Application and New Developments in Fluorescence Spectroscopic Techniques in Studying Individual Molecules

2008 ◽  
Vol 43 (5) ◽  
pp. 389-415 ◽  
Author(s):  
Digambara Patra
Keyword(s):  
Spectroscopic Techniques ◽  
New Developments

Whole-Organism Analysis by Vibrational Spectroscopy

2019 ◽  
Vol 12 (1) ◽  
pp. 89-108 ◽  
Author(s):  
Dale Christensen ◽  
Anja Rüther ◽  
Kamila Kochan ◽  
David Pérez-Guaita ◽  
Bayden Wood
Keyword(s):  
Vibrational Spectroscopy ◽  
Biological Materials ◽  
Diagnosis And Treatment ◽  
Spectroscopic Techniques ◽  
New Developments ◽  
Raman Spectroscopic ◽  
Spectroscopic Instrumentation ◽  
Near Future ◽  
Made In

Vibrational spectroscopy has contributed to the understanding of biological materials for many years. As the technology has advanced, the technique has been brought to bear on the analysis of whole organisms. Here, we discuss advanced and recently developed infrared and Raman spectroscopic instrumentation to whole-organism analysis. We highlight many of the recent contributions made in this relatively new area of spectroscopy, particularly addressing organisms associated with disease with emphasis on diagnosis and treatment. The application of vibrational spectroscopic techniques to entire organisms is still in its infancy, but new developments in imaging and chemometric processing will likely expand in the field in the near future.

Millimeterwave and Submillimeterwave Laboratory Spectroscopy in Support of Observational Astronomy

2019 ◽  
Vol 57 (1) ◽  
pp. 79-112 ◽  
Author(s):  
Susanna L. Widicus Weaver
Keyword(s):  
Far Infrared ◽  
Rotational Spectroscopy ◽  
Spectroscopic Techniques ◽  
New Techniques ◽  
Observational Astronomy ◽  
New Developments ◽  
Detection Techniques ◽  
Current State ◽  
Acquisition Speed ◽  
Ir Astronomy

The recent advancements in far-infrared (far-IR) astronomy brought about by the Herschel, SOFIA, and ALMA observatories have led to technological advancements in millimeterwave and submillimeterwave laboratory spectroscopy that is used to support molecular observations. This review gives an overview of rotational spectroscopy and its relationship with observational astronomy, as well as an overview of laboratory spectroscopic techniques focusing on both historical approaches and new advancements. Additional topics discussed include production and detection techniques for unstable molecular species of astrochemical interest, data analysis approaches that address spectral complexity and line confusion, and the current state of and limitations to spectral line databases. Potential areas for new developments in this field are also reviewed. To advance the field, the following challenges must be addressed: ▪ Data acquisition speed, spectral sensitivity, and analysis approaches for complex mixtures and broadband spectra are the greatest limitations—and hold the greatest promise for advancement—in this field of research. ▪ Full science return from far-IR observatories cannot be realized until laboratory spectroscopy catches up with the data rate for observations. ▪ New techniques building on those used in the microwave and IR regimes are required to fill the terahertz gap.

Differential polarization imaging of sickled cells

1988 ◽  
Vol 46 ◽  
pp. 62-63
Author(s):  
Marcos F. Maestre
Keyword(s):  
Optical Properties ◽  
Theoretical Approach ◽  
Polarized Light ◽  
Polarization Microscopy ◽  
Spectroscopic Techniques ◽  
Polarization Imaging ◽  
Circularly Polarized Light ◽  
Circularly Polarized ◽  
Microscopic Scale ◽  
Chiral Structures

Recently we have developed a form of polarization microscopy that forms images using optical properties that have previously been limited to macroscopic samples. This has given us a new window into the distribution of structure on a microscopic scale. We have coined the name differential polarization microscopy to identify the images obtained that are due to certain polarization dependent effects. Differential polarization microscopy has its origins in various spectroscopic techniques that have been used to study longer range structures in solution as well as solids. The differential scattering of circularly polarized light has been shown to be dependent on the long range chiral order, both theoretically and experimentally. The same theoretical approach was used to show that images due to differential scattering of circularly polarized light will give images dependent on chiral structures. With large helices (greater than the wavelength of light) the pitch and radius of the helix could be measured directly from these images.

Characterization of intergranular cuprous oxide in polycrystalline YBa2Cu3O7-x

1988 ◽  
Vol 46 ◽  
pp. 880-881
Author(s):  
Bradley L. Thiel ◽  
Chan Han R. P. ◽  
Kurosky L. C. Hutter ◽  
I. A. Aksay ◽  
Mehmet Sarikaya
Keyword(s):  
Grain Boundary ◽  
Cuprous Oxide ◽  
Room Temperature ◽  
Boundary Phase ◽  
Spectroscopic Techniques ◽  
Transition Width ◽  
Practical Applications ◽  
Thin Foils ◽  
Superconducting Oxides

The identification of extraneous phases is important in understanding of high Tc superconducting oxides. The spectroscopic techniques commonly used in determining the origin of superconductivity (such as RAMAN, XPS, AES, and EXAFS) are surface-sensitive. Hence a grain boundary phase several nanometers thick could produce irrelevant spectroscopic results and cause erroneous conclusions. The intergranular phases present a major technological consideration for practical applications. In this communication we report the identification of a Cu2O grain boundary phase which forms during the sintering of YBa2Cu3O7-x (1:2:3 compound).Samples are prepared using a mixture of Y2O3. CuO, and BaO2 powders dispersed in ethanol for complete mixing. The pellets pressed at 20,000 psi are heated to 950°C at a rate of 5°C per min, held for 1 hr, and cooled at 1°C per min to room temperature. The samples show a Tc of 91K with a transition width of 2K. In order to prevent damage, a low temperature stage is used in milling to prepare thin foils which are then observed, using a liquid nitrogen holder, in a Philips 430T at 300 kV.

