Evening chronotype is associated with poor work ability and disability pensions at midlife: a Northern Finland Birth Cohort 1966 Study

ObjectivesThis is the first general population study to evaluate whether evening chronotypes (E) have poorer work ability (WA) and higher probability for early disability pensions (DPs) than morning types (M) in middle age.MethodsAmong non-retired individuals (n=5831; 2672 men, 3159 women) of the Northern Finland Birth Cohort 1966, chronotype was determined at the age of 46 years with shortened Morningness–Eveningness Questionnaires in 2012. The outcomes were poor WA in 2012, indicated by scores 0–7/10 of Work Ability Score, and registered emergence of DPs in 2013–2016. Multivariate logistic and Cox regression analyses were separately adjusted for factors related to sleep, health and behaviours, sociodemographic and economic factors, or working times.ResultsE-types represented 10% (n=264) of men and 12% (n=382) of women. Compared with M-types, the unadjusted ORs with 95% CIs of poor WA for E-type men and women were 2.24 (95% CI 1.62 to 3.08) and 2.33 (95% CI 1.74 to 3.10), respectively. The odds remained statistically significant and approximately twofold in all separate adjustment models tested. During 2013–2016, 8 (3.0%) E-type men and 10 (2.6%) E-type women were granted DP, which, compared with M-types, represented a higher HR that was statistically significant for men (HR 3.12, 95% CI 1.27 to 7.63) and remained significant except when multiple sleep variables or working times were adjusted for.ConclusionsEveningness appears a previously unrecognised risk factor for poor WA and early disability. We suggest that individual chronotype be considered in attempts to lengthen work careers.

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Intake of carbohydrates and SFA and risk of CHD in middle-age adults: the Hordaland Health Study (HUSK)

Public Health Nutrition ◽

10.1017/s1368980020003043 ◽

2020 ◽

pp. 1-15

Author(s):

Teresa R Haugsgjerd ◽

Grace M Egeland ◽

Ottar K Nygård ◽

Jannicke Igland ◽

Gerhard Sulo ◽

...

Keyword(s):

Lower Risk ◽

Cox Regression ◽

Middle Age ◽

Health Study ◽

Opposite Pattern ◽

Men And Women ◽

Food Items ◽

Chd Risk ◽

Hazard Ratios ◽

Total Fat

Abstract Objective: Limiting SFA intake may minimise the risk of CHD. However, such reduction often leads to increased intake of carbohydrates. We aimed to evaluate associations and the interplay of carbohydrate and SFA intake on CHD risk. Design: Prospective cohort study. Setting: We followed participants in the Hordaland Health Study, Norway from 1997–1999 through 2009. Information on carbohydrate and SFA intake was obtained from a FFQ and analysed as continuous and categorical (quartiles) variables. Multivariable Cox regression estimated hazard ratios (HR) and 95 % CI. Theoretical substitution analyses modelled the substitution of carbohydrates with other nutrients. CHD was defined as fatal or non-fatal CHD (ICD9 codes 410–414 and ICD10 codes I20–I25). Participants: 2995 men and women, aged 46–49 years. Results: Adjusting for age, sex, energy intake, physical activity and smoking, SFA was associated with lower risk (HRQ4 v. Q1 0·44, 95 % CI 0·26, 0·76, Ptrend = 0·002). For carbohydrates, the opposite pattern was observed (HRQ4 v. Q1 2·10, 95 % CI 1·22, 3·63, Ptrend = 0·003). SFA from cheese was associated with lower CHD risk (HRQ4 v. Q1 0·44, 95 % CI 0·24, 0·83, Ptrend = 0·006), while there were no associations between SFA from other food items and CHD. A 5 E% substitution of carbohydrates with total fat, but not SFA, was associated with lower CHD risk (HR 0·75, 95 % CI 0·62, 0·90). Conclusions: Higher intake of predominantly high glycaemic carbohydrates and lower intake of SFA, specifically lower intake from cheese, were associated with higher CHD risk. Substituting carbohydrates with total fat, but not SFA, was associated with significantly lower risk of CHD.

