Sexual exposure and sexual behaviour in the interval between gonorrhoea treatment and test of cure: a cross-sectional cohort study

2021 ◽  
pp. sextrans-2021-055029
Author(s):  
Oluseyi Ayinde ◽  
Jonathan D C Ross
Keyword(s):  
Multivariable Analysis ◽  
Sexual Contact ◽  
Sexual Relationships ◽  
Inconsistent Condom ◽  
Cross Sectional ◽  
Behavioural Characteristics ◽  
Previous Infection ◽  
History Of ◽  
Specific Symptoms ◽  
Prevalence Ratios

ObjectivesWe explored sexual contact in the interval between the treatment for gonorrhoea and attending for a test of cure (ToC) and identified factors associated with sexual contact in this period.MethodsMultivariable analysis of demographic, behavioural and clinical data with self-reported sexual contact prior to attending for a gonorrhoea ToC evaluation among participants recruited into the ‘Gentamicin for the Treatment of Gonorrhoea’ trial in England, between October 2014 and November 2016. Associations with sexual contact were expressed as prevalence ratios (PR) and their corresponding 95% CI.ResultsThe median time to ToC was 15 days (interquartile range 14–20 days). 197/540 (37%) participants reported sexual contact in the time between treatment and ToC. Of these, 173/197 (88%) participants reported inconsistent condom use, including with previous partners (133/197 (68%)). A history of gonorrhoea (adjusted PR (aPR) 1.32 (1.03 to 1.69)) or syphilis (aPR 1.19 (1.08 to 1.32)), being in regular (aPR 1.71 (1.41 to 2.09)) sexual relationships, high number of partners in the last 3 months (aPR 1.77 (1.25 to 2.51))—‘more than 5 partners’ vs ‘0 to 1 partner’, and attending for a ToC more than 14 days after treatment (aPR 1.40 (1.08 to 1. 81)) were associated with reporting sexual contact before the ToC appointment. However, age (aPR (1.00 (0.99 to 1.01)) and presenting with specific symptoms at baseline (aPR 1.17 (0.95 to 1.44)) were not associated with sexual contact by the ToC attendance.ConclusionSexual activity after receiving treatment for gonorrhoea and prior to a ToC evaluation was common. This was associated with previous infection history and specific behavioural characteristics. Knowledge of these factors can help guide safe sex counselling at the time of treatment.

scholarly journals Prevalence of positive TST among Healthcare workers in high-burden TB setting in Peru

2020 ◽  
Author(s):  
Juana Sedamano ◽  
Alvaro Schwalb ◽  
Rodrigo Cachay ◽  
Carlos Zamudio ◽  
Cesar Ugarte-Gil ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Cross Sectional Study ◽  
Positive Tuberculin Skin Test ◽  
Control Measures ◽  
Occupational Hazard ◽  
Cross Sectional ◽  
High Burden ◽  
History Of ◽  
The Individual ◽  
Prevalence Ratios

Abstract Background: Tuberculosis (TB) transmission has long been recognized as an important occupational hazard for healthcare workers (HCWs). HCWs possess a 5.8% annual risk of exposure and three times greater risk of developing active TB than the general population.Methods: We conducted an observational cross-sectional study between September 2014 and March 2015 among HCWs in a high-burden TB setting in Lima to estimate the prevalence of positive Tuberculin Skin Test (TST) and to investigate factors associated with a positive TST.Results: 240 participants were included in the analysis; TST was administered to 190 (79.2%) while the rest were exempt due to a previous positive TST result, history of TB or refused the test. A positive TST result was found among 56.2% of participants who were applied the TST (95% CI: 49.22% - 63.55%). When considering those who had a previous positive TST result and those with a history of TB, the prevalence was 64.3% (95% CI: 57.8% - 70.3%). No significant differences were observed between clinical/paramedical and administrative staff in the health center. The use of N95 mask during work hours was reported by 142 (69.9%) participants. Prevalence ratios (PR) show that workers with more than 120 months as a HCW were 1.44 times more likely to be TST positive. The multivariate analysis found that HCWs with over 10 years of service were 1.52 times more likely to be TST positive.Conclusion: This study supports previous reports that TB infection is an occupational hazard for HCWs. Prevention of TB transmission through control measures, as well as timely diagnosis of LTBI in this selected risk group, is critical for the individual and for public health.

