Graham W. Mainwood (1929–1990)
Canada's biomedical research community was deeply saddened by the untimely death of Graham Mainwood on June 10, 1990, after a brief but courageous battle with cancer.A native of Birmingham, U.K., Graham joined the Physiology Department at the fledgling Faculty of Medicine at the University of Ottawa in 1955. Since then, he has been a tireless force in building the reputation of the Department and of the Faculty. He became well known beyond Canada's borders for his studies on the electrophysiology and energetics of muscle and the mechanism of fatigue. His work on the effects of lactate flux and the role of changes in intracellular pH in muscle fatigue (e.g., Mainwood and Worsley-Brown 1975; Mainwood and Cechetto 1982; Renaud, Allard, and Mainwood 1986) is still cited in virtually every paper in this area. These studies, together with an ongoing interest in cardiac muscle, formed a natural platform from which he moved into the area of the elucidation of muscle metabolism by means of magnetic resonance spectroscopy–work he was actively pursuing up to the time of his death. Indeed, he had taken early retirement to be able to spend more time at the bench at the National Research Council of Canada. Three of the papers in this special issue arise from this work.All of us have been greatly touched by his sparkling intellect and generous helpfulness. We felt that the most appropriate way to recognize Graham's contributions to science and to our personal scientific development was to dedicate to his memory a special issue of the Journal which he served with distinction as a member of the Editorial Board for many years.