Villoglandular adenocarcinoma of the cervix recurrent in an episiotomy scar: a case report in a 32-year-old female

2005 ◽  
Vol 15 (2) ◽  
pp. 366-371 ◽  
Author(s):  
D. E. Heron ◽  
A. Axtel ◽  
K. Gerszten ◽  
A. Amortegui ◽  
J. Kelley ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Preoperative Radiotherapy ◽  
Complete Response ◽  
Therapeutic Value ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Considerable Controversy ◽  
Long Term Prognosis ◽  
Well Differentiated

Cervical cancer during pregnancy is rare, occurring in approximately 3% of cervical cancer cases. Considerable controversy exists as to the long-term prognosis of patients diagnosed during pregnancy. A 32-year-old female presented with vaginal spotting in April 1998. A prenatal smear in December 1996 revealed atypical glandular cells of undetermined significance. A sterile speculum exam in April 1997 at 31-week gestational age revealed a polyp on the anterior lip of the cervix, pathology consistent with a well-differentiated villoglandular adenocarcinoma. In August 1997, the patient underwent a radical hysterectomy with pelvic/para-aortic lymphadenectomy. In April 2001, she represented with nodular perineal mass in the episiotomy incision. She received preoperative radiotherapy with a near-complete response and remained without disease for >10 months. It appears that a less radical procedure can offer significant therapeutic value. Preoperative radiotherapy proved effective at achieving a near-complete response. The patient underwent a wide local excision of the perineal area with resultant negative margins

Long-term prognosis of well-differentiated adenocarcinoma in endoscopically removed colorectal adenomas

1994 ◽  
Vol 39 (9) ◽  
pp. 2034-2037 ◽  
Author(s):  
Kent N. Cunningham ◽  
Luther R. Mills ◽  
Bernard M. Schuman ◽  
David H. Mwakyusa
Keyword(s):  
Colorectal Adenomas ◽  
Long Term Prognosis ◽  
Well Differentiated

Significance of Tumor Capsular Invasion in Well-Differentiated Thyroid Carcinomas

2007 ◽  
Vol 73 (5) ◽  
pp. 484-491 ◽  
Author(s):  
Julio C. Furlan ◽  
Yvan C. Bedard ◽  
Irving B. Rosen
Keyword(s):  
Clinical Outcome ◽  
Prognostic Index ◽  
University Teaching ◽  
Biological Behavior ◽  
Capsular Invasion ◽  
Short Term ◽  
European Organization ◽  
Long Term Prognosis ◽  
Well Differentiated

This study examines the influence of tumor capsular invasion on the biological behavior of papillary (PTC) and follicular thyroid carcinoma (FTC) and the prognosis of surgically treated patients. This retrospective cohort study included 350 cases of PTC or FTC from a university teaching hospital. Patient charts were randomly selected and reviewed. The study population was divided into PTC and FTC groups. Each group was subdivided into CI+ (with tumor capsular invasion) and CI- subgroups (without tumor capsule or without capsular invasion). The long-term prognosis was assessed using the American Joint Committee on Cancer pTNM staging and the prognostic index was elaborated by the European Organization for Research and Treatment of Cancer. There were 284 women and 66 men (ages 19–89 years, mean of 44) with an incidence of 53.1 per cent for CI+ tumors. There were no significant differences between the PTC subgroups regarding the short-term clinical outcome and the long-term prognosis. Although patients with CI+ FTC showed lower incidence of lymph node metastasis than patients with CI- FTC, the FTC subgroups were comparable regarding the short-term clinical outcome and the long-term prognosis. Our results suggest that presence of tumor capsular invasion does not adversely influence biological behavior or survival of PTC or FTC. Moreover, the presence of tumor capsular invasion appears to not have significance for the long-term prognosis of patients with PTC or FTC.

scholarly journals Risk of invasive cervical cancer after atypical glandular cells in cervical screening: nationwide cohort study

BMJ ◽  
2016 ◽  
pp. i276 ◽  
Author(s):  
Jiangrong Wang ◽  
Bengt Andrae ◽  
Karin Sundström ◽  
Peter Ström ◽  
Alexander Ploner ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cohort Study ◽  
Cervical Screening ◽  
Invasive Cervical Cancer ◽  
Glandular Cells ◽  
Atypical Glandular Cells

scholarly journals Long Term Effectiveness of Photodynamic Therapy for CIN Treatment

2019 ◽  
Vol 12 (3) ◽  
pp. 107 ◽  
Author(s):  
Natalia Mayumi Inada ◽  
Hilde Harb Buzzá ◽  
Marieli Fernanda Martins Leite ◽  
Cristina Kurachi ◽  
Jose Roberto Trujillo ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Photodynamic Therapy ◽  
Placebo Group ◽  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
Complete Response ◽  
Incidence Rates ◽  
South Central

