scholarly journals Patient perceptions and preferences of biologic therapies in SLE

2019 ◽  
Vol 6 (1) ◽  
pp. e000322 ◽  
Author(s):  
S Sam Lim ◽  
Hong Kan ◽  
Bonnie F Pobiner ◽  
Gaobin Bao ◽  
Cristina Drenkard
Keyword(s):  
Ad Hoc ◽  
Large Population ◽  
Population Based ◽  
Cross Sectional Study ◽  
Patient Perceptions ◽  
Biologic Therapies ◽  
Full Spectrum ◽  
Cross Sectional ◽  
Significant Difference ◽  
Blacks And Whites

ObjectiveTo evaluate patient perceptions of biologic therapies from a large, population-based cohort of patients with SLE with significant numbers of blacks and whites and across the full spectrum of socioeconomic strata and disease severity.MethodsThis was a cross-sectional study of validated patients with SLE enrolled in the Georgians Organized Against Lupus Cohort between September 2014 and August 2015. The survey instrument was developed ad hoc by the authors and contained an introduction on biologics.ResultsA total of 676 participants were on average 48.4 years old with 15.9 years of disease; 93.2% were female and 80.6% were black; 34.2% had private health insurance and 9.8% had no insurance; and 26.8% and 27.5% had Medicare or Medicaid, respectively. Of all respondents, 30.8% had heard of biologics, with a significant difference between blacks and whites (25.2% vs 53.4%, respectively). There were no significant differences, however, between blacks and whites with respect to ever having been on biologics (7.6% and 11.5%, respectively) or where they got their information about biologics. Out of 202 individuals who had heard of biologics, 102 (51.3%) were familiar with potential benefits or side effects, and most (n=129, 66.5%) had a neutral perception to risks associated with biologic use. There was no perception of biologics working differently between races/ethnicities. More (n=76, 62.8%) blacks preferred intravenous over subcutaneous modalities compared with whites (n=12, 37.5%) but were not as willing to pay as much out of pocket for it. Individuals with Medicare were significantly more likely to have been on biologics.ConclusionsThere are important similarities and differences between blacks and whites with lupus with respect to their perceptions of biologic therapies and their impact. There are opportunities to increase patient exposure to information about biologics and improve their understanding in order for them to make the best informed decision possible.

scholarly journals Socio-Economic Status and Prevalence of Self-Reported Osteoporosis in Tehran: Results from a Large Population-Based Cross-Sectional Study (Urban HEART-2)

2018 ◽  
Vol 95 (5) ◽  
pp. 682-690 ◽  
Author(s):  
M. Asadi-Lari ◽  
Y. Salimi ◽  
M. R. Vaez-Mahdavi ◽  
S. Faghihzadeh ◽  
A. A. Haeri Mehrizi ◽  
...  
Keyword(s):  
Economic Status ◽  
Large Population ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Socio Economic Status

scholarly journals Multimorbidity as an important issue among women: results of a gender difference investigation in a large population-based cross-sectional study in West Asia

BMJ Open ◽  
2017 ◽  
Vol 7 (5) ◽  
pp. e013548 ◽  
Author(s):  
Masoomeh Alimohammadian ◽  
Azam Majidi ◽  
Mehdi Yaseri ◽  
Batoul Ahmadi ◽  
Farhad Islami ◽  
...  
Keyword(s):  
Gender Difference ◽  
Large Population ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

Daytime napping is associated with retinal microcirculation: a large population-based study in China

SLEEP ◽  
2021 ◽  
Author(s):  
Xin Liu ◽  
Guowei Wang ◽  
Xiaoyan Wang ◽  
Yueye Wang ◽  
Yan Min ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Large Population ◽  
Vascular Diseases ◽  
Population Based ◽  
Cross Sectional Study ◽  
Cubic Spline ◽  
Fundus Photography ◽  
Cross Sectional ◽  
Retinal Microcirculation ◽  
Cubic Spline Curve

Abstract Study Objectives To investigate the association between daytime napping and retinal microcirculation. Methods This is a cross-sectional study from a prospective population-based cohort. 2,662 participants were recruited after quota sampling. Information on napping was collected through face-to-face interviews. Retinal vascular calibers (RVCs), including central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE), and arterio-to-venous ratio (AVR), were obtained from fundus photography. Multivariate regression and restricted cubic spline curve were performed to determine the association between RVCs and daytime napping duration. Results 56.4% participants reported daytime napping regularly. Compared to no nap, daytime nap was related to higher CRAE, with nap duration of 0.5–1 h showing the most significant association. 0.5–1 h daytime nappers displayed an average of 4.18 µm (95% confidence interval [CI] 2.45–5.91, p < 0.001) wider CRAE than non-nappers after adjustment. No significant association was found between CRVE and daytime napping. Moreover, individuals with 0.5–1 h daytime napping had a lower risk for AVR reduction (odds ratio [OR] 0.70, 95% confidence interval [CI] 0.56–0.86, p = 0.001) than non-nappers. Similar association persisted in non-hypertensive population. Restricted cubic spline indicated a J-shaped relationship between AVR reduction and nap duration. Conclusion Retinal microcirculation was positively associated with self-reported 0.5–1 h daytime napping. Better indicators of retinal microcirculation were probably related to nap duration in a J-shaped manner. Also, the possibly beneficial role of 0.5–1 h daytime napping on retinal microcirculation might be independent of clinically diagnosed vascular diseases.

