports and dance. After looking into this matter and analyzing the special case of dancesport, I conclude that the main difference can be found in the competitive character of sports and the subsequent concern about competitive justice.

scholarly journals Cyanobacteria, cyanotoxins, and their histopathological effects on fish tissues in Fehérvárcsurgó reservoir, Hungary

2021 ◽  
Vol 193 (9) ◽  
Author(s):  
Damjana Drobac Backović ◽  
Nada Tokodi ◽  
Zoran Marinović ◽  
Jelena Lujić ◽  
Tamara Dulić ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Fish Tissue ◽  
Freshwater Ecosystems ◽  
Abramis Brama ◽  
Histopathological Changes ◽  
Fish Tissues ◽  
The World ◽  
Encoding Gene ◽  
Microcystis Wesenbergii ◽  
Histopathological Effects

AbstractCyanobacteria are important members of lake plankton, but they have the ability to form blooms and produce cyanotoxins and thus cause a number of adverse effects. Freshwater ecosystems around the world have been investigated for the distribution of cyanobacteria and their toxins and the effects they have on the ecosystems. Similar research was performed on the Fehérvárcsurgó reservoir in Hungary during 2018. Cyanobacteria were present and blooming, and the highest abundance was recorded in July (2,822,000 cells/mL). The species present were Aphanizomenon flos-aquae, Microcystis flos-aquae, Microcystis wesenbergii, Cuspidothrix issatschenkoi, Dolichospermum flos-aquae, and Snowella litoralis. In July and September, the microcystin encoding gene mcyE and the saxitoxin encoding gene sxtG were amplified in the biomass samples. While a low concentration of microcystin-RR was found in one water sample from July, analyses of Abramis brama and Carassius gibelio caught from the reservoir did not show the presence of the investigated microcystins in the fish tissue. However, several histopathological changes, predominantly in gills and kidneys, were observed in the fish, and the damage was more severe during May and especially July, which coincides with the increase in cyanobacterial biomass during the summer months. Cyanobacteria may thus have adverse effects in this ecosystem.

scholarly journals Interpreting Locked Photographic Data: The Case of Apollo 17 Photo GPN-2000-00113

Designs ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 8
Author(s):  
Pyrrhon Amathes ◽  
Paul Christodoulides
Keyword(s):  
Experimental Data ◽  
Computer Simulations ◽  
The Moon ◽  
Geometrical Analysis ◽  
Apparent Position ◽  
Apollo Program ◽  
The Earth ◽  
Novel Approach ◽  
The World ◽  
The Moment

Photography can be used for pleasure and art but can also be used in many disciplines of science, because it captures the details of the moment and can serve as a proving tool due to the information it preserves. During the period of the Apollo program (1969 to 1972), the National Aeronautics and Space Administration (NASA) successfully landed humans on the Moon and showed hundreds of photos to the world presenting the travel and landings. This paper uses computer simulations and geometry to examine the authenticity of one such photo, namely Apollo 17 photo GPN-2000-00113. In addition, a novel approach is employed by creating an experimental scene to illustrate details and provide measurements. The crucial factors on which the geometrical analysis relies are locked in the photograph and are: (a) the apparent position of the Earth relative to the illustrated flag and (b) the point to which the shadow of the astronaut taking the photo reaches, in relation to the flagpole. The analysis and experimental data show geometrical and time mismatches, proving that the photo is a composite.

scholarly journals A Comprehensive Review of the Ethnotraditional Uses and Biological and Pharmacological Potential of the Genus Mimosa

2021 ◽  
Vol 22 (14) ◽  
pp. 7463
Author(s):  
Ismat Majeed ◽  
Komal Rizwan ◽  
Ambreen Ashar ◽  
Tahir Rasheed ◽  
Ryszard Amarowicz ◽  
...  
Keyword(s):  
Web Of Science ◽  
Scientific Literature ◽  
Therapeutic Potential ◽  
Current Knowledge ◽  
Folk Medicine ◽  
Nutritional Values ◽  
Biological Potential ◽  
The World ◽  
The Future ◽  
Pharmacological Potential