(1) Background: Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in women worldwide. The highest incidence rates are in Africa, followed by South-Central Asia and South America. According to the Brazilian National Institute of Cancer (INCA), 16,370 new cases of cervical cancer were estimated for each year of the biennium of 2018–2019. About 90% of cervical cancers originate from the malignant progression of cervical intraepithelial neoplasia (CIN) which is classified based on cytohistological characteristics (low- and high-grade lesions). The present study reports the long-term effectiveness of topical photodynamic therapy (PDT) for CIN grades 1 and 2/3 with up to two years of follow up. (2) Methods: A total of 56 patients with CIN 1, ten with CIN 2, and 14 patients for the placebo group were enrolled in this study. (3) Results: 75% (n = 42) of CIN 1 patients presented a complete response to PDT and only 23.2% (n = 13) of recurrence, progression, and/or lesions remaining two years after PDT. For CIN 2/3 patients, 90% were observed to be cured after one and two years of follow up. (4) Conclusions: PDT presented best results two years after a non-invasive, fast, and low-cost procedure and in comparison with the placebo group, preventing the progression of cervical intraepithelial neoplasia and preserving the cervix.

Long-term results of concurrent radiation and chemotherapy for carcinoma of the cervix recurrent after surgery

1993 ◽  
Vol 3 (4) ◽  
pp. 193-198 ◽  
Author(s):  
G. M. Thomas ◽  
A. J. Dembo ◽  
T. Myhr ◽  
B. Black ◽  
J. F. Pringle ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Prognostic Significance ◽  
Side Wall ◽  
Distant Metastases ◽  
Complete Response ◽  
Long Term Results ◽  
Disease Extent ◽  
Short Intervals ◽  
Initial Surgery

Between 1981 and 1991, 41 patients with carcinoma of the cervix recurrent only in the pelvis, or pelvis and para-aortic nodes after initial surgery, were treated with concurrent chemo-radiation (CT-RT). The total dose of radiation was tailored to the disease extent. Radiation was delivered to the pelvis and/or pelvis plus para-aortic nodes. Concurrent infusional 5-fluorouracil 1.5 g m-2 day-1 was delivered with bid radiation for one to three courses of 3 or 4 days. In addition, 10 patients received one or two courses of intravenous mitomycin C (Mit C) 6 mg m−2. Twenty-three of 40 evaluable (58%) had a complete response to CT-RT. Five have subsequently relapsed, two in pelvis alone, one in pelvis and distant sites and two with distant metastases only. Eighteen of 40 (45%) remain alive without disease from 3 to 113 months (median 57 months) after CT-RT. Sustained complete remissions and apparent cure have occured even in poor pronosis patients with pelvic side wall or common iliac nodal diease and those recurrent at short intervals from surgery. Using logistic regression the following varibles were examined for their prognostic significance for pelvic control and survival: Mit C, extent of pelvic diseases number of course of 5-FU, nodal status at original surgery and radiation dose. On multivariate analysis only the number of courses of 5-FU used was predictive of pelvic control and survival. Concurrent 5-FU and radiation is recommended as salvage therapy for patients wth recurrent locoregional cervical cancer.

scholarly journals Importance of cytology in the identification of villoglandular adenocarcinoma

2017 ◽  
Author(s):  
Ana Correia ◽  
Madalena Vilar ◽  
Cidália Teixeira
Keyword(s):  
Screening Program ◽  
Cervical Adenocarcinoma ◽  
Reproductive Age ◽  
Local Health ◽  
Sample Collection ◽  
Local Health Unit ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Well Differentiated ◽  
Conclusive Diagnosis

Endocervical villoglandular adenocarcinoma is a rare subtype of cervical adenocarcinoma. It arises mainly in young and reproductive age women and it has a lower incidence and better prognosis compared to cervical adenocarcinoma. The present case study refers to a conventional cytology performed on a 48-year-old woman within a screening program carried out at a health center of the Local Health Unit of Matosinhos. The objective of this study is to verify the importance of the cytological sample collection method for a better observation and interpretation of the cytological findings in rare neoplastic entities, as well as to reinforce the importance of the application of complementary tests for the elaboration of a conclusive diagnosis. The cytological result of the present case report was atypical glandular cells (AGC) of the endocervical type. Subsequently, a biopsy of the uterine cervix, a conization and a curettage of endocervix were performed, whose histological diagnosis was well differentiated villoglandular adenocarcinoma from the endocervix.

scholarly journals Cervical Lesion: Types and Etiology

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Fasogbon Samuel Ayobami
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Cervical Screening ◽  
Cervical Lesion ◽  
Early Age ◽  
Related Factors ◽  
Squamous Cells ◽  
Multiple Sex Partners ◽  
Glandular Cells ◽  
Atypical Glandular Cells

A cervical lesion is an area of abnormal tissue found on the cervix, which is the lower end of a woman’s uterus. The type of the lesion can be atypical squamous cells, squamous intraepithelianeoplasia, and atypical glandular cells. The early stages of cervical cancer may be asymptomatic. In advanced disease, there may be metastases to the abdomen, lungs or any other organ. Infection with some types of human papilloma virus (HPV) is the highest risk factor for cervical cancer which can be transmitted due to multiple sex partners, followed by smoking. Other risk factors include human immunodeficiency virus (HIV), early age at first sexual intercourse, early age at first pregnancy, tobacco use, exposure to passive smoke and other related factors. It is therefore recommended that all the risk factors should be avoided to reduce cervical cancer in the society and women should go for regular cervical screening as early detection can easily be treated.

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