NANOTECHNOLOGY IN PHARMACEUTICAL AND BIOMEDICAL APPLICATIONS: DENDRIMERS

NANO ◽  
2011 ◽  
Vol 06 (06) ◽  
pp. 509-539 ◽  
Author(s):  
PAWEŁ SZYMAŃSKI ◽  
MAGDALENA MARKOWICZ ◽  
ELŻBIETA MIKICIUK-OLASIK
Keyword(s):  
Drug Delivery ◽  
Genetic Material ◽  
Drug Carriers ◽  
Dendritic Polymers ◽  
Complex Molecules ◽  
Pharmacokinetic Properties ◽  
Potential Applications ◽  
Biomedical Diagnostics ◽  
Inflammatory Drugs ◽  
Magnetic Resonance Imaging Mri

Nanotechnology, a separate field of knowledge since 1980s, involves utilization of nanomaterials not only in electronics and catalysis, but also in biomedical research including drug delivery, bioimaging, biomedical-diagnostics and tissue engineering. Multidisciplinary of this science has led to the development of different areas of technology and might contribute to innovations that will, as a final consequence, help humanity. Dendrimers are large and complex molecules that are characterized by well-defined nanoscale architecture, monodispersity and structural versatility. These highly interesting polymers consist of three elements: core, branches and peripheral groups. There is a wide variety of potential applications of dendritic polymers. One of the most promising is utilization of polyamidoamine (PAMAM) dendrimers as drug delivery devices. Among pharmaceuticals that have been connected with different types of dendrimers are nonsteroidal anti-inflammatory drugs (NSAIDs), anticancer drugs and other. Dendrimers application as drug carriers improves pharmacokinetic properties of drug particles, decreases drugs' side effects and, by possibility of surface modification with different ligands, enables to target specific tissues and tumor cells. Dendrimers might be also utilized as devices for delivery of genetic material and contrast agents for magnetic resonance imaging (MRI).

Modified chitosan coated mesoporous strontium hydroxyapatite nanorods as drug carriers

2015 ◽  
Vol 3 (29) ◽  
pp. 5991-6000 ◽  
Author(s):  
M. Filippousi ◽  
P. I. Siafaka ◽  
E. P. Amanatiadou ◽  
S. G. Nanaki ◽  
M. Nerantzaki ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Carriers ◽  
Polymeric Matrix ◽  
Modified Chitosan ◽  
Strontium Hydroxyapatite ◽  
Potential Applications

Strontium hydroxyapatite nanorods were loaded with two different model drugs and encapsulated in a modified chitosan polymeric matrix for potential applications in the field of drug delivery.

scholarly journals Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics

Pharmaceutics ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 211 ◽  
Author(s):  
Esen Sokullu ◽  
Hoda Soleymani Abyaneh ◽  
Marc A. Gauthier
Keyword(s):  
Drug Delivery ◽  
Drug Discovery ◽  
Genetic Material ◽  
Drug Carriers ◽  
Plant Viruses ◽  
Therapeutic Agents ◽  
Biotechnological Applications ◽  
Challenges And Opportunities ◽  
Therapeutic Peptides ◽  
Organ Targeting

Viruses have recently emerged as promising nanomaterials for biotechnological applications. One of the most important applications of viruses is phage display, which has already been employed to identify a broad range of potential therapeutic peptides and antibodies, as well as other biotechnologically relevant polypeptides (including protease inhibitors, minimizing proteins, and cell/organ targeting peptides). Additionally, their high stability, easily modifiable surface, and enormous diversity in shape and size, distinguish viruses from synthetic nanocarriers used for drug delivery. Indeed, several plant and bacterial viruses (e.g., phages) have been investigated and applied as drug carriers. The ability to remove the genetic material within the capsids of some plant viruses and phages produces empty viral-like particles that are replication-deficient and can be loaded with therapeutic agents. This review summarizes the current applications of plant viruses and phages in drug discovery and as drug delivery systems and includes a discussion of the present status of virus-based materials in clinical research, alongside the observed challenges and opportunities.