scholarly journals Risk factors related to childbirth in El Salvador

2019 ◽  
Vol 2 (2) ◽  
pp. 144-152
Author(s):  
Fátima Larisa Chavarría Rodríguez
Keyword(s):  
Public Health ◽  
Risk Factors ◽  
Preterm Birth ◽  
El Salvador ◽  
Multiple Pregnancy ◽  
Public Health Problem ◽  
Clinical History ◽  
Cross Sectional ◽  
History Of ◽  
Prevalence Ratios

Introduction. Preterm birth is a public health problem, considered a high risk factor for morbidity, disability and neonatal mortality. Objective. Characterize risk factors related to preterm birth in El Salvador. Methodology. Analytical cross-sectional study of risk factors related to preterm birth, in women who received childbirth care in the national public health system, during 2017. Data was obtained from the Perinatal Information System. 44 891 cases were analyzed. Qualitative variables were analyzed through absolute values and frequencies, and the quantitative variables, through absolute values, frequency and central tendency measures, using the Statistical Package for the Social Science (SPSS) version 24 program. The analysis of relation of variables, was performed with the Epidat version 3.1 program, through the calculation of prevalence ratios (PR) and the calculation of Odds Ratio (OR), both analysis with a 95% confidence interval and a value of p <0.05. Results. 9.5% of the deliveries attended were preterm. The risk analysis through the calculation of prevalence ratios showed that women with a multiple pregnancy were 14 times more likely to have a preterm birth. Preterm birth was 4.7 times more frequent in women with a clinical history of diabetes mellitus and 2.4 times more frequent, with a history of high blood pressure. Conclusions. Women who have a multiple pregnancy and pregnant women with a clinical history of chronic diseases, and an obstetric history of preeclampsia, are more likely to have a preterm birth. Likewise, obesity and inadequate age for pregnancy, mainly women over 35 years, are also related to preterm birth.

scholarly journals Seroepidemiologi toksoplasmosis pada masyarakat di Desa Kumu Kabupaten Minahasa tahun 2015

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Vanessa J. T. Seran ◽  
Billy J. Kepel ◽  
Fatimawali .
Keyword(s):  
Toxoplasma Gondii ◽  
Latex Agglutination ◽  
Agglutination Test ◽  
Latex Agglutination Test ◽  
Serological Tests ◽  
Cross Sectional ◽  
History Of ◽  
Blood Specimens ◽  
Toxoplasma Gondii Infection ◽  
Specific Symptoms

Abstract: Toxoplasmosis is a disease caused by Toxoplasma gondii in humans and also in animals. Toxoplasma gondii infection is widespread in the world, about 20-90% of the populations have been exposed to this parasite, and most take place without showing specific symptoms. The purpose of this study was to determine the seroepidemiology of toxoplasmosis among the villagers of kumu in district minahasa on 2015. This study was a cross sectional descriptive study. The study population was Kumu Village community. This study using blood specimens to be tested by latex agglutination test and interviews to determine the distribution of toxoplasmosis is based on risk factors. Seropositive obtained if agglutination occurs on the results of serological tests. Respondents consisted of 20 (90.90%) females and 2 (9.10%) men. The results showed 11 (50%) of respondents has toxoplasma seropositivity were distributed by age, sex, level of education, occupation, diet, hygiene, exposure to dogs, exposure to cats, and a history of miscarriage.Keywords: latex agglutination test, parasites, seropositivity, toxoplasma gondiiAbstrak: Toksoplasmosis merupakan penyakit yang disebabkan oleh Toxoplasma gondii pada manusia dan juga pada hewan. Infeksi Toxoplasma gondii tersebar luas di dunia, sekitar 20-90% populasi dunia pernah terpapar parasit ini, dan sebagian besar berlangsung tanpa menunjukkan gejala yang spesifik. Tujuan penelitian ini adalah untuk mengetahui seroepidemiologi toksoplasmosis pada masyarakat di Desa Kumu Kabupaten Minahasa tahun 2015. Penelitian ini merupakan penelitian deskriptif cross sectional. Populasi penelitian ini adalah masyarakat Desa Kumu. Penelitian ini menggunakan spesimen darah untuk diuji dengan uji aglutinasi lateks dan hasil wawancara untuk mengetahui distribusi toksoplasmosis berdasarkan faktor resiko. Seropositif didapat bila terjadi aglutinasi pada hasil tes serologis. Responden terdiri dari 20 (90,90%) wanita dan 2 (9,10%) pria. Hasil penelitian menunjukkan 11 (50%) responden seropositif toksoplasmosis yang terdistribusi berdasarkan umur, jenis kelamin, tingkat pedidikan, pekerjaan, pola makan, higienitas, paparan anjing, paparan kucing, dan riwayat keguguran.Kata kunci: uji aglutinasi lateks, parasit, seropositif, toxoplasma gondii

