Measurement of Regional Sodium Turnover Rates and Their Application to the Estimation of Regional Blood Flow

1957 ◽  
Vol 189 (2) ◽  
pp. 269-276 ◽  
Author(s):  
Ernest L. Dobson ◽  
George F. Warner
Keyword(s):  
Blood Flow ◽  
Turnover Rate ◽  
Regional Blood Flow ◽  
Removal Rate ◽  
Subcutaneous Administration ◽  
Blood Perfusion ◽  
Turnover Rates ◽  
Epinephrine Administration ◽  
Vascular Bed ◽  
Flow Through

It has been possible to estimate the regional blood flow through quantitative analysis of the sodium wash out curve obtained by a method which involves the injection of sodium 24 into an artery and the subsequent monitoring of the region (limb) supplied by this artery with external counters. The normal resting sodium turnover rate in the human forearm was found to be 10%/min. corresponding to a blood perfusion factor of 0.040 liters of blood per liter of tissue per minute. In addition to these quantitative values this method has given qualitative information on the pattern of the vascular bed. Analysis of the manner in which the removal rate changes with time has indicated that there are regions of widely differing vascularities in the area seen by the counter. Measurements following epinephrine administration have demonstrated not only a quantitative change in flow but a qualitative one as well. The subcutaneous administration of 1 mg epinephrine caused a doubling of the average total sodium turnover rate indicating a twofold increase in blood flow. The observed changes in the shape of the clearance curves could not be explained by a simple increase in linear flow rate and therefore must have involved some change in the character of the vascular bed, i.e. the conversion of some regions of low vascularity to regions of high vascularity.

scholarly journals Blood Perfusion of the Kidney of Lophius Piscatorius L.

1953 ◽  
Vol 32 (2) ◽  
pp. 329-336 ◽  
Author(s):  
L. Brull ◽  
E. Nizet ◽  
E. B. Verney
Keyword(s):  
Blood Flow ◽  
Critical Level ◽  
Perfusion Pressure ◽  
Blood Perfusion ◽  
Urine Flow ◽  
The Other ◽  
Protein Nitrogen ◽  
Other Hand ◽  
Flow Through

Lophius kidneys perfused with the heparinized blood (venous) of the fish secrete urine in which total non-protein nitrogen is concentrated, magnesium highly concentrated, and chloride only slightly so or not at all. Oxygenation of the blood, or lowering the temperature of the perfusate from c. 20° to c. 5° C. does not appear to influence secretion. The blood flow through the kidneys increases with the perfusion pressure, the increase often becoming disproportionately large. The urine flow, on the other hand, above a certain critical level is largely independent of changes in perfusion pressure.

scholarly journals ANGIOPULMONOGRAPHY WITH NITROGLYCERIN TEST IN THE DIAGNOSIS OF ACUTE INFECTIOUS LUNG DESTRUCTION

2021 ◽  
Vol 29 (4) ◽  
pp. 412-419
Author(s):  
V.I. Petukhov ◽  
◽  
V.I. Derkach ◽  
S.N. Ermashkevich ◽  
M.V. Kuntsevich ◽  
...  
Keyword(s):  
Blood Flow ◽  
Differential Diagnosis ◽  
Test Performance ◽  
Blood Circulation ◽  
Lung Parenchyma ◽  
Inflammatory Infiltration ◽  
Affected Area ◽  
Vascular Bed ◽  
Pulmonary Parenchyma ◽  
Flow Through

