scholarly journals Sport-related concussion induces transient cardiovascular autonomic dysfunction

2017 ◽  
Vol 312 (4) ◽  
pp. R575-R584 ◽  
Author(s):  
John L. Dobson ◽  
Mary Beth Yarbrough ◽  
Jose Perez ◽  
Kelsey Evans ◽  
Thomas Buckley
Keyword(s):  
Blood Pressure ◽  
Repeated Measures ◽  
Cardiovascular Control ◽  
Group Differences ◽  
Recreational Athletes ◽  
Autonomic Tests ◽  
Autonomic Cardiovascular Control ◽  
Forced Breathing ◽  
Autonomic Reflex ◽  
And Control

Recent evidence suggests that concussions may disrupt autonomic cardiovascular control. This study investigated the initial effects of concussion on cardiovascular function using three autonomic reflex tests. Twenty-three recreational athletes (12 women, 11 men) were divided into concussed ( n = 12) and control ( n = 11) groups. Concussed participants performed forced breathing, standing, and Valsalva autonomic tests four times: 1) within 48 h of injury; 2) 24 h later; 3) 1 wk after injury; and 4) 2 wk after injury. The controls performed the same tests on the same schedule. Differences in heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) responses to the tests were continuously measured using finger photoplethysmography and were analyzed using repeated-measures multivariate ANOVAs and ANOVAs. Within 48 h of injury, the concussed group had significantly greater resting SBP ( t21= 2.44, P = 0.02, d = 1.03), HR ( t21= 2.33, P = 0.03, d = 1.01), and SBP responses to standing ( t21= 2.98, P = 0.01, d = 1.24), and 90% SBP normalization times ( t21= 2.64, P = 0.02, d = 1.10) after the Valsalva, but those group differences subsided 24 h later. There was also a significant interaction with the HR responses to forced breathing ( F3,60= 4.13, P = 0.01, ηp2= 0.17), indicating the concussed responses declined relative to the control’s over time. The results demonstrate that concussion disrupted autonomic cardiovascular control, and that autonomic reflex tests are practical means by which to evaluate that dysfunction.

scholarly journals Effects of Supplementing the Usual Diet with a Daily Dose of Walnuts for Two Years on Metabolic Syndrome and Its Components in an Elderly Cohort

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 451 ◽  
Author(s):  
Ahmed Al Abdrabalnabi ◽  
Sujatha Rajaram ◽  
Edward Bitok ◽  
Keiji Oda ◽  
W. Lawrence Beeson ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Retention Rate ◽  
Fasting Blood Glucose ◽  
Group Differences ◽  
Control Group ◽  
Habitual Diet ◽  
Daily Dose ◽  
Elderly Cohort ◽  
And Control

Accumulating evidence links nut consumption with an improved risk of metabolic syndrome (MetS); however, long-term trials are lacking. We examined the effects of a daily dose of walnuts for two years on MetS in a large elderly cohort. A total of 698 healthy elderly participants were randomly assigned to either a walnut supplemented or a control diet. The participants in the walnut group were provided with packaged walnuts (1, 1.5, or 2 oz. or ~15% of energy) and asked to incorporate them into their daily habitual diet. The participants in the control group were asked to continue with their habitual diet and abstain from eating walnuts and other tree nuts. Intake of n-3 fatty acid supplements was not permitted in either group. Fasting blood chemistries, blood pressure, and anthropometric measurements were obtained at baseline and at the end of intervention. A total of 625 participants (67% women, mean age 69.1 y) completed this two-year study (90% retention rate). Triglycerides decreased in both walnut (−0.94 mg/dl) and control (−0.96 mg/dl) groups, with no significant between-group differences. There was a non-significant decrease in systolic and diastolic blood pressure in the walnut group (−1.30 and −0.71 mm Hg, respectively) and no change in the control group. Fasting blood glucose decreased by ~1 point in both the walnut and control groups. There were no significant between-group differences in the development or reversion of MetS. In conclusion, supplementing the diet of older adults with a daily dose of walnuts had no effect on MetS status or any of its components, although the walnut group tended to have lower blood pressure.

Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification

2002 ◽  
Vol 282 (6) ◽  
pp. R1545-R1564 ◽  
Author(s):  
Ben J. A. Janssen ◽  
Jos F. M. Smits
Keyword(s):  
Blood Pressure ◽  
Genetic Modification ◽  
Mouse Genome ◽  
Cardiovascular Control ◽  
Autonomic Nerves ◽  
Control Mechanisms ◽  
Hemodynamic State ◽  
Autonomic Cardiovascular Control ◽  
Made In

Control of blood pressure and of blood flow is essential for maintenance of homeostasis. The hemodynamic state is adjusted by intrinsic, neural, and hormonal mechanisms to optimize adaptation to internal and environmental challenges. In the last decade, many studies showed that modification of the mouse genome may alter the capacity of cardiovascular control systems to respond to homeostatic challenges or even bring about a permanent pathophysiological state. This review discusses the progress that has been made in understanding of autonomic cardiovascular control mechanisms from studies in genetically modified mice. First, from a physiological perspective, we describe how basic hemodynamic function can be measured in conscious conditions in mice. Second, we focus on the integrative role of autonomic nerves in control of blood pressure in the mouse, and finally, we depict the opportunities and insights provided by genetic modification in this area.

scholarly journals Functional organization of the insula in men and women with obstructive sleep apnea during Valsalva

SLEEP ◽  
2020 ◽  
Author(s):  
Amrita Pal ◽  
Jennifer A Ogren ◽  
Andrea P Aguila ◽  
Ravi Aysola ◽  
Rajesh Kumar ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Repeated Measures ◽  
Functional Organization ◽  
Valsalva Maneuver ◽  
Group Differences ◽  
Apnea Hypopnea Index ◽  
Functional Reorganization ◽  
Obstructive Sleep ◽  
And Control

Abstract Study Objectives Obstructive sleep apnea (OSA) patients show impaired autonomic regulation, perhaps related to functional reorganization of the insula, which in healthy individuals shows sex-specific anterior and right dominance during sympathetic activation. We examined insular organization of responses to a Valsalva maneuver in OSA with functional magnetic resonance imaging (fMRI). Methods We studied 43 newly diagnosed OSA (age mean ± SD: 46.8 ± 8.7 years; apnea-hypopnea index (AHI) ± SD: 32.1 ± 20.1 events/hour; 34 males) and 63 healthy (47.2 ± 8.8 years; 40 males) participants. Participants performed four 18-second Valsalva maneuvers (1-minute intervals, pressure ≥ 30 mmHg) during scanning. fMRI time trends from five insular gyri—anterior short (ASG); mid short (MSG); posterior short (PSG); anterior long (ALG); and posterior long (PLG)—were assessed for within-group responses and between-group differences with repeated measures ANOVA (p < 0.05); age and resting heart rate (HR) influences were also assessed. Results Right and anterior fMRI signal dominance appeared in OSA and controls, with no between-group differences. Separation by sex revealed group differences. Left ASG anterior signal dominance was lower in OSA versus control males. Left ASG and ALG anterior dominance was higher in OSA versus control females. In all right gyri, only OSA females showed greater anterior dominance than controls. Right dominance was apparent in PSG and ALG in all groups; females showed right dominance in MSG and PLG. OSA males did not show PLG right dominance. Responses were influenced substantially by HR but modestly by age. Conclusions Anterior and right insular fMRI dominance appears similar in OSA versus control participants during the sympathetic phase of the Valsalva maneuver. OSA and control similarities were present in just males, but not necessarily females, which may reflect sex-specific neural injury.

