scholarly journals Dietary acid load and renal function have varying effects on blood acid-base status and exercise performance across age and sex

2017 ◽  
Vol 42 (12) ◽  
pp. 1330-1340 ◽  
Author(s):  
Enni-Maria Hietavala ◽  
Jeffrey R. Stout ◽  
Lynda A. Frassetto ◽  
Risto Puurtinen ◽  
Hannu Pitkänen ◽  
...  
Keyword(s):  
Renal Function ◽  
Oxygen Uptake ◽  
Exercise Performance ◽  
Maximal Oxygen Uptake ◽  
The Body ◽  
Acid Base ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load ◽  
Acid Base Status

Diet composition influences acid-base status of the body. This may become more relevant as renal functional capacity declines with aging. We examined the effects of low (LD) versus high dietary acid load (HD) on blood acid-base status and exercise performance. Participants included 22 adolescents, 33 young adults (YA), and 33 elderly (EL), who followed a 7-day LD and HD in a randomized order. At the end of both diet periods the subjects performed a cycle ergometer test (3 × 10 min at 35%, 55%, 75%, and (except EL) until exhaustion at 100% of maximal oxygen uptake). At the beginning of and after the diet periods, blood samples were collected at rest and after all workloads. Oxygen uptake, respiratory exchange ratio (RER), and heart rate (HR) were monitored during cycling. In YA and EL, bicarbonate (HCO3−) and base excess (BE) decreased over the HD period, and HCO3−, BE, and pH were lower at rest after HD compared with LD. In YA and EL women, HCO3− and BE were lower at submaximal workloads after HD compared with LD. In YA women, the maximal workload was 19% shorter and maximal oxygen uptake, RER, and HR were lower after HD compared with LD. Our data uniquely suggests that better renal function is associated with higher availability of bases, which may diminish exercise-induced acidosis and improve maximal aerobic performance. Differences in glomerular filtration rate between the subject groups likely explains the larger effects of dietary acid load in the elderly compared with younger subjects and in women compared with men.

Influence of Dietary Acid Load on Exercise Performance

2017 ◽  
Vol 27 (3) ◽  
pp. 213-219 ◽  
Author(s):  
Catherine Applegate ◽  
Mackenzie Mueller ◽  
Krystle E. Zuniga
Keyword(s):  
Exercise Performance ◽  
Sports Nutrition ◽  
The Body ◽  
Treadmill Running ◽  
Dietary Recommendations ◽  
Exercise Tests ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load ◽  
Dietary Strategies

Diet composition can affect systemic pH and acid-base regulation, which may in turn influence exercise performance. An acidic environment in the muscle impairs performance and contributes to fatigue; therefore, current trends in sports nutrition place importance on maximizing the alkalinity of the body with ergogenic aids and dietary strategies. This review examines the evidence on the effects of dietary manipulations on acid load and exercise performance. Ten studies that investigated the effect of high versus low dietary acid loads on athletic performance generally identified that low dietary acid loads increased plasma pH, but did not consistently improve exercise performance at maximal or submaximal exercise intensities. In addition, the few studies conducted have several limitations including lack of female subjects and use of exercise tests exclusive to cycling or treadmill running. Although the research does not strongly support a performance benefit from low dietary acid loads, a more alkaline dietary pattern may be beneficial for overall health, as dietary induced acidosis has been associated with greater risk of cardiovascular disease and bone disease. The review includes dietary recommendations for athletes to reduce dietary acid load while still meeting sports nutrition recommendations.

scholarly journals The Association of Dietary Acid Load with Resting Metabolic Rate and Metabolic Components in Overweight and Obese Women: A Cross Sectional Study

2021 ◽  
Author(s):  
Atieh Mirzababaei ◽  
Farideh Shiraseb ◽  
Leila Setayesh ◽  
Atefeh Tavakoli ◽  
Cain C. T. Clark ◽  
...  
Keyword(s):  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Cross Sectional Study ◽  
The Body ◽  
Adult Women ◽  
Sectional Study ◽  
Cross Sectional ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load

