scholarly journals Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics

Pharmaceutics ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 211 ◽  
Author(s):  
Esen Sokullu ◽  
Hoda Soleymani Abyaneh ◽  
Marc A. Gauthier
Keyword(s):  
Drug Delivery ◽  
Drug Discovery ◽  
Genetic Material ◽  
Drug Carriers ◽  
Plant Viruses ◽  
Therapeutic Agents ◽  
Biotechnological Applications ◽  
Challenges And Opportunities ◽  
Therapeutic Peptides ◽  
Organ Targeting

Viruses have recently emerged as promising nanomaterials for biotechnological applications. One of the most important applications of viruses is phage display, which has already been employed to identify a broad range of potential therapeutic peptides and antibodies, as well as other biotechnologically relevant polypeptides (including protease inhibitors, minimizing proteins, and cell/organ targeting peptides). Additionally, their high stability, easily modifiable surface, and enormous diversity in shape and size, distinguish viruses from synthetic nanocarriers used for drug delivery. Indeed, several plant and bacterial viruses (e.g., phages) have been investigated and applied as drug carriers. The ability to remove the genetic material within the capsids of some plant viruses and phages produces empty viral-like particles that are replication-deficient and can be loaded with therapeutic agents. This review summarizes the current applications of plant viruses and phages in drug discovery and as drug delivery systems and includes a discussion of the present status of virus-based materials in clinical research, alongside the observed challenges and opportunities.

Molecularly imprinted polymers for the detection of viruses: challenges and opportunities

The Analyst ◽  
2021 ◽  
Author(s):  
Ghazaleh Jamalipour Soufi ◽  
Siavash Iravani ◽  
Rajender S Varma
Keyword(s):  
Drug Delivery ◽  
Drug Discovery ◽  
Structure Determination ◽  
Molecularly Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Cell Culturing ◽  
Challenges And Opportunities

Molecularly imprinted polymers (MIPs) have numerous applications in sensing field, the detection/recognition of virus, the structure determination of proteins, drug delivery, artificial/biomimetic antibodies, drug discovery, and cell culturing. There are...

Nanosponge Approach -A Plethora Of Opportunities As A Promising Nanocarrier For Novel Drug Delivery

2021 ◽  
Vol 15 ◽  
Author(s):  
Shah Esha Bhavin ◽  
Gajjar Anuradha
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Genetic Material ◽  
Analytical Techniques ◽  
Controlled Drug Release ◽  
Drug Carriers ◽  
Synthetic Methods ◽  
Ongoing Research ◽  
Factors Affecting ◽  
Novel Drug

Background: Nanotechnology is the need of the hour! The design of nanotechnology aided carriers as a tool for the delivery of low solubility molecules offers a potential platform to overcome the issues of current clinical treatment and achieve good targeted release and bioaccessibility. Objective: Nanosponges (NS) are encapsulating type of nanocarriers capable of carrying both lipophilic and hydrophilic substances. They are synthesized by mixing a solution of polyester which is biodegradable with cross linkers. These tiny porous structures are round shaped having multiple cavities wherein drugs can be housed to offer programmable release. Method: The detailed literature review and patent search summarize the ongoing research on NS. Substances such as poorly soluble drugs, nutraceuticals, gases, proteins and peptides, volatile oils, genetic material, etc. can be loaded on these novel carriers, which are characterized using various analytical techniques. Target-specific drug delivery and controlled drug release are the advantages offered by NS along with a myriad of other promising applications. Results: This review stresses on the development of cyclodextrin based NS, the synthetic methods and characterization of NS along with factors affecting NS formation, their applications and information on the patented work in this area. NS are solid in character and can be formulated in various dosage forms such as parenteral, topical, oral or inhalation. Conclusion: Therefore, owing to their promising benefits over other nanocarriers in terms of drug loading, adaptability, sustainability, solubility and tailored release profile, NS are immediate technological revolution for drug entrapment and as novel drug carriers. The authors expect that these fundamental applications of NS could help the researchers to develop and gain insight about NS in novel drug delivery applications.

scholarly journals A REVIEW ON NANOEMULSIONS: FORMULATION, COMPOSITION, AND APPLICATIONS

2021 ◽  
pp. 22-28
Author(s):  
KHAN MOHAMMAD HAMID ◽  
MOHAMMAD WAIS ◽  
GAURANG SAWANT
Keyword(s):  
Drug Delivery ◽  
Droplet Diameter ◽  
Controlled Drug Delivery ◽  
Drug Carriers ◽  
Therapeutic Agents ◽  
Potential Drug ◽  
Systemic Delivery ◽  
Routes Of Administration ◽  
Detailed Assessment ◽  
Nanoparticulate Systems

