Millimeterwave and Submillimeterwave Laboratory Spectroscopy in Support of Observational Astronomy

2019 ◽  
Vol 57 (1) ◽  
pp. 79-112 ◽  
Author(s):  
Susanna L. Widicus Weaver
Keyword(s):  
Far Infrared ◽  
Rotational Spectroscopy ◽  
Spectroscopic Techniques ◽  
New Techniques ◽  
Observational Astronomy ◽  
New Developments ◽  
Detection Techniques ◽  
Current State ◽  
Acquisition Speed ◽  
Ir Astronomy

The recent advancements in far-infrared (far-IR) astronomy brought about by the Herschel, SOFIA, and ALMA observatories have led to technological advancements in millimeterwave and submillimeterwave laboratory spectroscopy that is used to support molecular observations. This review gives an overview of rotational spectroscopy and its relationship with observational astronomy, as well as an overview of laboratory spectroscopic techniques focusing on both historical approaches and new advancements. Additional topics discussed include production and detection techniques for unstable molecular species of astrochemical interest, data analysis approaches that address spectral complexity and line confusion, and the current state of and limitations to spectral line databases. Potential areas for new developments in this field are also reviewed. To advance the field, the following challenges must be addressed: ▪ Data acquisition speed, spectral sensitivity, and analysis approaches for complex mixtures and broadband spectra are the greatest limitations—and hold the greatest promise for advancement—in this field of research. ▪ Full science return from far-IR observatories cannot be realized until laboratory spectroscopy catches up with the data rate for observations. ▪ New techniques building on those used in the microwave and IR regimes are required to fill the terahertz gap.

scholarly journals New Methods for Assessing Rapid Changes in Suicide Risk

2021 ◽  
Vol 12 ◽  
Author(s):  
Elizabeth D. Ballard ◽  
Jessica R. Gilbert ◽  
Christina Wusinich ◽  
Carlos A. Zarate
Keyword(s):  
Suicide Risk ◽  
Suicidal Thoughts ◽  
New Techniques ◽  
Current State ◽  
Digital Phenotyping ◽  
Rapid Changes ◽  
And Behavior ◽  
Ecological Momentary ◽  
Assessment Strategies ◽  
Suicidal Thoughts And Behaviors

Rapid-acting interventions for the suicide crisis have the potential to transform treatment. In addition, recent innovations in suicide research methods may similarly expand our understanding of the psychological and neurobiological correlates of suicidal thoughts and behaviors. This review discusses the limitations and challenges associated with current methods of suicide risk assessment and presents new techniques currently being developed to measure rapid changes in suicidal thoughts and behavior. These novel assessment strategies include ecological momentary assessment, digital phenotyping, cognitive and implicit bias metrics, and neuroimaging paradigms and analysis methodologies to identify neural circuits associated with suicide risk. This review is intended to both describe the current state of our ability to assess rapid changes in suicide risk as well as to explore future directions for clinical, neurobiological, and computational markers research in suicide-focused clinical trials.

Whole-Organism Analysis by Vibrational Spectroscopy

2019 ◽  
Vol 12 (1) ◽  
pp. 89-108 ◽  
Author(s):  
Dale Christensen ◽  
Anja Rüther ◽  
Kamila Kochan ◽  
David Pérez-Guaita ◽  
Bayden Wood
Keyword(s):  
Vibrational Spectroscopy ◽  
Biological Materials ◽  
Diagnosis And Treatment ◽  
Spectroscopic Techniques ◽  
New Developments ◽  
Raman Spectroscopic ◽  
Spectroscopic Instrumentation ◽  
Near Future ◽  
Made In

Vibrational spectroscopy has contributed to the understanding of biological materials for many years. As the technology has advanced, the technique has been brought to bear on the analysis of whole organisms. Here, we discuss advanced and recently developed infrared and Raman spectroscopic instrumentation to whole-organism analysis. We highlight many of the recent contributions made in this relatively new area of spectroscopy, particularly addressing organisms associated with disease with emphasis on diagnosis and treatment. The application of vibrational spectroscopic techniques to entire organisms is still in its infancy, but new developments in imaging and chemometric processing will likely expand in the field in the near future.

scholarly journals Vaccination into the Dermal Compartment: Techniques, Challenges, and Prospects

Vaccines ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 534 ◽  
Author(s):  
Johanna Hettinga ◽  
Robert Carlisle
Keyword(s):  
Thermal Ablation ◽  
Influenza Pandemic ◽  
Vaccine Hesitancy ◽  
Vaccination Site ◽  
New Techniques ◽  
Diverse Range ◽  
Chemical Enhancers ◽  
Humoral And Cellular Immunity ◽  
Current State ◽  
Opening Up

In 2019, an ‘influenza pandemic’ and ‘vaccine hesitancy’ were listed as two of the top 10 challenges to global health by the WHO. The skin is a unique vaccination site, due to its immune-rich milieu, which is evolutionarily primed to respond to challenge, and its ability to induce both humoral and cellular immunity. Vaccination into this dermal compartment offers a way of addressing both of the challenges presented by the WHO, as well as opening up avenues for novel vaccine formulation and dose-sparing strategies to enter the clinic. This review will provide an overview of the diverse range of vaccination techniques available to target the dermal compartment, as well as their current state, challenges, and prospects, and touch upon the formulations that have been developed to maximally benefit from these new techniques. These include needle and syringe techniques, microneedles, DNA tattooing, jet and ballistic delivery, and skin permeabilization techniques, including thermal ablation, chemical enhancers, ablation, electroporation, iontophoresis, and sonophoresis.