Cardiovascular responses to military antishock trouser inflation during standing arm exercise

1987 ◽  
Vol 63 (3) ◽  
pp. 1224-1229 ◽  
Author(s):  
A. V. Ng ◽  
P. Hanson ◽  
E. A. Aaron ◽  
R. B. Demment ◽  
J. M. Conviser ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Repeated Measures ◽  
Peripheral Resistance ◽  
Cardiovascular Responses ◽  
Gravitational Effect ◽  
Positive Pressure ◽  
Arm Cranking ◽  
Lower Body Positive Pressure ◽  
Arterial Blood ◽  
And Control

Military antishock trousers (MAST) inflated to 50 mmHg were used with 12 healthy males (mean age 28 +/- 1 yr) to determine the effects of lower-body positive pressure on cardiac output (Q), stroke volume (SV), heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MABP), total peripheral resistance (TPR), and O2 uptake (VO2) during graded arm-cranking exercise. Subjects were studied while standing at rest and at 25, 50, and 75% of maximal arm-cranking VO2. At each level, rest or work was continued for 6 min with MAST inflated and for 6 min with MAST deflated. Order of inflation and deflation was alternated at each experimental rest or exercise level. Measurements were obtained during the last 2 min at each level. Repeated-measures analysis of variance revealed significant increases (P less than 0.001) in Q, SV, and MABP and a consistent decrease in HR with MAST inflation. There was no apparent change in Q/VO2 between inflated and control conditions. There was no effect of MAST inflation on VO2 or TPR. MAST inflation counteracts the gravitational effect of venous return in upright exercise, restoring central blood volume and thereby increasing Q and MABP from control. HR is decreased consequent to increased MABP through arterial baroreflexes. The associated decrease in TPR is not observed, being offset by the mechanical compression of leg vasculature with MAST inflation.

The Study of Laryngoscopic and Autonomic Patterns in Exercise-Induced Laryngeal Obstruction

2018 ◽  
Vol 127 (11) ◽  
pp. 754-762 ◽  
Author(s):  
Adrianna C. Shembel ◽  
Christopher J. Hartnick ◽  
Glenn Bunting ◽  
Catherine Ballif ◽  
Jessie Vanswearingen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Systolic Blood Pressure ◽  
Heart Rate Recovery ◽  
Group Differences ◽  
Control Group ◽  
Laryngeal Obstruction ◽  
Exercise Induced ◽  
Blood Pressure Responses ◽  
And Control

Objectives: (1) Identify laryngeal patterns axiomatic to exercise-induced laryngeal obstruction (EILO) and (2) investigate the role of autonomic function in EILO. Methods: Twenty-seven athletic adolescents (13 EILO, 14 control) underwent laryngoscopy at rest and exercise. Glottal configurations, supraglottic dynamics, systolic blood pressure responses, and heart rate recovery were compared between conditions and groups. Results: Inspiratory glottal angles were smaller in the EILO group than the control group with exercise. However, group differences were not statistically significant ( P > .05), likely due to high variability of laryngeal responses in the EILO group. Expiratory glottal patterns showed statistically greater abductory responses to exercise in the control group ( P = .001) but not the EILO group ( P > .05). Arytenoid prolapse occurred variably in both groups. Systolic blood pressure responses to exercise were higher in the control group, and heart rate recovery was faster in the EILO group. However, no significant differences were seen between the 2 groups on either autonomic parameter ( P > .05). Conclusions: “Paradoxical” inspiratory and blunted expiratory vocal fold pattern responses to exercise best characterize EILO. Group differences were only seen with exercise challenge, thus highlighting the utility of provocation and control groups to identify EILO.

scholarly journals Relationship between Ischemic Stroke and Pulse Rate Variability as a Surrogate of Heart Rate Variability

2019 ◽  
Vol 9 (7) ◽  
pp. 162 ◽  
Author(s):  
Ajay K. Verma ◽  
Parshuram N. Aarotale ◽  
Parastoo Dehkordi ◽  
Jau-Shin Lou ◽  
Kouhyar Tavakolian
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Ischemic Stroke ◽  
Arterial Stiffness ◽  
Pulse Rate ◽  
Stroke Survivors ◽  
Pulse Rate Variability ◽  
Autonomic Cardiovascular Control ◽  
Autonomic Reflex

