scholarly journals Space radiation-associated lung injury in a murine model

2015 ◽  
Vol 308 (5) ◽  
pp. L416-L428 ◽  
Author(s):  
Melpo Christofidou-Solomidou ◽  
Ralph A. Pietrofesa ◽  
Evguenia Arguiri ◽  
Kelly S. Schweitzer ◽  
Evgeny V. Berdyshev ◽  
...  
Keyword(s):  
Lung Injury ◽  
National Laboratory ◽  
Space Radiation ◽  
High Energy ◽  
Galactic Cosmic Rays ◽  
Sirtuin 1 ◽  
Laboratory Animals ◽  
Solar Particle Events ◽  
The Impact ◽  
Dose Dependent

Despite considerable progress in identifying health risks to crewmembers related to exposure to galactic/cosmic rays and solar particle events (SPE) during space travel, its long-term effects on the pulmonary system are unknown. We used a murine risk projection model to investigate the impact of exposure to space-relevant radiation (SR) on the lung. C3H mice were exposed to 137Cs gamma rays, protons (acute, low-dose exposure mimicking the 1972 SPE), 600 MeV/u 56Fe ions, or 350 MeV/u 28Si ions at the NASA Space Radiation Laboratory at Brookhaven National Laboratory. Animals were irradiated at the age of 2.5 mo and evaluated 23.5 mo postirradiation, at 26 mo of age. Compared with age-matched nonirradiated mice, SR exposures led to significant air space enlargement and dose-dependent decreased systemic oxygenation levels. These were associated with late mild lung inflammation and prominent cellular injury, with significant oxidative stress and apoptosis (caspase-3 activation) in the lung parenchyma. SR, especially high-energy 56Fe or 28Si ions markedly decreased sphingosine-1-phosphate levels and Akt- and p38 MAPK phosphorylation, depleted anti-senescence sirtuin-1 and increased biochemical markers of autophagy. Exposure to SR caused dose-dependent, pronounced late lung pathological sequelae consistent with alveolar simplification and cellular signaling of increased injury and decreased repair. The associated systemic hypoxemia suggested that this previously uncharacterized space radiation-associated lung injury was functionally significant, indicating that further studies are needed to define the risk and to develop appropriate lung-protective countermeasures for manned deep space missions.

scholarly journals Long-Term Changes in Cognition and Physiology after Low-Dose 16O Irradiation

2019 ◽  
Vol 20 (1) ◽  
pp. 188 ◽  
Author(s):  
Alexis Howe ◽  
Frederico Kiffer ◽  
Tyler C. Alexander ◽  
Vijayalakshmi Sridharan ◽  
Jing Wang ◽  
...  
Keyword(s):  
Object Recognition ◽  
Dentate Gyrus ◽  
National Laboratory ◽  
Space Radiation ◽  
High Energy ◽  
Galactic Cosmic Rays ◽  
High Mass ◽  
Novel Object Recognition ◽  
Novel Object ◽  
Y Maze

Astronauts traveling to Mars will be exposed to high levels of ionizing radiation upon leaving low-Earth orbit. During prolonged space travel, astronauts are exposed to galactic cosmic rays (GCRs) composed of protons; oxygen molecules; and high energy, high mass charged particles. Notably, oxygen molecules can travel through the shielding of spacecraft, potentially impacting 25% of the hippocampus. The aim of the current study was to assess whether 16O-particle radiation induced a behavioral deficit and histological changes in mice. Mice were sent to the National Aeronautics and Space Administration (NASA) Space Radiation Laboratory at Brookhaven National Laboratory and exposed to particulate 16O radiation at doses of 0 and 0.05 Gy. Nine months after irradiation, the mice were tested for novel object recognition and in the Y-maze, after which the animals were sacrificed. The brains were then dissected along the midsagittal plane for Golgi staining. Exposure to 0.05 Gy significantly impaired novel object recognition. However, short term memory and exploratory activity in the Y-maze were not affected. Micromorphometric analysis revealed significant decreases in mushroom spine density in the dentate gyrus and cornu Ammonis-1 and -3 of the hippocampus. Sholl analysis revealed a significant decrease in dendritic complexity in the dentate gyrus. The present data provide evidence that space radiation has deleterious effects on mature neurons associated with hippocampal learning and memory.

scholarly journals Middle atmosphere response to the solar cycle in irradiance and ionizing particle precipitation

