Prediction of drug synergy in cancer using ensemble-based machine learning techniques

2018 ◽  
Vol 32 (11) ◽  
pp. 1850132 ◽  
Author(s):  
Harpreet Singh ◽  
Prashant Singh Rana ◽  
Urvinder Singh
Keyword(s):  
Machine Learning ◽  
Fuzzy Inference System ◽  
Fuzzy Inference ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Prediction Errors ◽  
Learning Approaches ◽  
Inference System ◽  
Drug Synergy ◽  
Learning Techniques

Drug synergy prediction plays a significant role in the medical field for inhibiting specific cancer agents. It can be developed as a pre-processing tool for therapeutic successes. Examination of different drug–drug interaction can be done by drug synergy score. It needs efficient regression-based machine learning approaches to minimize the prediction errors. Numerous machine learning techniques such as neural networks, support vector machines, random forests, LASSO, Elastic Nets, etc., have been used in the past to realize requirement as mentioned above. However, these techniques individually do not provide significant accuracy in drug synergy score. Therefore, the primary objective of this paper is to design a neuro-fuzzy-based ensembling approach. To achieve this, nine well-known machine learning techniques have been implemented by considering the drug synergy data. Based on the accuracy of each model, four techniques with high accuracy are selected to develop ensemble-based machine learning model. These models are Random forest, Fuzzy Rules Using Genetic Cooperative-Competitive Learning method (GFS.GCCL), Adaptive-Network-Based Fuzzy Inference System (ANFIS) and Dynamic Evolving Neural-Fuzzy Inference System method (DENFIS). Ensembling is achieved by evaluating the biased weighted aggregation (i.e. adding more weights to the model with a higher prediction score) of predicted data by selected models. The proposed and existing machine learning techniques have been evaluated on drug synergy score data. The comparative analysis reveals that the proposed method outperforms others in terms of accuracy, root mean square error and coefficient of correlation.

scholarly journals Machine Learning Frameworks in Cancer Detection

2021 ◽  
Vol 297 ◽  
pp. 01073
Author(s):  
Sabyasachi Pramanik ◽  
K. Martin Sagayam ◽  
Om Prakash Jena
Keyword(s):  
Machine Learning ◽  
Prediction Models ◽  
Supervised Machine Learning ◽  
Machine Learning Techniques ◽  
Cancer Development ◽  
Support Vector ◽  
Learning Approaches ◽  
Learning Techniques ◽  
Fact Finding ◽  
Risk Of Cancer

Cancer has been described as a diverse illness with several distinct subtypes that may occur simultaneously. As a result, early detection and forecast of cancer types have graced essentially in cancer fact-finding methods since they may help to improve the clinical treatment of cancer survivors. The significance of categorizing cancer suffers into higher or lower-threat categories has prompted numerous fact-finding associates from the bioscience and genomics field to investigate the utilization of machine learning (ML) algorithms in cancer diagnosis and treatment. Because of this, these methods have been used with the goal of simulating the development and treatment of malignant diseases in humans. Furthermore, the capacity of machine learning techniques to identify important characteristics from complicated datasets demonstrates the significance of these technologies. These technologies include Bayesian networks and artificial neural networks, along with a number of other approaches. Decision Trees and Support Vector Machines which have already been extensively used in cancer research for the creation of predictive models, also lead to accurate decision making. The application of machine learning techniques may undoubtedly enhance our knowledge of cancer development; nevertheless, a sufficient degree of validation is required before these approaches can be considered for use in daily clinical practice. An overview of current machine learning approaches utilized in the simulation of cancer development is presented in this paper. All of the supervised machine learning approaches described here, along with a variety of input characteristics and data samples, are used to build the prediction models. In light of the increasing trend towards the use of machine learning methods in biomedical research, we offer the most current papers that have used these approaches to predict risk of cancer or patient outcomes in order to better understand cancer.

scholarly journals Estimating Forest Carbon Fluxes Using Machine Learning Techniques Based on Eddy Covariance Measurements

2018 ◽  
Vol 10 (1) ◽  
pp. 203 ◽  
Author(s):  
Xianming Dou ◽  
Yongguo Yang ◽  
Jinhui Luo
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Eddy Covariance ◽  
Carbon Flux ◽  
Carbon Fluxes ◽  
Forest Carbon ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Inference System ◽  
Learning Techniques

