scholarly journals Neurocomputational Models of Language Processing

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
John T. Hale ◽  
Luca Campanelli ◽  
Jixing Li ◽  
Shohini Bhattasali ◽  
Christophe Pallier ◽  
...  
Keyword(s):  
Language Processing ◽  
Computational Models ◽  
Annual Review ◽  
Publication Date ◽  
Data Sets ◽  
Linguistic Features ◽  
Neural Signals ◽  
Data Set ◽  
Interpretable Models ◽  
Compare And Contrast

Efforts to understand the brain bases of language face the Mapping Problem: At what level do linguistic computations and representations connect to human neurobiology? We review one approach to this problem that relies on rigorously defined computational models to specify the links between linguistic features and neural signals. Such tools can be used to estimate linguistic predictions, model linguistic features, and specify a sequence of processing steps that may be quantitatively fit to neural signals collected while participants use language. Progress has been helped by advances in machine learning, attention to linguistically interpretable models, and openly shared data sets that allow researchers to compare and contrast a variety of models. We describe one such data set in detail in the Supplementary Appendix. Expected final online publication date for the Annual Review of Linguistics, Volume 8 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Biotic and Abiotic Controls on the Phanerozoic History of Marine Animal Biodiversity

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Andrew M. Bush ◽  
Jonathan L. Payne
Keyword(s):  
Biotic Interactions ◽  
Annual Review ◽  
Publication Date ◽  
Data Sets ◽  
Marine Animal ◽  
Marine Animals ◽  
Marine Habitat ◽  
Positive Feedbacks ◽  
Abiotic Controls ◽  
Time Changes

During the past 541 million years, marine animals underwent three intervals of diversification (early Cambrian, Ordovician, Cretaceous–Cenozoic) separated by nondirectional fluctuation, suggesting diversity-dependent dynamics with the equilibrium diversity shifting through time. Changes in factors such as shallow-marine habitat area and climate appear to have modulated the nondirectional fluctuations. Directional increases in diversity are best explained by evolutionary innovations in marine animals and primary producers coupled with stepwise increases in the availability of food and oxygen. Increasing intensity of biotic interactions such as predation and disturbance may have led to positive feedbacks on diversification as ecosystems became more complex. Important areas for further research include improving the geographic coverage and temporal resolution of paleontological data sets, as well as deepening our understanding of Earth system evolution and the physiological and ecological traits that modulated organismal responses to environmental change. Expected final online publication date for the Annual Review of Ecology, Evolution, and Systematics, Volume 52 is November 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

The Rise of Digital Money

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Tobias Adrian ◽  
Tommaso Mancini-Griffoli
Keyword(s):  
Central Bank ◽  
Financial Economics ◽  
Customer Orientation ◽  
Annual Review ◽  
Publication Date ◽  
Digital Money ◽  
Payments Systems ◽  
Bank Reserves ◽  
To Come ◽  
Compare And Contrast

Payments systems around the world are evolving with the emergence of digital money issued by private firms and central banks. We provide a conceptual framework to compare and contrast traditional forms of money with their new digital equivalents. We suggest that some forms of digital money, while less stable as a store of value, could be rapidly adopted given their advantages as a means of payment. We review the benefits and risks that would emerge. One approach to managing risks would be to require full backing of selected digital money with central bank reserves. We call the arrangement synthetic central bank digital currency (sCBDC), a private-public partnership that combines the advantages of private sector innovation and customer orientation with the safety and stability of central bank–backed money. We offer policy considerations, directions for research, and an overview of the literature to date. The analysis of digital currencies is an exciting new field crossing into monetary and financial economics that will reshape the monetary and financial systems for many years to come. Expected final online publication date for the Annual Review of Financial Economics, Volume 13 is March 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Testing Causal Theories with Learned Proxies

2022 ◽  
Vol 25 (1) ◽  
Author(s):  
Dean Knox ◽  
Christopher Lucas ◽  
Wendy K. Tam Cho
Keyword(s):  
Political Science ◽  
Best Practice ◽  
Computational Models ◽  
Annual Review ◽  
Publication Date ◽  
Social Scientists ◽  
Theoretical Concepts ◽  
Point Estimates ◽  
Causal Diagrams ◽  
Causal Theories

Social scientists commonly use computational models to estimate proxies of unobserved concepts, then incorporate these proxies into subsequent tests of their theories. The consequences of this practice, which occurs in over two-thirds of recent computational work in political science, are underappreciated. Imperfect proxies can reflect noise and contamination from other concepts, producing biased point estimates and standard errors. We demonstrate how analysts can use causal diagrams to articulate theoretical concepts and their relationships to estimated proxies, then apply straightforward rules to assess which conclusions are rigorously supportable. We formalize and extend common heuristics for “signing the bias”—a technique for reasoning about unobserved confounding—to scenarios with imperfect proxies. Using these tools, we demonstrate how, in often-encountered research settings, proxy-based analyses allow for valid tests for the existence and direction of theorized effects. We conclude with best-practice recommendations for the rapidly growing literature using learned proxies to test causal theories. Expected final online publication date for the Annual Review of Political Science, Volume 25 is May 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Smartphones and the Neuroscience of Mental Health

