Antibacterial Drug Releasing Materials by Post-Polymerization Surface Modification

2017 ◽  
Vol 05 (01) ◽  
pp. 1740005 ◽  
Author(s):  
Shuyun Chng ◽  
Mark G. Moloney ◽  
Linda Y. L. Wu

Functional materials are available by the post-polymerization surface modification of diverse polymers in a three-step process mediated, firstly, by carbene insertion chemistry, secondly, by diazonium coupling, and thirdly by modification with a remotely tethered spiropyran unit, and these materials may be used for the reversible binding and release of Penicillin V. Surface loading densities of up to 0.19[Formula: see text]mmol/g polymer are achievable, leading to materials with higher loading densities and release behavior relative to unmodified controls, and observable antibacterial biocidal activity.

Nanoscale ◽  
2021 ◽  
Author(s):  
Wipakorn Jevasuwan ◽  
Naoki Fukata

Vertical Al-catalyzed SiNW arrays with shaped surfaces were synthesized by a one-step process and NW-based solar cells were demonstrated with optimized NW surface defects through surface modification and length reduction.


2014 ◽  
Vol 6 (11) ◽  
pp. 8729-8743 ◽  
Author(s):  
Tao Liu ◽  
Zheng Zeng ◽  
Yang Liu ◽  
Jian Wang ◽  
Manfred F. Maitz ◽  
...  

2015 ◽  
Vol 16 (4) ◽  
Author(s):  
Svea Petersen ◽  
Christiane Häcker ◽  
Gökmen Turan ◽  
Stefanie Knödler ◽  
Andreas Brodehl ◽  
...  

AbstractFunctionality of implant surfaces is considerably determined by the conformations of immobilized biomolecules adjustable by the applied surface modification approach. Moreover, surface modification of drug eluting systems often needs to be thoroughly optimized with regard to possible drug losses associated with a loss of functionality. Here, we thoroughly investigate biomolecule surface loading, functionality, morphology and stability in dependence of modification conditions at the example of a site-selective immobilization of anti-CD34 antibodies (CD34-Ab) to drug-eluting stents with the aim of providing general information on the biofunctionalization of drug eluting systems. In this context, we demonstrate that the reaction time of biomolecule immobilization defines achievable surface loads but also drug loss. We could moreover show that the used site-selective immobilization procedure elevated the surface functionality considerably in comparison to surfaces modified by random physisorption. Furthermore investigated bionfunctional stability gives important indications for storage conditions of biofunctionalized implants.


2009 ◽  
Vol 137 (1) ◽  
pp. 170-179 ◽  
Author(s):  
R.R. Lima ◽  
R.A.M. Carvalho ◽  
L.M. Silva ◽  
E.W. Simões ◽  
M.L.P. da Silva

Author(s):  
Niels R. Ostyn ◽  
Sreeprasanth Pulinthanathu Sree ◽  
Jin Li ◽  
Ji-Yu Feng ◽  
Maarten BJ Roeffaers ◽  
...  

Oxidative modification of graphene-based materials is an attractive route to functional materials. The use of strong oxidants to achieve surface modification of the carbon often leads to poor uniformity and...


2021 ◽  
Vol 21 (5) ◽  
pp. 3065-3071
Author(s):  
Sihao Pan ◽  
Guanhua Huang ◽  
Hui Ding ◽  
Ke Wang ◽  
Hong Wang

Towards addressing water pollution issues, the development of multifunctional chlorella with applications ranging from sensing pollutants to heavy metal and oil removal is described. The use of chlorella cells, which are widely abundant natural structures, leads to simple and low-cost mass production of effective functional materials. Bioinspired surface modification approaches mediated by polydopamine can endow chlorella with enhanced adsorption capacity for heavy metals, as well as superhydrophobic, fluorescence and magnetic properties according to the desired application. The resulting chlorella exhibits excellent heavy metal and oil removal ability, while magnetic propulsion and guidance allow directional motion over long distances for implementation in situ removal. Moreover, it is further demonstrated that chlorella can be used as a biosensor to detect metal ions by taking advantage of the fluorescence properties of carbon dots. Such use of chlorella provides a new way for the large-scale production of functional materials to tackle water pollution.


2012 ◽  
Vol 20 (10) ◽  
pp. 1029-1036 ◽  
Author(s):  
Jumi Yun ◽  
Ae-Ri Oh ◽  
Ji Sun Im ◽  
Hyung-Il Kim ◽  
Young-Seak Lee

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