Approximating the complex nonlinear relationships that dominate the exchange of carbon dioxide fluxes between the biosphere and atmosphere is fundamentally important for addressing the issue of climate change. The progress of machine learning techniques has offered a number of useful tools for the scientific community aiming to gain new insights into the temporal and spatial variation of different carbon fluxes in terrestrial ecosystems. In this study, adaptive neuro-fuzzy inference system (ANFIS) and generalized regression neural network (GRNN) models were developed to predict the daily carbon fluxes in three boreal forest ecosystems based on eddy covariance (EC) measurements. Moreover, a comparison was made between the modeled values derived from these models and those of traditional artificial neural network (ANN) and support vector machine (SVM) models. These models were also compared with multiple linear regression (MLR). Several statistical indicators, including coefficient of determination (R2), Nash-Sutcliffe efficiency (NSE), bias error (Bias) and root mean square error (RMSE) were utilized to evaluate the performance of the applied models. The results showed that the developed machine learning models were able to account for the most variance in the carbon fluxes at both daily and hourly time scales in the three stands and they consistently and substantially outperformed the MLR model for both daily and hourly carbon flux estimates. It was demonstrated that the ANFIS and ANN models provided similar estimates in the testing period with an approximate value of R2 = 0.93, NSE = 0.91, Bias = 0.11 g C m−2 day−1 and RMSE = 1.04 g C m−2 day−1 for daily gross primary productivity, 0.94, 0.82, 0.24 g C m−2 day−1 and 0.72 g C m−2 day−1 for daily ecosystem respiration, and 0.79, 0.75, 0.14 g C m−2 day−1 and 0.89 g C m−2 day−1 for daily net ecosystem exchange, and slightly outperformed the GRNN and SVM models. In practical terms, however, the newly developed models (ANFIS and GRNN) are more robust and flexible, and have less parameters needed for selection and optimization in comparison with traditional ANN and SVM models. Consequently, they can be used as valuable tools to estimate forest carbon fluxes and fill the missing carbon flux data during the long-term EC measurements.

scholarly journals A Machine Learning View on Momentum and Reversal Trading

Algorithms ◽  
2018 ◽  
Vol 11 (11) ◽  
pp. 170 ◽  
Author(s):  
Zhixi Li ◽  
Vincent Tam
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Stock Market ◽  
Short Term Memory ◽  
Predictive Ability ◽  
Trading Strategies ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Learning Approaches ◽  
Learning Techniques

Momentum and reversal effects are important phenomena in stock markets. In academia, relevant studies have been conducted for years. Researchers have attempted to analyze these phenomena using statistical methods and to give some plausible explanations. However, those explanations are sometimes unconvincing. Furthermore, it is very difficult to transfer the findings of these studies to real-world investment trading strategies due to the lack of predictive ability. This paper represents the first attempt to adopt machine learning techniques for investigating the momentum and reversal effects occurring in any stock market. In the study, various machine learning techniques, including the Decision Tree (DT), Support Vector Machine (SVM), Multilayer Perceptron Neural Network (MLP), and Long Short-Term Memory Neural Network (LSTM) were explored and compared carefully. Several models built on these machine learning approaches were used to predict the momentum or reversal effect on the stock market of mainland China, thus allowing investors to build corresponding trading strategies. The experimental results demonstrated that these machine learning approaches, especially the SVM, are beneficial for capturing the relevant momentum and reversal effects, and possibly building profitable trading strategies. Moreover, we propose the corresponding trading strategies in terms of market states to acquire the best investment returns.

scholarly journals Sentiment Analysis of Lithuanian Texts Using Traditional and Deep Learning Approaches

Computers ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 4 ◽  
Author(s):  
Jurgita Kapočiūtė-Dzikienė ◽  
Robertas Damaševičius ◽  
Marcin Woźniak
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Sentiment Analysis ◽  
Short Term Memory ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Learning Approaches ◽  
Full Dataset ◽  
Learning Techniques ◽  
Long Short Term Memory

We describe the sentiment analysis experiments that were performed on the Lithuanian Internet comment dataset using traditional machine learning (Naïve Bayes Multinomial—NBM and Support Vector Machine—SVM) and deep learning (Long Short-Term Memory—LSTM and Convolutional Neural Network—CNN) approaches. The traditional machine learning techniques were used with the features based on the lexical, morphological, and character information. The deep learning approaches were applied on the top of two types of word embeddings (Vord2Vec continuous bag-of-words with negative sampling and FastText). Both traditional and deep learning approaches had to solve the positive/negative/neutral sentiment classification task on the balanced and full dataset versions. The best deep learning results (reaching 0.706 of accuracy) were achieved on the full dataset with CNN applied on top of the FastText embeddings, replaced emoticons, and eliminated diacritics. The traditional machine learning approaches demonstrated the best performance (0.735 of accuracy) on the full dataset with the NBM method, replaced emoticons, restored diacritics, and lemma unigrams as features. Although traditional machine learning approaches were superior when compared to the deep learning methods; deep learning demonstrated good results when applied on the small datasets.