2011 ◽  
Vol 11 (10) ◽  
pp. 5045-5077 ◽  
Author(s):  
K. Semeniuk ◽  
V. I. Fomichev ◽  
J. C. McConnell ◽  
C. Fu ◽  
S. M. L. Melo ◽  
...  
Keyword(s):  
Solar Cycle ◽  
Radiative Forcing ◽  
Climate Model ◽  
Middle Atmosphere ◽  
High Energy ◽  
Galactic Cosmic Rays ◽  
Particle Precipitation ◽  
Solar Cycle Variation ◽  
Cycle Variation ◽  
The Impact

Abstract. The impact of NOx and HOx production by three types of energetic particle precipitation (EPP), auroral zone medium and high energy electrons, solar proton events and galactic cosmic rays on the middle atmosphere is examined using a chemistry climate model. This process study uses ensemble simulations forced by transient EPP derived from observations with one-year repeating sea surface temperatures and fixed chemical boundary conditions for cases with and without solar cycle in irradiance. Our model results show a wintertime polar stratosphere ozone reduction of between 3 and 10 % in agreement with previous studies. EPP is found to modulate the radiative solar cycle effect in the middle atmosphere in a significant way, bringing temperature and ozone variations closer to observed patterns. The Southern Hemisphere polar vortex undergoes an intensification from solar minimum to solar maximum instead of a weakening. This changes the solar cycle variation of the Brewer-Dobson circulation, with a weakening during solar maxima compared to solar minima. In response, the tropical tropopause temperature manifests a statistically significant solar cycle variation resulting in about 4 % more water vapour transported into the lower tropical stratosphere during solar maxima compared to solar minima. This has implications for surface temperature variation due to the associated change in radiative forcing.

The Drugs and Natural Antioxidants as the Components of Anti-radiation Countermeasures during Cosmic Flights

2017 ◽  
pp. 66-73 ◽  
Author(s):  
И. Ушаков ◽  
I. Ushakov ◽  
М. Васин ◽  
M. Vasin
Keyword(s):  
Solar Activity ◽  
Cosmic Rays ◽  
Radiation Effects ◽  
High Energy ◽  
Galactic Cosmic Rays ◽  
Stress Factors ◽  
Solar Cosmic Rays ◽  
Post Radiation ◽  
The Impact

Radiation situation for cosmonauts over long-term cosmic flights is caused by low-rate radiation of galactic cosmic rays and solar cosmic rays consisting of high-energy proton as well as heavy particles (Z>10) within 1-2 % that is exclusively a threat of stochastic radiation effects (small increase of cancer risk and decrease of mean life span) for men. During interplanetary expedition periods the small probability of raised solar activity there is a threat of exposure to astronauts at doses that cause deterministic radiation effects leading to the development of the disease as a clinical manifestation of radiation injuries,. In a similar scenario it is necessary to have available to cosmic ship anti-radiation countermeasures for cosmonaut protection. Among radioprotective equipment can be provided with radiation protective agents and partial shielding of body separate section providing the best condition for post-radiation repair of radiosensitive body tissues. Preparation B-190 (indralin) is the most perspective from a small numbers of other radioprotectors permitting for men administration. Besides high radioprotective efficacy and large broadness of protective action B-190 is well tolerated including the impact of extrem flight factors. Antiemetic agent latran (ondansetron) is most interesting among preparation for prophylaxis and reduction of prodromal radiation reaction. To accelerate post-radiation hematopoietic recovery after raised solar activity an administration of radiomitigators (riboxin et al.) is substantiated. Neupomax (neupogen) is recommended as a preparation for pathogenesis therapy of acute radiation syndrome. Possible consequences of long-term cosmic voyages for oxidative stress development are taken into consideration. On their basis of nNatural antioxidants, preparations and nutrients radiomodulators, fully qualitative nutrition including vegetable food enriched flavonoids, vitamins C, E and carotene potentially prevent a shorten of cosmonaut biological age induced by solar cosmic rays and galactic cosmic rays and stress factors of long-term cosmic voyages. Radiomodulators are low and non-toxic and have not side effects in recommended doses. Their radioprotective effect is directly induced by adaption reaction on cellular and organismic levels through gene expression modulation and in that way the increase of non-specific body tolerance. The implementation of radiomodulator action is possible through hormesis mechanism.