Abstract Background: Several epidemiologic studies have reported that dietary acid load is associated with metabolic profiles; however, to our knowledge, the relationship of this dietary pattern with resting metabolic rate (RMR) among obese and overweight females remains unreported. Therefore, this study aimed to evaluate the association of dietary acid load RMR and metabolic components among overweight and obese adult women.Methods: This cross-sectional study was conducted on 375 Iranian adults, aged 18–48 years. Dietary acid load indexes were calculated by using a validated 147-item semi-quantitative FFQ. Biochemical and anthropometric measures were assessed using standard methods. An impedance fat analyzer was used to obtain the body composition and an indirect calorimeter was used to assess the RMR. Result: It was observed that after correction for potential confounders, DBP and NEAP and PRAL scores were inversely associated (P<0.05). NEAP index was inversely associated with RMR (β= -0.25, 95% CI=-0.1.5 to 2.08, P=0.02), and positively associated with WC (β= 1.009, 95% CI=-1.43 to 3.45, P=0.05) and WHR (β= 0.01, 95% CI= -0.01 to0.04, P=0.03), such that subjects with higher scores in NEAP had lower RMR and higher WC and WHR. We also observed that DAL (β= -0.02, 95% CI= -0.08 to0.03, P=0.08) and PRAL (β= -0.037, 95% CI= -1.05 to 0.03 P=0.07) were marginally associated with RMR.Conclusion:The results of the present study suggested that higher dietary acid load scores may be negatively associated with lower RMR, while directly associated with greater WC, WHR, DBP, and HOMA-IR.

scholarly journals The Association of Dietary Acid Load with Resting Metabolic Rate and Metabolic Components in Overweight and Obese Women: A Cross Sectional Study

2021 ◽  
Author(s):  
Atieh Mirzababaei ◽  
Farideh Shiraseb ◽  
Leila Setayesh ◽  
Atefeh Tavakoli ◽  
Cain C. T. Clark Clark ◽  
...  
Keyword(s):  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Cross Sectional Study ◽  
The Body ◽  
Adult Women ◽  
Sectional Study ◽  
Cross Sectional ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load

Abstract Background: Several epidemiologic studies have reported that dietary acid load is associated with metabolic profiles; however, to our knowledge, the relationship of this dietary pattern with resting metabolic rate (RMR) among obese and overweight females remains unreported. Therefore, this study aimed to evaluate the association of dietary acid load RMR and metabolic components among overweight and obese adult women.Methods: This cross-sectional study was conducted on 375 Iranian adults, aged 18–48 years. Dietary acid load indexes were calculated by using a validated 147-item semi-quantitative FFQ. Biochemical and anthropometric measures were assessed using standard methods. An impedance fat analyzer was used to obtain the body composition and an indirect calorimeter was used to assess the RMR. Result: It was observed that after correction for potential confounders, DBP and NEAP and PRAL scores were inversely associated (P<0.05). NEAP index was inversely associated with RMR (β= -0.25, 95% CI=-0.1.5 to 2.08, P=0.02), and positively associated with WC (β= 1.009, 95% CI=-1.43 to 3.45, P=0.05) and WHR (β= 0.01, 95% CI= -0.01 to0.04, P=0.03), such that subjects with higher scores in NEAP had lower RMR and higher WC and WHR. We also observed that DAL (β= -0.02, 95% CI= -0.08 to0.03, P=0.08) and PRAL (β= -0.037, 95% CI= -1.05 to 0.03 P=0.07) were marginally associated with RMR.Conclusion:The results of the present study suggested that higher dietary acid load scores may be negatively associated with lower RMR, while directly associated with greater WC, WHR, DBP, and HOMA-IR.

scholarly journals Associations between Dietary Acid Load and Biomarkers of Inflammation and Hyperglycemia in Breast Cancer Survivors

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1913 ◽  
Author(s):  
Tianying Wu ◽  
Phoebe Seaver ◽  
Hector Lemus ◽  
Kathryn Hollenbach ◽  
Emily Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metabolic Acidosis ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Acid Base Balance ◽  
Acid Base ◽  
Dietary Acid Load ◽  
Base Balance ◽  
Dietary Acid ◽  
Acid Load

Metabolic acidosis can lead to inflammation, tissue damage, and cancer metastasis. Dietary acid load contributes to metabolic acidosis if endogenous acid–base balance is not properly regulated. Breast cancer survivors have reduced capacities to adjust their acid–base balance; yet, the associations between dietary acid load and inflammation and hyperglycemia have not been examined among them. We analyzed data collected from 3042 breast cancer survivors enrolled in the Women’s Healthy Eating and Living (WHEL) Study who had provided detailed dietary intakes and measurements of plasma C-reactive protein (CRP) and hemoglobin A1c (HbA1c). Using a cross-sectional design, we found positive associations between dietary acid load and plasma CRP and HbA1c. In the multivariable-adjusted models, compared to women with the lowest quartile, the intakes of dietary acid load among women with the highest quartile showed 30–33% increases of CRP and 6–9% increases of HbA1c. Our study is the first to demonstrate positive associations between dietary acid load and CRP and HbA1c in breast cancer survivors. Our study identifies a novel dietary factor that may lead to inflammation and hyperglycemia, both of which are strong risk factors for breast cancer recurrence and comorbidities.

