scholarly journals Historical Perspectives: An abridged history of sex steroid hormone receptor action

2001 ◽  
Vol 91 (4) ◽  
pp. 1854-1859 ◽  
Author(s):  
Stacey A. Fannon ◽  
Regina M. Vidaver ◽  
Sherry A. Marts
Keyword(s):  
Human Health ◽  
Steroid Hormones ◽  
Hormone Receptor ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors ◽  
Future Research ◽  
Steroid Hormone Receptor ◽  
Historical Perspectives ◽  
Receptor Action

The field of steroid hormone action is well established, although it is barely more than four decades old. Pivotal experiments in the late 1950s and 1960s showed that hormone-binding components exist within nuclei of target tissues and that steroid hormones act by regulating gene expression, rather than directly influencing enzymatic processes. The understanding that steroid hormone receptors interact with the general transcription machinery and alter chromatin structure came in the 1970s and 1980s, and details of this mechanism continue to be elucidated. In addition, the discovery of rapid cellular responses to steroid hormones has led to the identification of putative membrane-bound steroid receptors that act without affecting gene transcription. As noted in the recent Institute of Medicine report Exploring the Biological Contributions to Human Health: Does Sex Matter?, the effects of steroid hormones and defects in steroid hormone receptor action have a profound impact on human health and disease. Future research directives include the development of potent, selective steroid receptor modulators, the elucidation of nongenomic steroid hormone effects, and further exploration of hormone-genome interactions.

scholarly journals Steroid Hormone Receptor Signals as Prognosticators for Urothelial Tumor

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Hiroki Ide ◽  
Hiroshi Miyamoto
Keyword(s):  
Hormone Receptor ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Critical Role ◽  
Steroid Hormone Receptors ◽  
Steroid Hormone Receptor ◽  
Cancer Tissue ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptors ◽  
Tissue Specimens

There is a substantial amount of preclinical or clinical evidence suggesting that steroid hormone receptor-mediated signals play a critical role in urothelial tumorigenesis and tumor progression. These receptors include androgen receptor, estrogen receptors, glucocorticoid receptor, progesterone receptor, vitamin D receptor, retinoid receptors, peroxisome proliferator-activated receptors, and others including orphan receptors. In particular, studies using urothelial cancer tissue specimens have demonstrated that elevated or reduced expression of these receptors as well as alterations of their upstream or downstream pathways correlates with patient outcomes. This review summarizes and discusses available data suggesting that steroid hormone receptors and related signals serve as biomarkers for urothelial carcinoma and are able to predict tumor recurrence or progression.

scholarly journals Inhibitory cross-talk between steroid hormone receptors: differential targeting of estrogen receptor in the repression of its transcriptional activity by agonist- and antagonist-occupied progestin receptors.

1995 ◽  
Vol 15 (4) ◽  
pp. 1847-1857 ◽  
Author(s):  
W L Kraus ◽  
K E Weis ◽  
B S Katzenellenbogen
Keyword(s):  
Estrogen Receptor ◽  
Cross Talk ◽  
Hormone Receptor ◽  
Transcriptional Activity ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Primary Cultures ◽  
Steroid Hormone Receptors ◽  
Expression Vectors ◽  
Steroid Hormone Receptor

Although estrogen receptor (ER) and progestin receptor (PR) are members of different steroid hormone receptor subfamilies, there is considerable biological evidence for cross-talk between the estrogen and progestin hormone-receptor signaling pathways. We have developed a model system to analyze the mechanisms underlying this cross-talk, specifically the repression of ER-mediated transcriptional activity by PR complexed with agonistic or antagonistic ligands. Estrogen- and progestin-responsive reporter vectors containing a variety of promoters were transfected into primary cultures of rat uterine cells and 3T3 mouse fibroblasts with expression vectors for PR (the A and/or B isoforms) as well as ER. Our results demonstrate that both PR isoforms can act as potent ligand-dependent repressors of ER activity. The magnitude of the repression was dependent on the PR isoform (i.e., PR A or PR B), ligand type (i.e., agonist or antagonist), PR levels, and ligand concentration but was unaffected by the ER levels. The promoter context was important in determining both the magnitude and PR isoform specificity of the repression for agonist-occupied PR but not for antagonist-occupied PR. Ligand-occupied PR A was a stronger repressor of ER-mediated transcriptional activity than was ligand-occupied PR B, and antagonist-occupied PR was a more effective repressor than agonist-occupied PR. Mechanistic studies suggest that liganded PR represses ER activity by interfering with its ability to interact productively with the transcriptional machinery, a process known as quenching. The data do not support competitive repression, direct repression, or squelching as the mechanism of PR's inhibitory effect. Experiments with ER mutants demonstrated that the N-terminal portion of ER was required for repression by agonist-occupied PR but not by antagonist-occupied PR. These results, as well as other differences between the two PR-ligand complexes, suggest that they differentially target ER when repressing ER transcriptional activity. These findings underscore the mounting evidence for the importance of interactions between members of the steroid hormone receptor family.

scholarly journals Sirtuin 1 (SIRT1) and steroid hormone receptor activity in cancer

2011 ◽  
Vol 213 (1) ◽  
pp. 37-48 ◽  
Author(s):  
R L Moore ◽  
Y Dai ◽  
D V Faller
Keyword(s):  
Cancer Progression ◽  
Hormone Receptor ◽  
Histone Deacetylases ◽  
Molecular Mechanisms ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors ◽  
Sirtuin 1 ◽  
Steroid Hormone Receptor ◽  
Class Iii

Sirtuins, which are class III NAD-dependent histone deacetylases that regulate a number of physiological processes, play important roles in the regulation of metabolism, aging, oncogenesis, and cancer progression. Recently, a role for the sirtuins in the regulation of steroid hormone receptor signaling is emerging. In this mini-review, we will summarize current research into the regulation of estrogen, androgen, progesterone, mineralocorticoid, and glucocorticoid signaling by sirtuins in cancer. Sirtuins can regulate steroid hormone signaling through a variety of molecular mechanisms, including acting as co-regulatory transcription factors, deacetylating histones in the promoters of genes with nuclear receptor-binding sites, directly deacetylating steroid hormone nuclear receptors, and regulating pathways that modify steroid hormone receptors through phosphorylation. Furthermore, disruption of sirtuin activity may be an important step in the development of steroid hormone-refractory cancers.

