scholarly journals Heart rate, ischaemic heart disease, and sudden cardiac death in middle-aged British men.

Heart ◽  
1993 ◽  
Vol 70 (1) ◽  
pp. 49-55 ◽  
Author(s):  
A G Shaper ◽  
G Wannamethee ◽  
P W Macfarlane ◽  
M Walker
Keyword(s):  
Heart Rate ◽  
Heart Disease ◽  
Sudden Cardiac Death ◽  
Ischaemic Heart Disease ◽  
Cardiac Death ◽  
Middle Aged

scholarly journals A NovelSCN5AMutation in a Patient with Coexistence of Brugada Syndrome Traits and Ischaemic Heart Disease

2009 ◽  
Vol 2009 ◽  
pp. 1-4
Author(s):  
Anders G. Holst ◽  
Kirstine Calloe ◽  
Thomas Jespersen ◽  
Pernille Cedergreen ◽  
Bo G. Winkel ◽  
...  
Keyword(s):  
Heart Disease ◽  
Sudden Cardiac Death ◽  
Ischaemic Heart Disease ◽  
Brugada Syndrome ◽  
Cardiac Death ◽  
Novel Mutation ◽  
Index Patient ◽  
Proarrhythmic Effect ◽  
Electrical Heart Disease ◽  
Disease Entities

Brugada syndrome (BrS) is a primary electrical heart disease, which can lead to sudden cardiac death. In older patients with BrS, the disease may coexist with ischaemic heart disease (IHD) and recent studies support a synergistic proarrhythmic effect of the two disease entities. We report a case that illustrates this. The index patient was a middle-aged patient with BrS traits, IHD, and aborted sudden cardiac death. Mutation analysis discovered a novel mutation P468L in theNaV1.5 sodium channel. Surprisingly, voltage-clamp experiments on the wild-type and mutantNaV1.5 channels expressed in HEK cells revealed no functional effect of the mutation. In a patient like ours, the distinction between IHD and BrS as the cause of an aborted sudden cardiac death is hard to establish and mounting evidence shows that coexistence of the two may have a synergistic proarrhythmic effect.

scholarly journals Cold spells and ischaemic sudden cardiac death: effect modification by prior diagnosis of ischaemic heart disease and cardioprotective medication

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Niilo R. I. Ryti ◽  
Elina M. S. Mäkikyrö ◽  
Harri Antikainen ◽  
M. Juhani Junttila ◽  
Eeva Hookana ◽  
...  
Keyword(s):  
Heart Disease ◽  
Sudden Cardiac Death ◽  
Ischaemic Heart Disease ◽  
Cardiac Death ◽  
Effect Modification

scholarly journals Omega-3 index of erythrocytes and predictors of sudden cardiac death in patients with coronary heart disease and ventricular arrhythmias

2012 ◽  
Vol 11 (4) ◽  
pp. 16-22
Author(s):  
E. M. Gavva ◽  
D. A. Tsaregorodtsev ◽  
I. S. Mamedov ◽  
V. A. Sulimov
Keyword(s):  
Heart Rate ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Ventricular Arrhythmias ◽  
Omega 3 ◽  
Chromatography Method ◽  
Heart Rate Turbulence ◽  
Ventricular Extrasystoles

