COMBINED ESTIMATES IN COLORIMETRIC DETERMINATIONS WITH HIGH VARIABILITY

1960 ◽  
Vol 38 (1) ◽  
pp. 1223-1227 ◽  
Author(s):  
P. A. Anastassiadis

In a number of colorimetric determinations used in biochemistry, the absorbances of replicates are subject to variations. The resulting variability may be time-to-time variability, measured by the intervariance, or variability of simultaneous replicates, measured by the intravariance. In such determinations two estimates of the unknown may be derived according to the standards used, one based on the absorbance of simultaneous standards, a second based on the mean absorbance of all available standards. If intravariance does not exist, the first estimate is the more precise. If intervariance does not exist, the second estimate is the more precise. If both intravariance and intervariance exist, a weighted mean of two estimates, one based on the absorbances of simultaneous standards and a second based on the mean absorbance of all the available non-simultaneous standards, is a value with an increased precision. A method for calculating this value is given.

1960 ◽  
Vol 38 (11) ◽  
pp. 1223-1227 ◽  
Author(s):  
P. A. Anastassiadis

In a number of colorimetric determinations used in biochemistry, the absorbances of replicates are subject to variations. The resulting variability may be time-to-time variability, measured by the intervariance, or variability of simultaneous replicates, measured by the intravariance. In such determinations two estimates of the unknown may be derived according to the standards used, one based on the absorbance of simultaneous standards, a second based on the mean absorbance of all available standards. If intravariance does not exist, the first estimate is the more precise. If intervariance does not exist, the second estimate is the more precise. If both intravariance and intervariance exist, a weighted mean of two estimates, one based on the absorbances of simultaneous standards and a second based on the mean absorbance of all the available non-simultaneous standards, is a value with an increased precision. A method for calculating this value is given.


2021 ◽  
Vol 10 (3) ◽  
pp. e001214
Author(s):  
Jessalyn K Holodinsky ◽  
Vivian N Onaemo ◽  
Ruth Whelan ◽  
Gary Hunter ◽  
Brett R Graham ◽  
...  

BackgroundFor ischaemic stroke, outcome severity is heavily time dependent. Systems of care need to be in place to ensure that patients with stroke are treated quickly and appropriately across entire health regions. Prior to this study, the province of Saskatchewan, Canada did not have a provincial stroke strategy in place.MethodsA quality improvement project was undertaken to create and evaluate a provincial stroke strategy. The Saskatchewan Acute Stroke Pathway was created using a multidisciplinary team of experts, piloted at five stroke centres and then implemented provincially. The number of stroke alerts, door-to-imaging, door-to-needle, door-to-groin puncture times and treatment rates were collected at all centres. Improvements over time were analysed using run charts and individuals control charts.ResultsThe number of stroke alerts province-wide trended upwards in the last 6 months of the study. There were no clear trends or shifts in the proportion of stroke alerts treated with alteplase or endovascular therapy. Across the province, the weighted mean door-to-imaging time decreased from 21 to 15 min, the weighted mean door-to-needle time decreased from 62 to 47 min and the mean door-to-groin puncture time decreased from 83 to 70 min. There was high variability in the degree of improvement from centre to centre.ConclusionsThe implementation of a province wide acute stroke pathway has led to improvement in stroke care on a provincial basis. Further work addressing intercentre variability is ongoing.


1979 ◽  
Vol 53 ◽  
pp. 494-494
Author(s):  
Karl W. Kamper

An Allegheny parallax series of SS Cyg, consisting of 52 exposures obtained on 15 nights, was recently measured on the PDS microphotometer at the David Dunlap Observatory, and a value of (m.e.) derived for the absolute parallax. This is close to the mean of the two previous discordant measures for this star given in the table below. The weighted mean of the three determinations implies that the absolute magnitude, at quiescent phase, of the star is between 7.0 and 9.0 formally at a 90% confidence level. Recent parallax determinations made at Lick by Vasilevskls et al. (1975) for three other stars, listed below along with the Mt. Wilson value for U Gem, imply even fainter absolute magnitudes.


