Effects of protamine zinc insulin on chickens

1965 ◽  
Vol 208 (3) ◽  
pp. 589-592 ◽  
Author(s):  
S. Lepkovsky ◽  
R. Len ◽  
T. Koike ◽  
R. Bouthilet
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Body Weight ◽  
Feed Intake ◽  
Egg Production ◽  
Laying Hens ◽  
Protamine Zinc Insulin ◽  
The Central Nervous System

The injection of protamine zinc insulin into laying hens caused hypoglycemia as it does in other animals. While it increased feed intake and body weight in other animals, it did the opposite in chickens: it decreased feed intake, body weight, and egg production. Damage to the central nervous system in some of the chickens was indicated by their behavior. It was tentatively concluded that the aphagia in chickens following injection with protamine zinc insulin was due to the apparent damage to the nervous system.

scholarly journals Oestrogenic effects of neonatal administration of raloxifene on hypothalamic-pituitary-gonadal axis in male and female rats

Reproduction ◽  
2001 ◽  
pp. 915-924 ◽  
Author(s):  
L Pinilla ◽  
LC Gonzalez ◽  
F Gaytan ◽  
M Tena-Sempere ◽  
E Aguilar
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Body Weight ◽  
Oestrogen Receptor ◽  
Female Rats ◽  
Male Rats ◽  
Selective Oestrogen Receptor Modulators ◽  
Male And Female Rats ◽  
The Central Nervous System ◽  
Neonatal Administration

Selective oestrogen receptor modulators constitute a family of drugs that are used increasingly in the management of oestrogen-associated pathology. Raloxifene is a selective oestrogen receptor modulator that is used to treat and prevent osteoporosis in post-menopausal women. The actions of raloxifene on bone, breast, uterus and serum cholesterol concentrations have been widely analysed, but very few studies have investigated the possible actions of this drug on the central nervous system. The central nervous system of the newborn rat is very sensitive to oestrogen action. In this study a series of experiments was conducted to analyse the effects of different doses of raloxifene (50, 100, 250 or 500 microg per rat per day) administered to neonatal rats on days 1-5 of age. Female rats treated with raloxifene showed decreased gonadotrophin secretion, hyperprolactinaemia, advanced vaginal opening, decreased body weight, persistent presence of cornified epithelial cells in vaginal smears, anovulation, inhibition of positive feedback between oestradiol and LH, and infertility. Male rats showed delayed balanopreputial separation, reduced body weight and hyperprolactinaemia. All these changes resemble those obtained after neonatal administration of oestradiol benzoate, thus indicating, for the first time, that raloxifene exerts an oestrogenic action on the hypothalamic-pituitary structures controlling reproductive function in rats.

Insulin: its relationship to the central nervous system and to the control of food intake and body weight

1985 ◽  
Vol 42 (5) ◽  
pp. 1063-1071 ◽  
Author(s):  
S C Woods ◽  
D Porte ◽  
E Bobbioni ◽  
E Ionescu ◽  
J F Sauter ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Body Weight ◽  
Food Intake ◽  
The Central Nervous System

scholarly journals Warm Perches: A Novel Approach For Reducing Cold Stress Effect on Production, Plasma Hormones, and Immunity in Laying Hens

2021 ◽  
Author(s):  
Jiaying Hu ◽  
Heng Wei Cheng
Keyword(s):  
Body Weight ◽  
Cold Stress ◽  
Cold Exposure ◽  
Feed Intake ◽  
Plasma Levels ◽  
Egg Production ◽  
Laying Hens ◽  
Plasma Concentrations ◽  
Economic Losses ◽  
Stress Effect

Abstract Background: Cold temperature is a common environmental stressor that has a great impact on the poultry industries, inducing pathophysiological stress in birds with profound economic losses. Current methods used for preventing cold stress, such as reducing ventilation and using gas heaters, are facing challenges due to poor indoor air quality and its deleterious effects on bird and caretaker health. The aim of this study was to examine if the novelly designed warmed perch system, as a thermal device, can reduce cold stress-associated adverse effects on laying hens. Methods: Seventy-two 32-week-old DeKalb hens were randomly assigned to 36 cages arranged to 3 banks. The banks were assigned to 1 of 3 treatments: cages with warmed perches (WP; perches with circulating water at 30 oC), air perches (AP, regular perches only) or no perches (NP) for a 21- day trial. The room temperature was set at 10 oC during the entire experimental period. Rectal temperature and body weight were measured from the same bird of each cage at day 1, 8, 15, and 21 during the cold exposure. Egg production was recorded daily. Feed intake, egg and eggshell quality were determined during the 1st and 3rd week of cold stress. Plasma levels of corticosterone, thyroid hormones (3, 3’, 5-triiodothyronine and thyroxine), interleukin (IL)-6 and IL-10, were determined at day 1 and 21 post initiation of cold exposure. Results: Compared to both AP and NP hens, WP hens were able to maintain their body temperature without increasing feed intake and losing body weight. The eggs laid by WP hens had thicker eggshell during the 3rd week of cold exposure. Warmed perch hens also had a lower thyroxine conversion rate (3, 3’, 5-triiodothyronine/thyroxine) at day 1, while higher plasma concentrations of IL-6 at day 21. Plasma levels of corticosterone, 3, 3’, 5-triiodothyronine, and IL-10 were not different among treatments. Conclusions: Our results indicate that the warmed perch system can be used as a novel thermal device for preventing cold stress-induced negative effects on hen health and welfare through regulating innate immunity and metabolic hormonal homeostasis.