scholarly journals Prevalence of positive TST among Healthcare workers in a high-burden TB setting in Peru

2020 ◽  
Author(s):  
Juana Sedamano ◽  
Alvaro Schwalb ◽  
Rodrigo Cachay ◽  
Carlos Zamudio ◽  
Cesar Ugarte-Gil ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Cross Sectional Study ◽  
Positive Tuberculin Skin Test ◽  
High Risk Group ◽  
Control Measures ◽  
Occupational Hazard ◽  
Cross Sectional ◽  
High Burden ◽  
History Of ◽  
Prevalence Ratios

Abstract Background: Tuberculosis (TB) transmission has long been recognized as an important occupational hazard for healthcare workers (HCWs). HCWs have a 5.8% annual risk of exposure and three times greater risk of developing active TB than the general population.Methods: We conducted an observational cross-sectional study between September 2014 and March 2015 among HCWs in a high-burden TB setting in Lima to estimate the prevalence of positive Tuberculin Skin Test (TST) and to investigate factors associated with a positive TST.Results: 240 participants were included in the analysis; TST was administered to 190 (79.2%) while the rest were exempt due to a previous positive TST result, history of TB, or test refusal. A positive TST result was found among 56.2% of participants to whom the TST was applied (95% CI: 49.22% - 63.55%). When considering those who had a previous positive TST result and those with a history of TB, the prevalence of a positive TST result was 64.3% (95% CI: 57.8% - 70.3%). No significant differences were observed between clinical/paramedical and administrative staff in the health center. The use of N95 masks during work hours was reported by 142 (69.9%) participants. Prevalence ratios (PR) show that workers with more than 120 months as a HCW were 1.44 times more likely to be TST positive. The multivariate analysis found that HCWs with over 10 years of service were 1.52 times more likely to be TST positive.Conclusion: This study supports previous reports that TB infection is an occupational hazard for HCWs. Prevention of TB transmission through control measures, as well as timely diagnosis of LTBI in this particular high-risk group, is critical for individual and public health.

scholarly journals Prevalence of positive TST among Healthcare workers in a high-burden TB setting in Peru

2020 ◽  
Author(s):  
Juana Sedamano ◽  
Alvaro Schwalb ◽  
Rodrigo Cachay ◽  
Carlos Zamudio ◽  
Cesar Ugarte-Gil ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Cross Sectional Study ◽  
Positive Tuberculin Skin Test ◽  
Control Measures ◽  
Occupational Hazard ◽  
Cross Sectional ◽  
High Burden ◽  
History Of ◽  
The Individual ◽  
Prevalence Ratios

