Sweating responses to central and peripheral heating in spinal man

1976 ◽  
Vol 40 (5) ◽  
pp. 701-706 ◽  
Author(s):  
J. A. Downey ◽  
C. E. Huckaba ◽  
P. S. Kelley ◽  
H. S. Tam ◽  
R. C. Darling ◽  
...  
Keyword(s):  
Core Temperature ◽  
Rapid Decrease ◽  
Central Temperature ◽  
Ambient Temperatures ◽  
The Core ◽  
Central Heating ◽  
Temperature Thresholds ◽  
Skin Cooling ◽  
Skin Temperatures

Studies of central and peripheral heating of a resting spinal man (T6) were performed under various ambient temperatures (20–34 degrees C). It was found that at a constant core temperature, sweating could not be initiated by sentient skin heating alone, but skin cooling alone did produce a rapid decrease in sweating response. Central heating alone induced sweating responses and the central temperature thresholds of sweating were inversely related to the ambient (sentient skin) temperatures. The local and mean sweating rates were found to be linearly related to the core temperature. The slopes of local sweating rates versus the core temperature vary increasingly with the following locations: chest, forearm, and forehead; but the slopes of mean sweating rates versus core temperature were essentially constant.

Increasing Mean Skin Temperature Linearly Reduces the Core- temperature Thresholds for Vasoconstriction and Shivering in Humans 

1995 ◽  
Vol 82 (5) ◽  
pp. 1160-1168 ◽  
Author(s):  
Christi Cheng ◽  
Takashi Matsukawa ◽  
Daniel I. Sessler ◽  
Ozaki Makoto ◽  
Andrea Kurz ◽  
...  
Keyword(s):  
Skin Temperature ◽  
Core Temperature ◽  
Central Venous ◽  
Men And Women ◽  
Ringer’S Solution ◽  
The Core ◽  
Temperature Thresholds ◽  
Venous Infusion ◽  
Lactated Ringer's Solution ◽  
Skin Temperatures

Background The contribution of mean skin temperature to the thresholds for sweating and active precapillary vasodilation has been evaluated in numerous human studies. In contrast, the contribution of skin temperature to the control of cold responses such as arteriovenous shunt vasoconstriction and shivering is less well established. Accordingly, the authors tested the hypothesis that mean skin and core temperatures are linearly related at the vasoconstriction and shivering thresholds in men. Because the relation between skin and core temperatures might vary by gender, the cutaneous contribution to thermoregulatory control also was determined in women. Methods In the first portion of the study, six men participated on 5 randomly ordered days, during which mean skin temperatures were maintained near 31, 34, 35, 36, and 37 degrees C. Core hypothermia was induced by central venous infusion of cold lactated Ringer's solution sufficient to induce peripheral vasoconstriction and shivering. The core-temperature thresholds were then plotted against skin temperature and a linear regression fit to the values. The relative skin and core contributions to the control of each response were calculated from the slopes of the regression equations. In the second portion of the study, six women participated on three randomly ordered days, during which mean skin temperatures were maintained near 31, 35, and 37 degrees C. At each designated skin temperature, core hypothermia sufficient to induce peripheral vasoconstriction and/or shivering was again induced by central venous infusion of cold lactated Ringer's solution. The cutaneous contributions to control of each response were then calculated from the skin- and core-temperature pairs at the vasoconstriction and shivering thresholds. Results There was a linear relation between mean skin and core temperatures at the response thresholds in the men: r = 0.90 +/- 0.06 for vasoconstriction and r = 0.94 +/- 0.07 for shivering. Skin temperature contributed 20 +/- 6% to vasoconstriction and 19 +/- 8% to shivering. Skin temperature in the women contributed to 18 +/- 4% to vasoconstriction and 18 +/- 7% to shivering, values not differing significantly from those in men. There was no apparent correlation between the cutaneous contributions to vasoconstriction and shivering in individual volunteers. Conclusions These data indicate that skin and core temperatures contribute linearly to the control of vasoconstriction and shivering in men and that the cutaneous contributions average approximately 20% in both men and women. The same coefficients thus can be used to compensate for experimental skin temperature manipulations in men and women. However, the cutaneous contributions to each response vary among volunteers; furthermore, the contributions to the two responses vary within volunteers.