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Pre-Metabolic Syndrome and Incidence of Type 2 Diabetes and Hypertension: From the Korean Genome and Epidemiology Study

Journal of Personalized Medicine ◽

10.3390/jpm11080700 ◽

2021 ◽

Vol 11 (8) ◽

pp. 700

Author(s):

A-Ra Cho ◽

Yu-Jin Kwon ◽

Jong-Koo Kim

Keyword(s):

Type 2 Diabetes ◽

Cox Regression ◽

Hdl Cholesterol ◽

Regression Analyses ◽

Epidemiology Study ◽

Men And Women ◽

Elevated Glucose ◽

Low Hdl ◽

New Onset

The aim of this study was to investigate the prevalence of premetabolic syndrome (pre-MetSyn) and its components and to longitudinally examine their association with new-onset type 2 diabetes (T2D) or hypertension. A total of 4037 men and 4400 women aged 40 to 69 years were selected from the Korean Genome and Epidemiology Study, observed from 2001 to 2014. Pre-MetSyn was defined as the presence of one or two components of MetSyn (B, elevated blood pressure; G, elevated glucose; H, low HDL-cholesterol; T, elevated triglycerides; W, increased waist circumference). The prevalence of pre-MetSyn was higher than that of non-MetSyn and MetSyn in both men and women. In multivariate Cox regression analyses, G, T, G+T, W+G, B+G, B+T, W+T, B+H, and H+T in men and G, T, G+H, B+T, and H+T in women were significantly associated with new-onset T2D. B, W, B+H, B+T, W+H, and W+T in men and B, B+T, B+H, B+W, and W+H in women were significantly associated with new-onset hypertension. The prevalence of pre-MetSyn components and their associations with new-onset T2D or hypertension differed according to sex and disease. Our results suggest that specific phenotypes of pre-MetSyn may be important factors for predicting and preventing the development of T2D and hypertension.

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The comparison of clinical signs presentation in middle age men and women with myocardial infarction

hormozgan medical journal ◽

10.29252/hmj.21.2.96 ◽

2017 ◽

Vol 21 (2) ◽

pp. 96-104

Author(s):

Hossein Sharafi ◽

Zahra Moshtaghe Eshgh ◽

Mohammad Zare ◽

Qasem Sobhani ◽

Fatima Rezaei ◽

...

Keyword(s):

Myocardial Infarction ◽

Middle Age ◽

Clinical Signs ◽

Men And Women

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Measurement Properties of the Work Ability Score in Sick-Listed Workers with Chronic Musculoskeletal Pain

Journal of Occupational Rehabilitation ◽

10.1007/s10926-021-09982-7 ◽

2021 ◽

Author(s):

M. Stienstra ◽

M. J. A. Edelaar ◽

B. Fritz ◽

M. F. Reneman

Keyword(s):

Musculoskeletal Pain ◽

Work Ability ◽

Chronic Musculoskeletal Pain ◽

Measurement Properties ◽

Work Ability Score

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Nonparental Caregivers, Parents, and Early Academic Achievement Among Children from Latino/a Immigrant Households

Sociological Perspectives ◽

10.1177/0731121419851093 ◽

2019 ◽

Vol 62 (6) ◽

pp. 884-906

Author(s):

Lilla K. Pivnick

Keyword(s):

Academic Achievement ◽

Social Capital ◽

Early Childhood ◽

Longitudinal Study ◽

Birth Cohort ◽

Math Achievement ◽

Academic Skills ◽

Ecological Systems ◽

Regression Analyses ◽

Early Academic Achievement

Drawing on ecological systems and social capital perspectives, this study uses the Early Childhood Longitudinal Study–Birth Cohort to investigate links between early nonparental caregiver beliefs about early academic skills and children’s math and reading achievement in kindergarten with special attention to the children from Latino/a immigrant households. Regression analyses revealed that nonparental caregiver beliefs were associated with academic achievement at kindergarten entry and that types of alignment or misalignment between nonparental caregiver and parental beliefs were differentially associated with math achievement but not reading. Notably, the association between nonparental caregiver beliefs and children’s academic achievement was more consequential for children from Latino/a immigrant households. Results suggest that having nonparental caregivers with low early academic skills beliefs may be especially detrimental for children from Latino/a immigrant households.