Andy Sessler: The Full Life of an Accelerator Physicist

2014 ◽  
Vol 07 ◽  
pp. 225-240
Author(s):  
Kwang-Je Kim ◽  
Robert J. Budnitz ◽  
Herman Winick
Keyword(s):  
Human Rights ◽  
Atomic Energy Commission ◽  
National Laboratory ◽  
High Energy ◽  
Department Of Energy ◽  
Structure Theory ◽  
Fourth Generation ◽  
Acceleration Process ◽  
Research Association ◽  
The Impact

This article describes the distinguished career of Andrew M. Sessler, the visionary former director of the Lawrence Berkeley National Laboratory (LBNL), one of the most influential accelerator physicists, and a strong, dedicated human-rights activist. Andy died on 17 April 2014 from cancer at age 85. He grew up in New York City, and attended Harvard (BA in Mathematics, 1949) and then Columbia (PhD in Physics, 1953.) After an NSF postdoc at Cornell with Hans Bethe and a stint on the faculty at the Ohio State University in 1954–59, he joined the Lawrence Radiation Laboratory (now LBNL) in 1959, and spent the remainder of his career there. Although Andy left his mark on several areas of physics, including nuclear structure theory, elementary-particle physics, and many-body problems, his lasting and most important contributions came from his efforts in accelerator physics and engineering, to which he devoted most of his life's work. In collaboration with his colleagues of the legendary Midwestern Universities Research Association, he developed theories for the RF acceleration process and the collective instability phenomena, helping to realize the colliding-beam accelerators with which most of the high-energy-physics discoveries of the last few decades have been made. His work in connection with the free-electron-laser (FEL) amplifier for high-power microwave generation constructed at the Lawrence Livermore National Laboratory anticipated the optical-guiding and the self-amplified spontaneous-emission principles, upon which the success of the X-ray FELs as the fourth-generation light sources is based. Throughout his career Andy made major contributions to issues related to the impact of science and technology on society. He helped usher in a new era of research on energy efficiency and sustainable-energy technology and was instrumental in building the research agendas in those areas for the Atomic Energy Commission (AEC) and later the Department of Energy. With a lifelong interest in promoting the human rights of scientists, Andy was instrumental in initiating the American Physical Society's Committee on International Freedom of Scientists and in raising funds to endow the APS Andrei Sakharov Prize. He and Moishe Pripstein cofounded Scientists for Sakharov, Orlov, and Sharansky; the group's protests along with those of other groups led to the release of the three Soviet dissidents. More importantly, Andy's voice and example became a major force in helping call the world's attention to the plight of scientists trapped in places where their human rights and their ability to do science were severely compromised. Andy received many honors, including the AEC's Ernest Orlando Lawrence Award in 1970, the APS's Dwight Nicholson Medal in 1994, and the Enrico Fermi Award from the US Department of Energy in 2014.

scholarly journals Cosmic-Ray Transport and Acceleration

1994 ◽  
Vol 142 ◽  
pp. 926-936
Author(s):  
Reinhard Schlickeiser
Keyword(s):  
Cosmic Rays ◽  
Decisive Role ◽  
Cosmic Ray ◽  
High Energy ◽  
Galactic Cosmic Rays ◽  
Diffusion Term ◽  
Solar Particle Events ◽  
High Energy Cosmic Rays ◽  
Propagation Parameters ◽  
And Diffusion

AbstractWe review the transport and acceleration of cosmic rays concentrating on the origin of galactic cosmic rays. Quasi-linear theory for the acceleration rates and propagation parameters of charged test particles combined with the plasma wave viewpoint of modeling weak cosmic electromagnetic turbulence provides a qualitatively and quantitatively correct description of key observations. Incorporating finite frequency effects, dispersion, and damping of the plasma waves are essential in overcoming classical discrepancies with observations as the Kfit - Kql discrepancy of solar particle events. We show that the diffusion-convection transport equation in its general form contains spatial convection and diffusion terms as well as momentum convection and diffusion terms. In particular, the latter momentum diffusion term plays a decisive role in the acceleration of cosmic rays at super-Alfvénic supernova shock fronts, and in the acceleration of ultra-high-energy cosmic rays by distributed acceleration in our own galaxy.Subject headings: acceleration of particles — convection — cosmic rays — diffusion — shock waves

Assessment of Shielding Material Performance for Deep Space Missions

2004 ◽  
Vol 851 ◽  
Author(s):  
L. K. Mansur ◽  
B. J. Frame ◽  
N. C. Gallego ◽  
S. B. Guetersloh ◽  
J. O. Johnson ◽  
...  
Keyword(s):  
National Laboratory ◽  
Radiation Risk ◽  
Large Mass ◽  
High Energy ◽  
Brookhaven National Laboratory ◽  
Galactic Cosmic Rays ◽  
Shielding Effectiveness ◽  
Deep Space ◽  
Structural Support ◽  
Initial Work

