Treatment of ruptured and unruptured cerebral aneurysms in the USA: a paradigm shift

2018 ◽  
Vol 10 (Suppl 1) ◽  
pp. i69-i76 ◽  
Author(s):  
Ning Lin ◽  
Kevin S Cahill ◽  
Kai U Frerichs ◽  
Robert M Friedlander ◽  
Elizabeth B Claus

BackgroundIntegration of data from clinical trials and advancements in technology predict a change in selection for treatment of patients with cerebral aneurysm.ObjectiveTo describe patterns of use and in-hospital mortality associated with surgical and endovascular treatments of cerebral aneurysms over the past decade.Materials and methodsThe data are 34 899 hospital discharges with a diagnosis of ruptured or unruptured cerebral aneurysm from 1998 to 2007 identified from the Nationwide Inpatient Sample (NIS). The rates of endovascular coiling and surgical clipping and in-hospital mortality among patients with an aneurysm are examined over a decade by hospital and patient demographic characteristics.ResultsFrom 1998 to 2007, 20 134 discharges with a ruptured aneurysm and 14 765 discharges with an unruptured aneurysm were identified. Over this decade, the number of patients discharged with a ruptured aneurysm was stable while the number discharged with an unruptured aneurysm increased significantly. The use of endovascular coiling increased at least twofold for both groups of patient (p<0.001) with the majority of unruptured aneurysms treated with coiling by 2007. Although whites were more likely than non-whites to undergo coiling versus clipping for a ruptured aneurysm (OR=1.30; 95% CI 1.13 to 1.48) and men with unruptured aneurysms were more likely than women to undergo coiling (OR=1.26; 95% CI 1.13 to 1.40), by 2007 differences in treatment selection by gender and racial subgroups were decreased or statistically non-significant. Over time the use of coiling spread from primarily large, teaching hospitals to smaller, non-teaching hospitals.ConclusionsThe majority of unruptured aneurysms in the USA are now treated with endovascular coiling. Although surgical clipping is used for treatment of most ruptured aneurysms, its use is decreasing over time. Dissemination of endovascular procedures appears widespread across patient and hospital subgroups.

Author(s):  
Hamidreza Saber ◽  
Naoki Kaneko ◽  
David Kimball ◽  
Jose Morales ◽  
Satoshi Tateshima ◽  
...  

Introduction : Age is an important determinant of outcome in patients with unruptured or ruptured cerebral aneurysms. Advancements in endovascular therapies have significantly impacted patient selection and treatment of patients with cerebral aneurysm. Recent release of the National claims data for 2017–2018 provides the opportunity to explore novel population‐level outcomes following clipping vs endovascular treatment of ruptured and unruptured cerebral aneurysms in different age groups. Methods : Analysis of US National Inpatient Sample of hospitalizations with aneurysmal subarachnoid hemorrhage (aSAH) or unruptured aneurysms treated with clipping or endovascular therapy from January 1, 2017 to December 31, 2018. Pre‐defined age strata included: younger than 50 years; 50–64 years; 65–79 years; and 80 years or older. Primary outcomes included in‐hospital mortality and favorable outcome defined as discharge to home. Results : Overall, 34,955 hospitalizations with unruptured aneurysm treatment, (26,695 endovascular and 8,260 surgical clipping), and 17,525 hospitalizations with aSAH were identified in the study period. In unruptured aneurysm group, endovascular therapy was associated with significantly higher favorable outcome across all age groups, and lower mortality in those 65 years or older (all P<0.001) when compared to clipping. Median hospital length‐of‐stay was 1 day (IQR 1–4) in endovascular vs 4 days (IQR 3–8) in clipping group (P<0.001). In aSAH group, endovascular therapy was associated with higher favorable outcome in 50–80 years age groups when compared to clipping, with no significant differences for in‐hospital mortality outcome (Table). Significantly more favorable outcomes were achieved with coiling vs clipping in those aged 65 or above with unruptured aneurysms. Conclusions : In 2017–2018 in US, unruptured aneurysm patients treated with endovascular therapy had significantly lower morbidity and mortality compared to those treated with surgical clipping, and differences were more pronounced with age. Similar but less strong association was observed in patients with aSAH.


2014 ◽  
Vol 14 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Aws Alawi ◽  
Randall C. Edgell ◽  
Samer K. Elbabaa ◽  
R. Charles Callison ◽  
Yasir Al Khalili ◽  
...  