1973 ◽  
Vol 72 (2) ◽  
pp. 265-271 ◽  
Author(s):  
J. H. Dussault ◽  
D. A. Fisher ◽  
J. T. Nicoloff ◽  
V. V. Row ◽  
R. Volpe

ABSTRACT In order to determine the effect of alterations in binding capacity of thyroxine binding globulin (TBG) on triiodothyronine (T3) metabolism, studies were conducted in 10 patients with idiopathically low (7 subjects) or elevated (3 subjects) TBG levels and 10 subjects given norethandrolone (7 male subjects) or oestrogen (3 female subjects). Measurements of serum thyroxine (T4) concentration, maximal T4 binding capacity, serum T3 concentration and per cent dialyzable T3 were conducted. Serum T3 was measured both by chemical and radioimmunoassay methods. In patients with idiopathically low TBG, the mean serum T4 concentration was low (2.4 μg/100 ml), the mean serum T3 level low (55 ng/100 ml), the mean per cent dialyzable T3 increased (0.52%), and the calculated free T3 concentration normal (186 pg/100 ml). In patients with idiopathically high TBG levels the mean T4 concentration was high (10.3 μg/100 ml), the mean T3 level slightly elevated (127 ng/100 ml), the% dialyzable T3 low (0.10%) and the calculated free T3 concentration low normal (123 pg/100 ml). The correlation coefficient between the per cent dialyzable T3 and maximal TBG binding capacity in the 20 subjects was 0.68, a value significant at the P < 0.01 level. Thus, alterations in binding capacity of TBG seem to influence T3 and T4 metabolism similarly; the inverse relationship between the % of dialyzable hormone and total hormone concentration tends to keep the absolue levels of free hormones stable.


2020 ◽  
Vol 1 (2) ◽  
pp. 56-66
Author(s):  
Irma Linda

Background: Early marriages are at high risk of marital failure, poor family quality, young pregnancies at risk of maternal death, and the risk of being mentally ill to foster marriage and be responsible parents. Objective: To determine the effect of reproductive health education on peer groups (peers) on the knowledge and perceptions of adolescents about marriage age maturity. Method: This research uses the Quasi experimental method with One group pre and post test design, conducted from May to September 2018. The statistical analysis used in this study is a paired T test with a confidence level of 95% (α = 0, 05). Results: There is an average difference in the mean value of adolescent knowledge between the first and second measurements is 0.50 with a standard deviation of 1.922. The mean difference in mean scores of adolescent perceptions between the first and second measurements was 4.42 with a standard deviation of 9.611. Conclusion: There is a significant difference between adolescent knowledge on the pretest and posttest measurements with a value of P = 0.002, and there is a significant difference between adolescent perceptions on the pretest and posttest measurements with a value of p = 0.001. Increasing the number of facilities and facilities related to reproductive health education by peer groups (peers) in adolescents is carried out on an ongoing basis at school, in collaboration with local health workers as prevention of risky pregnancy.


2020 ◽  
Vol 15 (S359) ◽  
pp. 33-34
Author(s):  
K. A. Cutiva-Alvarez ◽  
R. Coziol ◽  
J. P. Torres-Papaqui ◽  
H. Andernach ◽  
A. C. Robleto-Orús

AbstractUsing WISE data, we calibrated the W2-W3 colors in terms of star formation rates (SFRs) and applied this calibration to a sample of 1285 QSOs with the highest flux quality, covering a range in redshift from z ˜ 0.3 to z ˜ 3.8. According to our calibration, the SFR increases continuously, reaching a value at z ˜ 3.8 about 3 times higher on average than at lower redshift. This increase in SFR is accompanied by an increase of the BH mass by a factor 100 and a gradual increase of the mean Eddington ratio from 0.1 to 0.3 up to z ˜ 1.5 – 2.0, above which the ratio stays constant, despite a significant increase in BH mass. Therefore, QSOs at high redshifts have both more active BHs and higher levels of star formation activity.


Energies ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2525
Author(s):  
Kamil Krasuski ◽  
Damian Wierzbicki

In the field of air navigation, there is a constant pursuit for new navigation solutions for precise GNSS (Global Navigation Satellite System) positioning of aircraft. This study aims to present the results of research on the development of a new method for improving the performance of PPP (Precise Point Positioning) positioning in the GPS (Global Positioning System) and GLONASS (Globalnaja Nawigacionnaja Sputnikovaya Sistema) systems for air navigation. The research method is based on a linear combination of individual position solutions from the GPS and GLONASS systems. The paper shows a computational scheme based on the linear combination for geocentric XYZ coordinates of an aircraft. The algorithm of the new research method uses the weighted mean method to determine the resultant aircraft position. The research method was tested on GPS and GLONASS kinematic data from an airborne experiment carried out with a Seneca Piper PA34-200T aircraft at the Mielec airport. A dual-frequency dual-system GPS/GLONASS receiver was placed on-board the plane, which made it possible to record GNSS observations, which were then used to calculate the aircraft’s position in CSRS-PPP software. The calculated XYZ position coordinates from the CSRS-PPP software were then used in the weighted mean model’s developed optimization algorithm. The measurement weights are a function of the number of GPS and GLONASS satellites and the inverse of the mean error square. The obtained coordinates of aircraft from the research model were verified with the RTK-OTF solution. As a result of the research, the presented solution’s accuracy is better by 11–87% for the model with a weighting scheme as a function of the inverse of the mean error square. Moreover, using the XYZ position from the RTKLIB program, the research method’s accuracy increases from 45% to 82% for the model with a weighting scheme as a function of the inverse of the square of mean error. The developed method demonstrates high efficiency for improving the performance of GPS and GLONASS solutions for the PPP measurement technology in air navigation.