Aim. To assess the association between ω-3 index of erythrocytes and demographic, electrophysiological, and echocardiographic (EchoCG) predictors of sudden cardiac death (SCD) in patients with coronary heart disease (CHD) and ventricular arrhythmias (VA). Material and methods. The study included 25 patients with a verified diagnosis of CHD and VA. Gas chromatography method was used to measure the content (%) of eicosapentaenoic (EPA) and docosahexaenoic (DHA) polyunsaturated fatty acids (PUFA) in peripheral blood erythrocytes, with the calculation of a summary (EPA + DHA) ω-3 index. All participants underwent 24-hour electrocardiography (ECG) monitoring, with the assessment of maximal, minimal, and mean heart rate (HR), heart rate variability (HRV) parameters (SDNN and pNN50), heart rate turbulence (TO and TS), microvolt T wave alternans (mTWA), and the number of ventricular extrasystoles (VE) and transient and persistent ventricular tachycardia (VT) episodes. All patients also underwent EchoCG. Results. In examined patients, the values of ω-3 index of erythrocytes varied from 1,12% to 6,4% (mean 3,74%, 95% CI 2,02-4,38%). There was a weak correlation between ω-3 index or EPA levels (%) and the HRV parameter of pNN50. In addition, ω-3 index or DHA levels (%) negatively correlated with the daily VE number. The 5:00 AM value of mTWA (II lead, update factor 1/8) weakly correlated withω-3 index and DHA levels. There was a moderate positive correlation between E/A ratio and omega-3 index, or EPA and DHA levels. Conclusion. Patients with CHD and VA were characterised by low ω-3 index values and high (56%) or moderate (44%) levels of cardiovascular risk. The values of ω-3 index positively correlated with the daily VE number and negatively correlated with E/A ratio and pNN50 parameter of HRV.

scholarly journals Relative peak exercise oxygen pulse is related to sudden cardiac death, cardiovascular and all-cause mortality in middle-aged men

2018 ◽  
Vol 25 (7) ◽  
pp. 772-782 ◽  
Author(s):  
Jari A Laukkanen ◽  
Claudio Gil S Araújo ◽  
Sudhir Kurl ◽  
Hassan Khan ◽  
Sae Y Jae ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Heart Disease ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Peak Exercise ◽  
Middle Aged ◽  
Oxygen Pulse ◽  
Hazard Ratios ◽  
Disease Mortality ◽  
All Cause Mortality

Background Preliminary evidence suggests that peak exercise oxygen pulse – peak oxygen uptake/heart rate-, a variable obtained during maximal cardiopulmonary exercise testing and a surrogate of stroke volume, is a predictor of mortality. We aimed to assess the associations of peak exercise oxygen pulse with sudden cardiac death, fatal coronary heart disease and cardiovascular disease and all-cause mortality. Design A prospective study. Methods Peak exercise oxygen pulse was assessed in a maximal cycling test at baseline in 2227 middle-aged men of the Kuopio Ischaemic Heart Disease cohort study using expired gas variables and electrocardiograms. Relative peak exercise oxygen pulse was obtained by dividing the absolute value by body weight. Results During a median follow-up of 26.1 years 1097 subjects died; there were 220 sudden cardiac deaths, 336 fatal coronary heart diseases and 505 fatal cardiovascular diseases. Relative peak exercise oxygen pulse (mean 19.5 (4.1) mL per beat/kg/102) was approximately linearly associated with each outcome. Comparing extreme quartiles of relative peak exercise oxygen pulse, hazard ratios (95% confidence intervals) for sudden cardiac death, fatal coronary heart disease and cardiovascular disease, and all-cause mortality on adjustment for cardiovascular risk factors were 0.55 (0.36–0.83), 0.58 (0.42–0.81), 0.60 (0.46–0.79) and 0.59 (0.49–0.70), respectively ( P < 0.001 for all). The hazard ratios were unchanged on further adjustment for C-reactive protein and the use of beta-blockers. The addition of relative peak exercise oxygen pulse to a cardiovascular disease mortality risk prediction model significantly improved risk discrimination (C-index change 0.0112; P = 0.030). Conclusion Relative peak exercise oxygen pulse measured during maximal exercise was linearly and inversely associated with fatal cardiovascular and all-cause mortality events in middle-aged men. In addition, relative peak exercise oxygen pulse provided significant improvement in cardiovascular disease mortality risk assessment beyond conventional risk factors.

scholarly journals B-PO05-190 ATHLETES WITH SUDDEN CARDIAC DEATH-PREDISPOSING GENETIC HEART DISEASE: WINNING THE ‘RETURN-TO-PLAY’ GAME

Heart Rhythm ◽  
2021 ◽  
Vol 18 (8) ◽  
pp. S449
Author(s):  
Kathryn E. Tobert ◽  
Johan Martijn Bos ◽  
Ramin Garmany ◽  
Michael John Ackerman
Keyword(s):  
Heart Disease ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Return To Play ◽  
Play Game ◽  
Genetic Heart Disease
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