scholarly journals Nutrient Patterns and Their Relation With Obesity in Iranian Adults: A Population-based Study

2020 ◽  
Author(s):  
Mohammad Reza Amini ◽  
Zahra Akbarzade ◽  
Farhang Djafari ◽  
Habib Yarizadeh ◽  
Mahshid Shahavandi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nutrient Intake ◽  
Factor Loading ◽  
Population Based ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Population Based Study ◽  
Significant Difference ◽  
Major Nutrient ◽  
Nutrient Patterns

Abstract Objective: In spite of growing evidence on the associations between nutrient patterns and obesity. A few study examined the association between patterns of nutrient intake and obesity we aimed to explore the association between nutrient pattern and obesity in Iranian adults.Results: In this cross-sectional study, a total of 850 subjects aged years 20 to 59 were randomly selected. Our statistical analysis revealed three major nutrient patterns that show the principle factor loading of nutrient intake. We observed a significant association between quintiles in men for Fasting Blood Sugar (FBS) (P<0.006) in the first nutrient pattern. Moreover, we identified a significant difference between quintiles in the first nutrient pattern in women for obesity (P=0.007), Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) (P<0.02). In the third nutrient pattern, we identified a significant association for SBP in women (P<0.02).

scholarly journals The Pattern of Medication Use amongst a Migrant Population Residing in Southern Iran: A Population-Based Study

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Marziyeh Zare ◽  
Saba Afifi ◽  
Iman Karimzadeh ◽  
Mohammad Salehi-Marzijarani ◽  
Leila Zarei ◽  
...  
Keyword(s):  
Large Population ◽  
Medication Use ◽  
Healthcare Services ◽  
Population Based ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Southern Iran ◽  
Present Cross Sectional Study ◽  
City Population ◽  
First Time

Background: Iran has welcomed a large population of immigrants and refugees, which has led to new demands and priorities in many aspects of life, such as healthcare services. Objectives: For the first time in Southern Iran, in Shiraz City, population-based research was conducted on the patterns of medication use in native non-Iranian residents. Methods: The present cross-sectional study was conducted amongst Shiraz citizens from 2017 to 2018. The population consisted of 43 migrants. Data were collected using a multipart data form. All statistical analyses were performed using SPSS. Results: A total of 43 Afghan migrants were included in the study. Most of them were female (72.1%), aged under 40 years (67.4%), and homemaker (62.8%) with an education level of non-completed high school diploma (97.7%). The majority of the subjects did not have insurance or family physician coverage (93%), and 85.7% got medications without prescription. The three most common medications used by the subjects were iron supplements, acetaminophen, and cold medicines. Conclusions: Iran is now hosting Afghan nationals as one of the largest population of refugees in the world. The health conditions of the Afghan population need more attention in order to improve the health status of their community in Iran.

scholarly journals Incidence, Pattern and Mechanisms of Injuries and Fractures in Children Under Two Years of Age

2021 ◽  
Author(s):  
Karen Rosendahl ◽  
Ramona Myklebust ◽  
Kjersti Foros Forseth ◽  
Andreas Nøttveit ◽  
Pernille Eide ◽  
...  
Keyword(s):  
Large Population ◽  
Population Based ◽  
Cross Sectional Study ◽  
Healthy Children ◽  
Sectional Study ◽  
Accidental Injury ◽  
Level Of Evidence ◽  
Cross Sectional ◽  
Fractures In Children ◽  
Tibia Fractures

Abstract Background: Fractures in children under two years of age are rare, and little has been published on their mechanisms. We aimed at examining the incidence, mechanisms, pattern and fracture characteristics in a large, population-based cohort of otherwise healthy children.Methods: This retrospective, cross-sectional study includes all children aged 0-2 years, attending the Accident and Emergency department in Bergen between 2010 and 2015, due to an injury warranting radiography. Clinical data was categorized from the medical notes, and all radiographs were reviewed by an experienced paediatric radiologist. Results: 408 children (212 male), 3-23 months of age (mean 17.7 months), were included. 149 (77 male) children had a total of 162 fractures, yielding an annual incidence of 5.4 per 1000, varying from 0.7 per 1000 for those under 12 months of age, increasing tenfold to 7.3 per 1000 for children aged 12-24 months of age. More than half of the fractures (53.1%) were seen in children aged 18-23 months, while none was found in those under 7 months of age. The youngest age group had mostly femur and tibia fractures, the oldest mostly forearm fractures (n=55, 34.0%), followed by tibia fractures (21.6%) and fractures to the clavicle (14.8%). The reported mechanisms for the 162 fractures were fall from a chair/bed/table (41.4%), fall from own height (18.5%) or crush injury (15.4%). In 5% of the injuries, the fracture history was clearly inconsistent and suspicious of non-accidental injury (NAI). Conclusion: Injuries and fractures in young children in general, and non-ambulant children in particular, are rare and should be thoroughly assessed for NAI. Level of evidence: Retrospective, population based cross-sectional study. Level 3.

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