Objective. To develop a method for additional and differential diagnosis of acute infectious lung destruction (AILD) based on angiopulmonography with the nitroglycerin test. Methods. Angiopulmonography with the nitroglycerin test was used in 10 patients with suppurative diseasesof thelung and pleura for additional and differential diagnosis of AILD The method was used in such situations when chest computed tomography did not allow to determine unambiguously the presence and / or prevalence of necrosis of the lung parenchyma. Results. In 3 patients with the lung abscess, a clear restriction of the decay cavity was registered with the preservation of the main blood flow and weakening of the parenchymal phase of the blood circulation along the periphery of the destructive area. During the nitroglycerin test performance there was no change in the filling of the microvascular bed with contrast along the periphery of the decay cavity, which made it possible to determine the presence of parietal sequesters. According to the results of the study, the lung gangrene was diagnosed in 6 patients. At the same time, two variants of circulatory disorders were noted: the first - with preservation of the blood flow through the main vessels and with the absence of a parenchymal phase in the lesion focus, the second - with the violation of the main blood flow. In the affected area no change in blood flow was observed after the nitroglycerin test performance. Similar results of the study indicated the development of necrosis of the pulmonary parenchyma, which was subsequently confirmed during the operations performed. In the site of inflammatory infiltration of the pulmonary parenchyma with preserved main blood flow, the depletion of the parenchymal phase of blood circulation was determined, but after the nitroglycerin test, a pronounced enrichment of the vascular architecture to the parenchymal phase in the pneumonia affecting part of the lung was noted. Conclusion. It has been established that AILD is characterized by irreversible changes in the vascular bed of the lung parenchyma in the lesion focus. Angiopulmonography with the nitroglycerin test is considered to be an additional highly informative method improving the early and differential diagnosis of AILD in difficult clinical situations. What this paper adds It has been found out that during angiopulmonography the areas of pulmonary necrosis are characterized by the absence of a vascular pattern with or without disturbance of the blood flow through the segmental arteries. At the same time, in contrast to the foci of pneumonia, the nitroglycerin test is not accompanied by an evaluation of the filling of the pulmonary vascular bed in the affected area, i.e. blood supply disorders are irreversible. Thus, based on an assessment of the nature and reversibility of the blood flow disturbances in the affected lung, it is possible to carry out differential diagnosis of the early stages of acute infectious lung destruction (AILD) and pneumonia.

Effect of muscle strength and endurance development on blood flow

1961 ◽  
Vol 16 (5) ◽  
pp. 873-877 ◽  
Author(s):  
Ellen R. Vanderhoof ◽  
Charles J. Imig ◽  
H. M. Hines
Keyword(s):  
Blood Flow ◽  
Muscle Strength ◽  
Training Program ◽  
Strength Development ◽  
Flow Response ◽  
Hand Grip ◽  
Vascular Bed ◽  
Flow Through ◽  
Test Exercise ◽  
Strength Improvement

Studies were carried out to investigate the effect of hand grip strength and/or endurance improvement on blood flow through the muscles involved. One group of subjects trained for strength development and another for endurance development throughout a 29-week period. At regular intervals blood flow was measured under resting conditions and also following three different test exercise stresses designed to test the functional capacity of the vascular bed. Subjects who participated in the strength training program made significant gains in strength but not in endurance, while those subjects who trained for endurance improved in both strength and endurance. Resting blood flow was not changed significantly as a result of either training program. Significant changes in the blood flow response to the test exercise stresses were noted; these changes were associated with endurance rather than strength improvement. Submitted on April 3, 1961

Noninvasive Blood Perfusion Measurement on the Liver of an Anesthetized Rat

2007 ◽  
Author(s):  
Patricia L. Ricketts ◽  
Ashvinikumar V. Mudaliar ◽  
Brent E. Ellis ◽  
Thomas E. Diller ◽  
Elaine P. Scott ◽  
...  
Keyword(s):  
Blood Flow ◽  
Environmental Factors ◽  
Large Range ◽  
Volumetric Flow Rate ◽  
Blood Perfusion ◽  
Tissue Type ◽  
Living Tissue ◽  
Measurement Sensitivity ◽  
Perfusion Measurement ◽  
Flow Through

Blood perfusion is the local, non-directional blood flow through living tissue. It is measured as the volumetric flow rate of blood per volume of tissue and a large range of perfusion values have been reported for human tissue (i.e. 0.002–0.5 ml/ml/s). This large range is thought to be due to measurement sensitivity, environmental factors, and tissue type and location.

Regional blood flow during simulated diving in the conscious Weddell seal

1979 ◽  
Vol 47 (5) ◽  
pp. 968-973 ◽  
Author(s):  
W. M. Zapol ◽  
G. C. Liggins ◽  
R. C. Schneider ◽  
J. Qvist ◽  
M. T. Snider ◽  
...  
Keyword(s):  
Blood Flow ◽  
Regional Blood Flow ◽  
Bronchial Artery ◽  
Weddell Seal ◽  
Left Ventricular ◽  
Artery Blood Flow ◽  
Peripheral Vascular ◽  
Arteriovenous Shunting ◽  
Control Value ◽  
Vascular Bed

