Effects of load and duration of tension on pain induced by muscular contraction

1962 ◽  
Vol 203 (4) ◽  
pp. 735-738 ◽  
Author(s):  
Syuk Ryun Park ◽  
Simon Rodbard
Keyword(s):  
Severe Pain ◽  
Total Duration ◽  
Muscular Contraction ◽  
The Other ◽  
Cube Root ◽  
Similar Relationship ◽  
Moderate Pain ◽  
Slight Pain ◽  
Mercury Column ◽  
Local Accumulation

Pain was induced in the ischemic forearm in more than 300 tests in seven subjects by an exercise which consisted of compression of an air bulb to raise or maintain a mercury column at 50, 100, or 200 mm for periods of 1, 2, 4, or 5.5 sec. The rate of pain development could be correlated with the product ( P) of the number of contractions, square root of the load (in mm Hg), and cube root of the duration of contraction (in sec). Slight pain appeared at a product of about 345 P, moderate pain at approximately 433 P, severe pain at 536 P, and intolerable pain at 626 P. A similar relationship could be shown in maintained contraction provided the total duration was treated as if each 5.5 sec of the maintained contraction constituted a separate contraction. Ischemia of the arm for periods up to 15 min had no effect on product. Recovery from the effect of exercise was complete in 10 min. Simultaneous exercise of the other arm had no effect on the rate of pain development. The results support the concept that muscle pain results from the local accumulation of a slowly diffusible material released during muscle contraction.

scholarly journals Frequency and nature of pain following single visit root canal treatment

2018 ◽  
Vol 11 (4) ◽  
pp. 274-277
Author(s):  
Md. Abdul Hannan Sheikh ◽  
Golam Mohiuddin Chowdhury ◽  
Sultana Parveen ◽  
Kamrunnahar Shanta ◽  
Farzana Hoque Tanmi
Keyword(s):  
Root Canal ◽  
Severe Pain ◽  
The Other ◽  
Root Canal Treatment ◽  
Moderate Pain ◽  
Single Visit ◽  
Other Hand ◽  
Significant Difference

The purpose of this study was to compare the frequency and nature of pain between the vital inflamed (n=55) and non-vital (n=55) teeth that received single visit root canal treatment. The frequency and nature of pain were assessed as no pain, mild, moderate and severe pain on day 2 and day 7. The results showed that 76.4 and 85.5% participants felt no pain in vital inflamed teeth on day 2 and day 7, respectively. On the other hand, 63.6 and 74.5% participants felt no pain in non-vital teeth on day 2 and day 7, respectively. The remaining participants only felt mild to moderate pain. There were no significant difference between the two groups (p=0.435 on day 2 and p=0.371 on day 7). The results suggested that single visit root canal treatment is equally effective in both vital inflamed and non-vital teeth.

scholarly journals A Study of Post Obturation Pain Following Single Visit Root Canal Treatment

2013 ◽  
Vol 12 (3) ◽  
pp. 16-19 ◽  
Author(s):  
Salma Jabeen ◽  
Dr Khurshiduzzaman
Keyword(s):  
Root Canal ◽  
Severe Pain ◽  
Root Canal Treatment ◽  
Moderate Pain ◽  
Treatment Procedure ◽  
Common Procedure ◽  
Single Visit ◽  
Medical College ◽  
Slight Pain

Introduction: Root canal treatment (RCT) is a common procedure in dentistry. In recent year, single visit RCT has gained increased acceptance as a treatment procedure of RCT. One of the problem of RCT is post obturation pain. Objectives: This study was conducted to determine the incidence of post obturation pain related to single visit RCT in asymptomatic non-vital single rooted teeth. Methods: A total 60 cases of endodontically involved asymptomatic non-vital single rooted teeth without any evidence of periapical radiolucency in radiograph, were selected for this study. The canals of all teeth were prepared and filled using the standarized preparation and lateral condensation filling technique. The frequency of post obturation pain was recorded as no pain, slight, moderate and severe pain and evaluated at the day l and at the day 7 after obturation. Result: Out of the 60 patients involved in the study, 37 patients had no pain, 12 patients had slight pain and 11 patients had moderate pain at the day 1 after post obturation. At the day 7 after post obturation, 50 patients had no pain, 8 patients had slight pain and 2 patients had moderate pain. No one showed severe pain in both follow up days. Conclusion: Statistically significant differences were found in the incidence and degree of pain between two follow up days. Incidence of pain was more in 1st post obturation day and decreased thereafter. Chattagram Maa-O-Shishu Hospital Medical College Journal Volume 12, Issue 3, September 2013: 16-19

