Efficacy of the Kampo Medicine Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in), a Traditional Herbal Medicine, in the Treatment of Maternity Blues Syndrome in the Postpartum Period

2005 ◽  
Vol 33 (01) ◽  
pp. 117-126 ◽  
Author(s):  
Takahisa Ushiroyama ◽  
Kou Sakuma ◽  
Minoru Ueki
Keyword(s):  
Herbal Medicine ◽  
Postpartum Period ◽  
Depressive Mood ◽  
Psychological State ◽  
Control Group ◽  
Clinical Effects ◽  
Traditional Herbal Medicine ◽  
College Hospital ◽  
Normal Delivery ◽  
Significant Difference

This study was to evaluate the clinical efficacy of Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in), a Japanese traditional herbal medicine, in stabilizing postpartum psychological state. We enrolled 268 women who had a normal delivery in Osaka Medical College Hospital or its affiliated clinics and randomly assigned them to the following two groups: a group of 134 women who received Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in) at a dose of 6.0 g/day and another group of 134 women without Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in) (control group). We observed 2.06-fold and 1.67-fold higher incidences of depressive mood and nervousness, respectively, after delivery in the control group than in the Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in) group. Within 3 weeks of postpartum, there was a significant difference in the incidences of maternity blues between the Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in) group (15.7%; 21/134) and the control group (32.1%; 43/134) (p=0.0195). No adverse effects were observed in this study. The results of this study demonstrate the beneficial clinical effects of Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in) in stabilizing psychological state in the postpartum period. Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in) can be expected to improve the mental health of women in the postpartum period and prevent maternity blues.

Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in), a Traditional Herbal Medicine, Stimulates Lactation with Increase in Secretion of Prolactin but not Oxytocin in the Postpartum Period

2007 ◽  
Vol 35 (02) ◽  
pp. 195-202 ◽  
Author(s):  
Takahisa Ushiroyama ◽  
Kou Sakuma ◽  
Hekiko Souen ◽  
Gou Nakai ◽  
Shouko Morishima ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Postpartum Period ◽  
Plasma Prolactin ◽  
Traditional Herbal Medicine ◽  
College Hospital ◽  
Normal Delivery ◽  
Medical College ◽  
Beneficial Effects ◽  
Pharmacological Studies ◽  
Oxytocin Level

The aim of the present investigation was to evaluate the clinical efficacy of Xiong-gui-tiao-xue-yin, a traditional Japanese herbal medicine, in stimulating lactation in the postpartum period. We enrolled 82 women who had a normal delivery in Osaka Medical College Hospital, and randomly assigned them to the following two groups: a group of 41 women who received Xiong-gui-tiao-xue-yin at a dose of 6.0 g/day (Group X), and a group of 41 women who received ergometrine (methylergometrine maleate) at a dose of 0.375 mg/day (Group E). Volume of lactation was determined daily until Day 6 postpartum. Plasma prolactin and oxytocin concentration were measured at Days 1 and 6 postpartum. The results showed that volume of lactation was significantly higher in Group X than in Group E at Days 4 ( p = 0.042), 5 ( p = 0.038), and 6 ( p = 0.046). Significant differences between Groups X and E were noted in plasma prolactin concentration at Days 1 (157.9 ± 78.2 ng/ml and 129.1 ± 64.8 ng/ml ; p = 0.037) and 6 (167.5 ± 95.4 ng/ml and 117.1 ± 53.6 ng/ml ; p = 0.0042) postpartum. On the other hand, at Day 1, oxytocin concentration was significantly higher in Group E than in Group X ( p = 0.0024). No adverse effects were observed in this study. The results of our study demonstrate the beneficial effects of Xiong-gui-tiao-xue-yin on lactation, with increase in prolactin level without increase in oxytocin level in the postpartum period. Therefore, Xiong-gui-tiao-xue-yin can be expected to improve lactation in women in the postpartum period. Further detailed bio-pharmacological studies and clinical trials to investigate the properties of this drug are warranted.