Object Endovascular coiling and surgical clipping are viable treatment options of cerebral aneurysms. Outcome data of these treatments in children are limited. The objective of this study was to determine hospital mortality and complication rates associated with surgical clipping and coil embolization of cerebral aneurysms in children, and to evaluate the trend of hospitals' use of these treatments. Methods The authors identified a cohort of children admitted with the diagnoses of cerebral aneurysms and aneurysmal subarachnoid hemorrhage from the Kids' Inpatient Database for the years 1998 through 2009. Hospital-associated complications and in-hospital mortality were compared between the treatment groups and stratified by aneurysmal rupture status. A multivariate regression analysis was used to identify independent variables associated with in-hospital mortality. The Cochrane-Armitage test was used to assess the trend of hospital use of these operations. Results A total of 1120 children were included in this analysis; 200 (18%) underwent aneurysmal clipping and 920 (82%) underwent endovascular coiling. Overall in-hospital mortality was higher in the surgical clipping group compared with the coil embolization group (6.09% vs 1.65%, respectively; adjusted odds ratio [OR] 2.52, 95% CI 0.97–6.53, p = 0.05). The risk of postoperative stroke or hemorrhage was similar between the two treatment groups (p = 0.86). Pulmonary complications and systemic infection were higher in the surgical clipping population (p < 0.05). The rate of US hospitals' use of endovascular coiling has significantly increased over the years included in this study (p < 0.0001). Teaching hospitals were associated with a lower risk of death (OR 0.13, 95% CI 0.03–0.46; p = 0.001). Conclusions Although both treatments are valid, endovascular coiling was associated with fewer deaths and shorter hospital stays than clip placement. The trend of hospitals' use of coiling operations has increased in recent years.


2020 ◽  
Vol 132 (3) ◽  
pp. 788-796 ◽  
Author(s):  
Christian Lopez Ramos ◽  
Robert C. Rennert ◽  
Michael G. Brandel ◽  
Peter Abraham ◽  
Brian R. Hirshman ◽  
...  

OBJECTIVESafety-net hospitals deliver care to a substantial share of vulnerable patient populations and are disproportionately impacted by hospital payment reform policies. Complex elective procedures performed at safety-net facilities are associated with worse outcomes and higher costs. The effects of hospital safety-net burden on highly specialized, emergent, and resource-intensive conditions are poorly understood. The authors examined the effects of hospital safety-net burden on outcomes and costs after emergent neurosurgical intervention for ruptured cerebral aneurysms.METHODSThe authors conducted a retrospective analysis of the Nationwide Inpatient Sample (NIS) from 2002 to 2011. Patients ≥ 18 years old who underwent emergent surgical clipping and endovascular coiling for aneurysmal subarachnoid hemorrhage (SAH) were included. Safety-net burden was defined as the proportion of Medicaid and uninsured patients treated at each hospital included in the NIS database. Hospitals that performed clipping and coiling were stratified as low-burden (LBH), medium-burden (MBH), and high-burden (HBH) hospitals.RESULTSA total of 34,647 patients with ruptured cerebral aneurysms underwent clipping and 23,687 underwent coiling. Compared to LBHs, HBHs were more likely to treat black, Hispanic, Medicaid, and uninsured patients (p < 0.001). HBHs were also more likely to be associated with teaching hospitals (p < 0.001). No significant differences were observed among the burden groups in the severity of subarachnoid hemorrhage. After adjusting for patient demographics and hospital characteristics, treatment at an HBH did not predict in-hospital mortality, poor outcome, length of stay, costs, or likelihood of a hospital-acquired condition.CONCLUSIONSDespite their financial burden, safety-net hospitals provide equitable care after surgical clipping and endovascular coiling for ruptured cerebral aneurysms and do not incur higher hospital costs. Safety-net hospitals may have the capacity to provide equitable surgical care for highly specialized emergent neurosurgical conditions.