Assessment of Pain During Laser-based Procedures in the Treatment of Glaucoma

2019 ◽  
Vol 70 (6) ◽  
pp. 2105-2107
Author(s):  
Gheorghita Popa ◽  
Olimpiu L. Karancsi ◽  
Maria Alexandra Preda ◽  
Marius Cristian Suta ◽  
Lavinia Stelea ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Pain Score ◽  
The Other ◽  
Study Group ◽  
Moderate Pain ◽  
Pain Level ◽  
Analog Scale ◽  
Intense Pain ◽  
The Individual ◽  
Individual Information

Our study aimed to determine pain levels and the state of welfare connected to laser-based procedures in the treatment of patients diagnosed with uncontrolled glaucoma. The study group included 100 eyes of 100 patients diagnosed with glucoma, 50 of them being treated with micropulse transscleral laser cyclophotocoagulation, and the other 50 eyes being treated with continuous transscleral laser cyclophotocoagulation. We used visual analog scale to gather information from each patient. After analysing the individual information the following results were obtained: the pain level for the micropulse transscleral laser cyclophotocoagulation was 60.23 mm, signifying moderate pain; and the pain score for the continuous transscleral laser cyclophotocoagulation was 76.34 mm, corresponding to moderate-intense pain. Pain level generated by minimally invasive laser procedures is discussed.

scholarly journals Pain management after lung surgery

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Maria Frödin ◽  
Margareta Warrén Stomberg
Keyword(s):  
Quality Of Care ◽  
Pain Management ◽  
Postoperative Pain ◽  
Severe Pain ◽  
Postoperative Pain Management ◽  
Lung Surgery ◽  
Moderate Pain ◽  
Number Of Patients ◽  
Severe Postoperative Pain

Pain management is an integral challenge in nursing and includes the responsibility of managing patients’ pain, evaluating pain therapy and ensuring the quality of care. The aims of this study were to explore patients’ experiences of pain after lung surgery and evaluate their satisfaction with the postoperative pain management. A descriptive design was used which studied 51 participants undergoing lung surgery. The incidence of moderate postoperative pain varied from 36- 58% among the participants and severe pain from 11-26%, during their hospital stay. Thirty-nine percent had more pain than expected. After three months, 20% experienced moderate pain and 4% experienced severe pain, while after six months, 16% experienced moderate pain. The desired quality of care goal was not fully achieved. We conclude that a large number of patients experienced moderate and severe postoperative pain and more than one third had more pain than expected. However, 88% were satisfied with the pain management. The findings confirm the severity of pain experienced after lung surgery and facilitate the apparent need for the continued improvement of postoperative pain management following this procedure.

scholarly journals Cut-off points between pain intensities of the postoperative pain using receiver operating characteristic (ROC) curves

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sooyoung Cho ◽  
Youn Jin Kim ◽  
Minjin Lee ◽  
Jae Hee Woo ◽  
Hyun Jung Lee
Keyword(s):  
Postoperative Pain ◽  
Receiver Operating Characteristic ◽  
Severe Pain ◽  
Operating Characteristic ◽  
Rating Scale ◽  
Intraclass Correlation ◽  
Pain Medication ◽  
Patient Specific ◽  
Moderate Pain ◽  
Receiver Operating

