Principles of Ubiquitin-Dependent Signaling
2018 ◽
Vol 34
(1)
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pp. 137-162
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Keyword(s):
Ubiquitylation is an essential posttranslational modification that controls cell division, differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers), ubiquitin-binding effectors (readers), and de-ubiquitylases (erasers) with functionally distinct ubiquitylation tags, the ubiquitin system constitutes a powerful signaling network that is employed in similar ways from yeast to humans. Here, we discuss conserved principles of ubiquitin-dependent signaling that illustrate how this posttranslational modification shapes intracellular signaling networks to establish robust development and homeostasis throughout the eukaryotic kingdom.
Keyword(s):
Keyword(s):
2016 ◽
Vol 27
(9)
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pp. 1442-1450
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2021 ◽
2015 ◽
Vol 112
(25)
◽
pp. 7719-7724
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