Cytochrome p450 2C (CYP2C) in ischemic heart injury and vascular dysfunctionThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigator's Forum.

2006 ◽  
Vol 84 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Manreet K. Chehal ◽  
David J. Granville
Keyword(s):  
Cytochrome P450 ◽  
Ischemic Heart ◽  
Epoxyeicosatrienoic Acids ◽  
Special Issue ◽  
Ischemia And Reperfusion Injury ◽  
Current Review ◽  
Cytochrome P450 2C ◽  
Heart Injury ◽  
Selection Of

The cytochrome p450 2C (CYP2C) monooxygenase family is a key player in the generation of epoxyeicosatrienoic acids. It has recently become apparent that CYP plays an important role in cardiovascular physiology and contributes to the pathogenesis of various cardiovascular diseases. In particular, several studies have demonstrated a role for these enzymes in cardiac ischemia and reperfusion injury. The current review summarizes the role of the CYP epoxygenase, CYP2C9, in ischemic heart disease and vascular homeostasis.

scholarly journals Toward Best Practices in Quantitative, Qualitative, and Mixed- Method Research: A Social Justice Perspective

2013 ◽  
Vol 5 (2) ◽  
pp. 69-83 ◽  
Author(s):  
Ruth Fassinger ◽  
Susan L. Morrow
Keyword(s):  
Social Justice ◽  
Best Practices ◽  
Mixed Method ◽  
Research Method ◽  
Data Gathering ◽  
Team Formation ◽  
Mixed Method Research ◽  
Special Issue ◽  
Selection Of

Various research methods can be appropriate for social justice aims. Quantitative, qualitative, and mixed-method approaches offer different kinds of strengths in advancing a social justice agenda. This article recaptures and expands upon the ideas presented by the authors of this special issue, recommending best practices in research for social justice in the following areas: (a) cultural competence and the role of the researcher(s); (b) formulating the focus of the research; (c) selection of the underlying paradigm and research method/design; (d) the research team: formation, process, and issues of power; (e) power and relationship with research participants; and (f) data gathering, analysis, and reporting.

Employability of higher education graduates in Europe

2014 ◽  
Vol 35 (4) ◽  
pp. 418-424 ◽  
Author(s):  
Samo Pavlin ◽  
Ivan Svetlik
Keyword(s):  
Higher Education ◽  
Labour Market ◽  
Design Methodology ◽  
Global Changes ◽  
Special Issue ◽  
Strategic Development ◽  
Content Type ◽  
Scientific Approach ◽  
Selection Of

Purpose – The purpose of this paper is to introduce the special issue on “Employability of higher education graduates in europe” from the perspective of global changes. Design/methodology/approach – The empirically based papers of the special issue address six main areas related to the transition of graduates from education to the labour market: employment and employability, job (mis)match, development of particular areas of competency, new certificates of higher education, along with the disciplinarity and status of the self-perceived role of academics in supporting graduates’ careers. Findings – This issue provides empirical findings relevant to various stakeholders of higher education systems which are essential for strategic development in the area. Originality/value – The selection of papers proposes an interdisciplinary scientific approach in the areas of bridging (higher) education with the labour market.

scholarly journals PREFACE: SOCIAL JUSTICE IN CHILD, YOUTH AND FAMILY STUDIES

2011 ◽  
Vol 2 (3/4) ◽  
pp. 353 ◽  
Author(s):  
Shannon A. Moore
Keyword(s):  
Health Promotion ◽  
Human Rights ◽  
Social Justice ◽  
Critical Pedagogy ◽  
Family Studies ◽  
Special Issue ◽  
Children And Young People ◽  
Post Colonial ◽  
Selection Of

<p>This special issue of the <em>International Journal of Child, Youth and Family Studies</em> offers critical insights into contemporary social justice issues impacting the lives of children and young people, their caregivers, and their communities. The authors write from a range of fields as they question taken-for-granted knowledges within social work, child welfare, health promotion, psychology, sociology, education, human rights, and women’s studies. As such, the collection includes feminist, post-colonial, post-structural, and post-modern analyses organized through an editorial standpoint of critical pedagogy. The preface offers additional insights into my own personal, professional, epistemological, and pedagogical locations that illuminate my role of guest editor, and further contextualizes the transdisciplinary selection of manuscripts within a social justice discourse.</p>

Editorial: Taste of City, transnational food and place marketing

2016 ◽  
Vol 4 (2) ◽  
pp. 59-61
Author(s):  
Evinc Dogan ◽  
Ibrahim Sirkeci
Keyword(s):  
Social Sciences ◽  
Place Marketing ◽  
Special Issue ◽  
Migration Studies ◽  
Wide Range ◽  
The World ◽  
Culinary Traditions ◽  
The University ◽  
Selection Of

In this special issue of Transnational Marketing Journal, we brought together a selection of articles drawn from presentations at the Taste of City Conference 2016: Food and Place Marketing which was held at the University of Belgrade, Serbia on 1st September 2016. We have supported the event along with Transnational Press London. We thank to Goran Petkovic, the Faculty of Economics at the University of Belgrade, and Goran’s volunteer students team who helped with the conference organisation. Mobilities are often addressed within social sciences varying across a wide range of disciplines including geography, migration studies, cultural studies, tourism, sociology and anthropology. Food mobilities capture eating, tasting, producing and consuming practices as well as traveling and transferring. Food and tastes are carried around the world, along the routes of mobility through out the history. As people take their own culture to the places, they take their food too. Food meets and mingles with other cultures on the way. Fusion food is born when food transcends the borders and mix with different ingredients from different culinary traditions. Although certain places are associated and branded with food, it is a challenging job to understand the role of food and taste in forming and reformulating the identity of places. 

scholarly journals Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition

2011 ◽  
Vol 165 (2) ◽  
pp. 520-531 ◽  
Author(s):  
Jacky TC Liu ◽  
Erfei Song ◽  
Aimin Xu ◽  
Thorsten Berger ◽  
Tak W Mak ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Endothelial Dysfunction ◽  
Lipocalin 2 ◽  
Cytochrome P450 2C ◽  
Dietary Obesity

The role of sex in cardiac function and diseaseThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigator's Forum.