Influence of Respiratory Heat Transfer on Thermogenesis and Heat Storage after Cold Immersion

1982 ◽  
Vol 63 (2) ◽  
pp. 127-135 ◽  
Author(s):  
J. B. Morrison ◽  
M. L. Conn ◽  
P. A. Hayes
Keyword(s):  
Heat Production ◽  
Heat Input ◽  
Heat Storage ◽  
Metabolic Heat Production ◽  
Central Temperature ◽  
The Core ◽  
Metabolic Heat ◽  
Male Subjects ◽  
Skin Temperatures ◽  
Cold Immersion

1. Ten male subjects were cooled on three occasions to a rectal temperature of 35°C by immersion to the neck in water at 11·3°C. The subjects were rewarmed for 60 min, once by metabolic heat production alone (shivering), once by inhalation rewarming with spontaneous breathing of saturated air at 47°C (control) and once by inhalation rewarming with ventilation regulated at 40 litres/min by respiring a controlled fraction of CO2 (hyperventilation). 2. Metabolic heat production was substantially reduced by inhalation rewarming (P < 0·05), from 913 kJ when shivering to 766 kJ (control) and 613 kJ when hyperventilating. The fall in metabolic heat production was greater than the corresponding respiratory heat gain, which increased from a loss of 41 kJ when shivering to gains of 85 kJ (control) and 169 kJ (hyperventilation). 3. As differences in mean skin temperatures were small (<1·0°C), it is concluded that the lower metabolic heat production in response to increased respiratory heat input must result from more rapid central temperature gains. This conclusion is supported by the relative values of rectal and tympanic temperatures. It was calculated that the percentage of the total heat supply which was donated to the core increased from 13% during shivering to 16% for the control and 23% in hyperventilation. Results imply that respiratory heat input is more efficient than metabolic heat production in elevating central temperature.

Evaluation of the accuracy of body temperature measurement using external radio transmitters

1996 ◽  
Vol 74 (9) ◽  
pp. 1778-1781 ◽  
Author(s):  
Doris Audet ◽  
Donald W. Thomas
Keyword(s):  
Body Temperature ◽  
Core Temperature ◽  
Field Conditions ◽  
Temperature Sensitive ◽  
External Temperature ◽  
Ambient Temperatures ◽  
Body Temperature Measurement ◽  
Radio Transmitters ◽  
The Difference ◽  
Skin Temperatures

The facultative depression of body temperature represents an important energy strategy for small homeotherms. However, measuring body temperature under field conditions by means other than externally attached temperature-sensitive radio transmitters is problematical. We show that skin temperatures measured by external radio transmitters can accurately reflect core temperature for the bat Carollia perspicillata. We compared body and skin temperatures at three ambient temperatures (Ta; 21, 26, and 31 °C). The difference between skin and body temperature (ΔT) was linearly correlated with Ta and can be predicted by ΔT = 4.396 − 0.118Ta. We argue that external temperature-sensitive radio transmitters can provide a reliable index of core temperature and so permit the study of torpor or facultative hypothermia under field conditions.

Propofol Linearly Reduces the Vasoconstriction and Shivering Thresholds 

1995 ◽  
Vol 82 (5) ◽  
pp. 1169-1180 ◽  
Author(s):  
Takashi Matsukawa ◽  
Andrea Kurz ◽  
Daniel I. Sessler ◽  
Andrew R. Bjorksten ◽  
Benjamin Merrifield ◽  
...  
Keyword(s):  
Skin Temperature ◽  
Core Temperature ◽  
Response Curves ◽  
Target Concentration ◽  
The Core ◽  
Temperature Thresholds ◽  
Cutaneous Temperature ◽  
Response Thresholds ◽  
Temperature Manipulation ◽  
Sweating Threshold

Background Skin temperature is best kept constant when determining response thresholds because both skin and core temperatures contribute to thermoregulatory control. In practice, however, it is difficult to evaluate both warm and cold thresholds while maintaining constant cutaneous temperature. A recent study shows that vasoconstriction and shivering thresholds are a linear function of skin and core temperatures, with skin contributing 20 +/- 6% and 19 +/- 8%, respectively. (Skin temperature has long been known to contribute approximately 10% to the control of sweating). Using these relations, we were able to experimentally manipulate both skin and core temperatures, subsequently compensate for the changes in skin temperature, and finally report the results in terms of calculated core-temperature thresholds at a single-designated skin temperature. Methods Five volunteers were each studied on 4 days: (1) control; (2) a target blood propofol concentration of 2 micrograms/ml; (3) a target concentration of 4 micrograms/ml; and (4) a target concentration of 8 micrograms/ml. On each day, we increased skin and core temperatures sufficiently to provoke sweating. Skin and core temperatures were subsequently reduced to elicit peripheral vasoconstriction and shivering. We mathematically compensated for changes in skin temperature by using the established linear cutaneous contributions to the control of sweating (10%) and to vasoconstriction and shivering (20%). From these calculated core-temperature thresholds (at a designated skin temperature of 35.7 degrees C), the propofol concentration-response curves for the sweating, vasoconstriction, and shivering thresholds were analyzed using linear regression. We validated this new method by comparing the concentration-dependent effects of propofol with those obtained previously with an established model. Results The concentration-response slopes for sweating and vasoconstriction were virtually identical to those reported previously. Propofol significantly decreased the core temperature triggering vasoconstriction (slope = -0.6 +/- 0.1 degrees C.micrograms-1.ml-1; r2 = 0.98 +/- 0.02) and shivering (slope = -0.7 +/- 0.1 degrees C.micrograms -1.ml-1; r2 = 0.95 +/- 0.05). In contrast, increasing the blood propofol concentration increased the sweating threshold only slightly (slope = 0.1 +/- 0.1 degrees C.micrograms -1.ml-1; r2 = 0.46 +/- 0.39). Conclusions Advantages of this new model include its being nearly noninvasive and requiring relatively little core-temperature manipulation. Propofol only slightly alters the sweating threshold, but markedly reduces the vasoconstriction and shivering thresholds. Reductions in the shivering and vasoconstriction thresholds are similar; that is, the vasoconstriction-to-shivering range increases only slightly during anesthesia.