2015 ◽  
Vol 21 (6) ◽  
pp. 654-658 ◽  
Author(s):  
Peng Liu ◽  
Xianli Lv ◽  
Youxiang Li ◽  
Ming Lv

We present three cases of cerebral aneurysms (1 unruptured; 2 ruptured) treated with endovascular techniques in pregnancies. The first ruptured case is a 28-year-old female on 20th gestational week. After the endovascular coiling, the patient suffered persistent hemiparesis and delivered a healthy baby by cesarean section. The second ruptured case is a 25-year-old female on 36th week of pregnancy. She died of aneurysm re-rupture after delivery of a healthy baby by cesarean section. The third unruptured case is a 31-year-old woman on the 26th gestational week of pregnancy who died of a giant basilar tip aneurysm after stent-assisted coiling. Ruptured aneurysm obliteration should be prioritized followed by vaginal delivery or cesarean section. The decision regarding the treatment of unruptured aneurysms should be carefully considered on a case-by-case basis. Stent-assisted coiling may be applicable to aneurysm during pregnancy.


2020 ◽  
Vol 12 (7) ◽  
pp. 682-687 ◽  
Author(s):  
Evan Luther ◽  
David J McCarthy ◽  
Marie-Christine Brunet ◽  
Samir Sur ◽  
Stephanie H Chen ◽  
...  

BackgroundFollowing publication of the International Subarachnoid Aneurysm Trial (ISAT), treatment paradigms for cerebral aneurysms (CAs) shifted from open surgical clipping to endovascular embolization as primary therapy in a majority of cases. However, comprehensive analyses evaluating more recent CA diagnosis patterns, patient populations and outcomes as a function of treatment modality remain rare.MethodsThe National Inpatient Sample from 2004 to 2014 was reviewed. Aneurysmal subarachnoid hemorrhages (aSAHs) and unruptured intracranial aneurysms (UIAs) with a treatment of surgical clipping or endovascular therapy (EVT) were identified. Time trend series plots were created. Linear and logistic regressions were utilized to quantify treatment changes.Results114 137 aSAHs and 122 916 UIAs were reviewed. aSAH (+732/year, p=0.014) and UIA (+2550/year, p<0.0001) discharges increased annually. The annual caseload of surgical clippings for aSAH decreased (−264/year, p=0.0002) while EVT increased (+366/year, p=0.0003). For UIAs, the annual caseload for surgical clipping remained stable but increased for EVT (+615/year, p<0.0001). The rate of incidentally diagnosed UIAs increased annually (+1987/year; p<0.0001). Inpatient mortality decreased for clipping (p<0.0001) and EVT in aSAH (p<0.0001) (2004 vs 2014—clipping 13% vs 11.7%, EVT 15.8% vs 12.7%). Mortality rates for clipped UIAs decreased over time (p<0.0001) and remained stable for EVT (2004 vs 2014—clipping 1.57% vs 0.40%, EVT 0.59% vs 0.52%).ConclusionRuptured and unruptured CAs are increasingly being treated with EVT over clipping. Incidental unruptured aneurysm diagnoses are increasing dramatically. Mortality rates of ruptured aneurysms are improving regardless of treatment modality, whereas mortality in unruptured aneurysms is only improving for surgical clipping.


Author(s):  
Haithem Babiker ◽  
L. Fernando Gonzalez ◽  
Felipe Albuquerque ◽  
Daniel Collins ◽  
Arius Elvikis ◽  
...  

Treatment options for cerebral aneurysms have drastically evolved in the last decade. In the past, surgical clipping through craniotomy was the predominant treatment option for cerebral aneurysms. Presently, endovascular coiling, a minimally invasive technique, has superseded clipping in many centers [1]. However, the coiling of wide-neck aneurysms is still a challenge [2]. Complete aneurysmal occlusion is often impossible [3]. Recently, stand-alone stents have been explored as an alternative treatment option for wide-neck aneurysms [4].


2007 ◽  
Vol 5 (1) ◽  
pp. 0-0
Author(s):  
Gytis Šustickas ◽  
Jurgita Ušinskienė ◽  
Gintaras Migauskas ◽  
Ugnius Kšanas ◽  
Robertas Kvaščevičius ◽  
...  