Abstract Background Tuberculosis (TB) transmission has long been recognized as an important occupational hazard for healthcare workers (HCWs). HCWs possess a 5.8% annual risk of exposure and three times greater risk of developing active TB than the general population.Methods We conducted an observational cross-sectional study between September 2014 and March 2015 among HCWs in a high-burden TB setting in Lima to estimate the prevalence of positive Tuberculin Skin Test (TST) and to investigate factors associated with a positive TST.Results 240 participants were included in the analysis; TST was administered to 190 (79.2%) while the rest were exempted due to a previous positive TST result, history of TB or refused the test. A positive TST result was found among 56.2% of participants (95% CI: 49.22% - 63.55%). When considering those who had a previous positive TST result and those with a history of TB, the prevalence of a positive TST was 64.3% (95% CI: 57.8% - 70.3%). No significant differences of TST results were observed between clinical/paramedical and administrative staff in the health center. The use of N95 mask during work hours was reported by 142 (69.9%) participants. Prevalence ratios (PR) show that workers with more than 120 months as a HCW were 1.44 times more likely to be TST positive. The multivariate analysis found that HCWs with over 10 years of service were 1.62 times more likely to be TST positive.Conclusion This study supports previous reports that TB infection is an occupational hazard for HCWs. Prevention of TB transmission through control measures, as well as timely diagnosis of LTBI in this selected risk group, is critical for the individual and for public health.

scholarly journals Mental health outcomes and associations during the coronavirus disease 2019 pandemic: A cross-sectional survey of the US general population

2020 ◽  
Author(s):  
Bella Nichole Kantor ◽  
Jonathan Kantor
Keyword(s):  
Mental Health ◽  
General Population ◽  
Multivariable Analysis ◽  
Anxiety And Depression ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
The Us ◽  
History Of ◽  
Male Sex ◽  
Baseline Demographic

AbstractPandemic coronavirus disease 2019 (COVID-19) may lead to significant mental health stresses, potentially with modifiable risk factors. To determine the presence of and magnitude of associations between baseline associations and anxiety and depression in the US general population, we performed an internet-based cross-sectional survey of an age-, sex-, and race-stratified representative sample from the US general population. Degrees of anxiety, depression, and loneliness were assessed using the 7-item Generalized Anxiety Disorder scale (GAD-7), the 9-item Patient Health Questionnaire (PHQ-9), and the 8-item UCLA Loneliness Scale, respectively. Unadjusted and multivariable logistic regression analyses were performed to determine associations with baseline demographic characteristics. A total of 1,005 finished surveys were returned of the 1,020 started, yielding a completion rate of 98.5% in the survey panel. The mean (SD) age of respondents was 45 (16), and 494 (48.8%) were male. Baseline demographic data were similar between those that were (n=663, 66.2%) and were not (n=339, 33.8%) under a shelter in place/ stay at home order, with the exception of sex and geographic location. Overall, 264 subjects (26.8%) met criteria for an anxiety disorder based on a GAD-7 cutoff of 10; a cutoff of 7 yielded 416 subjects (41.4%) meeting clinical criteria for anxiety. On multivariable analysis, male sex (OR 0.65, 95% CI [0.49, 0.87]) and living in a larger home (OR 0.46, 95% CI [0.24, 0.88]) were associated with a decreased odds of meeting anxiety criteria. Rural location (OR 1.39, 95% CI [1.03, 1.89]), loneliness (OR 4.92, 95% CI [3.18, 7.62]), and history of hospitalization (OR 2.04, 95% CI [1.38, 3.03]), were associated with increased odds of meeting anxiety criteria. 232 subjects (23.6%) met criteria for clinical depression. On multivariable analysis, male sex (OR 0.71, 95% CI [0.53, 0.95]), increased time outdoors (OR 0.51, 95% CI [0.29, 0.92]), and living in a larger home (OR 0.35, 95% CI [0.18, 0.69]), were associated with decreased odds of meeting depression criteria. Having lost a job (OR 1.64, 95% CI [1.05, 2.54]), loneliness (OR 10.42, 95% CI [6.26, 17.36]), and history of hospitalization (OR 2.42, 95% CI [1.62, 3.62]), were associated with an increased odds of meeting depression criteria. Income, media consumption, and religiosity were not associated with mental health outcomes. Anxiety and depression are common in the US general population in the context of the COVID-19 pandemic, and are associated with potentially modifiable factors.