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Comparison of the work ability index and the work ability score for predicting health-related quality of life

International Archives of Occupational and Environmental Health ◽

10.1007/s00420-021-01740-9 ◽

2021 ◽

Author(s):

Hamidreza Mokarami ◽

Rosanna Cousins ◽

Haji Omid Kalteh

Keyword(s):

Quality Of Life ◽

Work Ability ◽

Health Related Quality ◽

Work Ability Index ◽

Related Quality ◽

Health Related ◽

Ability Index ◽

Work Ability Score

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Identification and Validation of a Seven m6A-related lncRNAs Signature Predicting Prognosis of Ovarian Cancer

10.21203/rs.3.rs-915700/v1 ◽

2021 ◽

Author(s):

Yan Li ◽

Xiaoying Wang ◽

Yue Han ◽

Xun Li

Keyword(s):

Ovarian Cancer ◽

Regression Analysis ◽

Correlation Analysis ◽

Prognostic Value ◽

Cox Regression ◽

Risk Group ◽

Pearson Correlation ◽

Regression Analyses ◽

Cox Regression Analysis ◽

Pearson Correlation Analysis

Abstract Background: Long non-coding RNAs (lncRNAs) play an important role in angiogenesis, immune response, inflammatory response and tumor development and metastasis. m6 A (N6 - methyladenosine) is one of the most common RNA modifications in eukaryotes. The aim of our research was to investigate the potential prognostic value of m6A-related lncRNAs in ovarian cancer (OC).Methods: The data we need for our research was downloaded from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database. Pearson correlation analysis between 21 m6A regulators and lncRNAs was performed to identify m6A-related lncRNAs. Univariate Cox regression analysis was implemented to screen for lncRNAs with prognostic value. A least absolute shrinkage and selection operator (LASSO) Cox regression and multivariate Cox regression analyses was used to further reduct the lncRNAs with prognostic value and construct a m6A-related lncRNAs signature for predicting the prognosis of OC patients. Results: 275 m6A-related lncRNAs were obtained using pearson correlation analysis. 29 m6A-related lncRNAs with prognostic value was selected through univariate Cox regression analysis. Then, a seven m6A-related lncRNAs signature was identified by LASSO Cox regression. Each patient obtained a riskscore through multivariate Cox regression analyses and the patients were classified into high-and low-risk group using the median riskscore as a cutoff. Kaplan-Meier curve revealed that the patients in high-risk group have poor outcome. The receiver operating characteristic curve revealed that the predictive potential of the m6A-related lncRNAs signature for OC was powerful. The predictive potential of the m6A-related lncRNAs signature was successfully validated in the GSE9891, GSE26193 datasets and our clinical specimens. Multivariate analyses suggested that the m6A-related lncRNAs signature was an independent prognostic factor for OC patients. Moreover, a nomogram based on the expression level of the seven m6A-related lncRNAs was established to predict survival rate of patients with OC. Finally, a competing endogenous RNA (ceRNA) network associated with the seven m6A-related lncRNAs was constructed to understand the possible mechanisms of the m6A-related lncRNAs involed in the progression of OC.Conclusions: In conclusion, our research revealed that the m6A-related lncRNAs may affect the prognosis of OC patients and identified a seven m6A-related lncRNAs signature to predict the prognosis of OC patients.

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Abstract P036: Parathyroid Hormone is Associated with All-Cause and Cardiovascular Mortality: The Hoorn Study

Circulation ◽

10.1161/circ.127.suppl_12.ap036 ◽

2013 ◽

Vol 127 (suppl_12) ◽

Author(s):

Adriana J van Ballegooijen ◽

Ilse Reinders ◽

Marjolein Visser ◽

Jacqueline M Dekker ◽

Giel Nijpels ◽

...

