Coenzyme A metabolism

1985 ◽  
Vol 248 (1) ◽  
pp. E1-E9 ◽  
Author(s):  
J. D. Robishaw ◽  
J. R. Neely
Keyword(s):  
Enzyme Activity ◽  
Cardiac Muscle ◽  
Heart Muscle ◽  
Coenzyme A ◽  
Free Carnitine ◽  
Pantothenate Kinase ◽  
Acetyl Coenzyme A ◽  
Synthetic Pathway ◽  
And Control ◽  
Inhibited Enzyme

The metabolism of coenzyme A and control of its synthesis are reviewed. Pantothenate kinase is an important rate-controlling enzyme in the synthetic pathway of all tissues studied and appears to catalyze the flux-generating reaction of the pathway in cardiac muscle. This enzyme is strongly inhibited by coenzyme A and all of its acyl esters. The cytosolic concentrations of coenzyme A and acetyl coenzyme A in both liver and heart are high enough to totally inhibit pantothenate kinase under all conditions. Free carnitine, but not acetyl carnitine, deinhibits the coenzyme A-inhibited enzyme. Carnitine alone does not increase enzyme activity. Thus changes in the acetyl carnitine-to-carnitine ratio that occur with nutritional states provides a mechanism for regulation of coenzyme A synthetic rates. Changes in the rate of coenzyme A synthesis in liver and heart occurs with fasting, refeeding, and diabetes and in heart muscle with hypertrophy. The pathway and regulation of coenzyme A degradation are not understood.

scholarly journals Rate-limiting step and control of coenzyme A synthesis in cardiac muscle.

1982 ◽  
Vol 257 (18) ◽  
pp. 10967-10972 ◽  
Author(s):  
J D Robishaw ◽  
D Berkich ◽  
J R Neely
Keyword(s):  
Cardiac Muscle ◽  
Coenzyme A ◽  
Rate Limiting Step ◽  
Limiting Step ◽  
And Control ◽  
Rate Limiting

scholarly journals Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Xiaoyun Lu ◽  
Yuwan Liu ◽  
Yiqun Yang ◽  
Shanshan Wang ◽  
Qian Wang ◽  
...  
Keyword(s):  
Coenzyme A ◽  
Enzyme Design ◽  
Acetyl Coenzyme A ◽  
Synthetic Pathway ◽  
Acetyl Coenzyme

scholarly journals The eutD Gene of Salmonella enterica Encodes a Protein with Phosphotransacetylase Enzyme Activity

2004 ◽  
Vol 186 (6) ◽  
pp. 1890-1892 ◽  
Author(s):  
Shaun R. Brinsmade ◽  
Jorge C. Escalante-Semerena
Keyword(s):  
Mass Spectrometry ◽  
High Pressure ◽  
Enzyme Activity ◽  
Liquid Chromatography ◽  
High Pressure Liquid Chromatography ◽  
Salmonella Enterica ◽  
Coenzyme A ◽  
Catalytic Domain ◽  
Activity Level ◽  
Acetyl Coenzyme A

ABSTRACT The EutD protein of Salmonella enterica is homologous to the catalytic domain of the phosphotransacetylase (Pta) enzyme. The Pta-like activity level of the EutD enzyme compared favorably to that of other Pta enzymes. High-pressure liquid chromatography and mass spectrometry verified that acetyl-coenzyme A was the product of the reaction. The EutD protein restored growth of an S. enterica pta strain on acetate as the source of carbon and energy.

SIALIC ACID IN THE PRIMARY AND DIFFERENTIAL DIAGNOSIS OF LUNG CANCER

2017 ◽  
Vol 63 (6) ◽  
pp. 926-932
Author(s):  
Lyudmila Belskaya ◽  
Viktor Kosenok ◽  
Ж. Массард
Keyword(s):  
Lung Cancer ◽  
Enzyme Activity ◽  
Optimization Problems ◽  
Primary Lung Cancer ◽  
Nonparametric Test ◽  
Nonsmall Cell Lung Cancer ◽  
Group Differences ◽  
Diagnosis Of Lung Cancer ◽  
And Control ◽  
Control Study

So far optimization problems for diagnostics and prognostication aids remained relevant for lung cancer as a leader in the structure of cancers. Objective: a search for regularities of changes in the saliva enzyme activity in patients with nonsmall cell lung cancer. In the case-control study, 505 people took part, divided into 2 groups: primary (lung cancer, n=290) and control (conventionally healthy, n=215). All the participants went through a questionnaire survey, saliva biochemical counts, and a histological verification of their diagnosis. The enzyme activity was measured with spectrophotometry. Between-group differences were measured with the nonparametric test. It was shown that in terms of lung cancer, we observe metabolic changes, described with the decreased de Ritis coefficient (p

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