Therapeutic Effects of Kyuki-chouketsu-in in Restoring Postpartum Physical Condition

2003 ◽  
Vol 31 (03) ◽  
pp. 437-444 ◽  
Author(s):  
Takahisa Ushiroyama ◽  
Kou Sakuma ◽  
Hekiko Souen ◽  
Gou Nakai ◽  
Shouko Morishima ◽  
...  
Keyword(s):  
Physical Condition ◽  
Postpartum Period ◽  
Hemoglobin Concentration ◽  
Therapeutic Effects ◽  
College Hospital ◽  
Normal Delivery ◽  
Blood Hemoglobin ◽  
Significant Difference ◽  
Uterine Fundus ◽  
Blood Hemoglobin Concentration

The aim of the present investigation was to evaluate the clinical efficacy of Kyuki-chouketsu-in, a Japanese traditional herbal medicine, in restoring postpartum physical condition. We enrolled 171 women who had a normal delivery in Osaka Medical College Hospital or its affiliated clinics, and randomly assigned them to the following two groups: a group of 85 women who received Kyuki-chouketsu-in at a dose of 6.0 g/day (Group K), and a group of 86 women who received ergometrine (methylergometrine maleate) at a dose of 0.375 mg/day (Group E). The height of the uterine fundus, blood hemoglobin concentration and biochemical blood values were determined until day 6 postpartum. The height of the uterine fundus was significantly lower in women of Group K (8.9 ± 2.4 cm) than in those of Group E (10.5 ± 2.7 cm) on day 5 postpartum (p = 0.071). A significant difference between Groups K and E was noted in change in blood hemoglobin concentration between days 1 and 6 postpartum (4.6 ± 7.2% in Group K; -1.57 ± 7.3% in Group E). Significant differences between Groups K and E were noted in decrease in serum C-reactive protein (CRP) concentration and increases in serum total protein (TP) and albumin concentrations between days 1 and 6 postpartum. No adverse effects were observed in this study. The results of our study demonstrate the beneficial effects of Kyuki-chouketsu-in on physical recovery in the postpartum period. Kyuki-chouketsu-in can be expected to improve the health of women in the postpartum period. Biopharmacological research and clinical trials to investigate the properties of this drug in detail are warranted.

scholarly journals EFEKTIVITAS PENDIDIKAN KESEHATAN DENGAN MEDIA KIPAS EDUKASI TERHADAP IMPLEMENTASI BUDAYA NIFAS

2021 ◽  
Vol 7 (3) ◽  
pp. 383-390
Author(s):  
Sinta Nuryati ◽  
Fuadah Ashri Nurfurqoni
Keyword(s):  
Herbal Medicine ◽  
Health Education ◽  
Postpartum Period ◽  
Total Sample ◽  
Postpartum Care ◽  
Personal Hygiene ◽  
Control Group ◽  
P Value ◽  
Research Subjects ◽  
Traditional Herbal Medicine