Abstract Background Pain assessment and management are important in postoperative circumstances as overdosing of opioids can induce respiratory depression and critical consequences. We aimed this study to check the reliability of commonly used pain scales in a postoperative setting among Korean adults. We also intended to determine cut-off points of pain scores between mild and moderate pain and between moderate and severe pain by which can help to decide to use pain medication. Methods A total of 180 adult patients undergoing elective non-cardiac surgery were included. Postoperative pain intensity was rated with a visual analog scale (VAS), numeric rating scale (NRS), faces pain scale revised (FPS-R), and verbal rating scale (VRS). The VRS rated pain according to four grades: none, mild, moderate, and severe. Pain assessments were performed twice: when the patients were alert enough to communicate after arrival at the postoperative care unit (PACU) and 30 min after arrival at the PACU. The levels of agreement among the scores were evaluated using intraclass correlation coefficients (ICCs). The cut-off points were determined by receiver operating characteristic curves. Results The ICCs among the VAS, NRS, and FPS-R were consistently high (0.839–0.945). The pain categories were as follow: mild ≦ 5.3 / moderate 5.4 ~ 7.1 /severe ≧ 7.2 in VAS, mild ≦ 5 / moderate 6 ~ 7 / severe ≧ 8 in NRS, mild ≦ 4 / moderate 6 / severe 8 and 10 in FPS-R. The cut-off points for analgesics request were VAS ≧ 5.5, NRS ≧ 6, FPS-R ≧ 6, and VRS ≧ 2 (moderate or severe pain). Conclusions During the immediate postoperative period, VAS, NRS, and FPS-R were well correlated. The boundary between mild and moderate pain was around five on 10-point scales, and it corresponded to the cut-off point of analgesic request. Healthcare providers should consider VRS and other patient-specific signs to avoid undertreatment of pain or overdosing of pain medication.

Frequency and nature of pain in patients undergoing neurorehabilitation

2020 ◽  
pp. 026921552095678
Author(s):  
Alicja Timm ◽  
Stefan Knecht ◽  
Matthias Florian ◽  
Heidrun Pickenbrock ◽  
Bettina Studer ◽  
...  
Keyword(s):  
Treatment Period ◽  
Daily Living ◽  
Severe Pain ◽  
Pain Medication ◽  
Daily Activities ◽  
Inpatient Stay ◽  
Moderate Pain ◽  
Group Level ◽  
Analog Scale ◽  
Pain Scores

Objective: This prospective study investigated the extent to which patients undergoing neurorehabilitation reported pain, how this pain developed during inpatient stay and whether patients were treated accordingly (using pain medication). Methods: The extent of pain, performance in daily activities, with a focus on possible impairment from pain, and pain medication were assessed at the beginning and the end of neurorehabilitation treatment. Overall 584 patients, with various neurological diagnoses, such as stroke, intracerebral hemorrhage, polyneuropathy, etc. were classified into four groups based on whether they reported having “no pain,” “mild pain,” “moderate pain,” or “severe pain.” All patients received conventional neurorehabilitation therapy in the Mauritius Hospital, Germany. Results: A total of 149 patients had clinically relevant pain at the beginning of their inpatient stay, at a group level this did not change significantly during the treatment period. At the end of inpatient stay, a slight increase was noted in patients reporting pain. Overall 164 patients suffered from moderate or severe pain, operationalized of pain scores >3 on the visual analog scale. A total of 145 patients who had pain at the end of inpatient stay, did not receive pain medication. There was a weak negative association between pain at baseline and activities of daily living at the end of the treatment period, such that, patients with higher pain levels tended to showed lower Barthel Index scores at the end. Conclusion: In our study, about one-third of patients suffered from clinically relevant pain during neurorehabilitation treatment and most of them did not receive any pain medication.

Electrical interactions between the giant axons of a polychaete worm (Sabella penicillus L.)

1980 ◽  
Vol 84 (1) ◽  
pp. 119-136
Author(s):  
D. Mellon ◽  
J. E. Treherne ◽  
N. J. Lane ◽  
J. B. Harrison ◽  
C. K. Langley
Keyword(s):  
Safety Factor ◽  
Nerve Cord ◽  
Action Potentials ◽  
Divalent Cations ◽  
Muscular Contraction ◽  
The Body ◽  
The Other ◽  
Intracellular Recordings ◽  
Giant Axons ◽  
Other Hand

