Plants with Hypotensive, Antiatheromatous and Coronarodilatating Action

1979 ◽  
Vol 07 (03) ◽  
pp. 197-236 ◽  
Author(s):  
V. Petkov
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Traditional Medicine ◽  
Coronary Spasm ◽  
Medical Knowledge ◽  
Atherogenic Diet ◽  
Ischemic Heart ◽  
World Health ◽  
Screening Methods ◽  
Health Organization

However great the success in the therapy of hypertension, atherosclerosis and ischemic heart disease has been gained today by recent efficient drugs, the definite healing of patients is not yet attained. The late discovery of reserpine, such an efficient drug of plant origin against hypertension, convinced so far reluctant scientists to consider the chemical compounds of the plant world. With respect to this traditional medical knowledge, it seems to define more accurately the specificity of these healings-sometimes recommended unspecifically for a whole branch of medicine. This experimental verification should not use inconsiderably the present-day classification of diseases; there should be an awareness that conventional experimental methods in pharmacology are often unsuitable for revealing the real biological activity of one or another medicinal plant. The interest in the mellennial empirical field of health care is acknowledged by the World Health Organization which promotes research and development of traditional medicine, along with investigations into its psychosocial and ethnographic aspects. These studies cover a number of plants growing in Bulgaria that have a healing effect in hypertension, atherosclerosis and ischemic heart disease according to the data of traditional medicine. Using screening methods, extracts and chemically pure substances were investigated; extraction was done with solvents such as water, ether, chloroform, dichloretan, ethanol, methanol, and acetone. Most of the experiments were carried out on anesthetized cats, rabbits and dogs. The substances tested were applied mainly intravenously, and in some experiments orally. Chronic experiments were also carried out on wakeful dogs with induced hypertension, on animals fed on an atherogenic diet, and on animals with induced arrhythmia and coronary spasm. Data are presented of clinical examination of some plants of active substances isolated from them. Major results of these studies are presented for the following plants: Garlic; Geranium; Hellebore; Mistletoe; Olive; Valerian; Hawthorn; Peucedanum arenarium; Periwinkle; Fumitory. For another 50 plants growing in Bulgaria and in other countries the author presents his and other investigators' experimental and clinical data about hypertensive, antiatheromatous and coronarodilatating action.

scholarly journals The prediction model for cardiovascular disease using Yazd's health study data (YaHS)

2019 ◽  
Author(s):  
Seyed MohammadReza Tabatabaei Nodoushan1 ◽  
Fatemeh Saadatjoo ◽  
Masoud Mirzaei
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Cost Effective ◽  
Mortality Rates ◽  
Study Data ◽  
Ischemic Heart ◽  
Health Study ◽  
Screening Methods ◽  
The People ◽  
Health And Disease

Introdution: Ischemic heart disease is one of the most common diseases, which has led to high mortality rates all over the world. This disease is caused by narrowing or blockage of coronary arteries, which are the provider of blood to the heart. Identifying the people susceptible to this disease and bringing changes in their lifestyles has been said to reduce the related mortality rates and increase the patient's longevity. Methods: Yazd people Health Study (YaHS) was conducted on a random sample of 10,000 people living in the city of Yazd, Iran in the years 2014-15 for a general health and disease survey. These data were first balanced by bootstrapping technique due to their unbalanced nature. Next, classification methods were used in the training phase. Various classifiers, such as artificial neural network, rule inducer, regression, and AdaBoost were used in order to evaluate the proposed method with two scenarios. Results: The results showed that the screening of the people susceptible to ischemic heart disease had the most significant effect on increasing the sensitivity of the discovery classifier of CN2 subgroup through using balanced data by bootstrapping method followed by their analysis for the purpose of producing a sample of the patients. This classifier proved to have the potential for detecting 83.6% of the people susceptible to this disease. Conclusion: Therefore, it can be concluded that data mining methods are effective in screening for susceptible people with ischemic heart disease. This method can be compared with other traditional screening methods in that it is more cost-effective and faster.

ROLE OF GRAY-SCALE AND DOPPLER ULTRASOUND OF CAROTID ARTERY IN RISK STRATIFICATION OF STABLE ISCHEMIC HEART DISEASE AND ITS CORRELATION WITH CORONARY ANGIOGRAPHY

2021 ◽  
pp. 42-44
Author(s):  
Sukanya Banerjee ◽  
Mainak Mukhopadhyay ◽  
Auriom Kar ◽  
Shivesh Sahai
Keyword(s):  
Heart Disease ◽  
Carotid Artery ◽  
Coronary Angiography ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
World Health ◽  
Atheromatous Plaque ◽  
Gray Scale ◽  
Stable Ischemic Heart Disease