scholarly journals The Association of Dietary Acid Load with Resting Metabolic Rate and Metabolic Components in Overweight and Obese Women: A Cross Sectional Study

2021 ◽  
Author(s):  
Atieh Mirzababaei ◽  
Farideh Shiraseb ◽  
Leila Setayesh ◽  
Atefeh Tavakoli ◽  
Cain C. T. Clark Clark ◽  
...  
Keyword(s):  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Cross Sectional Study ◽  
The Body ◽  
Adult Women ◽  
Sectional Study ◽  
Cross Sectional ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load

Abstract Background: Several epidemiologic studies have reported that dietary acid load is associated with metabolic profiles; however, to our knowledge, the relationship of this dietary pattern with resting metabolic rate (RMR) among obese and overweight females remains unreported. Therefore, this study aimed to evaluate the association of dietary acid load RMR and metabolic components among overweight and obese adult women.Methods: This cross-sectional study was conducted on 375 Iranian adults, aged 18–48 years. Dietary acid load indexes were calculated by using a validated 147-item semi-quantitative FFQ. Biochemical and anthropometric measures were assessed using standard methods. An impedance fat analyzer was used to obtain the body composition and an indirect calorimeter was used to assess the RMR. Result: It was observed that after correction for potential confounders, DBP and NEAP and PRAL scores were inversely associated (P<0.05). NEAP index was inversely associated with RMR (β= -0.25, 95% CI=-0.1.5 to 2.08, P=0.02), and positively associated with WC (β= 1.009, 95% CI=-1.43 to 3.45, P=0.05) and WHR (β= 0.01, 95% CI= -0.01 to0.04, P=0.03), such that subjects with higher scores in NEAP had lower RMR and higher WC and WHR. We also observed that DAL (β= -0.02, 95% CI= -0.08 to0.03, P=0.08) and PRAL (β= -0.037, 95% CI= -1.05 to 0.03 P=0.07) were marginally associated with RMR.Conclusion:The results of the present study suggested that higher dietary acid load scores may be negatively associated with lower RMR, while directly associated with greater WC, WHR, DBP, and HOMA-IR.

scholarly journals Dietary acid load and risk of cardiovascular disease: a prospective population-based study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Parvin Mirmiran ◽  
Zeinab Houshialsadat ◽  
Zahra Bahadoran ◽  
Sajjad Khalili‑Moghadam ◽  
Mohammad Karim Shahrzad ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Asian Population ◽  
Cardiovascular Effects ◽  
The Body ◽  
Dietary Intakes ◽  
Food Frequency ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load ◽  
The Impact

Abstract Background and aim Considering the inconsistencies in the cardiovascular effects of dietary acid load and the impact of dietary acidity on the acid–base homeostasis within the body, we aimed to assess the association of dietary acid load and the risk of cardiovascular disease (CVD) in a prospective community-based study. Materials and methods Participants (n = 2369) free of CVD at baseline (2006–2008) were included from the Tehran Lipid and Glucose Study (TLGS) and followed up for a mean of 6.7 ± 1.4 years. Dietary intakes of the participants were assessed using a semi-quantitative food frequency questionnaire (FFQ). The dietary acid load was evaluated by Potential Renal Acid Load (PRAL) and Net Endogenous Acid Production (NEAP) scores. Both scores have used the macronutrient and micronutrient data of the Food Frequency Questionnaires. Multivariate Cox proportional hazard regression models were used to estimate the 6-years incident risk of CVDs across tertiles of PRAL and NEAP scores. Results Mean age and body mass index of participants were 38.5 ± 13.3 years and 26.6 ± 4.8 kg/m2 at baseline. Within 6.7 ± 1.4 years of follow-up, 79 cases of cardiovascular events were reported. NEAP was significantly associated with the incidence of CVDs (HRs = 0.50, CI 0.32–0.96; P for trend = 0.032); however, after adjusting for potential confounders, no significant associations were observed between PRAL and NEAP scores and the risk of CVDs. Conclusions This study failed to obtain independent associations between dietary acid load and the incidence of CVDs among an Asian population.

scholarly journals Keseimbangan asam-basa tubuh dan kejadian sindrom metabolik pada remaja obesitas

2017 ◽  
Vol 14 (1) ◽  
pp. 36
Author(s):  
Firdananda Fikri Jauharany ◽  
Nurmasari Widyastuti
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Acid Base Balance ◽  
Acid Base ◽  
Dietary Acid Load ◽  
Base Balance ◽  
Dietary Acid ◽  
Acid Load