scholarly journals Effects of supplementing various linoleic to α-linolenic acid ratios and vitamin A on production performance and egg characteristics of laying hens during summer months

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Muhammad Naeem Tahir
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Vitamin A ◽  
Linolenic Acid ◽  
Feed Intake ◽  
Egg Production ◽  
Laying Hens ◽  
Body Weight Gain ◽  
Production Performance ◽  
Dietary Treatments

In the present feeding trial, responses of laying hens, kept at high ambient temperature, to various dietary ratios of linoleic acid (LNA) to α-linolenic acid (ALA) and vitamin A levels on performance and egg characteristics were evaluated. A total of 360, 40-wk-old, Leghorn laying hens were fed on diets with various combinations of canola oil and linseed oil to achieve LNA to ALA dietary ratios of 20:1, 10:1, 4:1, 2:1, 1:1 and 1:2, each supplemented with 3000 IU or 10000 IU vitamin A/kg of diet. The diets were fed in a 6×2 factorial Completely Randomized Design that continued for 12 weeks. Feed intake, weight gain, egg production and egg quality traits were recorded during the trial. Decreasing dietary LNA to ALA ratio in the diet affected negatively (P<0.05) on body weight gain and yolk percentage in laying hens. While, feed intake, hen-day and hen-housed egg production, feed conversion ratio (FCR) per dozen of eggs and shell quality remained unaffected (P>0.05) by dietary treatments, with the exception of FCR per kg eggs, egg weight and egg-shell thickness which responded significantly (P<0.05) to various dietary treatments. Although the dietary ratio of LNA to ALA of 4:1 or less could produce eggs by the hens with desirable quantities of n-6 and n-3 poly unsaturated fatty acids – that are characteristics of functional diets – the performance of laying hens in terms of body weight gain and egg-yolk percentage was slightly compromised.

Pharmacogenomics and pharmacokinetics of efavirenz 400 or 600 mg in 184 treatment-naive HIV-infected patients in China

2020 ◽  
Vol 21 (13) ◽  
pp. 945-956
Author(s):  
Rong Chen ◽  
Jun Chen ◽  
Jingna Xun ◽  
Zhiliang Hu ◽  
Qiong Huang ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Body Weight ◽  
Plasma Levels ◽  
Dose Group ◽  
Adverse Reactions ◽  
Standard Dose ◽  
Treatment Naïve ◽  
The Central Nervous System ◽  
To Receive

Background: The pharmacogenomics and pharmacokinetics/pharmacodynamics of 400 mg efavirenz have rarely been reported. Materials & methods: A total of 184 treatment-naive HIV-infected patients were randomly assigned (1:1) to receive a lower dose (tenofovir disoproxil 200 mg, efavirenz 400 mg and lamivudine) or a standard dose regimen. Relationships between pharmacogenomics and efavirenz pharmacokinetics/pharmacodynamics were explored at 48 weeks. Results: There was no relationship between pharmacogenomics and adverse reactions of the central nervous system and antiretoviral efficacy. CYP2B6 516G>T, 785A>G, 18492C>T and ABCB1 3435C>T T/C were associated with higher efavirenz plasma levels in the standard but not the lower dose group. No relationship was found between pharmacogenomics and antiretoviral efficacy. Patients who were <60 kg had higher efavirenz concentration compared with those with weight ≥60 kg when using 600 mg efavirenz, this was not observed with 400 mg efavirenz. Conclusion: The effect of pharmacogenomics and body weight on the efavirenz concentration was significant in the 600 mg group but not in the 400 mg group.

scholarly journals High doses of cefotaxime in treatment of adult meningitis due to Streptococcus pneumoniae with decreased susceptibilities to broad-spectrum cephalosporins.

1996 ◽  
Vol 40 (1) ◽  
pp. 218-220 ◽  
Author(s):  
P F Viladrich ◽  
C Cabellos ◽  
R Pallares ◽  
F Tubau ◽  
J Martínez-Lacasa ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Body Weight ◽  
Streptococcus Pneumoniae ◽  
Broad Spectrum ◽  
Adjunctive Therapy ◽  
Maximum Dose ◽  
Central Nervous System Infection ◽  
The Central Nervous System ◽  
High Doses

We treated nine patients (10 episodes) with meningitis caused by Streptococcus pneumoniae isolates with decreased susceptibilities to broad-spectrum cephalosporins with high doses of cefotaxime (300 mg/kg of body weight per day; maximum dose, 24 g/day). Early adjunctive therapy with dexamethasone was also administered. Cefotaxime MICs were 0.5 (three episodes), 1 (five episodes), and 2 (two episodes) micrograms/ml, and MBCs ranged from 1 to 4 micrograms/ml. Therapy was well tolerated, and all patients experienced prompt clinical improvement. One patient died 8 days after the end of therapy, the central nervous system infection had already been cured, and the remaining patients recovered without relapses.

