scholarly journals Study of efficacy of ischemia reversal program (IRP) in ischemic heart disease (IHD) patients with VO2max and Duke’s treadmill score

Author(s):  
Rohit Sane ◽  
Varada Sugwekar ◽  
Aarti Nadapude ◽  
Archana Hande ◽  
Gayatri Depe ◽  
...  

Background: Number of people dying from IHD has increased from 0.61 million in 1990 to 1.13 million in 2010, which is a disturbing fact. According to report by World Health Organization, India would be spending a whopping 237 billion US dollars, owing to direct spending on health care and indirectly due to loss of productivity due to IHD. Ischemia Reversal Program (IRP) is a combination of Panchakarma and allied therapy. This study was conducted to evaluate the effect of IRP on VO2max, Duke’s treadmill score, systolic blood pressure (SBP), diastolic blood pressure (DBP), and dependency on conventional therapy in IHD patients.Methods: This observational study was conducted in January 2017, wherein the data of IHD patients (inducible ischemia on stress testing) who attended out-patient departments (OPDs) at Madhavbaug clinics in Maharashtra, India were identified. Data of patients who were administered IRP (60-75 minutes) with minimum 7 sittings over 90 days (±15 days) were considered. Variables were compared between day 1 and day 90 of the IRP.Results: Out of 38 enrolled patients, 25 were males while 13 females. There was significant improvement in Duke’s score with  subjects at moderate (50%) and high (31.6%) risk at baseline were significantly decreased to low (52.6%) and moderate (47.4%) after the 90th day of therapy.  IRP also showed significant improvement in VO2max by 9.11 (from 20.29±6.72 to 29.40±6.71; p<0.001), SBP by 5.78 (from 128.78±17.40 to 123±12.23, p<0.03), DBP by 4.76 (from 80.53±8.10 to 75.76±6.85, p<0.005). Dependency on concomitant medicines was reduced.Conclusions: IRP was effective in IHD; it had dual benefits, i.e. anti-ischemic effect, as well as reducing the dependency on allopathic medicines.

Author(s):  
Florentina Sita Murti ◽  
Hari Kusnanto Josef ◽  
Wahyudi Istiono

Background: People with hypertension over age 25 years reached 40% in 2008 according to the World Health Organization and 75% occurred in developing countries. Hypertension management must be focused on first-rate health care which could reduce death-risk, disabilities, and the cost burden. Badan Pengelola Jaminan Social obliges every first-rate health care to have to apply Program Pengelolaan Penyakit Kronis (Prolanis).Objectives: This study aims to determine the difference of decreased blood pressure in Prolanis and Non-Prolanis groups in Puskesmas Pandak II.Methods: This quantitative research with cohort retrospective design used secondary data of hypertension patients who are following Prolanis compared with those who are not in Puskesmas Pandak II. Data covered characteristics of patients, blood pressure, and Body-Mass Index (BMI) over one year. The analysis used repeated measures ANOVA. Results: The comparison with the treatment group showed significant differences in blood pressure variable, diastolic pressure variable, and BMI, interaction and measureable differences during the study period in all three variables. There was an uptrend in the Non-Prolanis group and a downtrend in the Prolanis group.Conclusions: Decreased blood pressure of patients with hypertension is better in Prolanis than Non-Prolanis groups.


1979 ◽  
Vol 07 (03) ◽  
pp. 197-236 ◽  
Author(s):  
V. Petkov

However great the success in the therapy of hypertension, atherosclerosis and ischemic heart disease has been gained today by recent efficient drugs, the definite healing of patients is not yet attained. The late discovery of reserpine, such an efficient drug of plant origin against hypertension, convinced so far reluctant scientists to consider the chemical compounds of the plant world. With respect to this traditional medical knowledge, it seems to define more accurately the specificity of these healings-sometimes recommended unspecifically for a whole branch of medicine. This experimental verification should not use inconsiderably the present-day classification of diseases; there should be an awareness that conventional experimental methods in pharmacology are often unsuitable for revealing the real biological activity of one or another medicinal plant. The interest in the mellennial empirical field of health care is acknowledged by the World Health Organization which promotes research and development of traditional medicine, along with investigations into its psychosocial and ethnographic aspects. These studies cover a number of plants growing in Bulgaria that have a healing effect in hypertension, atherosclerosis and ischemic heart disease according to the data of traditional medicine. Using screening methods, extracts and chemically pure substances were investigated; extraction was done with solvents such as water, ether, chloroform, dichloretan, ethanol, methanol, and acetone. Most of the experiments were carried out on anesthetized cats, rabbits and dogs. The substances tested were applied mainly intravenously, and in some experiments orally. Chronic experiments were also carried out on wakeful dogs with induced hypertension, on animals fed on an atherogenic diet, and on animals with induced arrhythmia and coronary spasm. Data are presented of clinical examination of some plants of active substances isolated from them. Major results of these studies are presented for the following plants: Garlic; Geranium; Hellebore; Mistletoe; Olive; Valerian; Hawthorn; Peucedanum arenarium; Periwinkle; Fumitory. For another 50 plants growing in Bulgaria and in other countries the author presents his and other investigators' experimental and clinical data about hypertensive, antiatheromatous and coronarodilatating action.