2021 ◽  
Vol 5 (1) ◽  
Author(s):  
C. Carriere ◽  
P. Dillmann ◽  
S. Gin ◽  
D. Neff ◽  
L. Gentaz ◽  
...  

AbstractThe French concept developed to dispose high-level radioactive waste in geological repository relies on glassy waste forms, isolated from the claystone host rock by steel containers. Understanding interactions between glass and surrounding materials is key for assessing the performance of a such system. Here, isotopically tagged SON68 glass, steel and claystone were studied through an integrated mockup conducted at 50 °C for 2.5 years. Post-mortem analyses were performed from nanometric to millimetric scales using TEM, STXM, ToF-SIMS and SEM techniques. The glass alteration layer consisted of a crystallized Fe-rich smectite mineral, close to nontronite, supporting a dissolution/reprecipitation controlling mechanism for glass alteration. The mean glass dissolution rate ranged between 1.6 × 10−2 g m−2 d−1 to 3.0 × 10−2 g m−2 d−1, a value only 3–5 times lower than the initial dissolution rate. Thermodynamic calculations highlighted a competition between nontronite and protective gel, explaining why in the present conditions the formation of a protective layer is prevented.


2012 ◽  
Vol 58 (209) ◽  
pp. 529-539 ◽  
Author(s):  
Shin Sugiyama ◽  
Hiroyuki Enomoto ◽  
Shuji Fujita ◽  
Kotaro Fukui ◽  
Fumio Nakazawa ◽  
...  

AbstractDuring the Japanese-Swedish Antarctic traverse expedition of 2007/08, we measured the surface snow density at 46 locations along the 2800 km long route from Syowa station to Wasa station in East Antarctica. The mean snow density for the upper 1 (or 0.5) m layer varied from 333 to 439 kg m-3 over a region spanning an elevation range of 365-3800 ma.s.l. The density variations were associated with the elevation of the sampling sites; the density decreased as the elevation increased, moving from the coastal region inland. However, the density was relatively insensitive to the change in elevation along the ridge on the Antarctic plateau between Dome F and Kohnen stations. Because surface wind is weak in this region, irrespective of elevation, the wind speed was suggested to play a key role in the near-surface densification. The results of multiple regression performed on the density using meteorological variables were significantly improved by the inclusion of wind speed as a predictor. The regression analysis yielded a linear dependence between the density and the wind speed, with a coefficient of 13.5 kg m-3 (m s-1)-1. This relationship is nearly three times stronger than a value previously computed from a dataset available in Antarctica. Our data indicate that the wind speed is more important to estimates of the surface snow density in Antarctica than has been previously assumed.


1958 ◽  
Vol 51 (3) ◽  
pp. 257-264 ◽  
Author(s):  
J. M. Pilkington ◽  
A. F. Purser

A method has been described of assessing the average degree of medullation in fleece samples. This method combines information about the various fibre types and the proportion of each present in the sample, by assigning 100 fibres to classes with scores 1–5 according to the degree of medullation. A weighted mean score was determined, ten times this mean being defined as the ‘medullation index’. The index has been used for 2 years on samples taken from 2-month-old lambs and 14-month-old hoggs of the Blackface breed. Drawings of fibre types showed that the internal and external diameters and their ratio all increase with the score.The mean medullation index for the 2-month-old lambs in the 2 years was 25·6 and 24·8. The effects of sex and type of birth of lamb and age of dam were assessed by fitting constants, but their contribution to the total variance was very small. The regression of medullation on age of lamb when sampled was −0·11 units per day in both years, and was highly significant. Possible explanations for this decline of medullation are discussed.The mean medullation index for 14-month-old hoggs was 16·1 in both years. Estimate of correlation between lamb and hogg for the 2 years were + 0·45 and + 0·33. It is probable that variation in medullation within the fleece and in fibre shedding account for these low values.


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