Background: Most regions in Indonesia have a culture in the form of taboos or recommendations that mothers must do during the postpartum period. Some cultures applied during the puerperium have no logical basis, especially from a medical point of view. The implementation of an illogical or harmful postpartum culture can harm both mother and child. Thus, there is a need for health education that can prevent the implementation of negative postpartum culture. Midwives need to have the right health education strategy with simple, easy-to-remember, and understand media. One of the strategies is health education using Education Fan Media. This fan-shaped media is a visual media that is more attractive, easy to remember, and easy to read anywhere.Purpose: this study was to determine the effectiveness of health education with educational fan media on the implementation of postpartum culture in Bogor Regency.Methods: This study uses a Quasi-Experimental design, using a Non-randomized approach with Control Posttest only Design. The research subjects were early postpartum mothers (0-7 days postpartum) with a total sample of 25 people in each intervention and control group who met the inclusion and exclusion criteria—the research held in the Kemang District, Bogor Regency, July to October 2019. The research instrument used was a questionnaire. The intervention provided was health education with a fan for postpartum education to the closest family, including husband, mother, in-laws, or grandmother who lived at home. This educational fan contains about postpartum care and negative culture during the postpartum period. The independent variable in this study is Health Education with educational fan media. The dependent variable is culture during the puerperium with sub-variables of abstinence, traditional herbal medicine, personal hygiene, and postpartum care.Results: The results of data analysis using unpaired t-test showed that health education with educational fan media had a significant effect on implementing personal hygiene culture and postpartum care with p <0.005. Health education with educational fan media has no significant effect on the implementation of dietary restrictions and traditional herbal medicine with a p-value > 0.005Conclusion: Health education with Education Fan Media has a significant effect on implementing personal hygiene culture and postpartum care in Bogor Regency. Suggestion Health education using educational fans for postpartum more effective if carried out more than once. This health education should repeat during the postpartum home visit. Keywords: Health education, education fan, postpartum culture ABSTRAK Latar Belakang: Sebagian besar daerah di Indonesia memiliki budaya berupa pantangan ataupun anjuran tertentu yang harus dilakukan ibu pada masa nifas. Beberapa budaya yang diterapkan pada masa nifas tidak memiliki dasar logis, terutama dari segi medis.  Praktik penerapan budaya nifas yang tidak logis  atau negatif dapat membahayakan ibu dan anak. Dengan demikian perlu adanya pendidikan kesehatan yang dapat mencegah praktik penerapan budaya nifas yang negatif.  Sebagai Bidan perlu memiliki strategi pendidikan kesehatan yang tepat dengan media yang sederhana, mudah diingat dan difahami. Salah satu strateginya adalah pendidikan kesehatan dengan menggunakan Media Kipas Edukasi. Media berbentuk kipas ini merupakan media visual uang diharapkan lebih menarik, mudah di ingat dan mudah dibaca dimana sajaTujuan: dalam penelitian ini adalah untuk mengetahui Efektivitas Pendidikan Kesehatan dengan Media Kipas Edukasi Terhadap Implementasi Budaya Nifas di Kabupaten Bogor.Metode: Penelitian ini menggunakan desain Quasi Eksperiment, dengan menggunakan pendekatan  Non-randomized with  Control Postest only Design. Subjek Penelitian adalah ibu nifas dini (0-7 hari postpartum) dengan jumlah sampel 25 orang pada setiap kelompok intervensi dan kontrol yang memenuhi kriteria inklusi dan eksklusi. Penelitian dilakukan  di wilayah Kecamatan Kemang, Kabupaten Bogor pada bulan Juli sampai Oktober 2019. Instrument penelitian yang digunakan adalah kuesioner. Intervensi yang diberikan yaitu pendidikan kesehatan dengan Kipas edukasi nifas  kepada keluarga terdekat diantaranya suami, ibu,mertua atau nenek yang tinggal serumah. Kipas edukasi  ini berisi mengenai perawatan masa nifas dan budaya negatif selama masa nifas. Variabel independent dalam penelitian ini yaitu Pendidikan Kesehatan dengan media kipas edukasi, sedangkan variabel dependent yaitu Budaya pada masa nifas dengan sub variabel budaya pantangan makan, jamu tradisional, dan kebersihan diri, serta perawatan nifasHasil: Hasil analisis data  dengan menggunakan menggunakan uji t tidak berpasangan didapatkan hasil bahwa, pendidikan kesehatan dengan media kipas edukasi berpengaruh secara signifikan terhadap implementasi  budaya kebersihan diri dan perawatan masa nifas dengan nilai p <0.005.  Pendidikan kesehatan dengan media kipas edukasi tidak  berpengaruh secara signifikan terhadap implementasi  budaya pantangan makan dan   jamu tradisonal dengan nilai p > 0.005Kesimpulan: pendidikan kesehatan dengan Media Kipas Edukasi berpengaruh secara signifikan terhadap implementasi  budaya kebersihan diri dan perawatan masa nifas di Kabupaten Bogor.Saran supaya lebih efektif, pendidikan kesehatan dengan menggunakan  kipas edukasi terhadap ibu nifas, sebaiknya  dilakukan lebih dari satu kali. Pendidikan kesehatan ini  dapat diulangi pada saat kunjungan rumah ibu nifas Kata kunci: Pendidikan kesehatan, kipas edukasi, Budaya nifas

Efficacy of Intravitreal Triamcinolone after or Concomitant with Laser Photocoagulation in Nonproliferative Diabetic Retinopathy with Macular Edema

2009 ◽  
Vol 19 (4) ◽  
pp. 630-637 ◽  
Author(s):  
Erdinc Aydin ◽  
Helin Deniz Demir ◽  
Huseyin Yardim ◽  
Unal Erkorkmaz
Keyword(s):  
Diabetic Retinopathy ◽  
Macular Edema ◽  
Laser Photocoagulation ◽  
Control Group ◽  
Clinical Effects ◽  
Intravitreal Triamcinolone ◽  
Nonproliferative Diabetic Retinopathy ◽  
Significant Difference ◽  
Group 3 ◽  
The Mean