Intracellular recordings demonstrated a transfer of impulses between the paired giant axons of Sabella, apparently along narrow axonal processes contained within the paired commissures which link the nerve cords in each segment of the body. This transfer appears not to be achieved by chemical transmission, as has been previously supposed. This is indicated by the spread of depolarizing and hyperpolarizing voltage changes between the giant axons, the lack of effects of changes in the concentrations of external divalent cations on impulse transmission and by the effects of hyperpolarization in reducing the amplitude of the depolarizing potential which precedes the action potentials in the follower axon. The ten-to-one attenuation of electronic potentials between the giant axons argues against the possibility of an exclusively passive spread of potential along the axonal processes which link the axons. Observation of impulse traffic within the nerve cord commissures indicates, on the other hand, that transmission is achieved by conduction of action potentials along the axonal processes which link the giant axons. At least four pairs of intact commissures are necessary for inter-axonal transmission, the overall density of current injected at multiple sites on the follower axon being, it is presumed, sufficient to overcome the reduction in safety factor imposed by the geometry of the system in the region where axonal processes join the giant axons. The segmental transmission between the giant axons ensures effective synchronization of impulse traffic initiated in any region of the body and, thus, co-ordination of muscular contraction, during rapid withdrawal responses of the worm.

scholarly journals Pancreatic secretion and pressure biomechanics in pancreatic acinus

2020 ◽  
Vol 19 (1) ◽  
pp. 6-12
Author(s):  
G. Ya. Kostyuk ◽  
O. G. Kostyuk ◽  
M. V Burkov ◽  
I. A. Golubovsky ◽  
M. P. Bulko ◽  
...  
Keyword(s):  
Flow System ◽  
Dynamic Pressure ◽  
Excretory Duct ◽  
The Other ◽  
Duct System ◽  
First Order ◽  
Pancreatic Acinus ◽  
Mercury Column ◽  
The Mathematical Model ◽  
Oddi Sphincter

The article highlights the mechanism of the mathematical model of acinus, the components of the formation of pressure in its cavity and the formation of pancreatic juice. It has been established that the mechanism for creating pressure in the acinus cavity is similar to the intraductal one. In this case, the question remains open about the causes of such high pressure, which is measured in several hundred millimeters of a mercury column, especially since, as histologically established, the pancreas and its ducts do not have muscle structures, and those rudiments of myofibrils, which are noted in some places of the flow system, of course, cannot ensure the development of such pressure. The increase in pressure in the cavity of the acinus is associated with the phenomenon of osmosis in its cells. Since cell membranes have the property of conductivity, as a result of osmosis, water through the membrane first passes from the blood to the cell, then from the cell through the membrane into the acinus cavity. In addition to the mechanism of osmosis through the membrane, in the cells of the acinus epithelium, there is a filtering mechanism through the pores of the layer of connective tissue to the lymph channel. It has now been established that, together with simple osmosis, the phenomenon of electroosmosis takes place in secreting cells and organs of excretion, not only accelerates the transfer of substances, but also increases the pressure on the other side of the membrane against the gradient by almost several first-order units. Thus, the outflow of fluid from the acinus cavity proceeds continuously, but only with a change in the speed of movement, it is determined by the pressure drop in the acinus – tubule – excretory duct system, the opening of the Oddi sphincter and the pulse of the cardiovascular wave, which creates dynamic pressure in the capillary. This whole mechanism, as a result, leads to the filling of the cavity of the acinus and the creation of a certain pressure in it.

Comparison of analgesic efficacy between rectus sheath blockade, intrathecal morphine with bupivacaine, and intravenous patient-controlled analgesia in patients undergoing robot-assisted laparoscopic prostatectomy: a prospective, observational clinical study

2020 ◽  
Author(s):  
Jung-Woo Shim ◽  
Yun Jeong Cho ◽  
Minhee Kim ◽  
Sang Hyun Hong ◽  
Hyong Woo Moon ◽  
...  
Keyword(s):  
Severe Pain ◽  
Intrathecal Morphine ◽  
Rectus Sheath ◽  
Postoperative Recovery ◽  
The Other ◽  
Patient Controlled Analgesia ◽  
Research Information ◽  
Robot Assisted ◽  
Laparoscopic Prostatectomy ◽  
Pain At Rest