Introduction: Coronary heart disease (CHD) is a major cause of mortality and morbidity all over the world. According to a report of World Health Organization (WHO) in 2005, cardiovascular disease (CVD) caused 17.5 million (30%) of the 58 million deaths that occurred worldwide. While the prevalence and mortality due to CHD is declining in the developed nations the same cannot be held true for developing countries. Aims And Objective: This study aimed to establish the role of Gray Scale USG and carotid artery Doppler study as a leading investigation in general population presenting with Stable Ischemic Heart Disease. It intended to evaluate the frequency and degree of carotid artery stenosis in these patients & also assess the morphology of atherosclerotic plaque and IMT which are clearly related to pathogenesis and aid in planning and management. Materials And Methods: Adult persons attending to Nilratan Sircar Medical College & Hospital, Kolkata both at OPD and Ward, with Stable Ischemic Heart disease that has undergone coronary angiography were chosen as the Study population. Result And Analysis: Our study showed that 62 % of the patients were above 60 years of age. 84 % of our patients were male.74% of our patients had history of smoking. 70 % of our patients had type 2 diabetes mellitus. 72 % of our patients were dyslipidemic. 78% of the patients were hypertensive. 80 % of patients had increased carotid artery tunica intima media thickening. 66 % of patients had presence of atheromatous plaque in carotid arteries. Summary And Conclusion: However, our study did corroborate with the other available studies except for few deviations like increased number of modiable risk factors in our group. Our study clearly demonstrated Metabolic syndrome –X as a strong risk factor for ischemic heart disease and also suggested early medical treatment can prevent future recurrence. Larger multicentric trials may be necessary in future, for further validation

scholarly journals Study of efficacy of ischemia reversal program (IRP) in ischemic heart disease (IHD) patients with VO2max and Duke’s treadmill score

2018 ◽  
Vol 7 (8) ◽  
pp. 1642 ◽  
Author(s):  
Rohit Sane ◽  
Varada Sugwekar ◽  
Aarti Nadapude ◽  
Archana Hande ◽  
Gayatri Depe ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Health Care ◽  
Heart Disease ◽  
Observational Study ◽  
Ischemic Heart Disease ◽  
Conventional Therapy ◽  
Stress Testing ◽  
World Health ◽  
Inducible Ischemia ◽  
Health Organization

Background: Number of people dying from IHD has increased from 0.61 million in 1990 to 1.13 million in 2010, which is a disturbing fact. According to report by World Health Organization, India would be spending a whopping 237 billion US dollars, owing to direct spending on health care and indirectly due to loss of productivity due to IHD. Ischemia Reversal Program (IRP) is a combination of Panchakarma and allied therapy. This study was conducted to evaluate the effect of IRP on VO2max, Duke’s treadmill score, systolic blood pressure (SBP), diastolic blood pressure (DBP), and dependency on conventional therapy in IHD patients.Methods: This observational study was conducted in January 2017, wherein the data of IHD patients (inducible ischemia on stress testing) who attended out-patient departments (OPDs) at Madhavbaug clinics in Maharashtra, India were identified. Data of patients who were administered IRP (60-75 minutes) with minimum 7 sittings over 90 days (±15 days) were considered. Variables were compared between day 1 and day 90 of the IRP.Results: Out of 38 enrolled patients, 25 were males while 13 females. There was significant improvement in Duke’s score with  subjects at moderate (50%) and high (31.6%) risk at baseline were significantly decreased to low (52.6%) and moderate (47.4%) after the 90th day of therapy.  IRP also showed significant improvement in VO2max by 9.11 (from 20.29±6.72 to 29.40±6.71; p<0.001), SBP by 5.78 (from 128.78±17.40 to 123±12.23, p<0.03), DBP by 4.76 (from 80.53±8.10 to 75.76±6.85, p<0.005). Dependency on concomitant medicines was reduced.Conclusions: IRP was effective in IHD; it had dual benefits, i.e. anti-ischemic effect, as well as reducing the dependency on allopathic medicines.

Pathogenesis Of Clinical Events In Coronary Artery Disease. Clinical Observations

1981 ◽  
Author(s):  
A Maseri
Keyword(s):  
Myocardial Infarction ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Coronary Spasm ◽  
Clinical Manifestations ◽  
Ischemic Heart ◽  
Variable Degree ◽  
Clinical Events ◽  
Functional Factors ◽  
Angina At Rest

