Simple circuit for pacing hearts of experimental animals

1992 ◽  
Vol 262 (6) ◽  
pp. H1939-H1940 ◽  
Author(s):  
G. L. Freeman ◽  
J. T. Colston

In this paper we describe a simple pacing circuit which can be used to drive the heart over a wide range of rates. The circuit is an astable multivibrator, based on an LM555 integrated circuit. It is powered by a 9-V battery and is small enough for use in rabbits. The circuit is easily constructed and inexpensive, making it attractive for numerous applications in cardiovascular research.

1987 ◽  
Vol 7 (1) ◽  
pp. 36-37
Author(s):  
P. Mitchell ◽  
E. Ollier

AbstractA simple circuit has been designed for reading out at TV rate the two-dimensional CCD on the Automated Patrol Telescope. Because it is controlled by a programmable Cathode Ray Tube Controller integrated circuit it is very flexible and applicable to frame transfer CCDs having a wide range of formats.


1995 ◽  
Vol 05 (03) ◽  
pp. 455-463 ◽  
Author(s):  
S. FINCO ◽  
F. H. BEHRENS ◽  
J. GUILHERME ◽  
M. I. CASTRO SIMAS ◽  
M. LANÇA

A smart power integrated circuit to be fabricated with standard CMOS technologies was developed in view to obtain a versatile, high performance and low cost basic building block, suitable for a wide range of low power applications. This circuit merges together two transistors, connected in a low-side/high-side switch configuration, with specific control and protection circuitries. These transistors are NMOS medium-voltage lateral structures, which use the lightly doped drain concept and are targeted to handle currents up to 2 A and to support 25 V at OFF state. Experimental results on different applications and topologies show the applicability of the smart switching cell on portable systems power supplies and amplifiers (up to 20 W). Its performance also proves the ability of standard CMOS technologies to implement smart power circuits.


MRS Bulletin ◽  
1989 ◽  
Vol 14 (6) ◽  
pp. 35-38 ◽  
Author(s):  
Dirk Denoyelle

The Interuniversity Microelectronics Center, Leuven, Belgium (IMEC) is one of the world's largest independent research centers for microelectronics. It was established in 1984 by the Flemish government as a part of a comprehensive program to promote high technology in Flanders, Belgium. Benefiting from existing experience available mainly at the University of Leuven, IMEC moved into its present facilities in 1986 (Figure 1).The Center covers a wide range of research topics in the microelectronics domain—VLSI systems design methodologies, advanced semiconductor processing, materials, packaging, and more.About 50 people work on computer-aided design, developing a series of “true” silicon compilers: CATHEDRAL. With this software, ASIC (application specific integrated circuit) design becomes extremely attractive, since CATHEDRAL covers design from the high system level down to layout.INVOMEC, the training division of IMEC, supports universities in ASIC design. It trains people for both educational institutes and industry in chip design, makes available the necessary software, and has a well-established Multi Project Chip—Multi Project Wafer service.The Processing Technologies and Materials Divisions involve about 200 people and have a 3,600 m2 clean room at their disposal. The clean room consists of a 20% class 10 area with a fast-turnaround prototyping line and an 80% class 1000 area.IMEC's objectives are: to perform research in the microelectronics field, supporting both industry and universities, and to stimulate the microelectronics industry in Flanders.IMEC performs research on both silicon and III-V technologies.


2021 ◽  
Vol 12 ◽  
Author(s):  
Jianglin Fan ◽  
Yanli Wang ◽  
Y. Eugene Chen

Rabbits are one of the most used experimental animals for investigating the mechanisms of human cardiovascular disease and lipid metabolism because they are phylogenetically closer to human than rodents (mice and rats). Cholesterol-fed wild-type rabbits were first used to study human atherosclerosis more than 100 years ago and are still playing an important role in cardiovascular research. Furthermore, transgenic rabbits generated by pronuclear microinjection provided another means to investigate many gene functions associated with human disease. Because of the lack of both rabbit embryonic stem cells and the genome information, for a long time, it has been a dream for scientists to obtain knockout rabbits generated by homologous recombination-based genomic manipulation as in mice. This obstacle has greatly hampered using genetically modified rabbits to disclose the molecular mechanisms of many human diseases. The advent of genome editing technologies has dramatically extended the applications of experimental animals including rabbits. In this review, we will update genetically modified rabbits, including transgenic, knock-out, and knock-in rabbits during the past decades regarding their use in cardiovascular research and point out the perspectives in future.