Classification of volcanic and tectonic earthquakes in Kamchatka (Russia) with different machine learning techniques

2020 ◽  
Author(s):  
Natalia Galina ◽  
Nikolai Shapiro ◽  
Leonard Seydoux ◽  
Dmitry Droznin
Keyword(s):  
Machine Learning ◽  
Subduction Zone ◽  
Aftershock Sequence ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Learning Approaches ◽  
Shiveluch Volcano ◽  
Agglomerative Clustering ◽  
Learning Techniques ◽  
Single Station

<p>Kamchatka is an active subduction zone that exhibits intense seismic and volcanic activities. As a consequence, tectonic and volcanic earthquakes are often nearly simultaneously recorded at the same station. In this work, we consider seismograms recorded between December 2018 and April 2019. During this time period when the M=7.3 earthquake followed by an aftershock sequence occurred nearly simultaneously with a strong eruption of Shiveluch volcano. As a result, stations of the Kamchatka seismic monitoring network recorded up to several hundreds of earthquakes per day. In total, we detected almost 7000 events of different origin using a simple automatic detection algorithm based on signal envelope amplitudes. Then, for each detection different features have been extracted. We started from simple signal parameters (amplitude, duration, peak frequency, etc.), unsmoothed and smoothed spectra and finally used a multi-dimensional signal decomposition (scattering coefficients). For events classification both unsupervised (K-means, agglomerative clustering) and supervised (Support Vector Classification, Random Forest) classic machine learning techniques were performed on all types of extracted features. Obtained results are quite stable and do not vary significantly depending on features and method choice. As a result, the machine learning approaches allow us to clearly separate tectonic subduction-zone earthquakes and those associated with the Shiveluch volcano eruptions based on data of a single station.</p>

Investigating Machine Learning Techniques for User Sentiment Analysis

2019 ◽  
Vol 11 (3) ◽  
pp. 1-12 ◽  
Author(s):  
Nimesh V Patel ◽  
Hitesh Chhinkaniwala
Keyword(s):  
Machine Learning ◽  
Sentiment Analysis ◽  
Social Networking Sites ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Product Reviews ◽  
Learning Approaches ◽  
Current Trends ◽  
Learning Techniques ◽  
Benchmark Datasets

Sentiment analysis identifies users in the textual reviews available in social networking sites, tweets, blog posts, forums, status updates to share their emotions or reviews and these reviews are to be used by market researchers to do know the product reviews and current trends in the market. The sentiment analysis is performed by two methods. Machine learning approaches and lexicon methods which are also known as the knowledge base approach. These. In this article, the authors evaluate the performance of some machine learning techniques: Maximum Entropy, Naïve Bayes and Support Vector Machines on two benchmark datasets: the positive-negative dataset and a Movie Review dataset by measuring parameters like accuracy, precision, recall and F-score. In this article, the authors present the performance of various sentiment analysis and classification methods by classifying the reviews in binary classes as positive, negative opinion about reviews on different domains of dataset. It is also justified that sentiment analysis using the Support Vector Machine outperforms other machine learning techniques.

scholarly journals Multi-Step Ahead Wind Power Generation Prediction Based on Hybrid Machine Learning Techniques

Energies ◽  
2018 ◽  
Vol 11 (8) ◽  
pp. 1975 ◽  
Author(s):  
Wei Dong ◽  
Qiang Yang ◽  
Xinli Fang
Keyword(s):  
Machine Learning ◽  
Phase Space ◽  
Fuzzy Inference ◽  
Weather Prediction ◽  
Wind Farms ◽  
Machine Learning Techniques ◽  
Multiple Time ◽  
Inference System ◽  
Learning Techniques ◽  
Benchmark Solutions