Gytis Šustickas1, Jurgita Ušinskienė2, Gintaras Migauskas1, Ugnius Kšanas1, Robertas Kvaščevičius1, Saulius Širšinaitis1, Jolita Gaidelienė3, Virginija Gaigalaitė11 Vilniaus universiteto Neurologijos ir neurochirurgijos klinikaŠiltnamių g. 29, LT-04130 Vilnius2 Vilniaus universiteto Pulmonologijos ir radiologijos klinika,Santariškių g. 12, LT-08661 Vilnius3 VšĮ Vilniaus greitosios pagalbos universitetinės ligoninės Anesteziologijos skyrius,Šiltnamių g. 29, LT-04130 VilniusEl paštas: [email protected] Įvadas / tikslas Sparčiai tobulėjančios kompiuterinės technologijos, gerėjanti galvos smegenų kraujagyslių diagnostika iškėlė naują problemą gydytojams: kaip elgtis su neplyšusia galvos smegenų arterijos aneurizma (GSAA). Jos plyšimo rizikos įvertinimas, prognozinių veiksnių paieška sukėlė naują bangą pasaulinėje neurochirurgijoje ir neuroradiologijoje. Greitai ateis diena, kai kas dvidešimtam pasaulio gyventojui turėsime paaiškinti, koks optimalus jam diagnozuotos galvos smegenų arterijos aneurizmos gydymas. Pagrindinis mūsų tyrimo tikslas – įvertinti aneurizmos maišo ir kaklo santykio klinikinę reikšmę prognozuojant galimą aneurizmos plyšimą. Ligoniai ir metodai Prospektyviai ištirti visi 265 pacientai, 2000–2006 metais VšĮ Vilniaus greitosios pagalbos universitetinės ligoninės Neurochirurgijos ir Reanimacijos skyriuose gydyti nuo galvos smegenų arterijos maišelinės aneurizmos. 23 pacientams diagnozuota neplyšusi, 242 pacientams – plyšusi aneurizma. Šioje grupėje 36 pacientams aneurizma plyšo pakartotinai. Pacientai suskirstyti į tris grupes: neplyšusių (n = 23), plyšusių pirmą kartą (n = 206) ir plyšusių pakartotinai (n = 36) aneurizmų. Atlikti visų maišelinių aneurizmų maišo ir kaklo matavimai, įvertinta aneurizmos lokalizacija, paciento amžius, atlikta statistinė analizė. Verpstinės ir gigantinės aneurizmos į tyrimą neįtrauktos. Rezultatai Galvos smegenų arterijos maišelinės aneurizmos maišo ir kaklo santykis (MKS) statistiškai reikšmingai skyrėsi visose trijose pacientų grupėse: neplyšusių MKS 1,83 ± 0,2 (p < 0,01), plyšusių pirmą kartą – 2,36 ± 0,05 (p < 0,01) ir plyšusių pakartotinai – 3,1 ± 0,08 (p < 0,01). Didėjant MKS, labai daugėjo plyšusių aneurizmų, kad ir kokia būtų aneurizmos lokalizacija. Pats aneurizmos maišo dydis nebuvo toks reikšmingas tirtiems pacientams. Aneurizmos kaklas didesnis greitos kraujotakos arterijose (3,45 ± 0,17 mm), palyginti su lėtos kraujotakos jungiančiosiose arterijose (3,01 ± 0,07 mm; p < 0,05). Išvados Gauti statistiškai reikšmingi MKS duomenys į klinikinę praktiką mums leidžia įtraukti dar vieną labai svarbų GSAA parametrą, kuris gali būti papildomas veiksnys sprendžiant dėl neplyšusios besimptomės aneurizmos gydymo taktikos. Taip pat šis parametras gali būti naudingas numatant plyšusios GSAA aktyvaus gydymo terminus. Pagrindiniai žodžiai: maišo ir kaklo santykis, aneurizmos plyšimo rizika, neplyšusi aneurizma, plyšusi aneurizma, subarachnoidinė hemoragija Clinical significance of cerebral arterial aneurysm dome / neck ratio Gytis Šustickas1, Jurgita Ušinskienė2, Gintaras Migauskas1, Ugnius Kšanas1, Robertas Kvaščevičius1, Saulius Širšinaitis1, Jolita Gaidelienė3, Virginija Gaigalaitė11 Vilnius University, Clinic of Neurology and Neurosurgery,Šiltnamių 29, LT-04130 Vilnius, Lithuania2 Vilnius University, Clinic of Pulmonology and Radiology3 Vilnius University Emergency Hospital, Department of Anaesthesiology,Šiltnamių 29, LT-04130 Vilnius, LithuaniaE-mail: [email protected] Background / objective The present prospective study was undertaken to assess the reliability of the aspect ratio (i.e. aneurysm deph to aneurysm neck width) for predicting aneurysm rupture. Unruptured aneurysm, ruptured aneurysm and rebleeded aneurysm patient groups are compared. Aneurysm size, site, patient age and gender also are taken into account. Patients and methods Intraoperative measurements were made of consecutive patients with 265 aneurysms in three patient groups admitted between 2000 and 2006 to Department of Neurosurgery, Vilnius University Emergency Hospital. 23 unruptured aneurysms, 206 ruptured and 36 which rebled where included into the study. Giant and fusiform aneurysms were excuded from the study. Results Aspect ratio was 1.83 ± 0.2 (p < 0.01) for unruptured aneurysms, 2.36 ± 0.05 (p < 0.01) for ruptured and 3.1 ± 0.08 (p < 0.01) which rebled. Aneurysm size has not to be found significant factor for aneurysm rupture in our study. Aneurysm neck was wider on high flow arteries (i.g., MCA and ICA) to compare with low flow arteries (i.g., ACom and PCom) respectively 3.45 ± 0.17 mm and 3.01 ± 0.07 mm (p < 0.05). Conclusion The aspect ratio was found to be a statistically significant important index to calculate for predicting aneurysm rupture. Key words: aspect ratio, dome/neck ratio, aneurysm size, risk of aneurysm rupture, unruptured aneurysm, ruptured aneurysm, subarachnoid hemorrhage