Electronics ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 313
Author(s):  
Aaron Tan ◽  
Rui Toh ◽  
Alfred Lim ◽  
Yongfu Li ◽  
Zhi Kong

This paper analyzes the circuit complexity using Doherty power amplifier (DPA) as a case study and proposes a simplistic model to characterize the design complexity of a DPA circuit. Various fundamental building blocks of the DPA circuit are discussed and modeled to formulate the model. In one of our experiments, it is observed that a reduction of up to 400% in the normalized complexity factor (NCF) could enhance the gain performance by approximately up to 40% for UHF applications. This work can be used as a common benchmarking tool to compare various types of DPA architecture and allow design teams to optimize their building blocks in the DPA circuit. This model can also potentially become a platform for the improvement of many integrated circuit design components, allowing ready integration on a wide range of next generation applications, not only limited to DPA circuits.


Sensors ◽  
2020 ◽  
Vol 20 (6) ◽  
pp. 1794
Author(s):  
Udumbara Wijesinghe ◽  
Akash Neel Dey ◽  
Andrew Marshall ◽  
William Krenik ◽  
Can Duan ◽  
...  

Sensors that remotely track the displacement of a moving object have a wide range of applications from robotic control to motion capture. In this paper, we introduce a simple, small silicon integrated circuit sensor that tracks the angular displacement of an object tagged with a small light source, such as a light-emitting diode (LED). This sensor uses a new angular transduction mechanism, differential diffusion of photoelectrons generated from the light spot cast by the light tag onto a Si anode, that is described by a simple physics model using pinhole optics and carrier diffusion. Because the light spot is formed by a pinhole aperture integrated on the sensor chip, no external focusing optics are needed, reducing system complexity, size, and weight. Prototype sensors based on this model were fabricated and their basic characteristics are presented. These sensors transduce angular displacement of an LED across orthogonal latitudinal and longitudinal arcs into normalized differential photocathode currents with signal linearly proportional to LED angular position across a ± 40° field-of-view. These sensors offer potential performance and ease-of-use benefits compared to existing displacement sensor technologies.


Sensors ◽  
2019 ◽  
Vol 19 (4) ◽  
pp. 756 ◽  
Author(s):  
Nazanin Neshatvar ◽  
Peter Langlois ◽  
Richard Bayford ◽  
Andreas Demosthenous

An important component in bioimpedance measurements is the current driver, which can operate over a wide range of impedance and frequency. This paper provides a review of integrated circuit analog current drivers which have been developed in the last 10 years. Important features for current drivers are high output impedance, low phase delay, and low harmonic distortion. In this paper, the analog current drivers are grouped into two categories based on open loop or closed loop designs. The characteristics of each design are identified.


2015 ◽  
Vol 644 ◽  
pp. 133-136 ◽  
Author(s):  
Mitar Simić

The improved design of previously developed complex impedance measurement system is described. Realized system for measurement of complex impedance is based on integrated circuit AD5933 which is controlled by microcontroller ATmega128. Device has full standalone capabilities with LCD for displaying of results and keyboard for configuration on the field. Created report with measured values of impedance magnitude and phase angle is stored on micro SD card in format compatible with MS Excel which ensures easy off-line analysis on PC. Realized device is equipped with self-calibration system which ensures high accuracy in wide range of impedance and frequency. In the aim of the verification of developed system, the measurement results are plotted and compared with theoretical impedance values. Realized system can be used for complex impedance measurement, impedance spectrometry, biomedical and automotive sensors, proximity sensors, FFT processing, structural health monitoring, etc.


Nanophotonics ◽  
2018 ◽  
Vol 7 (5) ◽  
pp. 837-852 ◽  
Author(s):  
Yiwei Xie ◽  
Leimeng Zhuang ◽  
Arthur J. Lowery

AbstractChip-scale integrated optical signal processors promise to support a multitude of signal processing functions with bandwidths beyond the limit of microelectronics. Previous research has made great contributions in terms of demonstrating processing functions and device building blocks. Currently, there is a significant interest in providing functional reconfigurability, to match a key advantage of programmable microelectronic processors. To advance this concept, in this work, we experimentally demonstrate a photonic integrated circuit as an optical signal processor with an unprecedented combination of two key features: reconfigurability and terahertz bandwidth. These features enable a variety of processing functions on picosecond optical pulses using a single device. In the experiment, we successfully verified clock rate multiplication, arbitrary waveform generation, discretely and continuously tunable delays, multi-path combining and bit-pattern recognition for 1.2-ps-duration optical pulses at 1550 nm. These results and selected head-to-head comparisons with commercially available devices show our device to be a flexible integrated platform for ultrahigh-bandwidth optical signal processing and point toward a wide range of applications for telecommunications and beyond.


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