Nanosponge Approach -A Plethora Of Opportunities As A Promising Nanocarrier For Novel Drug Delivery

2021 ◽  
Vol 15 ◽  
Author(s):  
Shah Esha Bhavin ◽  
Gajjar Anuradha
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Genetic Material ◽  
Analytical Techniques ◽  
Controlled Drug Release ◽  
Drug Carriers ◽  
Synthetic Methods ◽  
Ongoing Research ◽  
Factors Affecting ◽  
Novel Drug

Background: Nanotechnology is the need of the hour! The design of nanotechnology aided carriers as a tool for the delivery of low solubility molecules offers a potential platform to overcome the issues of current clinical treatment and achieve good targeted release and bioaccessibility. Objective: Nanosponges (NS) are encapsulating type of nanocarriers capable of carrying both lipophilic and hydrophilic substances. They are synthesized by mixing a solution of polyester which is biodegradable with cross linkers. These tiny porous structures are round shaped having multiple cavities wherein drugs can be housed to offer programmable release. Method: The detailed literature review and patent search summarize the ongoing research on NS. Substances such as poorly soluble drugs, nutraceuticals, gases, proteins and peptides, volatile oils, genetic material, etc. can be loaded on these novel carriers, which are characterized using various analytical techniques. Target-specific drug delivery and controlled drug release are the advantages offered by NS along with a myriad of other promising applications. Results: This review stresses on the development of cyclodextrin based NS, the synthetic methods and characterization of NS along with factors affecting NS formation, their applications and information on the patented work in this area. NS are solid in character and can be formulated in various dosage forms such as parenteral, topical, oral or inhalation. Conclusion: Therefore, owing to their promising benefits over other nanocarriers in terms of drug loading, adaptability, sustainability, solubility and tailored release profile, NS are immediate technological revolution for drug entrapment and as novel drug carriers. The authors expect that these fundamental applications of NS could help the researchers to develop and gain insight about NS in novel drug delivery applications.

scholarly journals Solid Lipid Nanoparticles (SLN): Method, Characterization and Applications

2012 ◽  
Vol 1 (11) ◽  
pp. 384-393 ◽  
Author(s):  
Akanksha Garud ◽  
Deepti Singh ◽  
Navneet Garud
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Clinical Medicine ◽  
Drug Carriers ◽  
Pharmaceutical Journal ◽  
Lipid Nanoparticles ◽  
Conventional Chemotherapy ◽  
Solid Lipid ◽  
Potential Applications ◽  
Alternative Routes

Solid lipid nanoparticles (SLN) have emerged as a next-generation drug delivery system with potential applications in pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences. Recently, increasing attention has been focused on these SLN as colloidal drug carriers for incorporating hydrophilic or lipophilic drugs. Proteins and antigens intended for therapeutic purposes may be incorporated or adsorbed onto SLN, and further administered by parenteral routes or be alternative routes such as oral, nasal and pulmonary. The obstacles associated with conventional chemotherapy may be partially overcome by encapsulating them as SLN. The present review focuses on the utility of SLN in terms of their advantages, production methodology, characterization and applications. If properly investigated, SLNs may open new vistas in therapy of complex diseases.DOI: http://dx.doi.org/10.3329/icpj.v1i11.12065 International Current Pharmaceutical Journal 2012, 1(11): 384-393

Targeting Cancer using Curcumin Encapsulated Vesicular Drug Delivery Systems

2020 ◽  
Vol 26 ◽  
Author(s):  
Joel Hardwick ◽  
Jack Taylor ◽  
Meenu Mehta ◽  
Saurabh Satija ◽  
Keshav R. Paudel ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Therapeutic Potential ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Limiting Factors ◽  
Drug Bioavailability ◽  
Pharmacokinetic Properties ◽  
Anti Oxidant ◽  
Novel Drug

: Curcumin is a major curcuminoid present in turmeric. The compound is attributed with various therapeutic properties, which include, anti-oxidant, anti-inflammatory, anti-bacterial, anti-malarial, and neuroprotection. Due to its therapeutic potential, curcumin has been employed for centuries in treating different ailments. Curcumin has been investigated lately as a novel therapeutic agent in the treatment of cancer. However, the mechanisms by which curcumin exerts its cytotoxic effects on malignant cells are still not fully understood. One of the main limiting factors in the clinical use of curcumin is its poor bioavailability and rapid elimination. Advancements in drug delivery systems such as, nanoparticle based vesicular drug delivery platforms have improved several parameters, namely, drug bioavailability, solubility, stability, and controlled release properties. The use of curcumin-encapsulated niosomes to improve the physical and pharmacokinetic properties of curcumin is one such approach. This review provides an up-to-date summary on nanoparticle based vesicular drug carriers and their therapeutic applications. Specifically, we focus on niosomes as novel drug delivery formulations and their potential in improving the delivery of challenging small molecules, including curcumin. Overall, the applications of such carriers will provide a new direction for novel pharmaceutical drug delivery, as well as, biotechnology, nutraceutical, and functional food industries.