Quantitative nano-characterization of heterogeneous catalysts

1995 ◽  
Vol 53 ◽  
pp. 398-399
Author(s):  
P.A. Crozier ◽  
M. Pan
Keyword(s):  
Heterogeneous Catalysts ◽  
Low Dose ◽  
Imaging Techniques ◽  
Structural Features ◽  
Catalyst Characterization ◽  
New Developments ◽  
Double Phase ◽  
Phase Systems ◽  
Dose Imaging

Heterogeneous catalysts can be of varying complexity ranging from single or double phase systems to complicated mixtures of metals and oxides with additives to help promote chemical reactions, extend the life of the catalysts, prevent poisoning etc. Although catalysis occurs on the surface of most systems, detailed descriptions of the microstructure and chemistry of catalysts can be helpful for developing an understanding of the mechanism by which a catalyst facilitates a reaction. Recent years have seen continued development and improvement of various TEM, STEM and AEM techniques for yielding information on the structure and chemistry of catalysts on the nanometer scale. Here we review some quantitative approaches to catalyst characterization that have resulted from new developments in instrumentation.HREM has been used to examine structural features of catalysts often by employing profile imaging techniques to study atomic details on the surface. Digital recording techniques employing slow-scan CCD cameras have facilitated the use of low-dose imaging in zeolite structure analysis and electron crystallography. Fig. la shows a low-dose image from SSZ-33 zeolite revealing the presence of a stacking fault.

Instrumental Assessment in Cleft Palate Care

2013 ◽  
Vol 23 (2) ◽  
pp. 49-61 ◽  
Author(s):  
Jamie Perry ◽  
Graham Schenck
Keyword(s):  
Cleft Palate ◽  
New Developments ◽  
Perceptual Evaluation ◽  
Advantages And Disadvantages ◽  
Instrumental Assessment ◽  
Speech Language Pathologist ◽  
Hypernasal Speech ◽  
Perceptual Assessment ◽  
Velopharyngeal Function ◽  
And Function

Despite advances in surgical management, it is estimated that 20–30% of children with repaired cleft palate will continue to have hypernasal speech and require a second surgery to create normal velopharyngeal function (Bricknell, McFadden, & Curran, 2002; Härtel, Karsten, & Gundlach, 1994; McWilliams, 1990). A qualitative perceptual assessment by a speech-language pathologist is considered the most important step of the evaluation for children with resonance disorders (Peterson-Falzone, Hardin-Jones, & Karnell, 2010). Direct and indirect instrumental analyses should be used to confirm or validate the perceptual evaluation of an experienced speech-language pathologist (Paal, Reulbach, Strobel-Schwarthoff, Nkenke, & Schuster, 2005). The purpose of this article is to provide an overview of current instrumental assessment methods used in cleft palate care. Both direct and indirect instrumental procedures will be reviewed with descriptions of the advantages and disadvantages of each. Lastly, new developments for evaluating velopharyngeal structures and function will be provided.

New developments in hematopoetic stem cell transplantation

2002 ◽  
Vol 59 (11) ◽  
pp. 571-576 ◽  
Author(s):  
Gratwohl
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Ältere Patienten ◽  
Solide Tumoren ◽  
Aplastische Anämie ◽  
New Developments ◽  
Lymphoproliferative Erkrankungen ◽  
Hematopoetic Stem Cell ◽  
Angeborene Erkrankungen ◽  
Hematopoetic Stem Cell Transplantation

Die Transplantation hämatopoietischer Stammzellen umfasst heute Stammzellen aus Knochenmark, peripherem Blut oder Nabelschnurblut. Leukämien, Lymphoproliferative Erkrankungen, aplastische Anämie und schwere angeborene Erkrankungen des Knochenmarkes sind Hauptindikationen für allogene, lymphoproliferative Erkrankungen, Leukämien, solide Tumoren und schwere Autoimmunkrankheiten Hauptindikationen für autologe Transplantationen. Neue Verfahren wie reduzierte Konditionierung und selektive Gabe von Spenderlymphozyten eröffnen die Stammzelltransplantation auch für ältere Patienten und für solche mit vorbestehender Komorbidität. Wenn immer möglich, wird die Transplantation ab Diagnose in den Behandlungsplan integriert. Die Wahl des Verfahrens und des geeigneten Zeitpunktes wird nach individuellem Risikoprofil erstellt. Alter oder Diagnose sind nicht mehr alleinige Entscheidungskriterien. Als etablierte Therapieform dürfte die hämatopoietische Stammzelltransplantation als Modell dienen für Stammzelltransplantationen auch anderer Organe.

What’s Next?

2011 ◽  
Vol 23 (1) ◽  
pp. 60-63 ◽  
Author(s):  
Peter Vorderer
Keyword(s):  
Cultural Differences ◽  
Factor Model ◽  
New Developments ◽  
Theoretical Concepts ◽  
Open Questions ◽  
Entertainment Products ◽  
Entertainment Theory

This paper points to new developments in the context of entertainment theory. Starting from a background of well-established theories that have been proposed and elaborated mainly by Zillmann and his collaborators since the 1980s, a new two-factor model of entertainment is introduced. This model encompasses “enjoyment” and “appreciation” as two independent factors. In addition, several open questions regarding cultural differences in humans’ responses to entertainment products or the usefulness of various theoretical concepts like “presence,” “identification,” or “transportation” are also discussed. Finally, the question of why media users are seeking entertainment is brought to the forefront, and a possibly relevant need such as the “search for meaningfulness” is mentioned as a possible major candidate for such an explanation.

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