Syntheses and antibacterial activity of novel 6-fluoro-7-(gem-disubstituted piperazin-1-yl)-quinolines
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A series of quinoline and naphthyridine antibacterial agents possessing an acyclic or cyclic gem-disubstituted piperazine substituent at the C-7 position have been prepared and evaluated in vitro and in vivo for antibacterial activity against a variety of Gram-positive and Gram-negative organisms. They are, however, not as active as quinolones or naphthyridines with a monosubstituted piperazine substituent at C-7. The chemical synthesis of these derivatives is also described.
2006 ◽
Vol 50
(6)
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pp. 2261-2264
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2015 ◽
Vol 25
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pp. 79-93
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2020 ◽
Vol 9
(5)
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pp. 2218-2225
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1987 ◽
Vol 31
(2)
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pp. 328-330
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1941 ◽
Vol 73
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pp. 629-640
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