BIREFRINGENCE AND MAGNETO-OPTICAL PROPERTIES IN OLEIC ACID COATED Fe3O4 NANOPARTICLES: APPLICATION FOR OPTICAL SWITCH

2011 ◽  
Vol 10 (03) ◽  
pp. 515-520 ◽  
Author(s):  
SI-HUA XIA ◽  
JUN WANG ◽  
ZHANG-XIAN LU ◽  
FEIYAN ZHANG

We report magneto-optical properties in a kerosene colloidal suspension of oleic acid coated Fe3O4 nanoparticles (~14 nm). The magnetic colloids (fluids) show birefringence under a magnetic field. Systematical studies of the on–off switch times upon application of the on–off magnetic field with varied experimental parameters indicate that the switch response time depends strongly on the strength of the magnetic field and the concentration of the magnetic nanoparticles in the fluid. The data can be explained in terms of the formation of magnetic nanoparticle chains under a magnetic field. The important magneto-optical properties of the magnetic fluids allow us to design a tunable optical switch.

2015 ◽  
Vol 181 ◽  
pp. 403-421 ◽  
Author(s):  
Gurvinder Singh ◽  
Henry Chan ◽  
T. Udayabhaskararao ◽  
Elijah Gelman ◽  
Davide Peddis ◽  
...  

Self-assembly of inorganic nanoparticles has been studied extensively for particles having different sizes and compositions. However, relatively little attention has been devoted to how the shape and surface chemistry of magnetic nanoparticles affects their self-assembly properties. Here, we undertook a combined experiment–theory study aimed at better understanding of the self-assembly of cubic magnetite (Fe3O4) particles. We demonstrated that, depending on the experimental parameters, such as the direction of the magnetic field and nanoparticle density, a variety of superstructures can be obtained, including one-dimensional filaments and helices, as well as C-shaped assemblies described here for the first time. Furthermore, we functionalized the surfaces of the magnetic nanocubes with light-sensitive ligands. Using these modified nanoparticles, we were able to achieve orthogonal control of self-assembly using a magnetic field and light.


2020 ◽  
Vol 16 (11) ◽  
pp. 1623-1632
Author(s):  
Abbas Moghanizadeh ◽  
Fakhreddin Ashrafizadeh ◽  
Jaleh Varshousaz ◽  
Mahshid Kharaziha

This study aims to evaluate the efficiency of a novel in vitro technique in clot capturing and dissolving them by applying magnetic force on magnetic nanoparticles (MNP) carrying thrombolytic agents. It is a quick and simple method to protect patients from a life-threatening pulmonary embolism in an emergency to provide time for the medical team. To analyze the in vitro efficiency of nano-magnetic capturing and dissolving of clots (NCDC), different levels of process parameter including strength magnetic field (0.1, 0.2 and 0.3 T) and fluid flow rate (2.5, 5 and 7 l/min) are exposed to different blood clots sizes from 5 × 10 to 20 × 10 mm2 (length × diameter), in an in vitro flow model. The results show that by increasing the parameters to their maximum values, it is possible to immobilize 100% of the clots and dissolve around 61.4% of clots weight. In addition, the clot-dissolving is directly proportional to the magnetic field strength. NCDC is an efficient technique in immobilizing and dissolving the clots and its efficiency depends on process parameters especially the magnetic field.


2018 ◽  
Author(s):  
Mahendran Subramanian ◽  
Arkadiusz Miaskowski ◽  
Stuart Iain Jenkins ◽  
Jenson Lim ◽  
Jon Dobson

AbstractThe manipulation of magnetic nanoparticles (MNPs) using an external magnetic field, has been demonstrated to be useful in various biomedical applications. Some techniques have evolved utilizing this non-invasive external stimulus but the scientific community widely adopts few, and there is an excellent potential for more novel methods. The primary focus of this study is on understanding the manipulation of MNPs by a time-varying static magnetic field and how this can be used, at different frequencies and displacement, to manipulate cellular function. Here we explore, using numerical modeling, the physical mechanism which underlies this kind of manipulation, and we discuss potential improvements which would enhance such manipulation with its use in biomedical applications, i.e., increasing the MNP response by improving the field parameters. From our observations and other related studies, we infer that such manipulation depends mostly on the magnetic field gradient, the magnetic susceptibility and size of the MNPs, the magnet array oscillating frequency, the viscosity of the medium surrounding MNPs, and the distance between the magnetic field source and the MNPs. Additionally, we demonstrate cytotoxicity in neuroblastoma (SH-SY5Y) and hepatocellular carcinoma (HepG2) cells in vitro. This was induced by incubation with MNPs, followed by exposure to a magnetic field gradient, physically oscillating at various frequencies and displacement amplitudes. Even though this technique reliably produces MNP endocytosis and/or cytotoxicity, a better biophysical understanding is required to develop the mechanism used for this precision manipulation of MNPs, in vitro.


Nanoscale ◽  
2015 ◽  
Vol 7 (39) ◽  
pp. 16470-16480 ◽  
Author(s):  
Hyun-Chul Kim ◽  
Eunjoo Kim ◽  
Sang Won Jeong ◽  
Tae-Lin Ha ◽  
Sang-Im Park ◽  
...  