ABSTRACTRadiation doses from galactic cosmic rays (GCR) are a significant issue for spacecraft crew exposures in deep space. We report initial work to evaluate a range of materials for GCR shielding. Earlier work has shown that conventional spacecraft materials, aluminum and higher atomic number structural alloys, provide relatively little shielding and, under certain conditions, may increase radiation risk. Materials containing high proportions of hydrogen and other low atomic mass nuclei provide improved GCR shielding. Polyethylene (PE) is generally considered a good performance benchmark shield material. However, PE shielding occupies volume and adds mass to the spacecraft. In this work we investigate several materials that are shown to provide shielding similar to PE, but which could furnish additional spacecraft functions, possibly eliminating the need for materials currently used for structural support or thermal management. Carbon forms that can incorporate a large mass of hydrogen, as well as polymers and polymer composites are being explored. Calculations of shielding effectiveness in GCR spectra have been carried out. Experiments to measure shielding properties recently have been completed at the NASA Space Radiation Laboratory (NSRL) located at Brookhaven National Laboratory (BNL) using high energy beans of O16. In this paper we report preliminary shielding results.

Abstract 12651: Fine-Tuning of Lung Thrombosis is a Therapeutic Strategy Against Inflammatory Lung Injury

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Colin E Evans ◽  
Xianming Zhang ◽  
Narsa Machireddy ◽  
You-yang Zhao
Keyword(s):  
Lung Injury ◽  
Therapeutic Strategy ◽  
Hypoxia Inducible Factor ◽  
Fine Tuning ◽  
Dependent Manner ◽  
Murine Models ◽  
Survival Gene ◽  
The Impact ◽  
Dose Dependent ◽  
Different Levels

Introduction: Lung thrombosis (LT) and endothelial cell (EC) death are positively associated with mortality in sepsis-induced acute lung injury (ALI) patients, but anti-coagulants have failed in clinical trials of sepsis. Hypothesis: We hypothesized that different levels of LT mediate ALI by regulating lung EC viability. Methods: To assess the impact of different levels of LT on ALI, we used murine models of LT and ALI. To explore how LT level might alter lung EC viability and ALI, we assessed survival gene expression by RNA sequencing. To identify the mechanism(s) responsible for changes in ALI after varying levels of LT, we assessed lung EC viability and ALI in mice with cell-specific knockout of different survival genes. Results: In platelet-depleted mice, LT was reduced while ALI was increased. Intra-venous microbeads were then administered to induce LT in a dose-dependent manner, showing that restoration of LT to the level found in platelet-replete mice protected against thrombocytopenia-induced ALI. We next showed in wild type mice, that while excessive increases in LT worsened ALI, induction of a mild level of LT conversely protected against ALI. The opposing impact of diminished or excessive versus mild LT on ALI was associated with changes in lung EC apoptosis. Subsequent studies showed a panel of candidate survival factors were differentially expressed in the lungs of ALI mice with or without mild or excessive LT. Mechanistically, we found that the protective impact of mild LT on ALI is dependent upon hypoxia-inducible factor (HIF) 1α in Tie2-expressing cells. Remarkably, the same mild level of LT retained its protective impact in platelet-depleted and platelet-replete mice even when induced up to 8 hours after sepsis. Conclusions: ALI is enhanced by diminished or excessive LT but suppressed by mild LT through HIF1α. The control of LT represents a therapeutic strategy for the induction of a pro-survival response that protects against inflammatory lung injury.

scholarly journals The lunar surface as a recorder of astrophysical processes

2020 ◽  
Vol 379 (2188) ◽  
pp. 20190562 ◽  
Author(s):  
Ian A. Crawford ◽  
Katherine H. Joy ◽  
Jan H. Pasckert ◽  
Harald Hiesinger
Keyword(s):  
Solar System ◽  
Lunar Surface ◽  
High Energy ◽  
Galactic Cosmic Rays ◽  
Space Environment ◽  
The Moon ◽  
Solar Particle Events ◽  
The Past ◽  
Geological Processes ◽  
Wide Range

The lunar surface has been exposed to the space environment for billions of years and during this time has accumulated records of a wide range of astrophysical phenomena. These include solar wind particles and the cosmogenic products of solar particle events which preserve a record of the past evolution of the Sun, and cosmogenic nuclides produced by high-energy galactic cosmic rays which potentially record the galactic environment of the Solar System through time. The lunar surface may also have accreted material from the local interstellar medium, including supernova ejecta and material from interstellar clouds encountered by the Solar System in the past. Owing to the Moon's relatively low level of geological activity, absence of an atmosphere, and, for much of its history, lack of a magnetic field, the lunar surface is ideally suited to collect these astronomical records. Moreover, the Moon exhibits geological processes able to bury and thus both preserve and ‘time-stamp' these records, although gaining access to them is likely to require a significant scientific infrastructure on the lunar surface. This article is part of a discussion meeting issue ‘Astronomy from the Moon: the next decades'.