scholarly journals New Developments in DD4hep

2019 ◽  
Vol 214 ◽  
pp. 02037
Author(s):  
Marko Petricˇ ◽  
Markus Frank ◽  
Frank Gaede ◽  
André Sailer
Keyword(s):  
Large Set ◽  
Sensitive Detector ◽  
New Developments ◽  
Main Motivation ◽  
Detection Techniques ◽  
Successful Experiment ◽  
Recent Developments ◽  
Materials Used ◽  
Simple Integration ◽  
Processing Framework

For a successful experiment, it is of utmost importance to provide a consistent detector description. This is also the main motivation behind DD4hep, which addresses detector description in a broad sense including the geometry and the materials used in the device, and additional parameters describing, e.g., the detection techniques, constants required for alignment and calibration, description of the readout structures and conditions data. An integral part of DD4hep is DDG4 which is a powerful tool that converts arbitrary DD4hep detector geometries to Geant4 and provides access to all Geant4 action stages. It is equipped with a comprehensive plugins suite that includes handling of different IO formats; Monte Carlo truth linking and a large set of segmentation and sensitive detector classes, allowing the simulation of a wide variety of detector technologies. In the following, recent developments in DD4hep/DDG4 like the addition of a ROOT based persistency mechanism for the detector description and the development of framework support for DDG4 are highlighted. Through this mechanism an experiment’s data processing framework can interface its essential tools to all DDG4 actions. This allows for simple integration of DD4hep into existing experiment frameworks.

Dangerous liaisons: new developments in the law of defective premises

Legal Studies ◽  
1996 ◽  
Vol 16 (3) ◽  
pp. 387-416
Author(s):  
Carl F Stychin
Keyword(s):  
Supreme Court ◽  
Tort Law ◽  
Duty Of Care ◽  
New Developments ◽  
Current State ◽  
The Law ◽  
The Cost

In 1995, the highest courts in two Commonwealth jurisdictions - Canada and Australia - squarely faced the issue of the liability of builders of defective and, in the case of the Canadian Supreme Court, dangerous premises in tort.’ The determination in both cases that the builders were liable to the remote purchasers for the cost of repair, based on a duty of care owed to them, can be contrasted to the current state of tort law in this country dealing with defective and dangerous premises. In fact, the articulation of the reasons why a duty of care was imposed in these cases - as reflecting considerations both of principle and policy - provides a more compelling analysis than has been seen to date in the British law of negligence.

Recent Advances on Rotational Spectroscopy and Microwave Spectroscopic Techniques

2014 ◽  
Vol 42 (9) ◽  
pp. 1369-1378 ◽  
Author(s):  
Li LI ◽  
Ming SUN ◽  
Xiao-Hua LI ◽  
Zhen-Wen ZHAO ◽  
Hui-Min MA ◽  
...  
Keyword(s):  
Rotational Spectroscopy ◽  
Spectroscopic Techniques ◽  
Recent Advances

Platelets: New Understanding of Platelet Glycoproteins and Their Role in Disease

Hematology ◽  
2000 ◽  
Vol 2000 (1) ◽  
pp. 222-240 ◽  
Author(s):  
James B. Bussel ◽  
Thomas J. Kunicki ◽  
Alan D. Michelson
Keyword(s):  
Point Of View ◽  
Platelet Glycoprotein ◽  
Clinical Implications ◽  
New Developments ◽  
Advantages And Disadvantages ◽  
Current State ◽  
Platelet Antigen ◽  
Low Platelet Count ◽  
Case Presentations ◽  
Alloimmune Thrombocytopenia

Abstract This review covers new developments and their clinical implications in three areas: platelet antigen polymorphisms, inhibition of platelet glycoprotein IIb-IIIa, and autoimmune thrombocytopenia (ITP). In Section I, Dr. Kunicki reviews platelet polymorphisms and their clinical implications. A current tabulation of the numerous platelet antigens, both those that are platelet specific and not platelet specific, are summarized. The immunogenic clinical implications of these polymorphisms are considered, including fetal and neonatal alloimmune thrombocytopenia, post transfusion purpura, and refractoriness to platelet transfusion. The functional relationship to hemostasis and thrombosis is also discussed, in particular whether one haplotype of the PIA1/PIA2 (HPA-1a/1b) polymorphism predisposes to myocardial infarction. Finally, novel investigations of polymorphisms will be considered, including hormonal induction of certain polymorphisms. In Section II, Dr. Michelson reviews the newest generation of platelet inhibitors, those blocking glycoprotein IIB/IIIA, from the point of view of the hematologist who might be consulted about a patient receiving this form of treatment. The current use of available IIb-IIIa inhibitors and those in trial and the accepted and possible future indications for their use are addressed. The mechanism of action and actual and theoretical advantages and disadvantages of each inhibitor are explored. Scenarios that prompt consultation with a hematologist are presented, including management of bleeding, thrombocytopenia, and management of the patient requiring emergency surgery. In Section III, Dr. Bussel reviews controversies in ITP, looking at both the current state of the art and the potential for the future. Case presentations are used to illustrate the issues in both children and adults. Three primary areas are addressed: 1) the diagnosis of ITP, 2) when and for which patient to recommend splenectomy, and 3) the management of the refractory splenectomized patient who still has a low platelet count and bleeding symptoms.

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