Insulin in the Central Nervous System: A Regulator of Appetite and Body Weight

1987 ◽  
pp. 151-162 ◽  
Author(s):  
Dianne P. Figlewicz ◽  
Stephen C. Woods ◽  
Denis G. Baskin ◽  
Daniel M. Dorsa ◽  
Barbara J. Wilcox ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Body Weight ◽  
System A ◽  
The Central Nervous System

scholarly journals Central nervous system: cholesterol turnover, brain development and neurodegeneration

2009 ◽  
Vol 390 (4) ◽  
Author(s):  
John M. Dietschy
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Body Weight ◽  
Brain Development ◽  
Cholesterol Synthesis ◽  
De Novo ◽  
Brain Size ◽  
Average Amount ◽  
Early Brain Development ◽  
The Central Nervous System

Abstract The average amount of cholesterol in the whole animal equals approximately 2100 mg/kg body weight, and 15% and 23% of this sterol in the mouse and human, respectively, is found in the central nervous system. There is no detectable uptake across the blood-brain barrier of cholesterol carried in lipoproteins in the plasma, even in the newborn. However, high rates of de novo cholesterol synthesis in the glia and neurons provide the sterol necessary for early brain development. Once a stable brain size is achieved in the adult, cholesterol synthesis continues, albeit at a much lower rate, and this synthesis is just balanced by the excretion of an equal amount of sterol, either as 24(S)-hydroxycholesterol or, presumably, as cholesterol itself.

scholarly journals Amylin Acts in the Central Nervous System to Increase Sympathetic Nerve Activity

Endocrinology ◽  
2013 ◽  
Vol 154 (7) ◽  
pp. 2481-2488 ◽  
Author(s):  
Caroline Fernandes-Santos ◽  
Zhongming Zhang ◽  
Donald A. Morgan ◽  
Deng-Fu Guo ◽  
Andrew F. Russo ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Body Weight ◽  
Food Intake ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Nerve Activity ◽  
Peripheral Tissues ◽  
Brown Adipose ◽  
The Central Nervous System

Abstract The pancreatic hormone amylin acts in the central nervous system (CNS) to decrease food intake and body weight. We hypothesized that amylin action in the CNS promotes energy expenditure by increasing the activity of the sympathetic nervous system. In mice, ip administration of amylin significantly increased c-Fos immunoreactivity in hypothalamic and brainstem nuclei. In addition, mice treated with intracerebroventricular (icv) amylin (0.1 and 0.2 nmol) exhibited a dose-related decrease in food intake and body weight, measured 4 and 24 hours after treatment. The icv injection of amylin also increased body temperature in mice. Using direct multifiber sympathetic nerve recording, we found that icv amylin elicited a significant and dose-dependent increase in sympathetic nerve activity (SNA) subserving thermogenic brown adipose tissue (BAT). Of note, icv injection of amylin also evoked a significant and dose-related increase in lumbar and renal SNA. Importantly, icv pretreatment with the amylin receptor antagonist AC187 (20 nmol) abolished the BAT SNA response induced by icv amylin, indicating that the sympathetic effects of amylin are receptor-mediated. Conversely, icv amylin-induced BAT SNA response was enhanced in mice overexpressing the amylin receptor subunit, RAMP1 (receptor-activity modifying protein 1), in the CNS. Our data demonstrate that CNS action of amylin regulates sympathetic nerve outflow to peripheral tissues involved in energy balance and cardiovascular function.

scholarly journals RESPONSE OF WHITE LEGHORNS TO DIETS CONTAINING GROUND OR WHOLE TRITICALE

1987 ◽  
Vol 67 (2) ◽  
pp. 583-585 ◽  
Author(s):  
S. LEESON ◽  
J. D. SUMMERS
Keyword(s):  
Body Weight ◽  
Key Words ◽  
Feed Intake ◽  
Egg Production ◽  
Laying Hens ◽  
Energy Value ◽  
White Leghorns

Growing leghorn pullets and laying hens were fed diets containing triticale as the sole cereal source. Body weight of pullets was not affected (P > 0.05) by up to 70% dietary inclusion of triticale. When layer diets contained 70% whole or ground triticale in place of corn, egg production was depressed (P < 0.05) while birds consumed more feed (P < 0.05). The feed intake effect is discussed in relation to the energy value of triticale. Key words: Triticale, pullets

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