2021 ◽  
Vol 44 (1) ◽  
Author(s):  
Claire M. Gillan ◽  
Robb B. Rutledge
Keyword(s):  
Mental Health ◽  
Annual Review ◽  
Publication Date ◽  
Data Sets ◽  
Daily Lives ◽  
Neuroscience Research ◽  
Health And Illness ◽  
Passive Data ◽  
Smartphone Sensors ◽  
Rich Data

Improvements in understanding the neurobiological basis of mental illness have unfortunately not translated into major advances in treatment. At this point, it is clear that psychiatric disorders are exceedingly complex and that, in order to account for and leverage this complexity, we need to collect longitudinal datasets from much larger and more diverse samples than is practical using traditional methods. We discuss how smartphone-based research methods have the potential to dramatically advance our understanding of the neuroscience of mental health. This, we expect, will take the form of complementing lab-based hard neuroscience research with dense sampling of cognitive tests, clinical questionnaires, passive data from smartphone sensors, and experience-sampling data as people go about their daily lives. Theory- and data-driven approaches can help make sense of these rich data sets, and the combination of computational tools and the big data that smartphones make possible has great potential value for researchers wishing to understand how aspects of brain function give rise to, or emerge from, states of mental health and illness. Expected final online publication date for the Annual Review of Neuroscience, Volume 44 is July 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Synthetic Data

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Trivellore E. Raghunathan
Keyword(s):  
Synthetic Data ◽  
Future Research ◽  
Annual Review ◽  
Publication Date ◽  
Data Sets ◽  
Sensitive Information ◽  
Inferential Justification ◽  
Widespread Access ◽  
Access To Data ◽  
Privacy And Confidentiality

Demand for access to data, especially data collected using public funds, is ever growing. At the same time, concerns about the disclosure of the identities of and sensitive information about the respondents providing the data are making the data collectors limit the access to data. Synthetic data sets, generated to emulate certain key information found in the actual data and provide the ability to draw valid statistical inferences, are an attractive framework to afford widespread access to data for analysis while mitigating privacy and confidentiality concerns. The goal of this article is to provide a review of various approaches for generating and analyzing synthetic data sets, inferential justification, limitations of the approaches, and directions for future research. Expected final online publication date for the Annual Review of Statistics, Volume 8 is March 8, 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Model Distribution Effects on Likelihood Ratios in Fire Debris Analysis

Separations ◽  
2018 ◽  
Vol 5 (3) ◽  
pp. 44 ◽  
Author(s):  
Alyssa Allen ◽  
Mary Williams ◽  
Nicholas Thurn ◽  
Michael Sigman
Keyword(s):  
Computational Models ◽  
Area Under The Curve ◽  
Ground Truth ◽  
Data Sets ◽  
Likelihood Ratios ◽  
Data Set ◽  
Discriminant Model ◽  
Fire Debris ◽  
Characteristic Area ◽  
Ignitable Liquid

Computational models for determining the strength of fire debris evidence based on likelihood ratios (LR) were developed and validated against data sets derived from different distributions of ASTM E1618-14 designated ignitable liquid class and substrate pyrolysis contributions using in-silico generated data. The models all perform well in cross validation against the distributions used to generate the model. However, a model generated based on data that does not contain representatives from all of the ASTM E1618-14 classes does not perform well in validation with data sets that contain representatives from the missing classes. A quadratic discriminant model based on a balanced data set (ignitable liquid versus substrate pyrolysis), with a uniform distribution of the ASTM E1618-14 classes, performed well (receiver operating characteristic area under the curve of 0.836) when tested against laboratory-developed casework-relevant samples of known ground truth.

Simulation and Analysis Methods for Stochastic Compartmental Epidemic Models

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Tapiwa Ganyani ◽  
Christel Faes ◽  
Niel Hens
Keyword(s):  
Stochastic Models ◽  
Online Publication ◽  
Real Life ◽  
Likelihood Estimation ◽  
Annual Review ◽  
Publication Date ◽  
Data Set ◽  
Incidence Data ◽  
Mixed Populations ◽  
Application Volume

This article considers simulation and analysis of incidence data using stochastic compartmental models in well-mixed populations. Several simulation approaches are described and compared. Thereafter, we provide an overview of likelihood estimation for stochastic models. We apply one such method to a real-life outbreak data set and compare models assuming different kinds of stochasticity. We also give references for other publications where detailed information on this topic can be found. Expected final online publication date for the Annual Review of Statistics and Its Application, Volume 8 is March 8, 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Space-Time Covariance Structures and Models

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Wanfang Chen ◽  
Marc G. Genton ◽  
Ying Sun
Keyword(s):  
Climate Models ◽  
Space Time ◽  
Covariance Structures ◽  
Annual Review ◽  
Publication Date ◽  
Monitoring Networks ◽  
Data Set ◽  
Temporal Modeling ◽  
Covariance Models ◽  
Spatio Temporal