Purpose To investigate the clinical effects and outcomes of intravitreal injection of 4 mg of triamcinolone acetonide (IVTA) after or concomitant with macular laser photocoagulation (MP) for clinically significant macular edema (CSME). Methods Forty-nine eyes of 49 patients with nonproliferative diabetic retinopathy and CSME were randomized into three groups. The eyes in the laser group (n=17), group 1, were subjected to MP 3 weeks after IVTA; the eyes in the IVTA group (n=13), group 2, were subjected to MP, concomitant with IVTA; the eyes in the control group (n=19), group 3, underwent only IVTA application. Visual acuity (VA), fundus fluorescein angiography, and photography were performed in each group. Results In the first group, the mean VA improved from 0.17±0.09 at baseline to 0.28±0.15 (p=0.114) and in the second group, deteriorated from 0.19±0.08 at baseline to 0.14±0.08 at the sixth month (p=0.141), respectively. In Group 3, the mean VA improved from 0.16±0.08 at baseline to 0.28±0.18 (p=0.118) at the end of the follow-up. When VA was compared between the control and study groups, significant difference was detected at the sixth month (p=0.038). Conclusions MP after IVTA improved VA, rather than MP concomitant with IVTA, and only IVTA application for CSME. MP after IVTA may reduce the recurrence of CSME and needs further investigations in a longer period.

scholarly journals Surgery for primary intracerebral haemorrhage: is it safe and effective?

2013 ◽  
Vol 38 (3) ◽  
pp. 74-78
Author(s):  
MMH Talukder ◽  
KMT Islam ◽  
M Hossain ◽  
MU Jahan ◽  
F Mahmood ◽  
...  
Keyword(s):  
Intracerebral Haemorrhage ◽  
Glasgow Outcome Scale ◽  
Control Group ◽  
Intracerebral Haematoma ◽  
College Hospital ◽  
Conservative Group ◽  
Best Medical Treatment ◽  
Significant Difference ◽  
Group A ◽  
Group B

This prospective study was conducted to compare the outcome between medical and surgical treatment of primary intracerebral haemorrhage at the department of Neurosurgery, Dhaka Medical College Hospital from January 2006 to October 2007. All patients with primary intracerebral haematoma with Glasgow Coma Scale (GCS) 5-15 (on admission) and heamatoma volume 30 cc or above admitted at Neurosurgery department managed conservatively or surgically were included in this study. Total 60 patients were selected, of them 30 patients managed conservatively and 30 patients managed surgically. Conservatively managed patients regarded as control group (Group-A) and surgically managed patients regarded as experimental group (Group-B). Patients or attendants refused to operate were included in the conservative group. All the selected patients were evaluated on the basis of detailed history, clinical examination (general and neurological examination) and CT scan findings. Outcome was evaluated in term of Glasgow Outcome Scale (GOS). Best medical treatment was given for conservative group and operations were done for surgical group and followed up after surgery till discharge by observing GCS and GOS at discharge. Number of death were 15 (50%) patients in group- A and 13 (43%) patients in group-B. There was no significant difference in mortality rate between two groups but outcome was relatively better in group-B. According to Glasgow Outcome Scale, dependency in group-A and group-B was 26.6% and 23.4% respectively. So dependency were more in group-A. But there was no significant difference statistically. Seven (23.4%) patients were independent in group-A but 10(43.3%) patients were independent in group-B. However in relative terms of outcome of group-B was better than that of group-A. In our study we found no statistically significant difference in outcome between medical and surgical management of primary intracerebral haemorrhage. DOI: http://dx.doi.org/10.3329/bmrcb.v38i3.14328 Bangladesh Med Res Counc Bull 2012; 38(3): 74-78 (December)

scholarly journals A randomized controlled trial comparing oxytocin administration before and after placental delivery in the prevention of postpartum haemorrhage in a tertiary care hospital in Bankura district of West Bengal, India

2020 ◽  
Vol 9 (5) ◽  
pp. 1976
Author(s):  
Rahul Kirtania ◽  
Jayita Pal ◽  
Sisir Biswas ◽  
Aditi Aich
Keyword(s):  
Randomized Controlled Trial ◽  
Blood Loss ◽  
Controlled Trial ◽  
Active Management ◽  
Control Group ◽  
Care Hospital ◽  
Normal Delivery ◽  
Randomized Controlled ◽  
Significant Difference ◽  
The Mean