The Mimosa genus belongs to the Fabaceae family of legumes and consists of about 400 species distributed all over the world. The growth forms of plants belonging to the Mimosa genus range from herbs to trees. Several species of this genus play important roles in folk medicine. In this review, we aimed to present the current knowledge of the ethnogeographical distribution, ethnotraditional uses, nutritional values, pharmaceutical potential, and toxicity of the genus Mimosa to facilitate the exploitation of its therapeutic potential for the treatment of human ailments. The present paper consists of a systematic overview of the scientific literature relating to the genus Mimosa published between 1931 and 2020, which was achieved by consulting various databases (Science Direct, Francis and Taylor, Scopus, Google Scholar, PubMed, SciELO, Web of Science, SciFinder, Wiley, Springer, Google, The Plant Database). More than 160 research articles were included in this review regarding the Mimosa genus. Mimosa species are nutritionally very important and several species are used as feed for different varieties of chickens. Studies regarding their biological potential have shown that species of the Mimosa genus have promising pharmacological properties, including antimicrobial, antioxidant, anticancer, antidiabetic, wound-healing, hypolipidemic, anti-inflammatory, hepatoprotective, antinociceptive, antiepileptic, neuropharmacological, toxicological, antiallergic, antihyperurisemic, larvicidal, antiparasitic, molluscicidal, antimutagenic, genotoxic, teratogenic, antispasmolytic, antiviral, and antivenom activities. The findings regarding the genus Mimosa suggest that this genus could be the future of the medicinal industry for the treatment of various diseases, although in the future more research should be carried out to explore its ethnopharmacological, toxicological, and nutritional attributes.

An Analysis of the Structure of Trade Between Australia and China: An Australian Perspective

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Andrew Marks
Keyword(s):  
Adverse Effects ◽  
Employment Growth ◽  
Strategic Trade Policy ◽  
Negative Effects ◽  
Trade Surplus ◽  
Strategic Trade ◽  
Primary Products ◽  
The World ◽  
Balance Of Trade ◽  
Structure Of Trade

AbstractThe structure of exports from Australia to China reveals the dominance of primary products with the structure of imports from this country reflecting the over-reliance on manufacturing goods. This has restrained and led to fluctuations in the balance of trade surplus in Australia thereby leading to lower than otherwise and more volatile output and employment growth. The pattern of trade between Australia and China is representative of trade between Australia and the rest of the world thereby magnifying these adverse effects. Strategic trade policy has the potential to alleviate these negative effects on output and employment growth in Australia.

scholarly journals Elderly and drugs: risks and necessity of rational use

2010 ◽  
Vol 46 (4) ◽  
pp. 617-632 ◽  
Author(s):  
André de Oliveira Baldoni ◽  
Farah Maria Drumond Chequer ◽  
Elisa Raquel Anastácio Ferraz ◽  
Danielle Palma de Oliveira ◽  
Leonardo Régis Leira Pereira ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Adverse Effects ◽  
Elderly Population ◽  
Adverse Drug Events ◽  
The Elderly ◽  
External Factors ◽  
Access To Information ◽  
Inappropriate Use ◽  
The World

In recent decades, the world has undergone a demographic transformation with a rapid growth of the elderly population, resulting in an increased demand for funds to maintain their health and drug consumption. Pharmacokinetic and pharmacodynamic changes occurring in the elderly can interfere directly in the adverse effects of drugs and increase the risk of intoxication. In addition, there are external factors interfering with the pharmacotherapy of the elderly, such as inappropriate use and the lack of access to information. Many therapeutic classes of drugs should be used with caution or avoided in the elderly population, such as anti-inflammatory and some anti-hypertensive drugs, diuretics and digitalis. If not managed carefully, these medicines can affect the safety and quality of life in the elderly. Thus, the aim of this review was to identify drugs that should be used with caution in elderly patients in order to avoid intoxication and/or adverse drug events.

Improved Identification of Portraiture of the Julio-Claudian Period with Mobile Apps

2021 ◽  
Author(s):  
Dmitri A. Gusev
Keyword(s):  
Image Analysis ◽  
Cultural Heritage ◽  
Mobile Apps ◽  
Multiple Views ◽  
Novel Approach ◽  
The World ◽  
Mobile Imaging ◽  
Private Collections ◽  
Historical Periods

We present the results of our image analysis of portrait art from the Roman Empire’s Julio-Claudian dynastic period. Our novel approach involves processing pictures of ancient statues, cameos, altar friezes, bas-reliefs, frescoes, and coins using modern mobile apps, such as Reface and FaceApp, to improve identification of the historical subjects depicted. In particular, we have discovered that the Reface app has limited, but useful capability to restore the approximate appearance of damaged noses of the statues. We confirm many traditional identifications, propose a few identification corrections for items located in museums and private collections around the world, and discuss the advantages and limitations of our approach. For example, Reface may make aquiline noses appear wider or shorter than they should be. This deficiency can be partially corrected if multiple views are available. We demonstrate that our approach can be extended to analyze portraiture from other cultures and historical periods. The article is intended for a broad section of the readers interested in how the modern AI-based solutions for mobile imaging merge with humanities to help improve our understanding of the modern civilization’s ancient past and increase appreciation of our diverse cultural heritage.

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