In recent years, interest has grown in modeling spatio-temporal data generated from monitoring networks, satellite imaging, and climate models. Under Gaussianity, the covariance function is core to spatio-temporal modeling, inference, and prediction. In this article, we review the various space-time covariance structures in which simplified assumptions, such as separability and full symmetry, are made to facilitate computation, and associated tests intended to validate these structures. We also review recent developments on constructing space-time covariance models, which can be separable or nonseparable, fully symmetric or asymmetric, stationary or nonstationary, univariate or multivariate, and in Euclidean spaces or on the sphere. We visualize some of the structures and models with visuanimations. Finally, we discuss inference for fitting space-time covariance models and describe a case study based on a new wind-speed data set. Expected final online publication date for the Annual Review of Statistics, Volume 8 is March 8, 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals An Interpretable Computer-Aided Diagnosis Method for Periodontitis From Panoramic Radiographs

2021 ◽  
Vol 12 ◽  
Author(s):  
Haoyang Li ◽  
Juexiao Zhou ◽  
Yi Zhou ◽  
Qiang Chen ◽  
Yangyang She ◽  
...  
Keyword(s):  
Computational Models ◽  
Alveolar Bone ◽  
Calibration Method ◽  
Disease Diagnosis ◽  
Chronic Inflammatory Disease ◽  
Data Sets ◽  
Data Set ◽  
Panoramic Radiographs ◽  
The Individual ◽  
Severity Degree

Periodontitis is a prevalent and irreversible chronic inflammatory disease both in developed and developing countries, and affects about 20–50% of the global population. The tool for automatically diagnosing periodontitis is highly demanded to screen at-risk people for periodontitis and its early detection could prevent the onset of tooth loss, especially in local communities and health care settings with limited dental professionals. In the medical field, doctors need to understand and trust the decisions made by computational models and developing interpretable models is crucial for disease diagnosis. Based on these considerations, we propose an interpretable method called Deetal-Perio to predict the severity degree of periodontitis in dental panoramic radiographs. In our method, alveolar bone loss (ABL), the clinical hallmark for periodontitis diagnosis, could be interpreted as the key feature. To calculate ABL, we also propose a method for teeth numbering and segmentation. First, Deetal-Perio segments and indexes the individual tooth via Mask R-CNN combined with a novel calibration method. Next, Deetal-Perio segments the contour of the alveolar bone and calculates a ratio for individual tooth to represent ABL. Finally, Deetal-Perio predicts the severity degree of periodontitis given the ratios of all the teeth. The Macro F1-score and accuracy of the periodontitis prediction task in our method reach 0.894 and 0.896, respectively, on Suzhou data set, and 0.820 and 0.824, respectively on Zhongshan data set. The entire architecture could not only outperform state-of-the-art methods and show robustness on two data sets in both periodontitis prediction, and teeth numbering and segmentation tasks, but also be interpretable for doctors to understand the reason why Deetal-Perio works so well.

scholarly journals The importance of the accuracy of the experimental data for the prediction of solubility

2010 ◽  
Vol 75 (4) ◽  
pp. 483-495 ◽  
Author(s):  
Slavica Eric ◽  
Marko Kalinic ◽  
Aleksandar Popovic ◽  
Halid Makic ◽  
Elvisa Civic ◽  
...  
Keyword(s):  
Experimental Data ◽  
Computational Models ◽  
Linear Regression Analysis ◽  
Heuristic Method ◽  
Parameter Analysis ◽  
Solubility Data ◽  
Data Sets ◽  
Data Set ◽  
Experimental Solubility Data ◽  
Experimental Solubility

Aqueous solubility is an important factor influencing several aspects of the pharmacokinetic profile of a drug. Numerous publications present different methodologies for the development of reliable computational models for the prediction of solubility from structure. The quality of such models can be significantly affected by the accuracy of the employed experimental solubility data. In this work, the importance of the accuracy of the experimental solubility data used for model training was investigated. Three data sets were used as training sets - Data Set 1 containing solubility data collected from various literature sources using a few criteria (n = 319), Data Set 2 created by substituting 28 values from Data set 1 with uniformly determined experimental data from one laboratory (n = 319) and Data Set 3 created by including 56 additional components, for which the solubility was also determined under uniform conditions in the same laboratory, in the Data Set 2 (n = 375). The selection of the most significant descriptors was performed by the heuristic method, using one-parameter and multi-parameter analysis. The correlations between the most significant descriptors and solubility were established using multi-linear regression analysis (MLR) for all three investigated data sets. Notable differences were observed between the equations corresponding to different data sets, suggesting that models updated with new experimental data need to be additionally optimized. It was successfully shown that the inclusion of uniform experimental data consistently leads to an improvement in the correlation coefficients. These findings contribute to an emerging consensus that improving the reliability of solubility prediction requires the inclusion of many diverse compounds for which solubility was measured under standardized conditions in the data set.

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