Studies on angina at rest showing that an increase of myocardial demand beyond a fixed supply is not the only or even the most frequent cause of acute myocardial ischemia open a new avenue in our understanding of ischemic heart disease. Functional factors that transiently interfere with regional coronary blood supply, such as coronary spasm, seem to play a major role in determining the clinical events associated with coronary atherosclerotic heart disease. These functional factors appear to be the major cause of angina at rest, nocturnal, post-prandial and cold-induced angina and for variable threshold of exertional angina.Sudden death was also shown to be a possible consequence of coronary spasm which was shown to cause ventricular fibrillation and cardiac arrest during reversible ischemic episodes with or without anginal pain.Myocardial infarction consistently occurs in the same vascular bed shown to undergo transient ischemic episodes before the onset of the final, irreversible one. The transient episodes were shown to be caused by coronary spasm. The irreversible episode could not be relieved by intracoronary nitrates. A platelet mural thrombus was found at post mortem at the site of demonstrated persistent spasm.We suggest that coronary vasospasm and platelet aggregation may be responsible for the onset of acute myocardial infarction and, possibly, for the development of coronary thrombotic obstructions.Thus, the clinical manifestations of ischemic heart disease may largely depend on the presence and severity of functional factors, transiently and acutely interfering with flow, along with a variable degree of coronary atherosclerosis. In turn, prognosis may be determined by the severity of acute functional factors and the extent to which the coronary circulation and the myocardium are already chronically jeopardized by organic lesions.

scholarly journals Study of Electrocardiographic Findings in Severe Anaemia

2020 ◽  
Vol 7 (49) ◽  
pp. 2964-2967
Author(s):  
Appu Patil ◽  
Veena P. Munavalli ◽  
Krutika Morappanavar
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Sinus Tachycardia ◽  
World Health Organisation ◽  
Severe Anaemia ◽  
Ischemic Heart ◽  
World Health ◽  
Common Finding ◽  
Ecg Changes ◽  
Electrocardiographic Findings

BACKGROUND Anaemia is a worldwide problem which has major consequences on human health. It also poses a huge social and economic burden. World Health Organisation defines a haemoglobin level of less than 8 gm / dL as severe anaemia. It affects multiple organs, cardiovascular system being one of them. The clinical features of anaemia are a result of diminished oxygen carrying capacity of the blood. The clinical presentations vary depending on the age of the patient, rapidity of onset of anaemia and its severity. The cardiac changes are reflected as electrocardiographic abnormalities. In clinical practice such electrocardiographic findings simulate those of ischemic heart disease leading to a battery of investigations. METHODS This was a retrospective study. Forty five anaemia patients admitted in medicine wards of S. Nijalingappa Medical College and HSK hospital over a period of 6 months from 1st July 2019 to 31st Dec 2019 were studied. Complete hemogram and electrocardiography were obtained and analysed. RESULTS Anaemia was more common among females who constituted 30 (66.66 %) patients as compared to males constituting 15 (33.33 %) patients. 31 patients (68.88 %) with severe anaemia showed ECG changes. Most common finding was sinus tachycardia seen in 17 (37.77 %) of patients followed by T inversions 11 (24.44 %) and ST depressions 4 (8.88 %). Anaemia was most commonly seen in the age group of 15 - 30 years constituting 23 (51.11 %) patients. ECG findings were more common in females as compared to males. 22 (73.33 %) of female patients had ECG changes as compared to 9 (60 %) in males. CONCLUSIONS ECG abnormalities are common in patients with severe anaemia more so in females. These mimic changes seen in patients with ischemic heart disease. KEYWORDS Severe Anaemia, Electrocardiographic Findings, Sinus Tachycardia

scholarly journals Burden of Disease Due to Traffic Noise in Germany

2019 ◽  
Vol 16 (13) ◽  
pp. 2304 ◽  
Author(s):  
Tobollik ◽  
Hintzsche ◽  
Wothge ◽  
Myck ◽  
Plass
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Burden Of Disease ◽  
Road Traffic ◽  
Traffic Noise ◽  
Environmental Noise ◽  
Ischemic Heart ◽  
World Health ◽  
Road Traffic Noise ◽  
Life Years

Traffic noise is nearly ubiquitous and thus can affect the health of many people. Using the German noise mapping data according to the Directive 2002/49/EC of 2017 and exposure-response functions for ischemic heart disease, noise annoyance and sleep disturbance assessed by the World Health Organization’s Environmental Noise Guidelines for the European Region the burden of disease due to traffic noise is quantified. The burden of disease is expressed in disability-adjusted life years (DALYs) and its components. The highest burden was found for road traffic noise, with 75,896 DALYs when only considering moderate evidence. When including all available evidence, 176,888 DALYs can be attributable to road traffic noise. The burden due to aircraft and railway noise is lower because fewer people are exposed. Comparing the burden by health outcomes, the biggest share is due to ischemic heart disease (90%) in regard to aircraft noise, however, the lowest evidence was expressed for the association between traffic noise and ischemic heart disease. Therefore, the results should be interpreted with caution. Using alternative input parameters (e.g., exposure data) can lead to a much higher burden. Nevertheless, environmental noise is an important risk factor which leads to considerable loss of healthy life years.

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