2021 ◽  
Vol 10 (15) ◽  
pp. 1098-1101
Author(s):  
Aditi Vinay Chandak ◽  
Surekha Dubey Godbole ◽  
Tanvi Rajesh Balwani ◽  
Tanuj Sunil Patil

Ecosystem, which consists of the physical environment and all the living organisms, on which we all depend, is declining rapidly because of its destruction caused by humans. It’s a two-way relationship between the humans and mother nature. If we destroy the natural environment around us, human life will be seriously affected, and the life of next generation will be endangered unless serious steps are taken. One such effect of human overexploitations has come in the form of coronavirus outbreak. Coronavirus, a contagious disease of 2019 known as Covid-19, is the latest swiftly spreading global infection. The aetiology of Covid-19 is different from SARS-CoV which has the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but it has the same host receptor, human angiotensin converting enzyme 2 (ACE2). The novel coronavirus which is zoonotic (spreading from an animal to a human) and mainly found in the bats and pangolins is a single stranded ribonucleic acid virus of Coronaviridae family. 1 The typical structure of 2019-nCoV possessed ‘spike protein’ in the membrane envelope, also expressed various polyproteins, nucleoproteins and membrane protein. The S protein binds to the receptor cell of host to facilitate the entry of virus in the host. Currently four genera for coronavirus are found α-CoV, ßCoV, γ-CoV, δ-CoV. SARS-CoV first originated in Wuhan, China and has spread across the globe. World Health Organization (WHO) and public health emergency of international concern declared it as 2019 - 2020 pandemic disease.2 According to WHO report, (7th April 2020) update on this pandemic coronavirus disease, there have been more than 13,65,004 confirmed cases and 76,507 deaths across the world and these figures are rapidly increasing. Therefore, actions for proper recognition, management and its prevention must be prompted for relevant alleviation of its outspread.3 Health care professionals are mainly indulged in the national crises and are working diligently around-the-clock, small ratio of the health care workers have become affected and few died tragically. Dentists are most often the first ones to be affected because they work with patients in close proximity. On 15th March 2020, the New York Times published an article titled “The workers who face the greatest Coronavirus risk” described the dentists are highly exposed, than the paramedical staffs and general physicians, to the risk of novel coronavirus disease 19.4


PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256711
Author(s):  
Hiroyuki Kobayashi ◽  
Satoru Joshita ◽  
Yuki Akahane ◽  
Katsuhiko Matsuzaki ◽  
Hiromi Yamada ◽  
...  

Background The World Health Organization has set a goal of hepatitis C virus (HCV) elimination by the year 2030. However, no regions in Japan have succeeded in eradicating HCV. Micro-elimination is an approach to attain hepatitis C eradication in which national eradication goals are applied to specific populations so that viral treatment and control efforts can move forward quickly and efficiently. In order to eradicate HCV from Japan, this study aims to achieve HCV micro-elimination in the town of Nagawa. Methods and design The Nagawa Project is an ongoing, prospective, multiple-institution, observational study running from April 1, 2021, to March 31, 2024. All residents of Nagawa town, excluding those under 20 years of age, not consenting to the study, or unable to undergo health check-ups due to nursing care needs, will be included. If found to be HCV antibody-positive, the participant will be recommended to see a doctor in consideration of MAC-2 binding protein glycosylation isomer values. Then, the participant will undergo serum HCV RNA measurement with the real-time polymerase chain reaction by an attending physician. If the participant is HCV RNA-positive, he or she will be referred to a hepatologist for further evaluation. In the case of a definitive diagnosis of chronic hepatitis C, direct acting antiviral treatment will be initiated. Through this process, HCV will be systematically micro-eliminated from the region. Discussion The Nagawa Project will reveal the prevalence of chronic HCV in addition to the HCV eradication rate in Nagawa town towards achieving HCV micro-elimination. Trial registration This study is performed by Shinshu University School of Medicine and was registered as UMIN 000044114 on May 6, 2021.


2018 ◽  
Vol 16 (1) ◽  
pp. 95-109 ◽  
Author(s):  
María Alejandra Rodríguez-Echeverría ◽  
Angélica María Páez-Castro

A number of factors and conditions hinder and restrict access to the health care system and its different services; these barriers to access put at risk the health of people by affecting adequate processes. Objective: To carry out a literature review on barriers to access to the health care system and visual health services in Colombia and around the world. Methodology: A literature review was carried out based on a search of the Medline, ScienceDirect, and Pubmed databases, as well as indexed public health journals and the websites of the Local Health Authority, the World Health Organization, the Pan American Health Organization, the UNESCO, and the Brien Holden Vision Institute. Results: The main barriers related to demand, both in general services and in visual health, are the lack of perception on the need for service and lack of economic resources; at the offer level, the existing policies constitute a real obstacle. Conclusions: Awareness-raising in the population, together with the implementation of health policies that grant equal access to health care services, are fundamental to prevent people from being affected, to a large extent, by barriers related to demand or offer, regardless of their location or level of income.


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