Accurate generation prediction at multiple time-steps is of paramount importance for reliable and economical operation of wind farms. This study proposed a novel algorithmic solution using various forms of machine learning techniques in a hybrid manner, including phase space reconstruction (PSR), input variable selection (IVS), K-means clustering and adaptive neuro-fuzzy inference system (ANFIS). The PSR technique transforms the historical time series into a set of phase-space variables combining with the numerical weather prediction (NWP) data to prepare candidate inputs. A minimal redundancy maximal relevance (mRMR) criterion based filtering approach is used to automatically select the optimal input variables for the multi-step ahead prediction. Then, the input instances are divided into a set of subsets using the K-means clustering to train the ANFIS. The ANFIS parameters are further optimized to improve the prediction performance by the use of particle swarm optimization (PSO) algorithm. The proposed solution is extensively evaluated through case studies of two realistic wind farms and the numerical results clearly confirm its effectiveness and improved prediction accuracy compared to benchmark solutions.

scholarly journals Modeling Evapotranspiration Response to Climatic Forcings Using Data-Driven Techniques in Grassland Ecosystems

2018 ◽  
Vol 2018 ◽  
pp. 1-18 ◽  
Author(s):  
Xianming Dou ◽  
Yongguo Yang
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Water Vapor ◽  
Data Driven ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Group Method ◽  
Generalized Regression Neural Network ◽  
Learning Approaches ◽  
Inference System

Remarkable progress has been made over the last decade toward characterizing the mechanisms that dominate the exchange of water vapor between the biosphere and the atmosphere. This is attributed partly to the considerable development of machine learning techniques that allow the scientific community to use these advanced tools for approximating the nonlinear processes affecting the variation of water vapor in terrestrial ecosystems. Three novel machine learning approaches, namely, group method of data handling, extreme learning machine (ELM), and adaptive neurofuzzy inference system (ANFIS), were developed to simulate and forecast the daily evapotranspiration (ET) at four different grassland sites based on the flux tower data using the eddy covariance method. These models were compared with the extensively utilized data-driven models, including artificial neural network, generalized regression neural network, and support vector machine (SVM). Moreover, the influences of internal functions on their corresponding models (SVM, ELM, and ANFIS) were investigated together. It was demonstrated that most developed models did good job of simulating and forecasting daily ET at the four sites. In addition to strengths of robustness and simplicity, the newly proposed methods achieved the estimates comparable to those of the conventional approaches and accordingly can be used as promising alternatives to traditional methods. It was further discovered that the generalization performance of the ELM, ANFIS, and SVM models strongly depended on their respective internal functions, especially for SVM.

Prediction of the Hardness of Cu-Ti-Co Alloy Using Machine Learning Techniques

2018 ◽  
Vol 777 ◽  
pp. 372-376 ◽  
Author(s):  
Shan Feng Fang
Keyword(s):  
Machine Learning ◽  
Copper Alloys ◽  
Least Square ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Learning Approaches ◽  
Forecasting Accuracy ◽  
Learning Techniques ◽  
Vector Machines ◽  
Forecasting Performance

Diverse machine learning approaches were employed to build regression models for predicting mechanical property of Cu-Ti-Co alloy. The forecasting performance of the least-square support vector machines (LSSVM) model has been compared with other artificial intelligence methods such as GRNN, RBF-PLS and RBFNN. The models were developed and validated utilizing a cross-validation (CV) procedure to improve the forecasting accuracy and generalization ability. The result demonstrates that the generalization performance of the new LSSVM is slightly better or superior to those acquired using GRNN, RBF-PLS and RBFNN. In future, it would be expected that the relatively new model based on machine learning is used as an especially helpful implement to accelerate materials design of copper alloys.

Application of Machine Learning Techniques to Predict Software Reliability

2010 ◽  
Vol 1 (3) ◽  
pp. 70-86 ◽  
Author(s):  
Ramakanta Mohanty ◽  
V. Ravi ◽  
M. R. Patra
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Software Reliability ◽  
Fuzzy Inference ◽  
Back Propagation ◽  
Multivariate Adaptive Regression Splines ◽  
Machine Learning Techniques ◽  
Group Method ◽  
Inference System ◽  
Learning Techniques

In this paper, the authors employed machine learning techniques, specifically, Back propagation trained neural network (BPNN), Group method of data handling (GMDH), Counter propagation neural network (CPNN), Dynamic evolving neuro–fuzzy inference system (DENFIS), Genetic Programming (GP), TreeNet, statistical multiple linear regression (MLR), and multivariate adaptive regression splines (MARS), to accurately forecast software reliability. Their effectiveness is demonstrated on three datasets taken from literature, where performance is compared in terms of normalized root mean square error (NRMSE) obtained in the test set. From rigorous experiments conducted, it was observed that GP outperformed all techniques in all datasets, with GMDH coming a close second.

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