The role of Granzyme B in atheromatous diseasesThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigators' Forum.

2007 ◽  
Vol 85 (1) ◽  
pp. 89-95 ◽  
Author(s):  
Ciara M. Chamberlain ◽  
David J. Granville
Keyword(s):  
Cell Death ◽  
Inflammatory Disease ◽  
Apoptotic Cell ◽  
Granzyme B ◽  
Cardiac Allograft ◽  
Special Issue ◽  
Immune Mediated ◽  
Intense Research ◽  
Selection Of

The mechanism and role of apoptotic cell death in the pathogenesis of atheromatous diseases is an area of intense research. Atherosclerosis is an inflammatory disease and as such, immune-mediated cell killing plays an important role. Recent studies have suggested that Granzyme B and perforin play an important role in atherogenesis. The current manuscript reviews our current understanding pertaining to the role of Granzyme B in cardiac allograft vasculpathy and atherosclerosis.

Masterminds or minions? Cysteine proteinases in plant programmed cell deathThis review is one of a selection of papers published in the Special Issue on Plant Cell Biology.

2006 ◽  
Vol 84 (4) ◽  
pp. 651-667 ◽  
Author(s):  
Christopher P. Trobacher ◽  
Adriano Senatore ◽  
John S. Greenwood
Keyword(s):  
Cell Death ◽  
Cell Biology ◽  
Apoptotic Cell ◽  
Gene Families ◽  
Cysteine Proteinases ◽  
Special Issue ◽  
Multicellular Organisms ◽  
Protease Expression ◽  
Signalling Cascade ◽  
Selection Of

Cysteine proteinases are ubiquitously involved in programmed cell death (PCD) in multicellular organisms. In animals, one group of cysteine proteinases, the cysteine-dependent aspartate-specific proteinases (caspases), are involved in a proteolytic signalling cascade that controls apoptosis, the most studied form of PCD. The enzymes act as both masterminds and executioners in apoptotic cell death. In plants, members of the metacaspase family, as well as those of the papain-like and legumain families, of cysteine proteinases have all been implicated in PCD. These enzymes often belong to sizeable gene families, with Arabidopsis having 9 metacaspase, 32 papain-like, and 4 legumain genes. This redundancy has made it difficult to ascertain the functional importance of any particular enzyme in plant PCD, as many are often expressed in a given tissue undergoing PCD. As yet, mechanisms similar to the apoptotic caspase cascade in animals have not been uncovered in plants and, indeed, may not exist. Are the various cysteine proteinases, so often implicated in plant PCD, merely acting as minions in the process? This review will outline reports of cysteine proteinases associated with plant PCD, discuss problems in determining the function of specific proteases, and suggest avenues for determining how these enzymes might be regulated and how PCD pathways upstream of protease expression and activation might operate.

RETRACTED: A study of the role of apoptotic cell death and cell cycle events mediating the mechanism of action of 6-hydroxycoumarin-3-carboxylatosilver in human malignant hepatic cells

2013 ◽  
Vol 337 (1) ◽  
pp. 146
Author(s):  
Bhumika Thati ◽  
Andy Noble ◽  
Bernadette S. Creaven ◽  
Maureen Walsh ◽  
Malachy McCann ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Death ◽  
Mechanism Of Action ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Hepatic Cells

Mixed-ligand copper(ii) Schiff base complexes: the vital role of co-ligands in DNA/protein interactions and cytotoxicity

2017 ◽  
Vol 41 (3) ◽  
pp. 1267-1283 ◽  
Author(s):  
Sellamuthu Kathiresan ◽  
Subramanian Mugesh ◽  
Jamespandi Annaraj ◽  
Maruthamuthu Murugan
Keyword(s):  
Cell Death ◽  
Cell Wall ◽  
Schiff Base ◽  
Protein Interactions ◽  
Apoptotic Cell ◽  
Vital Role ◽  
Mixed Ligand ◽  
Schiff Base Complexes ◽  
Antibacterial Mechanism