Nanoemulsions are sub-micron sized emulsions that are undergoing detailed assessment as potential drug carriers for enhancing the delivery of therapeutic agents. These are to date the most developed nanoparticulate systems for the systemic delivery of active pharmaceutical for controlled drug delivery as well as targeting. These are the thermodynamically durable isotropic system, in which two incompatible liquids (water and oil) are blended to form a single homogenous phase by utilizing a required quantity of surfactants to achieve mixing with a droplet diameter approaching roughly in the range of 0.5–100 μm. They find applications in various fields such as cosmetics as well as are adopted in various routes of administration.

NANOTECHNOLOGY IN PHARMACEUTICAL AND BIOMEDICAL APPLICATIONS: DENDRIMERS

NANO ◽  
2011 ◽  
Vol 06 (06) ◽  
pp. 509-539 ◽  
Author(s):  
PAWEŁ SZYMAŃSKI ◽  
MAGDALENA MARKOWICZ ◽  
ELŻBIETA MIKICIUK-OLASIK
Keyword(s):  
Drug Delivery ◽  
Genetic Material ◽  
Drug Carriers ◽  
Dendritic Polymers ◽  
Complex Molecules ◽  
Pharmacokinetic Properties ◽  
Potential Applications ◽  
Biomedical Diagnostics ◽  
Inflammatory Drugs ◽  
Magnetic Resonance Imaging Mri

Nanotechnology, a separate field of knowledge since 1980s, involves utilization of nanomaterials not only in electronics and catalysis, but also in biomedical research including drug delivery, bioimaging, biomedical-diagnostics and tissue engineering. Multidisciplinary of this science has led to the development of different areas of technology and might contribute to innovations that will, as a final consequence, help humanity. Dendrimers are large and complex molecules that are characterized by well-defined nanoscale architecture, monodispersity and structural versatility. These highly interesting polymers consist of three elements: core, branches and peripheral groups. There is a wide variety of potential applications of dendritic polymers. One of the most promising is utilization of polyamidoamine (PAMAM) dendrimers as drug delivery devices. Among pharmaceuticals that have been connected with different types of dendrimers are nonsteroidal anti-inflammatory drugs (NSAIDs), anticancer drugs and other. Dendrimers application as drug carriers improves pharmacokinetic properties of drug particles, decreases drugs' side effects and, by possibility of surface modification with different ligands, enables to target specific tissues and tumor cells. Dendrimers might be also utilized as devices for delivery of genetic material and contrast agents for magnetic resonance imaging (MRI).

Nanoemulsion as Oral Drug Delivery - A Review

2020 ◽  
Vol 12 (1) ◽  
pp. 4-15 ◽  
Author(s):  
Khaleel Basha Sabjan ◽  
Syed Muzammil Munawar ◽  
Dhandayuthabani Rajendiran ◽  
Sugantha Kumari Vinoji ◽  
Kaviyarasu Kasinathan
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Drug Stability ◽  
Drug Carriers ◽  
Therapeutic Agents ◽  
Oral Drug ◽  
Advantages And Disadvantages ◽  
Insoluble Drugs ◽  
The Stability ◽  
Near Future

Background: Objective:: The stability and delivery of drugs remain one of the key hurdles in the present situation. The present study depends on the design of a novel nanoemulsion drugdelivery system that would encapsulate a drug and to improve drug stability. The charisma of nanotechnology is majorly due to the smallest particle size at the nanoscale. Methods: Nanoemulsions attention is focused on emphasizing formulation aspect, method of preparation characterization techniques, evaluation parameters and various application of the nanoemulsions, several techniques to be used for the preparation of nanoemulsions like microfluidization, high-pressure homogenization, low energy emulsification and solvent evaporation method and their parameters to be characterized. Results: The design of effective formulations for drugs is being applied to enhance the solubility and bioavailability of water-insoluble drugs. The nanosized droplets have led to considerable attraction for this formulation, for the delivery of hydrophilic as well as hydrophobic drugs as drug carriers because of their improved drug solubilization capacity, long shelf life, ease of preparation and improvement of bioavailability of drugs. Conclusion: The application of these nanoformulation preparations, limitations, their advantages and disadvantages as nanoemulsions will solve the various problems that current therapeutic agents face and has opened a new scenario to formulate nanoemulsions with various therapeutic agents with heightened competence along with oral drug delivery to treat diseases in the near future.