Background: PPH is the prime cause of maternal mortality worldwide. The incidence of PPH can be drastically combatted by application of uterotonic in active management of third stage labour. Timing of its administration is a matter of concern. This study aimed to assess whether timing of administration of oxytocin would have any impact on incidence or mean blood loss of PPH.Methods: It was a single blinded randomized controlled trial conducted in the department of Obstetrics and Gynecology, Bankura Sammilani Medical College for 6 months where 100 antenatal mothers admitted for normal delivery in labour room were allocated randomly in study and control group considering inclusion and exclusion criteria. Incidence of PPH and mean blood loss had been identified clinically by following them for 24 hours.Results: Only 9% of study population had experienced PPH. There was no statistically significant difference in incidence of PPH with difference in timing of administration of oxytocin (p >0.05). But there was statistically significant decrease in mean blood loss if oxytocin was administered before the placental delivery. The mean blood loss with oxytocin administered before placental delivery was 296.8 ml (102.45) and after placental delivery was 452.0 (128.87) ml respectively.Conclusions: Policy makers should keep in mind not only the incidence of PPH, but the mean blood loss amount too in a setting where anaemia in pregnancy is quite prevalent.

scholarly journals Chinese Herbal Medicine Bushen Qinggan Formula for Blood Pressure Variability and Endothelial Injury in Hypertensive Patients: A Randomized Controlled Pilot Clinical Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Chunxiao Wu ◽  
Jingchun Zhang ◽  
Yingke Zhao ◽  
Jing Chen ◽  
Yue Liu
Keyword(s):  
Blood Pressure ◽  
Herbal Medicine ◽  
Endothelial Function ◽  
Chinese Herbal Medicine ◽  
Blood Pressure Variability ◽  
Endothelial Injury ◽  
Control Group ◽  
Therapeutic Effects ◽  
Chinese Herbal ◽  
Significant Difference

Background.Blood pressure variability (BPV) independent of average blood pressure is related to cardiovascular damage. Meanwhile, BPV is also associated with measures of endothelial injury. Decoction, a traditional used form of Traditional Chinese Medicine (TCM), is inconvenient to prepare, carry, and store. Dispensing granules is now developing as an alternative to decoction, but the evidence supporting its clinical efficacy the same as decoction remains unclear.Objective.To examine the therapeutic effects on mean blood pressure (MBP), blood pressure variability, and endothelial function by giving Bushen Qinggan Formula, a compound Chinese Herbal Medicine and also to evaluate the difference in efficacy between decoction and granule.Methods.A total of 150 patients with hypertension were enrolled and randomly assigned to receive the placebo, Bushen Qinggan decoction, or Bushen Qinggan granule in addition to the standard medications (amlodipine-5 mg/d) for the treatment of essential hypertension (EH). The outcome was the reduction in the MBP and BPV and also included changes in the endothelial markers including endothelin-1 (ET-1) and nitric oxide (NO) after 8 weeks of treatment.Results.Compared with the control group, the Bushen Qinggan decoction and granule groups had significant improvement (P<0.01) in BPV and endothelial founction. The level of BPV and endothelial function between decoction and granule group had no significant difference (P>0.05).Conclusion.Based on the standard treatment, Bushen Qinggan Formula further improved BPV and endothelial function. The efficacy of Bushen Qinggan decoction and granule is similar in improving BPV and endothelial function. However, no significant antihypertensive effects could be demonstrated.

Acupuncture and Traditional Herbal Medicine Therapy Prevent Deliriumin Patients with Cardiovascular Disease in Intensive Care Units

2017 ◽  
Vol 45 (02) ◽  
pp. 255-268 ◽  
Author(s):  
Jun Matsumoto-Miyazaki ◽  
Hiroaki Ushikoshi ◽  
Shusaku Miyata ◽  
Nagisa Miyazaki ◽  
Takahide Nawa ◽  
...  
Keyword(s):  
Intensive Care ◽  
Treatment Group ◽  
Herbal Medicine ◽  
Combination Therapy ◽  
Incidence Rate ◽  
Control Period ◽  
Control Group ◽  
Large Sample Size ◽  
Traditional Herbal Medicine ◽  
Cv Disease

The aim of this study was to determine the effect of combination therapy consisting of acupuncture and traditional herbal medicine (Kampo medicine) for reducing the incidence rate of delirium in patients with cardiovascular (CV) disease in ICUs. Twenty-nine patients who had been urgently admitted to the ICU in the control period were treated with conventional intensive care. Thirty patients in the treatment period received conventional therapy plus a combination therapy consisting of acupuncture and herbal medicine. Acupuncture treatment was performed once a day, and the herbal formula was administered orally three times a day during the first week of the ICU stay. The standard acupuncture points were GV20, Ex-HN3, HT7, LI4, Liv3, and KI3, and the main herbal preparation was Kamikihito. The incident rates of delirium, assessed using the confusion assessment method for ICU, in the treatment and control period were compared. The incidence rate of delirium was significantly lower in the treatment group than in the control group (6.6% vs. 37.9%, [Formula: see text]). Moreover, sedative drugs and non-pharmacological approaches against aggressive behavior of patients who were delirious were used less in the treatment group than in the control group. No serious adverse events were observed in the treatment group. Combination therapy consisting of acupuncture and herbal medicine was found to be effective in lowering the incidence of delirium in patients with CV disease in ICUs. Further studies with a large sample size and parallel randomized controlled design would be required to establish the effects of this therapy.