Changes in regional blood flow during simulated normobaric diving were studied in the conscious Antarctic Weddell seal (Leptonychotes weddelli) by injecting 25-microns radioactive microspheres into the left ventricle. Injections were performed before and 8--12 min after submersion of the head in iced seawater. Diving was associated with a fall in cardiac output from a mean control value of 39.8 +/- 10.2 to 5.6 +/- 3.4 l/min (mean +/- SD) and in heart rate from 52 +/- 15 to 15 +/- 4 beats/min. Blood flow to the splanchnic and peripheral vascular bed was reduced by more than 90%, cerebral blood flow was unchanged, right and left ventricular blood flow decreased by 85%, and adrenal blood flow decreased by 39%. The pulmonary fraction of the injected microsphere dose increased from 7.9 to 29.9% during diving. This may signify a large increase of peripheral arteriovenous shunting during the dive and/or increased bronchial artery blood flow. It is concluded that blood flow during diving is directed to organs and tissues according to their metabolic requirements.

scholarly journals Blood perfusion of the kidney of Lophius piscatorius L.: II. Influence of perfusion pressure on urine volume

1954 ◽  
Vol 33 (3) ◽  
pp. 733-738 ◽  
Author(s):  
L. Brull ◽  
Y. Cuypers
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Critical Level ◽  
Perfusion Pressure ◽  
Urine Volume ◽  
Blood Perfusion ◽  
Urine Flow ◽  
Active Process ◽  
Flow Through ◽  
Water Secretion

SummaryThe urine secretion of the kidneys of Lophius piscatorius perfused with heparinized Lophius blood is very sensitive to perfusion pressure below a critical level, above which it becomes insensitive. The response of the urine flow to pressure takes the form of an exponential curve.The blood flow through the kidneys, while rising slowly at pressures of about 20–30 mm of water, responds arithmetically to pressure above such levels.At present it is impossible to make out whether pressure or blood flow has the greatest influence on secretion.Water secretion in the aglomerular kidney is an active process. The oxygen consumption of the Lophius kidney is unmeasurably low, yet remains a possible factor in secretion.

Resistance to blood flow through the vascular bed of the dog forelimb

1961 ◽  
Vol 8 (4) ◽  
pp. 533-541 ◽  
Author(s):  
Henry W. Overbeck ◽  
Joyce I. Molnar ◽  
Francis J. Haddy
Keyword(s):  
Blood Flow ◽  
Vascular Bed ◽  
Flow Through

Vasoconstrictor role for vasopressin in conscious, sodium-depleted rats

1987 ◽  
Vol 253 (4) ◽  
pp. H763-H769
Author(s):  
B. Jover ◽  
M. Dupont ◽  
A. Mimran ◽  
R. Woods ◽  
B. McGrath
Keyword(s):  
Blood Flow ◽  
Regional Blood Flow ◽  
Muscle Blood Flow ◽  
Flow Distribution ◽  
Renin Angiotensin System ◽  
Adrenergic System ◽  
Blood Flow Distribution ◽  
Sprague Dawley ◽  
Vascular Bed ◽  
Renal Vascular

To define the role of vasopressin as a vasoconstrictor hormone in sodium depletion, systemic hemodynamics and regional blood flow distribution were examined in conscious Sprague-Dawley rats after 6 days of a low-sodium diet. Studies were performed after selective or combined blockade with the vasopressin antagonist [d(CH2)5Tyr(Me)]AVP (AVPA), enalaprilat (CEI), and phentolamine (PHENTOL). Plasma levels of vasopressin were increased significantly after CEI and increased further after PHENTOL and CEI plus PHENTOL. AVPA had no effect on blood pressure, whether given alone or in the presence of PHENTOL, CEI, or CEI plus PHENTOL. Significant falls in peripheral vascular resistance associated with reflex increases in cardiac output were observed when AVPA was given to animals pretreated with either CEI or PHENTOL but not both. AVPA alone produced no significant changes in regional blood flow distribution, but a vasoconstrictor action of vasopressin in the renal vascular bed was revealed after prior treatment with CEI or PHENTOL. Muscle blood flow was also increased in the PHENTOL plus AVPA group compared with the PHENTOL group. No significant additional effects of AVPA were revealed by pretreatment with CEI, PHENTOL, or CEI plus PHENTOL for mesenteric, hepatic, splenic, or cerebral vascular beds. It is suggested that vasopressin acts as a vasoconstrictor hormone in conscious sodium-depleted rats when either the renin-angiotensin system or alpha-adrenergic system is inhibited but not when both systems are blocked. The renal vascular bed is an important site for vasopressin-induced vasoconstriction under these circumstances.

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