scholarly journals LIPOSOMES: A NOVEL DRUG DELIVERY SYSTEM

2017 ◽  
Author(s):  
Ayesha Naeem
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Size Range ◽  
Drug Carriers ◽  
Therapeutic Agents ◽  
Extensive Investigation ◽  
System P ◽  
Novel Drug Delivery System ◽  
Novel Drug ◽  
Aqueous Volume

Liposomes derived from two Greek words:Lipo(FAT) and soma(BODY).It is so named because of its composition is primarily of phopholipid.Liposomes are microparticulate lipoidal vesicales which are under extensive investigation as drug carriers for improving the drug delivery of therapeutic agents,relatively composed of biocompatible and bio degradable materials,and they consists of an aqueous volume entrapped by one or more bilayers of natural or synthetic lipids.A liposome is a spherical veicle having at least one lipid bilayer.the liposomes can be used as a vehicle for administration of nutrients and pharmaceutical drugs.liposomes can be prepared by disrupting biological membranes(such as by sonication).Size range:25-5000nm.

Liposome: A Powerful Approach Festinates Drug Delivery System

2010 ◽  
Vol 3 (1) ◽  
Author(s):  
Pawar Vinita ◽  
Mishra Shiv ◽  
Yadav Mahavir ◽  
Tiwari Archana
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Targeting ◽  
Drug Carriers ◽  
Therapeutic Agents ◽  
Extensive Investigation ◽  
Drug Molecules ◽  
Powerful Approach ◽  
Sites Of Action

Drug delivery systems have become important tools for the specific delivery of a large Number of drug molecules. Liposomes are microparticulate lipoidal vesicles which are under extensive investigation as drug carriers for improving the delivery of therapeutic agents. Initially they were used to study biomembrane behavior but later on developed into a drug delivery system for targeting specific sites of action like the tumor targeting, gene and antisense therapy, genetic vaccination, immunomodulation, topical, cytosolic, and respiratory various infections etc.

scholarly journals Nanomedicines: Nano based Drug Delivery Systems Challenges and Opportunities

2020 ◽  
Author(s):  
Rabia Hamid ◽  
Ifrah Manzoor
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Chemotherapeutic Agents ◽  
Human Diseases ◽  
Diagnostic Tools ◽  
Challenges And Opportunities ◽  
Recent Developments ◽  
Old Drugs

Nanomedicine and nano delivery systems, although relatively recent but fast-developing technology is one where nanoscale materials are used to function as diagnostic tools or to deliver therapeutic agents to specifically targeted sites in a controlled manner. It also provides many advantages in the management of human diseases. Recently, there has been a range of excellent uses of nanomedicine as chemotherapeutic agents, biological agents, immunotherapeutic agents, etc., for treatment of different diseases. In this chapter we discuss the recent developments and insights obtained in the field of nanomedicine. It provides a review of the numerous nano-based drug delivery systems that enhance the efficacy of new and old drugs. The new opportunities and challenges arising in the area of nanomedicine from therapeutic viewpoint are also addressed.

scholarly journals Nanoemulsion: A Review on Novel Profusion in Advanced Drug Delivery

2014 ◽  
Vol 2 (01) ◽  
pp. 122-127 ◽  
Author(s):  
Rohit Rajendra Bhosale ◽  
Riyaz Ali Osmani ◽  
Prasanna Prasad Ghodake ◽  
Sabir Majjid Shaikh ◽  
Sarika Raghunath Chavan
Keyword(s):  
Drug Delivery ◽  
Single Phase ◽  
Droplet Diameter ◽  
Drug Carriers ◽  
Therapeutic Agents ◽  
Immiscible Liquid ◽  
Great Promise ◽  
Extensive Investigation ◽  
Systemic Delivery ◽  
Micron Size

Nanoemulsions are submicron sized emulsion that is under extensive investigation as drug carriers for improving the delivery of therapeutic agents. These are by far the most advanced nanoparticle systems for the systemic delivery of active pharmaceutical for controlled drug delivery and targeting. These are the thermodynamically stable isotropic system in which two immiscible liquid (water and oil) are mixed to form a single phase by means of an appropriate surfactants or it mixes with a droplet diameter approximately in the range of 0.5-100 μm. Nanoemulsion droplet size falls typically in the range of 20-200 nm and shows a narrow size distribution. Nanoemulsion show great promise for the future of cosmetics, diagnostics, drug therapies and biotechnologies. Thus the aim of this review is focused on nanoemulsion advantage and disadvantage, various methods of preparation, characterization techniques and the various applications of sub micron size emulsion in different areas such as various route of administration, in chemotherapy, in cosmetic, etc.

Sign in / Sign up

Export Citation Format

Share Document