scholarly journals Viability of fibroblast cells on the clove (Syzygium aromaticum) leaves ethanol extract

2019 ◽  
Vol 31 (1) ◽  
pp. 67
Author(s):  
Anindhita Cindy Felicia ◽  
Vinna Kurniawati Sugiaman ◽  
Natallia Pranata
Keyword(s):  
Herbal Medicine ◽  
Cell Viability ◽  
Healing Process ◽  
Ethanol Extract ◽  
Control Group ◽  
Syzygium Aromaticum ◽  
Fibroblast Cells ◽  
Viability Test ◽  
Significant Difference ◽  
Mts Assay

Introduction: Various active compounds of herbal plants that are known to accelerate the wound healing process are flavonoids, tannins, and saponins. One amongst them is clove (Syzygium aromaticum), with the leaves as the most common part to be used as herbal medicine due to the antibacterial, anti-inflammatory, and antioxidant properties. However, the use of the biocompatibility of clove leaves as herbal medicine is still unknown. Therefore, this study was aimed to determine the cytotoxicity effects of clove leaves ethanol extract on the fibroblast cells and safe dosage (IC50) for medicinal use. Methods: Phytochemical tests using the Farnsworth method and viability test was performed using the laboratory experimental with post-test only control group design. The samples were divided into seven concentrations; 500, 250, 125, 62.5, 31.25, 15.63, and 7.81 μg/ml, with three repetitions (triplo) towards the fibroblast cells. Viability test was performed using MTS assay. Results: Based on the results obtained from one-way ANOVA statistical test, there was a significant difference between the percentage of cell viability and each concentration (α ≤ 0.05), with IC50 value of 344.814 μg/ml. Conclusion: Clove (Syzygium aromaticum) leaves ethanol extract showed a high percentage of cell viability at the concentrations below the IC50 value.Keywords: Clove leaves, cytotoxicity, fibroblast cell, MTS assay, periodontal diseases, viability.

scholarly journals The Efficacy of Tripterygium Glycosides Combined with LMWH in Treatment of HSPN in Children

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Yan Jin ◽  
Yanzheng Wang ◽  
Sai Wang ◽  
Qiongqiong Zhao ◽  
Donghua Zhang ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Clinical Symptoms ◽  
Effective Rate ◽  
Control Group ◽  
Clinical Effects ◽  
Observation Group ◽  
Significant Difference ◽  
Before And After ◽  
Qilu Hospital ◽  
Tripterygium Glycosides

Objective. This study aimed to explore the clinical efficacy and relevant mechanism of Tripterygium glycosides combined with low molecular weight heparin calcium (LMWH) in the treatment of Henoch–Schönlein purpura nephritis (HSPN) in children. Methods. 64 cases of children patients with HSPN treated at Qilu Hospital (Qingdao) from January 2015 to May 2020 were selected and randomly divided into the control group and the observation group and 32 cases in each group. Conventional medical treatment was applied in the two groups, besides which the control group was given LMWH while the observation group was given Tripterygium glycosides based on the control group. The clinical efficacy and the indexes of clinical symptoms of the two groups were compared. Immune globulin level, fibrinogen content (FIB), prothrombin time (PT), platelet level (PLT), and activated partial thromboplastin time (APTT) level of the two groups were compared before and after the treatment. Results. The total effective rate in the observation group was significantly higher than that of the control group, and the recurrence rate in the observation group was lower than that in the control group. After treatment, urine red blood cell count and 24 h urine protein were obviously better than those of the control group. There was no statistically significant difference in PT between the two groups of children before and after treatment. The levels of PLT and FIB in the two groups of patients after treatment were significantly lower than before treatment, and the PLT levels in the observation group were lower than those in the control group. Conclusion. The combination of Tripterygium glycosides and LMWH had good clinical effects in the treatment of children with HSPN, and it could improve the clinical symptoms, the mechanism of which might be related to the increase of PT, a decrease of PLT, and the improvement of coagulation function.

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