Neurosurgery ◽  
2011 ◽  
Vol 69 (3) ◽  
pp. 644-650 ◽  
Author(s):  
Brian L Hoh ◽  
Sunina Nathoo ◽  
Yueh-Yun Chi ◽  
J Mocco ◽  
Fred G Barker

Abstract BACKGROUND: It is not clear whether treatment modality (clipping or coiling) affects the risk of seizures after treatment for cerebral aneurysms. OBJECTIVE: To determine whether there is an increased risk of seizures after clipping vs coiling. METHODS: Hospitalizations for clipping or coiling of ruptured and unruptured aneurysms were identified in the Nationwide Inpatient Sample Database for 2002 to 2007 by International Classification of Diseases 9th Revision codes for subarachnoid hemorrhage or unruptured cerebral aneurysm and codes for clipping or coiling. Clipping and coiling were compared for the combined primary endpoint of seizures or epilepsy. The analysis was adjusted for patient-specific and hospital-specific factors using generalized linear models with generalized estimated equations. RESULTS: There were 10 899 hospitalizations for ruptured aneurysms (6593 clipping, 4306 coiling), and 9686 hospitalizations for unruptured aneurysms (4483 clipping, 5203 coiling). For ruptured aneurysm patients, clipping had a similar incidence of seizures or epilepsy compared with coiling (10.7% vs 11.1%, respectively, adjusted odds ratio: 0.596; 95% confidence interval: 0.158-2.248; P = .445 after adjustment for patient-specific and hospital-specific factors). For unruptured aneurysm patients, clipping was associated with a significantly higher risk of seizures or epilepsy (9.2%) compared with coiling (6.2%) (adjusted odds ratio: 1.362; 95% confidence interval: 0.155-1.606; P &lt; .001 after adjustment for patient-specific and hospital-specific factors). Seizures or epilepsy were significantly associated with longer hospitalizations (P &lt; .01) and higher hospital charges (P &lt; .0001), except in coiled unruptured aneurysm patients, in which seizures or epilepsy were not significantly associated with hospital charges (P = .31). CONCLUSION: In unruptured cerebral aneurysm patients, clipping is associated with a higher risk of seizures or epilepsy.


2018 ◽  
Vol 2 (1) ◽  
pp. 16-21
Author(s):  
F. Salle ◽  
A. Jaume ◽  
G. Castelluccio ◽  
E. Spagnuolo

Abstract The ideal treatment for intracranial aneurysms has been highly controversial in the last few decades. It is particularly difficult to decide between clipping vs. coiling when it comes to an aneurysm that has already been treated. The authors performed a review of the literature published in the last ten years amongst the main neurosurgical publications and make recommendations based on this evidence and the surgical experience of the eldest author of this paper (ES). A series of cases of recurrent, incompletely coiled aneurysms treated with surgery is presented. Conclusions: aneurysms with a convenient configuration and location for either clipping or coiling might be better managed by surgical clipping in young patients considering that this treatment achieves higher rates of occlusion with a lower incidence of rebleeding. In elderly patients, each case must be discussed.


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