Seroepidemiological Study of Hepatitis A in Medical Students of Mazandaran University of Medical Sciences in 2019

2021 ◽  
Author(s):  
Saman Shirazinia ◽  
Navid Reza Shayan ◽  
Negin Ghiyasi Moghaddam ◽  
Nima Ameli ◽  
Shahriar Alian ◽  
...  
Keyword(s):  
Medical Students ◽  
Hepatitis A ◽  
Demographic Data ◽  
Underlying Disease ◽  
Medical Sciences ◽  
Cross Sectional ◽  
Vaccination History ◽  
Previous Infection ◽  
Patient Demographic Data ◽  
History Of

Introduction: Hepatitis A (HA) is a common infectious disease caused by the HA virus that primarily affects the liver. We need to determine the safety status and infection rate in the community. Therefore, we decided to study the Seroepidemiological of HA in medical students of Mazandaran University of Medical Sciences in 2019.Material and Methods: This was a cross-sectional descriptive-analytical study prospectively examining anti-HAV antibodies in medical students of Mazandaran University of Medical Sciences in 2019. Patient demographic data, laboratory results of anti-HAV IgG and vaccination history were recorded. Four cc of blood were drawn from each student for the anti-HAV IgG test and after the test was performed. Data were analyzed using SPSS 24 software.Results: One hundred and fifty-five students were interviewed. The mean age (standard deviation) of the students in this study was 23.81 (1.47) years. Ninety-nine (63.9%) of the students were male. Therefore, it was caused by previous infection with HAV and 120 (77.4%) cases were considered susceptible individuals whose serum anti-HAV IgG was negative. This was not seen to be statistically significant (P=0.754). According to the test, 77.4% of the predictions were correct. None of the variables of sex, age, history of underlying disease, place of residence, and history of travel had a significant effect on the incidence and positivity of anti-HAV IgG.Conclusion: This study showed that the incidence of anti-HAV IgG was positive in 22.6% of the students, which is much lower than previous studies. This may be due to the higher level of health in this segment of the population.

scholarly journals A clinico-epidemiological study of HIV seroconcordant and serodiscordant couples

2019 ◽  
Vol 5 (1) ◽  
pp. 72
Author(s):  
K. Radha Raja Prabha ◽  
A. Sathish Selvakumar
Keyword(s):  
Risk Factors ◽  
Tamil Nadu ◽  
Hiv Transmission ◽  
Married Couples ◽  
Anal Intercourse ◽  
Cross Sectional Study ◽  
Sexual Contact ◽  
Cross Sectional ◽  
History Of ◽  
Madras Medical College

<p class="abstract"><strong>Background:</strong> The aim of the present study was to assess the epidemiological and risk factors that are likely to influence HIV transmission among married couples and to study the pattern of sexually transmitted infections among both concordant and discordant HIV infected couples..</p><p class="abstract"><strong>Methods:</strong> This cross-sectional study was done on 100 HIV patients and their married partners attending to Institute of Venereology, Madras Medical College, Tamil Nadu. Detailed history of their high risk sexual behaviour, previous veneral diseases (PVDs) was noted and physical and genital examination was done. All the partners of HIV cases were examined for HIV to know the serostatus (seroconcordant and serodiscordant).<strong></strong></p><p class="abstract"><strong>Results:</strong> Among the 100 married couples, 65 couples were seroconcordant for HIV and 35 couples were serodiscordant. Of them, 94 males and 71 females were positive for HIV. History of PVDs was found in 34 patients (28 were seroconcordants and 6 were serodiscordants). The most common STD in the males noticed was ano-genital warts (n=11) and genital ulceration (n=11) is associated with maximum seroconcordance rates. Whereas in the females it was bacterial vaginosis (n=11).</p><p class="abstract"><strong>Conclusions:</strong> The findings suggest that risk factors such as STDs, PVDs in males, anal intercourse, sexual contact during menstruation, avoidance of condom during sexual act and lack of circumcision was significantly associated with presence of HIV concordance in the study population. Duration and frequency of sexual contact with partner, previous venereal diseases in females and ART were found not to influence the transmission of HIV.</p>

scholarly journals Purchase of medications without prescription in Peru: a cross-sectional population-based study