The dead zone of thermoregulation in normal and paraplegie man

1978 ◽  
Vol 56 (6) ◽  
pp. 976-983 ◽  
Author(s):  
Hak-Shing Tam ◽  
Robert C. Darling ◽  
Huk-Yuk Cheh ◽  
John A. Downey
Keyword(s):  
Core Temperature ◽  
Dead Zone ◽  
Threshold Temperature ◽  
The Core ◽  
Heating And Cooling ◽  
The Dead ◽  
Skin Temperatures

Independent heating and cooling of the core and skin were performed to a normal and a paraplegic subject. It was found that the core threshold temperature for vasoconstriction release was between that for shivering and sweating. After the onset of sweating, vasodilation of the forearm was observed to increase sharply. The core threshold temperature of sweating of the paraplegic was 0.7 °C higher than that of the normal at corresponding mean sentient skin temperatures. No sweating was observed in the spinal man without raising his core temperature. It appeared that the dead zone of thermoregulation is shifted up in the spinal patient and the possible reasons for this are discussed.

Evidence of a defect in energy expenditure in 7-day-old Zucker rat (fa/fa)

1983 ◽  
Vol 245 (2) ◽  
pp. E107-E113 ◽  
Author(s):  
E. Planche ◽  
M. Joliff ◽  
P. de Gasquet ◽  
X. Leliepvre
Keyword(s):  
Energy Expenditure ◽  
Core Temperature ◽  
Co2 Production ◽  
Cold Environment ◽  
Zucker Rat ◽  
Ambient Temperatures ◽  
The Core ◽  
The Difference ◽  
Thermogenic Response

The aim of the investigation was to see whether a defect in energy expenditure could be found in the Zucker rat at the onset of obesity. Obese (fa/fa) and lean (Fa/fa) 7-day-old pups were studied at three ambient temperatures. At 33 degrees C fa/fa pups showed a reduction in oxygen consumption, respiratory CO2 production, in vivo oxidation of injected [1-14C]palmitic acid, as well as in core temperature. When the pups were kept at 28 degrees C, the difference between genotypes was considerably accentuated, thus indicating a subnormal thermogenic response of the fa/fa pups to a mildly cold environment. At 20 degrees C, however, the metabolic rates dropped to the same low level, and the core temperature equilibrated with ambient temperature in both genotypes. The results demonstrate that the 1-wk-old fa/fa pup has a defect in thermoregulatory thermogenesis. The magnitude of the deficit in energy expenditure was more than adequate to account for the 50% greater fat content of 7-day-old fa/fa pups.

scholarly journals Temperature Monitoring and Perioperative Thermoregulation

2008 ◽  
Vol 109 (2) ◽  
pp. 318-338 ◽  
Author(s):  
Daniel I. Sessler ◽  
David S. Warner ◽  
Mark A. Warner
Keyword(s):  
Body Temperature ◽  
General Anesthesia ◽  
Core Temperature ◽  
Core Body Temperature ◽  
Neuraxial Anesthesia ◽  
General Anesthetics ◽  
The Core ◽  
Core Body ◽  
Dose Dependent ◽  
Body Heat

Most clinically available thermometers accurately report the temperature of whatever tissue is being measured. The difficulty is that no reliably core-temperature-measuring sites are completely noninvasive and easy to use-especially in patients not undergoing general anesthesia. Nonetheless, temperature can be reliably measured in most patients. Body temperature should be measured in patients undergoing general anesthesia exceeding 30 min in duration and in patients undergoing major operations during neuraxial anesthesia. Core body temperature is normally tightly regulated. All general anesthetics produce a profound dose-dependent reduction in the core temperature, triggering cold defenses, including arteriovenous shunt vasoconstriction and shivering. Anesthetic-induced impairment of normal thermoregulatory control, with the resulting core-to-peripheral redistribution of body heat, is the primary cause of hypothermia in most patients. Neuraxial anesthesia also impairs thermoregulatory control, although to a lesser extent than does general anesthesia. Prolonged epidural analgesia is associated with hyperthermia whose cause remains unknown.