The cytotoxicity of magnetic nanoparticles-conjugated polymeric micelles encapsulated with an anticancer drug on cancer cells was enhanced by the synergistic effect of heat and the rapid release of the drug under an alternating magnetic field.


2013 ◽  
Vol 134 ◽  
pp. 88-95 ◽  
Author(s):  
M. Solaimani ◽  
Morteza Izadifard ◽  
H. Arabshahi ◽  
Sarkardei Mohammad Reza

2004 ◽  
Vol 820 ◽  
Author(s):  
Ramazan Asmatulu ◽  
Richard.O. Claus ◽  
Judy S. Riffle ◽  
Michael Zalich

AbstractBiodegradable magnetic nanoparticles were synthesized using Poly(L-Lactic Acid) and magnetite nanoparticles (∼14 nm) at different dosages, and then these nanaoparticles (nanocomposites) and pure magnetic particles were targeted in external magnetic fields by changing the test parameters. The magnetic field test results showed that magnetic saturation, fluid speed, magnetic field distance and particle size were extremely effective for a magnetic guidance system that is needed for an effective drug delivery approach. Thus, it is assumed that such nanoparticles can carry drugs (chemotherapy) to be able to cure cancer tumors as well as many other diseases.


2014 ◽  
Vol 25 (7) ◽  
pp. 2974-2978 ◽  
Author(s):  
Pan Sun ◽  
Yanchen Li ◽  
Xianquan Meng ◽  
Sheng Yu ◽  
Yihe Liu ◽  
...  

2006 ◽  
Author(s):  
Alicia Williams ◽  
Ashok Sinha ◽  
Pavlos Vlachos ◽  
Ishwar K. Puri

Magnetic Drug Targeting (MDT) has been shown to be a promising technique to effectively deliver medicinal drugs via functionalized [1] magnetic particles to target sites during the treatment of cancer and other diseases [2,3,4]. In this paper, we investigate the interaction of steady and pulsatile flows injected with a ferrofluid, which is a colloidal suspension of superparamagnetic nanoparticles in a glass tube under the influence of a magnetic field. Ferrofluids are colloidal suspensions of single domain magnetic nanoparticles that are of the order of 10 nm in diameter. In this experiment, the ferrofluid particles were directed to a particular region of interest within a 10 mm diameter glass vessel by means of an applied localized magnetic field that originated outside of the vessel. The magnetic field was generated using a rare earth sintered permanent magnet which produced the magnetic field gradient required for inducing a body force on the volume of the ferrofluid. The experimental results reveal flows with rich dynamical phenomena. The aggregation of the ferrofluid produces a self-assembled hemispherical structure which dynamically interacts with the host flow. The aggregation generates an occlusion creating a flow field that is similar to that past an obstruction. However, since the structure itself is of a fluidic nature, it is subject to shear forces caused by the host fluid. In addition, the wake of the flow behind the aggregation creates vortices which are critical to study the stability of the ferrofluid aggregate. This paper presents a detailed investigation of the dynamics of the flow using Time-Resolved Digital Particle Image Velocimetry. To the best of the authors’ knowledge, these are the first quantitative, spatiotemporally resolved measurements documenting the interaction of a host fluid with a ferrofluid aggregate under steady or pulsatile flow conditions.


Author(s):  
Chin-Yih Hong ◽  
Shieh-Yueh Yang ◽  
Herng-Er Horng ◽  
Hong-Chang Yang

A method involving the use of magnetic nanoparticles to suppress the cross-reactions in immunoassay is developed. Antibodies are coated onto magnetic nanoparticles. These antibodies bind with target and non-target molecules. Once an alternative-current magnetic field is applied, magnetic nanoparticles oscillate with the magnetic field. The target and non-target molecules attached onto magnetic nanoparticles via antibodies experience a centrifugal force, which is against the association between antibodies and target/non-target molecules. Theoretically, the centrifugal force is proportional to the square of the frequency of the applied magnetic field. Thus, the strength of the centrifugal force can be manipulated by changing the frequency of the applied magnetic field. By well controlling the frequency of applied magnetic field, the centrifugal force can be stronger than the binding between antibodies and non-target molecules, but still weaker than that of target molecules. Consequently, the binding between antibodies and non-target molecules is broken by the centrifugal force.


Author(s):  
Yasuhiro Sakuda ◽  
Masayuki Aoshima ◽  
Akira Satoh

We have investigated the internal aggregate structures of a colloidal suspension composed of magnetic plate-like particles with a magnetic moment normal to the particle axis by means of three-dimensional Monte Carlo simulations. In concrete, we have attempted to clarify the influences of the magnetic field strength, magnetic interactions between particles, and volumetric fraction of particles, on particle aggregation phenomena. In order to discuss quantitatively the aggregate structures of particles, we have focused on the radial distribution and orientational pair correlation function. For no applied magnetic field cases, long column-like clusters are formed as magnetic particle-particle interactions increase. Characteristics of these clusters are that particles incline in a certain direction with their magnetic moments alternating in direction between the neighboring particles. For applied magnetic field cases, the magnetic moments of the particles incline in the magnetic field direction, so that the columnar clusters are not formed. The brick wall-like aggregates are formed as the influences of the magnetic field and magnetic particle-particle interactions become significantly dominant.


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