scholarly journals Revisiting the cosmic-ray induced Venusian ionization with the Atmospheric Radiation Interaction Simulator (AtRIS)

2019 ◽  
Vol 624 ◽  
pp. A124 ◽  
Author(s):  
Konstantin Herbst ◽  
Saša Banjac ◽  
Tom A. Nordheim
Keyword(s):  
Secondary Particle ◽  
Cosmic Ray ◽  
High Energy ◽  
Planetary Atmospheres ◽  
Atmospheric Radiation ◽  
Solar Particle Events ◽  
Galactic Cosmic Ray ◽  
The Impact ◽  
Atmospheric Ionization ◽  
Venusian Atmosphere

Context. Cosmic ray bombardment represents a major source of ionization in planetary atmospheres. The higher the energy of the primary cosmic ray particles, the deeper they can penetrate into the atmosphere. In addition, incident high energy cosmic ray particles induce extensive secondary particle cascades (“air showers”) that can contain up to several billion secondary particles per incoming primary particle. To quantify cosmic ray-induced effects on planetary atmospheres it is therefore important to accurately model the entire secondary particle cascade. This is particularly important in thick planetary atmospheres where the secondary particle cascades can develop extensively before being absorbed by the surface. Aims. Inside the Venusian atmosphere, cosmic rays are the dominant driver for the ionization below an altitude of ~100 km. In this work we revisit the numerical modeling of the galactic and solar cosmic-ray induced atmospheric ionization for cosmic ray ions from Hydrogen (Z = 1) to Nickel (Z = 28) and investigate the influence of strong solar energetic particle events inside the Venusian atmosphere. Methods. The Atmospheric Radiation Interaction Simulator (AtRIS), a newly developed simulation code to model the interaction of the near-(exo)planet particle and radiation field with the (exo)planetary atmosphere, was used to revisit the modeling of the altitude-dependent Venusian atmospheric ionization. Thereby, spherical geometry, the newest version of Geant4 (10.5) as well as the newest Geant4-based hadronic and electromagnetic interaction models were utilized. Results. Based on our new model approach we show that previous studies may have underestimated the galactic cosmic ray-induced atmospheric ion pair production by, amongst others, underestimating the influence of galactic cosmic ray protons above 1 TeV/nuc. Furthermore, we study the influence of 71 exceptionally strong solar particle events that were measured as Ground Level Enhancements at the Earth’s surface, and show a detailed analysis of the impact of such strong events on the Venusian ionization.

scholarly journals The high SNR rate in the Galactic Center: origin of the cosmic rays excess?

2016 ◽  
Vol 11 (S322) ◽  
pp. 210-213
Author(s):  
L. Jouvin ◽  
A. Lemière ◽  
R. Terrier
Keyword(s):  
Spatial Distribution ◽  
Cosmic Rays ◽  
Massive Star ◽  
Galactic Center ◽  
High Energy ◽  
Galactic Cosmic Rays ◽  
Morphological Comparison ◽  
Massive Black Hole ◽  
The Impact ◽  
Very High

AbstractThe center of our Galaxy hosts a Super-Massive Black Hole (SMBH) of about 4 × 106 M⊙. Since it has been argued that the SMBH might accelerate particles up to very high energies, its current and past activity could contribute to the population of Galactic cosmic-rays (CRs). Additionally, the condition in the Galactic Center (GC) are often compared with the one of a starburst system. The high supernovae (SN) rate associated with the strong massive star formation in the region must create a sustained CR injection in the GC via the shocks produced at the time of their explosion.The presence of an excess of very high energy (VHE) cosmic rays in the inner 100 pc of the Galaxy in close correlation with the massive gas complex known as the central molecular zone (CMZ) has been revealed in 2006 by the H.E.S.S. collaboration. Recently, by analysing 10 years of H.E.S.S. data, the H.E.S.S. collaboration confirmed the presence of this extended VHE diffuse emission and deduced a CR density peaked toward the GC. The origin of the CR over-abundance in the GC still remains mysterious: Is it due to a single accelerator at the center or to multiple accelerators filling the region?In order to investigate the presence of these multiple CR accelerators, and in particular the impact of their spatial distribution on the VHE emission morphology, we build a 3D model of CR injection and diffusive propagation with a realistic 3D gas distribution. We discuss the CR injection in the region by a spectral and morphological comparison with H.E.S.S. data.We show that a peaked γ-ray profile towards the GC center is obtained using a realistic SN spatial distribution taking into account the central massive star clusters. The contribution of theses sources cannot be neglected in particular at high longitudes. In order to fit the very central excess observed with H.E.S.S., another central VHE component is probably necessary.

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