Abstract 10475: Heat Loss Augmented by Extracorporeal Circulation is Associated with Overcooling in Cardiac Arrest Survivors Who Underwent Targeted Temperature Management

Circulation ◽  
2021 ◽  
Vol 144 (Suppl_2) ◽  
Author(s):  
Byungkook Lee ◽  
Dong Hun Lee
Keyword(s):  
Water Temperature ◽  
Core Temperature ◽  
Neurological Outcome ◽  
Temperature Management ◽  
Extracorporeal Circuit ◽  
Matched Cohort ◽  
Maintenance Period ◽  
Neurological Outcomes ◽  
The Core ◽  
Poor Neurological Outcome

Introduction: Extracorporeal circuit-based salvage therapy can affect targeted temperature management (TTM) in comatose out-of-hospital cardiac arrest (OHCA) survivors. We investigated the association of patients with extracorporeal device with TTM and neurological outcome. Methods: We performed a retrospective analysis using prospectively collected data from adult comatose OHCA survivors who underwent TTM between October 2015 and December 2020. We defined patients with ECMO and/or CRRT as the extracorporeal group. We calculated the cooling rate during the induction period; the minimum, maximum, and mean time-weighted core temperatures (TWCT), and the standard deviation (SD) of the core temperature and water temperature during the maintenance period based on the temperature measured every minute. We defined the sum of TWCT more and less than 33°C as positive and negative TWCT, respectively. The primary outcome was a poor neurological outcome, defined as cerebral performance category 3-5. We used propensity score (PS) matching to adjust the characteristics of patients who required an extracorporeal circuit device. Results: Of the 223 included patients, 140 (62.8%) patients had poor neurological outcome and 40 (17.9%) patients were categorized into the extracorporeal group. The extracorporeal group had a rapid cooling rate (2.08°C/h [1.13-3.73] vs. 1.24°C/h [0.77-1.79]; p < 0.001). The extracorporeal group had lower mean core temperature; higher core temperature SD; lower positive TWCT; higher negative TWCT; and higher maximum, minimum, and mean water temperature than the no-extracorporeal group. In PS matched cohort, the extracorporeal group had a lower minimum core temperature, lower mean core temperature, higher core temperature SD, higher negative TWCT, higher maximum water temperature, and higher mean water temperature. The neurological outcomes were not different between the two groups, in either the whole or PS-matched cohort. Conclusions: The extracorporeal group achieved the target temperature earlier. The core temperature distribution during the maintenance period was further skewed below 33°C in the extracorporeal group. The extracorporeal group had similar neurological outcomes to the no-extracorporeal group.

Simulating the action of zeitgebers on a coupled two-oscillator model of the human circadian system

1984 ◽  
Vol 247 (3) ◽  
pp. R418-R426
Author(s):  
P. H. Gander ◽  
R. E. Kronauer ◽  
C. A. Czeisler ◽  
M. C. Moore-Ede
Keyword(s):  
Core Temperature ◽  
Activity Rhythm ◽  
Human Subjects ◽  
Model Performance ◽  
The Other ◽  
Oscillator Model ◽  
Temporal Isolation ◽  
The Core ◽  
Temperature Rhythm ◽  
Rest Activity

Our two-oscillator model was originally designed to describe the circadian rhythms of human subjects maintained in temporal isolation. The performance of this model in response to simulated environmental synchronizing cycles (zeitgebers) is examined here. Six distinct types of synchronization are demonstrated between the x oscillator (postulated to regulate the core temperature rhythm), the y oscillator (postulated to regulate the rest-activity rhythm), and z (the zeitgeber). Four types of synchronization are identifiable, if we consider only the periods of the three oscillators. Both x and y may be synchronized by z; either may synchronize with z while the other exhibits a different period; or x, y, and z may each show different periods. Two further classes of synchronization are discernible when phase criteria are taken into account. When either x or y is on the verge of desynchronizing from the other two oscillators, it undergoes periodic phase modulations while retaining the common overall period. The type of synchronization observed depends on the periods of x, y, and z and on the strength of the z drive. The effects of modifying each of these parameters have been systematically investigated by simulation, and model performance is summarized in terms of range of entrainment "maps." These constitute extensive sets of predictions about expected patterns of entrainment of the core temperature and rest-activity rhythms of human subjects exposed to various environmental zeitgebers. Experimental data are available against which model predictions can be tested.

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