Four new mixed-ligand copper(ii) complexes display an antibacterial mechanism of cell death via cell-wall rupture and cytotoxicity via apoptotic cell death.

scholarly journals Toward Best Practices in Quantitative, Qualitative, and Mixed- Method Research: A Social Justice Perspective

2013 ◽  
Vol 5 (2) ◽  
pp. 69-83 ◽  
Author(s):  
Ruth Fassinger ◽  
Susan L. Morrow
Keyword(s):  
Social Justice ◽  
Best Practices ◽  
Mixed Method ◽  
Research Method ◽  
Data Gathering ◽  
Team Formation ◽  
Mixed Method Research ◽  
Special Issue ◽  
Selection Of

Various research methods can be appropriate for social justice aims. Quantitative, qualitative, and mixed-method approaches offer different kinds of strengths in advancing a social justice agenda. This article recaptures and expands upon the ideas presented by the authors of this special issue, recommending best practices in research for social justice in the following areas: (a) cultural competence and the role of the researcher(s); (b) formulating the focus of the research; (c) selection of the underlying paradigm and research method/design; (d) the research team: formation, process, and issues of power; (e) power and relationship with research participants; and (f) data gathering, analysis, and reporting.

Cytochrome p450 2C (CYP2C) in ischemic heart injury and vascular dysfunctionThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigator's Forum.

2006 ◽  
Vol 84 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Manreet K. Chehal ◽  
David J. Granville
Keyword(s):  
Cytochrome P450 ◽  
Ischemic Heart ◽  
Epoxyeicosatrienoic Acids ◽  
Special Issue ◽  
Ischemia And Reperfusion Injury ◽  
Current Review ◽  
Cytochrome P450 2C ◽  
Heart Injury ◽  
Selection Of

The cytochrome p450 2C (CYP2C) monooxygenase family is a key player in the generation of epoxyeicosatrienoic acids. It has recently become apparent that CYP plays an important role in cardiovascular physiology and contributes to the pathogenesis of various cardiovascular diseases. In particular, several studies have demonstrated a role for these enzymes in cardiac ischemia and reperfusion injury. The current review summarizes the role of the CYP epoxygenase, CYP2C9, in ischemic heart disease and vascular homeostasis.

Role of Ion Transport in Control of Apoptotic Cell Death

2012 ◽  
Author(s):  
Florian Lang ◽  
Else K. Hoffmann
Keyword(s):  
Cell Death ◽  
Ion Transport ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

scholarly journals Caspase-9 cleavage, do you need it?

2007 ◽  
Vol 405 (1) ◽  
Author(s):  
Davina Twiddy ◽  
Kelvin Cain
Keyword(s):  
Cell Death ◽  
Apoptotic Cell ◽  
Caspase 9 ◽  
Autocatalytic Cleavage ◽  
Downstream Effector ◽  
Apoptosis Inhibition ◽  
Biochemical Journal ◽  
Effector Caspase ◽  
Effector Caspases

Caspase-9, which is activated by association with the Apaf-1 (apoptotic protease-activating factor-1) apoptosome complex, cleaves and activates the downstream effector caspases-3 and -7, thereby executing the caspase-cascade and cell-death programme. Although caspase-9 does not need to be cleaved to be active, apoptotic cell death is always accompanied by autocatalytic cleavage and by further downstream effector caspase-dependent cleavage of caspase-9. In this issue of the Biochemical Journal, Denault and co-workers evaluate the role of caspase-3-dependent cleavage of caspase-9 and conclude that this mechanism mainly serves to enhance apoptosis by alleviating XIAP (X-linked inhibitor of apoptosis) inhibition of the apical caspase.

scholarly journals The role of necrotic cell death in the pathogenesis of immune mediated nephropathies

2014 ◽  
Vol 153 (2) ◽  
pp. 243-253 ◽  
Author(s):  
Neelakshi R. Jog ◽  
Roberto Caricchio
Keyword(s):  
Cell Death ◽  
Necrotic Cell Death ◽  
Necrotic Cell ◽  
Immune Mediated
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