Abstract Background: We explored the analgesic outcomes on postoperative day (POD) 1 in patients undergoing robot-assisted laparoscopic prostatectomy (RALP) who received intravenous patient-controlled analgesia (IV-PCA), rectus sheath bupivacaine block (RSB), or intrathecal morphine with bupivacaine block (ITMB). Methods: This was a prospective, observational clinical trial. Patients were divided into three groups: IV-PCA (n = 30), RSB (n = 30), and ITMB (n = 30). Peak pain scores at rest and with coughing, cumulative IV-PCA drug consumption, the need for IV rescue opioids, and Quality of Recovery-15 (QoR-15) questionnaire scores collected on POD 1 were compared among the groups.Results: The preoperative and intraoperative findings were comparable among the groups; the ITMB group required the least remifentanil of all groups. During POD 1, the ITMB group reported lower levels of pain at rest and with coughing, compared with the other two groups. During POD 1, incidences of severe pain at rest (10.0% vs. 23.3% vs. 40.0%) and with coughing (16.7% vs. 36.7% vs. 66.7%) were the lowest in the ITMB group compared with the RSB and IV-PCA groups, respectively. After adjustment for age, body mass index, diabetes mellitus, hypertension, and intraoperative remifentanil infusion, severe pain at rest was 0.167-fold less common in the ITMB group than in the IV-PCA group, while pain with coughing was 0.1-fold lower in the ITMB group and 0.306-fold lower in the RSB group, compared with the IV-PCA group. The ITMB group required lower cumulative IV-PCA drug infusions and less IV rescue opioids, while exhibiting a better QoR-15 global score, compared with the other two groups. Complications (nausea and pruritus) were significantly more common in the ITMB group than in the other two groups; however, we noted no ITMB- or RSB-related anesthetic complications (respiratory depression, post-dural headache, nerve injury, or puncture site hematoma or infection), and all patients were assessed as Clavien-Dindo grade I or II during the hospital stay.Conclusion: Although ITMB induced complications of nausea and pruritus, this analgesic technique provided appropriate pain relief that enhanced patient perception related to early postoperative recovery.Trial registration: Clinical Research Information Service, Republic of Korea, (approval number: KCT0005040) on May 20, 2020https://cris.nih.go.kr/cris/search/search_result_st01_kren.jsp?seq=15943&sLeft=2&ltype=my&rtype=my

Effect of various stressors on muscular contraction induced by NaH2PO4 and NaClO4

1959 ◽  
Vol 196 (3) ◽  
pp. 681-684 ◽  
Author(s):  
Hans Selye ◽  
Eörs Bajusz
Keyword(s):  
Muscular Contraction ◽  
The Other ◽  
Muscle Dysfunction ◽  
Biochemical Processes ◽  
Muscular Work ◽  
Electric Shocks ◽  
Threshold Doses ◽  
Clonic Convulsions ◽  
Motor Disturbances ◽  
Muscular Action

Experiments in the rat indicate that the motor disturbances elicited by sudden overdosage with NaH2PO4 and NaClO4 are qualitatively different. NaH2PO4 produces a tetany-like condition, with generalized continuous tremor and occasional fits of generalized clonic convulsions. NaClO4, on the other hand, induces no tremor, but rather persistent, tonic extensor cramps, predominantly in the hind legs. Among a great variety of stressors, only those associated with increased muscular work (exercise in a revolving drum, forced restraint, electric shocks) enhanced the susceptibility to acute NaH2PO4 intoxication, while all the stressors that were examined elicited marked muscular contractions following treatment with threshold doses of NaClO4. These effects of NaH2PO4 and NaClO4 are not due to the Na-ion as such, since equimolecular amounts of NaCl were totally ineffective in producing muscular contractions. It appears that an excess of NaH2PO4 and NaClO4 interferes rather selectively with the biochemical processes responsible for muscular contraction; hence, these salts induce fatigue and muscle dysfunction, following comparatively brief periods of exercise. In addition, the muscular action of NaClO4 (unlike that of NaH2PO4) is greatly enhanced even by stressors which do not act preponderantly upon muscle.

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