scholarly journals Study on the safety and efficacy of miltefosine for the treatment of children and adolescents with post-kala-azar dermal leishmaniasis in Bangladesh, and an association of serum vitamin E and exposure to arsenic with post-kala-azar dermal leishmaniasis: an open clinical trial and case–control study protocol

BMJ Open ◽  
2016 ◽  
Vol 6 (5) ◽  
pp. e010050 ◽  
Author(s):  
D Mondal ◽  
M G Hasnain ◽  
M S Hossain ◽  
D Ghosh ◽  
P Ghosh ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Vitamin E ◽  
Children And Adolescents ◽  
Study Protocol ◽  
Case Control Study ◽  
Serum Vitamin ◽  
Case Control ◽  
Safety And Efficacy ◽  
Kala Azar ◽  
Control Study

Association of Cigarette Smoking and Serum Concentrations of Vitamins A and E in Men: A Case-Control Study

2021 ◽  
Author(s):  
Marjan Sohrabi ◽  
Mahmoud Djalali ◽  
Mohammad Hassan Javanbakht ◽  
Niloofar Shekoohi ◽  
Abed Ghavami ◽  
...  
Keyword(s):  
Vitamin E ◽  
Cigarette Smoking ◽  
Vitamin A ◽  
Case Control Study ◽  
Serum Vitamin ◽  
Case Control ◽  
Serum Concentrations ◽  
Blood Concentrations ◽  
Cholesterol Ratio ◽  
Control Study

Background: Cigarette smoking is associated with changes in blood concentrations of some antioxidant vitamins. This study aimed to determine the association of cigarette smoking with serum concentrations of vitamins A and E in men. Methods: This was a case-control study, in which the participants were 80 male smokers and 84 male nonsmokers (age range: 20-60 years). Data on dietary intake, health status, smoking habits, anthropometric characteristics, and vitamin levels were compared between cases and controls. Results: Smokers had significantly lower concentrations of serum vitamin E (p = 0.001) and vitamin A (p = 0.013) compared with nonsmokers. However, serum vitamin E to cholesterol ratio was not significantly different between smokers and nonsmokers. Moreover, the highest circulating concentrations of vitamin E was observed in smokers who smoked ≤9 cigarettes per day (p < 0.03), while and the lowest vitamin E was seen in men smoking ≥20 cigarettes per day. Conclusion: The results of this study identified that cigarette smoking is associated with lower levels of serum vitamin E and vitamin A, although it was not associated with vitamin E to cholesterol ratio.

scholarly journals Individual and occupational risk factors for knee osteoarthritis – Study protocol of a case control study

2008 ◽  
Vol 9 (1) ◽  
Author(s):  
André Klußmann ◽  
Hansjuergen Gebhardt ◽  
Falk Liebers ◽  
Lars Victor von Engelhardt ◽  
Andreas Dávid ◽  
...  
Keyword(s):  
Risk Factors ◽  
Knee Osteoarthritis ◽  
Study Protocol ◽  
Case Control Study ◽  
Case Control ◽  
Occupational Risk ◽  
Occupational Risk Factors ◽  
Control Study

scholarly journals A case control study of serum vitamin D levels in alopecia areata

2020 ◽  
Vol 8 (10) ◽  
pp. 3550
Author(s):  
Bobbili Tarun Kesava Naidu ◽  
Kavya Baddireddy
Keyword(s):  
Vitamin D ◽  
Alopecia Areata ◽  
Case Control Study ◽  
Serum Vitamin ◽  
Autoimmune Disorder ◽  
Case Control ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Severity Of The Disease ◽  
Control Study

Background: Alopecia areata is an autoimmune disorder of anagen hair follicle leading to distressing and relapsing non-scarring hair loss. Vitamin D is an immunomodulator and plays a role in regulating normal hair cycle. Recent evidence suggests inconsistent association between vitamin D deficiency and alopecia areata.Methods: This case control study included 70 newly diagnosed cases of alopecia areata and 70 healthy controls. Competitive chemiluminescence immunoassay was used to determine and compare the serum vitamin D (25‑hydroxyvitamin D) levels between these groups. Also, the serum vitamin D levels correlation with severity of the disease was studied. ANOVA test and student t test were used for the statistical analysis.Results: Serum Vitamin D levels were significantly decreased in alopecia areata patients than in controls (p<0.05). There was no stastically significant relationship between serum 25-OH Vitamin D levels and severity of the disease (p=0.06).Conclusions: Prevalence of serum 25 (OH) deficiency was significantly higher in alopecia areata group. However no significant relation was found with disease severity.

scholarly journals Application of the matched nested case-control design to the secondary analysis of trial data

2020 ◽  
Author(s):  
Christopher Partlett ◽  
Nigel J Hall ◽  
Alison Leaf ◽  
Edmund Juszczak ◽  
Louise Linsell
Keyword(s):  
Clinical Trial ◽  
Case Control Study ◽  
Secondary Analysis ◽  
Control Design ◽  
Case Control ◽  
Necrotising Enterocolitis ◽  
Trial Data ◽  
Standard Case ◽  
Nested Case Control ◽  
Control Study

Abstract Background A nested case-control study is an efficient design that can be embedded within an existing cohort study or randomised trial. It has a number of advantages compared to the conventional case-control design, and has the potential to answer important research questions using untapped prospectively collected data. Methods We demonstrate the utility of the matched nested case-control design by applying it to a secondary analysis of the Abnormal Doppler Enteral Prescription Trial. We investigated the role of milk feed type and changes in milk feed type in the development of necrotising enterocolitis in a group of 398 high risk growth-restricted preterm infants. Results Using matching, we were able to generate a comparable sample of controls selected from the same population as the cases. In contrast to the standard case-control design, exposure status was ascertained prior to the outcome event occurring and the comparison between the cases and matched controls could be made at the point at which the event occurred. This enabled us to reliably investigate the temporal relationship between feed type and necrotising enterocolitis. Conclusions A matched nested case-control study can be used to identify credible associations in a secondary analysis of clinical trial data where the exposure of interest was not randomised, and has several advantages over a standard case-control design. This method offers the potential to make reliable inferences in scenarios where it would be unethical or impractical to perform a randomised clinical trial.

scholarly journals Damaged cardiovascular autonomic control in wheelchair-using children and adolescents with myelomeningocele: a case–control study

2019 ◽  
Vol 23 (1) ◽  
pp. 27-32
Author(s):  
Marisa Maia Leonardi-Figueiredo ◽  
Hugo Celso Dutra de Souza ◽  
Emanuela Juvenal Martins ◽  
Monalisa Squiaveto ◽  
Ana Claudia Mattiello-Sverzut
Keyword(s):  
Children And Adolescents ◽  
Case Control Study ◽  
Case Control ◽  
Autonomic Control ◽  
Cardiovascular Autonomic Control ◽  
Control Study
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