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1392
Author(s):  
Akram Hernández-Vásquez ◽  
Christoper A. Alarcon-Ruiz ◽  
Deysi Díaz-Seijas ◽  
Luisa Magallanes-Quevedo ◽  
Diego Rosselli
Keyword(s):  
Prescription Drugs ◽  
Multivariable Analysis ◽  
Secondary Analysis ◽  
Sociodemographic Factors ◽  
Population Based ◽  
Medical Prescription ◽  
Self Medication ◽  
Cross Sectional ◽  
Comprehensive Health ◽  
History Of

Background: Low availability of medicines in health services, self-medication, inadequate use of medicines, and inadequate dispensing practices in pharmacies are frequent problems in Peru. We aimed to evaluate how frequent the purchase of medications without medical prescription is in Peru, and which factors are associated with this practice. Methods: We conducted a secondary analysis of the 2016 ENSUSALUD national survey data. Purchase of medicines that require a prescription was measured as a dichotomous coded as bought one or more medicines that requires medical prescription or bought medicines that do not require a prescription. Crude and adjusted prevalence ratios (PR) and their 95% confidence intervals (95% CI) were calculated using Poisson regressions model with robust variance to assess the association of purchasing of medicines that require prescriptions with sociodemographic factors. Results: There were 3858 participants in the dataset. The prevalence of purchasing medications without prescriptions was 47.2%. History of having previously consumed the same medication (31.6%), and the delay in receiving an appointment at health facilities (26.9%) were the main reasons to buy medications without a prescription. Regarding the recommendation of the medication purchased, the advice of the pharmacy, and remembering a previous old prescription, were the most frequent reasons (38.3%, and 25.9%, respectively). On the multivariable analysis, users that buy medications without prescription were more likely to be of aged 24-45; reside in the Amazon and Highlands regions; and self-consumption of the purchase. Individuals with Seguro Integral de Salud (Comprehensive Health Insurance) were less likely to buy medications without prescription. Conclusions: There is a high prevalence of prescription requiring medication being bought without one from pharmacies in Peru. It is necessary to include the evaluation of consumer patterns to develop strategies with the aim to regulate the consumption of prescription drugs in the Peruvian population.

scholarly journals HIV AND HCV COINFECTION: PREVALENCE, ASSOCIATED FACTORS AND GENOTYPE CHARACTERIZATION IN THE MIDWEST REGION OF BRAZIL

2014 ◽  
Vol 56 (6) ◽  
pp. 517-524 ◽  
Author(s):  
Solange Zacalusni Freitas ◽  
Sheila Araújo Teles ◽  
Paulo Cesar Lorenzo ◽  
Marco Antonio Moreira Puga ◽  
Tayana Serpa Ortiz Tanaka ◽  
...  
Keyword(s):  
Associated Factors ◽  
Illicit Drugs ◽  
Hiv Transmission ◽  
Multivariable Analysis ◽  
Cross Sectional Study ◽  
Genotype Distribution ◽  
Cross Sectional ◽  
History Of ◽  
Midwest Region ◽  
Hcv Coinfection

A cross-sectional study on prevalence, associated factors and genotype distribution of HCV infection was conducted among 848 HIV-infected patients recruited at reference centers in the Midwest Region of Brazil. The prevalence rate of HIV-HCV coinfection was 6.9% (95% CI: 5.2 to 8.6). In multivariable analysis, increasing age, use of illicit drugs (injection and non-injection), a history of blood transfusion before 1994, and the absence of a steady partnership were significant independent associated factors for HIV-HCV coinfection. The phylogenetic analysis based on the NS5B region revealed the presence of two major circulating genotypes of HCV: genotypes 1 (58.3%) and 3 (41.7%). The prevalence of HIV-HCV coinfection was lower than those reported in studies conducted with HIV-infected patients in different regions of Brazil, due to the fact that illicit drug use is not a frequent mode of HIV transmission in this region of Brazil. Serologic screening of HIV-patients for HCV before initiating antiretroviral treatment, a comprehensive identification of associated factors, and the implementation of effective harm reduction programs are highly recommended to provide useful information for treatment and to prevent HCV coinfection in these patients.

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