Recent Patents and Potential Applications of Homogenisation Techniques in Drug Delivery Systems

2021 ◽  
Vol 15 ◽  
Author(s):  
Harpreet Kaur Khanuja ◽  
Harish Dureja
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Drug Carriers ◽  
Size Reduction ◽  
Drug Dissolution ◽  
Particle Size Reduction ◽  
Easy Method ◽  
Potential Applications ◽  
The Stability ◽  
Homogenisation Process

Background: The term homogenize means "to force or provide coalesce." Homogenisation is a process to attain homogenous particle size. The objective of homogenisation process is to use fluid force to split the fragments or tiny particles contained in the fluids into minimal dimen-sions and form a sustainable dispersion suitable for further production. Results: The present study focus on the use of the homogenisation in drug delivery system. Homogenisation process aims to achieve the particle size in micro-and nano- range as it affects the different parameters in the formulation and biopharmaceutical profile of the drug. Particle size reduction plays a crucial role in influencing drug dissolution and absorption. The reduced particle size enhances the stability and therapeutic efficacy of the drug. Homogenisa-tion technology ensures to achieve effective, clinically efficient, and targeted drug delivery with minimal side effects Conclusion: Homogenization technology is an efficient and easy method of size reduction to increase solubility, bioavailability, and stability of drug carriers. This article gives an overview of the process attributes affecting the homogenisation process, the patenting of homogeniser types, design, the geometry of valves and nozzles, and its role in drug delivery.

Advances in Nanoparticles as Anticancer Drug Delivery Vector: Need of this Century

2020 ◽  
Vol 26 (15) ◽  
pp. 1637-1649 ◽  
Author(s):  
Imran Ali ◽  
Sofi D. Mukhtar ◽  
Heyam S. Ali ◽  
Marcus T. Scotti ◽  
Luciana Scotti
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Medical Science ◽  
Drug Carriers ◽  
Anticancer Drug Delivery ◽  
Ph Values ◽  
Delivery Vector ◽  
Future Challenges ◽  
Smart Drug ◽  
Smart Drug Delivery

Background: Nanotechnology has contributed a great deal to the field of medical science. Smart drugdelivery vectors, combined with stimuli-based characteristics, are becoming increasingly important. The use of external and internal stimulating factors can have enormous benefits and increase the targeting efficiency of nanotechnology platforms. The pH values of tumor vascular tissues are acidic in nature, allowing the improved targeting of anticancer drug payloads using drug-delivery vectors. Nanopolymers are smart drug-delivery vectors that have recently been developed and recommended for use by scientists because of their potential targeting capabilities, non-toxicity and biocompatibility, and make them ideal nanocarriers for personalized drug delivery. Method: The present review article provides an overview of current advances in the use of nanoparticles (NPs) as anticancer drug-delivery vectors. Results: This article reviews the molecular basis for the use of NPs in medicine, including personalized medicine, personalized therapy, emerging vistas in anticancer therapy, nanopolymer targeting, passive and active targeting transports, pH-responsive drug carriers, biological barriers, computer-aided drug design, future challenges and perspectives, biodegradability and safety. Conclusions: This article will benefit academia, researchers, clinicians, and government authorities by providing a basis for further research advancements.

Advances in the use of MOFs for Cancer Diagnosis and Treatment: An Overview

2020 ◽  
Vol 26 (33) ◽  
pp. 4174-4184
Author(s):  
Marina P. Abuçafy ◽  
Bruna L. da Silva ◽  
João A. Oshiro-Junior ◽  
Eloisa B. Manaia ◽  
Bruna G. Chiari-Andréo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Rational Design ◽  
Gas Adsorption ◽  
Drug Loading ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Academic Community ◽  
Anticancer Drug Delivery ◽  
Diagnostic Agents

Nanoparticles as drug delivery systems and diagnostic agents have gained much attention in recent years, especially for cancer treatment. Nanocarriers improve the therapeutic efficiency and bioavailability of antitumor drugs, besides providing preferential accumulation at the target site. Among different types of nanocarriers for drug delivery assays, metal-organic frameworks (MOFs) have attracted increasing interest in the academic community. MOFs are an emerging class of coordination polymers constructed of metal nodes or clusters and organic linkers that show the capacity to combine a porous structure with high drug loading through distinct kinds of interactions, overcoming the limitations of traditional drug carriers explored up to date. Despite the rational design and synthesis of MOFs, structural aspects and some applications of these materials like gas adsorption have already been comprehensively described in recent years; it is time to demonstrate their potential applications in biomedicine. In this context, MOFs can be used as drug delivery systems and theranostic platforms due to their ability to release drugs and accommodate imaging agents. This review describes the intrinsic characteristics of nanocarriers used in cancer therapy and highlights the latest advances in MOFs as anticancer drug delivery systems and diagnostic agents.

Sign in / Sign up

Export Citation Format

Share Document