Keyword(s):

Parathyroid Hormone ◽

Cox Regression ◽

Threshold Model ◽

Older Men ◽

Population Based ◽

Survival Curves ◽

Men And Women ◽

Serum Pth ◽

Older Men And Women ◽

Cvd Mortality

Introduction Higher parathyroid hormone (PTH) concentrations have been associated with increased cardiovascular disease (CVD) mortality, although data in the general population are scarce. Hypothesis We hypothesize that higher serum PTH concentrations are associated with all-cause and CVD mortality in a prospective, population-based cohort of older men and women. Methods We included 633 participants of the Hoorn Study, a population-based cohort with oversampling of subjects with impaired glucose regulation; mean age 70.1±6.6 years, 50.7% female. Serum intact PTH concentrations were measured using a 2-site immunoassay. Outcomes were all-cause and CVD mortality based on clinical files and coded according to the ICD-9. We used Cox-regression to estimate survival curves and hazard ratios (HR 95% CI) for all-cause and CVD mortality adjusted for potential confounders using season-specific PTH quartiles. Results During a median follow-up of 7.8 years, 112 participants died, of which 26 deaths (23%) were due to CVD. Survival curves showed an impaired survival for all-cause (Log-rank p=0.054) and CVD mortality (Log-rank p=0.022) for people in the highest PTH quartile (Figure 1). In a multivariate model adjusted for age, sex, smoking, education level, BMI, glucose status, systolic blood pressure, anti-hypertensive drug use, the highest PTH quartile was associated with higher all-cause mortality; HR 1.98 (1.08, 3.64). Kidney function (estimated glomerular filtration rate and micro-albuminuria) attenuated the PTH risk association, but risk persisted; HR 1.93 (95% CI 1.04, 3.58). The results for CVD mortality showed a similar pattern, although the association was only significant in a threshold model (Quartile 4 vs. Quartile 1-3) HR 2.56 (1.11, 5.94). Conclusion In conclusion, among older men and women, higher PTH concentrations are associated with higher mortality risk. We suggest to evaluate whether individuals with high PTH concentrations benefit from therapeutic approaches targeted to decrease PTH concentrations.

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Staying ‘stoked’: Surfing, ageing and post-youth identities

International Review for the Sociology of Sport ◽

10.1177/1012690217722522 ◽

2017 ◽

Vol 54 (4) ◽

pp. 387-409 ◽

Cited By ~ 5

Author(s):

Belinda Wheaton

Keyword(s):

Middle Age ◽

Cultural Barriers ◽

Physically Active ◽

Men And Women ◽

Male And Female ◽

South West ◽

Barriers And Challenges ◽

Ways Of Being ◽

Scholarly Attention ◽

Equipment Performance

Surfing has consistently been framed as a youth focused, male-dominated sport and culture. Despite surfing’s ageing demographic, neither the ways in which age impacts on surfing identities and mobilities, nor older surfer’s experiences and subjectivities, has been given scholarly attention. In this paper, I discuss research exploring the experiences and identities of middle-aged and older recreational male and female surfers in the south and south-west of England. The research illustrates that participation in surfing as a sport and lifestyle remains highly significant for some men and women through middle-age and into retirement. I consider the cultural barriers and challenges in dealing with a loss in physical performance through ageing, such as adaptations to their equipment, performance, and style, and the implications for how individuals negotiate bodily capital, space and identity. Nonetheless, older surfers also embrace different ways of being a surfer which challenge some of the more exclusionary aspects of surfing identities. Theoretically the paper develops an intersectional approach to sporting identity that explicitly recognises and accounts for the contribution of age to social identity. The research also contributes to the growing literature on physically active ‘post-youth’ leisure lifestyles, illustrating how shifting definitions of ageing have given ‘rise to new expectations, priorities and understandings’ of sporting lifestyles amongst those in middle age, and beyond.

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