Background: The prevalence of metabolic syndrome increased in young population, indicated by the rise in obesity among children and adolescent. The Western dietary pattern was one of the causes. A Western diet rich in animal protein can produce acid during the metabolic process and may cause an acid-excess in the body (dietary acid load). This process was contributed to acid-base balance through the metabolism of sulfur-containing amino acids (cysteine and methionine) which produce H+ ions as well as lowering the pH.Objective: To examine the association between acid-base balance and components of metabolic syndrome among obese adolescent.Method: A cross-sectional study was conducted on 40 obese adolescents in Semarang high school. We measured Potential Renal Acid Load (PRAL) score and pH urine as an acid-base indicator. MetS are defined ≥ 3 following risk factors: waist circumference ≥90th percentile, blood pressure ≥90th percentile, triglycerides ≥110 mg/dl, HDL levels ≤40 mg/dl, and fasting blood glucose levels ≥110 mg/dl. Normality test used the Shapiro-Wilk test (n <50). The bivariate analysis used Pearson test, Rank-Spearman test, and Chi-Square test. The multivariate analysis used Multivariate Linear Regression analysis of Backward.Results: PRAL score was associated with waist circumference (r=0,347; p=0,028), sistolic blood pressure (r=0,590; p=<0,001), diastolic blood pressure (r=0,668; p=<0,001), and triglyceride levels (r=0,362; p=0,022). pH urin was not associated with any risk factors of MetS.Conclusion: High dietary acid load may be a risk factor for the development of MetS.

scholarly journals Dietary Acid Load and Relationship with Albuminuria and Glomerular Filtration Rate in Individuals with Chronic Kidney Disease at Predialysis State

Nutrients ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 170
Author(s):  
Luísa Silva ◽  
Sara Alegria Moço ◽  
Maria Luz Antunes ◽  
Andreia Sousa Ferreira ◽  
Ana Catarina Moreira
Keyword(s):  
Systematic Review ◽  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Dietary Acid Load ◽  
Improved Outcomes ◽  
Dietary Acid ◽  
Acid Load ◽  
Excessive Consumption ◽  
Vegetables And Fruits

The Western diet, characterized by excessive consumption of animal protein and reduced intake of vegetables and fruits, is also rich in sulfur, chlorine, and organic acids, which are the main sources of dietary acid load. A relationship between dietary acid load, renal function, and progression of chronic kidney disease has been demonstrated. Dietary modifications seem to contribute to a reduction in dietary acid load, and are associated with improved outcomes in individuals with chronic kidney disease (CKD). The aim of this paper was to review the existing evidence concerning the association between dietary acid load and renal function in nondialyzed individuals with CKD. A systematic review was conducted by gathering articles in electronic databases (MEDLINE/PubMed, Scopus, and Web of Science) from January 2018 to May 2021. Dietary acid load and GFR and/or albuminuria were analyzed. A total of 1078 articles were extracted, of which 5 met the inclusion criteria. Only one study found no statistically significant associations between the study variables. The remaining showed a negative association between dietary acid load and renal function. This systematic review confirmed the existence of an association between dietary acid load and renal function, with a high dietary acid load contributing to a decreased renal function.

The Associations of Dietary Acid Load with Insulin Resistance and Type 2 Diabetes: A Systematic Review of Existing Human Studies

2019 ◽  
Vol 10 (1) ◽  
pp. 27-33
Author(s):  
Hadi Emamat ◽  
Hadith Tangestani ◽  
Zahra Bahadoran ◽  
Sajjad Khalili-Moghadam ◽  
Parvin Mirmiran
Keyword(s):  
Type 2 Diabetes ◽  
Human Studies ◽  
Metabolic Effects ◽  
Inclusion Criteria ◽  
Acid Base ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load ◽  
Load Indices

Background: Type 2 diabetes is a multifactorial disorder influenced by both genetic and environmental factors and is rising dramatically throughout the world. Recently, consideration to dietary acid-base load has been raised as a nutritional indicator that could have metabolic effects. </P><P> Objective: The aim of this study was to systematically investigate the associations of dietary acid load indices with glucose/insulin homeostasis and type 2 diabetes in a patent based review. </P><P> Methods: Systematic literature review was conducted using PubMed, Scopus and Google Scholar, from inception up to 10 January 2018. All human studies publications investigated the association of dietary acid load indices (PRAL or NEAP or Pro:K) and incidence of diabetes or glucose/insulin metabolism were included. </P><P> Results: In all, 174 studies were included for the title and abstract screening. A total of 164 articles were excluded because they did not meet the inclusion criteria. Finally, 10 articles (five crosssectional studies and five cohort studies) in accordance with our inclusion criteria were chosen for further evaluations that were published between 2008 and 2017. </P><P> Conclusion: Although there are some evidence of an association between dietary acid load and type 2 diabetes, definitive declarations in this regard will be needed to intervention human studies modifying acid-base dietary intake.

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