2006 ◽  
Vol 84 (1) ◽  
pp. 93-109 ◽  
Author(s):  
Michael P. Czubryt ◽  
Leon Espira ◽  
Lise Lamoureux ◽  
Bernard Abrenica
Keyword(s):  
Disease Susceptibility ◽  
Heart Function ◽  
Cardiac Diseases ◽  
Special Issue ◽  
Isolated Cardiomyocytes ◽  
The Past ◽  
Health And Disease ◽  
Shed Light ◽  
Selection Of

In the past decade, increasing attention has been paid to the importance of sex in the etiology of cardiac dysfunction. While focus has been primarily on how sex modulates atherogenesis, it is becoming clear that sex is both a predictor of outcome and an independent risk factor for a number of other cardiac diseases. Animal models and human studies have begun to shed light on the mechanisms by which sex influences the function of cardiomyocytes in health and disease. This review will survey the current literature on cardiac diseases that are influenced by sex and discuss the intracellular mechanisms by which steroid sex hormones affect heart function. A theory on how sex may regulate myocardial energy metabolism to affect disease susceptibility and progression will be presented, as well as a discussion of how sex may influence outcomes of experiments on isolated cardiomyocytes by epigenetic marking.

scholarly journals The Functions of Cytochrome P450 ω-hydroxylases and the Associated Eicosanoids in Inflammation-Related Diseases

2021 ◽  
Vol 12 ◽  
Author(s):  
Kai-Di Ni ◽  
Jun-Yan Liu
Keyword(s):  
Fatty Acids ◽  
Cytochrome P450 ◽  
Leukotriene B4 ◽  
Hydroxyl Group ◽  
Epoxyeicosatrienoic Acids ◽  
Oxidation Reactions ◽  
Hydroxylated Metabolites ◽  
Associated Diseases ◽  
Exogenous Compounds

The cytochrome P450 (CYP) ω-hydroxylases are a subfamily of CYP enzymes. While CYPs are the main metabolic enzymes that mediate the oxidation reactions of many endogenous and exogenous compounds in the human body, CYP ω-hydroxylases mediate the metabolism of multiple fatty acids and their metabolites via the addition of a hydroxyl group to the ω- or (ω-1)-C atom of the substrates. The substrates of CYP ω-hydroxylases include but not limited to arachidonic acid, docosahexaenoic acid, eicosapentaenoic acid, epoxyeicosatrienoic acids, leukotrienes, and prostaglandins. The CYP ω-hydroxylases-mediated metabolites, such as 20-hyroxyleicosatrienoic acid (20-HETE), 19-HETE, 20-hydroxyl leukotriene B4 (20-OH-LTB4), and many ω-hydroxylated prostaglandins, have pleiotropic effects in inflammation and many inflammation-associated diseases. Here we reviewed the classification, tissue distribution of CYP ω-hydroxylases and the role of their hydroxylated metabolites in inflammation-associated diseases. We described up-regulation of CYP ω-hydroxylases may be a pathogenic mechanism of many inflammation-associated diseases and thus CYP ω-hydroxylases may be a therapeutic target for these diseases. CYP ω-hydroxylases-mediated eicosanods play important roles in inflammation as pro-inflammatory or anti-inflammatory mediators, participating in the process stimulated by cytokines and/or the process stimulating the production of multiple cytokines. However, most previous studies focused on 20-HETE,and further studies are needed for the function and mechanisms of other CYP ω-hydroxylases-mediated eicosanoids. We believe that our studies of CYP ω-hydroxylases and their associated eicosanoids will advance the translational and clinal use of CYP ω-hydroxylases inhibitors and activators in many diseases.

Role of Cytochrome P450 2C Epoxygenases in Hypoxia-Induced Cell Migration and Angiogenesis in Retinal Endothelial Cells

2008 ◽  
Vol 49 (3) ◽  
pp. 1242 ◽  
Author(s):  
U. Ruth Michaelis ◽  
Ning Xia ◽  
Eduardo Barbosa-Sicard ◽  
John R. Falck ◽  
Ingrid Fleming
Keyword(s):  
Endothelial Cells ◽  
Cytochrome P450 ◽  
Cell Migration ◽  
Retinal Endothelial Cells ◽  
Cytochrome P450 2C

Is methylglyoxal a causative factor for hypertension development?This paper is one of a selection of papers published in this Special Issue, entitled Young Investigator's Forum.

2006 ◽  
Vol 84 (1) ◽  
pp. 129-139 ◽  
Author(s):  
Lingyun Wu
Keyword(s):  
Causative Factor ◽  
Vascular Damage ◽  
Special Issue ◽  
Cardiovascular Risks ◽  
Life Threatening ◽  
Hypertension Development ◽  
Pathogenic Process ◽  
Reactive Molecule ◽  
Selection Of

Hypertension is a life-threatening disease that is associated with increased cardiovascular risks. Causes and mechanisms for hypertension development remain poorly understood. Methylglyoxal (MG), a highly reactive molecule, is a metabolite of sugar. Increased circulation and tissue levels of MG have been documented not only in diabetes but also in hypertension. Many recent studies also link MG-induced vascular damage to the pathogenic process of hypertension. As such, an etiological role of MG in hypertension development is proposed.

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