Autonomic reflex ascertains cardiovascular homeostasis during standing. Impaired autonomic reflex could lead to dizziness and falls while standing; this is prevalent in stroke survivors. Pulse rate variability (PRV) has been utilized in the literature in lieu of heart rate variability (HRV) for ambulatory and portable monitoring of autonomic reflex predominantly in young, healthy individuals. Here, we compared the PRV with gold standard HRV for monitoring autonomic reflex in ischemic stroke survivors. Continuous blood pressure and electrocardiography were acquired from ischemic stroke survivors (64 ± 1 years) and age-matched controls (65 ± 2 years) during a 10-minute sit-to-stand test. Beat-by-beat heart period (represented by RR and peak-to-peak (PP) intervals), systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse arrival time (PAT), an indicator of arterial stiffness, were derived. Time and frequency domain HRV (from RR intervals) and PRV (from PP intervals) metrics were extracted. PAT was lower (248 ± 7 ms vs. 270 ± 8 ms, p < 0.05) suggesting higher arterial stiffness in stroke survivors compared to controls during standing. Further, compared to controls, the agreement between HRV and PRV was impaired in stroke survivors while standing. The study outcomes suggest that caution should be exercised when considering PRV as a surrogate of HRV for monitoring autonomic cardiovascular control while standing in stroke survivors.

Short term spaceflights influence autonomic cardiovascular control

2006 ◽  
Author(s):  
Dr. Frank Beckers ◽  
Mr. Bart Verheyden ◽  
Mr. Kurt Couckuyt ◽  
Mr. Jiexin Liu ◽  
Prof. André Aubert
Keyword(s):  
Cardiovascular Control ◽  
Short Term ◽  
Autonomic Cardiovascular Control

SIALIC ACID IN THE PRIMARY AND DIFFERENTIAL DIAGNOSIS OF LUNG CANCER

2017 ◽  
Vol 63 (6) ◽  
pp. 926-932
Author(s):  
Lyudmila Belskaya ◽  
Viktor Kosenok ◽  
Ж. Массард
Keyword(s):  
Lung Cancer ◽  
Enzyme Activity ◽  
Optimization Problems ◽  
Primary Lung Cancer ◽  
Nonparametric Test ◽  
Nonsmall Cell Lung Cancer ◽  
Group Differences ◽  
Diagnosis Of Lung Cancer ◽  
And Control ◽  
Control Study

So far optimization problems for diagnostics and prognostication aids remained relevant for lung cancer as a leader in the structure of cancers. Objective: a search for regularities of changes in the saliva enzyme activity in patients with nonsmall cell lung cancer. In the case-control study, 505 people took part, divided into 2 groups: primary (lung cancer, n=290) and control (conventionally healthy, n=215). All the participants went through a questionnaire survey, saliva biochemical counts, and a histological verification of their diagnosis. The enzyme activity was measured with spectrophotometry. Between-group differences were measured with the nonparametric test. It was shown that in terms of lung cancer, we observe metabolic changes, described with the decreased de Ritis coefficient (p

Feedback based on health advice via tracing bracelet and smartphone in the management of Blood Pressure among hypertensive patients: A Community-based RCT Trial in Chongqing, China (Preprint)

2020 ◽  
Author(s):  
Yong Zhang ◽  
Yang Tao ◽  
Yun Zhong ◽  
Jacqueline Thompson ◽  
Jamal Rahmani ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Control Group ◽  
Community Settings ◽  
Post Intervention ◽  
Attrition Rates ◽  
Hypertensive Patients ◽  
Professional Health ◽  
Group A ◽  
And Control ◽  
Study Intervention

UNSTRUCTURED Lifestyle interventions have been recognised as a line treatment of non-communicable diseases. The aimed of this study was to evaluate a bespoke mHealth approach to delivers personalised feedback to improve blood pressure and weight for hypertensive patients in community settings. A total of 307 participants, 50 from each community, were expected to be in the intervention or control group. A professional health facilitator was assigned for each of the 6 communities. The primary outcomes of the study are the reduction in blood pressure and weight at baseline and post-intervention. Of 307 recruited,192 (62.5%) participants completed the study (intervention: 104 and control: 88). There was no difference in attrition rates between the two groups (33.5%vs41.9%, p=0.291). After 6-months of intensive feedback intervention through mHealth approach, patients had better blood pressure, weight, and BMI compared with control. People who were adherent to the intervention demonstrated a clinical benefit with regards to weight and blood pressure.

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