Steroid hormone receptor expression and action in bone

2000 ◽  
Vol 98 (2) ◽  
pp. 217-240 ◽  
Author(s):  
Rosemary BLAND
Keyword(s):  
Steroid Hormones ◽  
Hormone Receptor ◽  
Bone Cells ◽  
Steroid Hormone ◽  
Hormonal Control ◽  
Receptor Expression ◽  
Bone Architecture ◽  
Steroid Hormone Receptor ◽  
Hormone Action ◽  
Hormone Receptor Expression

The skeleton is a complex tissue, and hormonal control of bone remodelling is elaborate. The important role that steroid hormones play in bone cell development and in the maintenance of normal bone architecture is well established, but it is only relatively recently that it has become possible to describe their precise mechanism of action. This review focuses not only on the steroid hormones (oestrogens, corticosteroids, androgens and progesterone), but also on related hormones (vitamin D, thyroid hormone and the retinoids), all of which act via structurally homologous nuclear receptors that form part of the steroid/thyroid receptor superfamily. By examining the actions of all of these hormones in vivo and in vitro, this review gives a general overview of the current understanding of steroid hormone action in bone. In addition, a comprehensive review of steroid hormone receptor expression in bone cells is included. Finally, the role that future developments, such as steroid hormone receptor knockout mice, will play in our understanding of steroid hormone action in bone is considered.

Coregulatory proteins in steroid hormone receptor action:

Steroids ◽  
1999 ◽  
Vol 64 (9) ◽  
pp. 576-586 ◽  
Author(s):  
Vida Senkus Melvin ◽  
Dean P. Edwards
Keyword(s):  
Hormone Receptor ◽  
Steroid Hormone ◽  
Steroid Hormone Receptor ◽  
Receptor Action ◽  
Coregulatory Proteins

Transcriptional cross-talk, the second mode of steroid hormone receptor action

1998 ◽  
Vol 76 (7) ◽  
pp. 480-489 ◽  
Author(s):  
Martin Göttlicher ◽  
Stefanie Heck ◽  
Peter Herrlich
Keyword(s):  
Cross Talk ◽  
Hormone Receptor ◽  
Steroid Hormone ◽  
Steroid Hormone Receptor ◽  
Second Mode ◽  
Receptor Action

scholarly journals Differential In Vivo Regulation of Steroid Hormone Receptor Activation by Cdc37p

1997 ◽  
Vol 8 (12) ◽  
pp. 2501-2509 ◽  
Author(s):  
Albert E. Fliss ◽  
Yifang Fang ◽  
Frank Boschelli ◽  
Avrom J. Caplan
Keyword(s):  
Glucocorticoid Receptors ◽  
Hormone Receptors ◽  
Androgen Receptors ◽  
Steroid Hormone ◽  
Receptor Activation ◽  
Steroid Hormone Receptors ◽  
Yeast Cells ◽  
Steroid Hormone Receptor ◽  
Restrictive Temperature

The CDC37 gene is essential for the activity of p60v-src when expressed in yeast cells. Since the activation pathway for p60v-src and steroid hormone receptors is similar, the present study analyzed the hormone-dependent transactivation by androgen receptors and glucocorticoid receptors in yeast cells expressing a mutant version of the CDC37gene. In this mutant, hormone-dependent transactivation by androgen receptors was defective at both permissive and restrictive temperatures, although transactivation by glucocorticoid receptors was mildly defective only at the restrictive temperature. Cdc37p appears to function via the androgen receptor ligand-binding domain, although it does not influence receptor hormone-binding affinity. Models for Cdc37p regulation of steroid hormone receptors are discussed.

scholarly journals Differential Responses to Steroid Hormones in Fibroblasts From the Vocal Fold, Trachea, and Esophagus

Endocrinology ◽  
2015 ◽  
Vol 156 (3) ◽  
pp. 1000-1009 ◽  
Author(s):  
Shigeyuki Mukudai ◽  
Ken Ichi Matsuda ◽  
Takeshi Nishio ◽  
Yoichiro Sugiyama ◽  
Hideki Bando ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Steroid Hormones ◽  
Vocal Fold ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Vocal Folds ◽  
Steroid Hormone Receptors ◽  
Male Rats ◽  
Target Cells ◽  
Cultured Fibroblasts

Abstract There is accumulating evidence that fibroblasts are target cells for steroids such as sex hormones and corticoids. The characteristics of fibroblasts vary among tissues and organs. Our aim in this study is to examine differences in responses to steroid hormones among fibroblasts from different cervicothoracic regions. We compared the actions of steroid hormones on cultured fibroblasts from the vocal folds, which are considered to be the primary target of steroid hormones, and the trachea and esophagus in adult male rats. Expression of steroid hormone receptors (androgen receptor, estrogen receptor α, and glucocorticoid receptor) was identified by immunofluorescence histochemistry. Androgen receptor was much more frequently expressed in fibroblasts from the vocal fold than in those from the trachea and esophagus. Cell proliferation analysis showed that administration of testosterone, estradiol, or corticosterone suppressed growth of all 3 types of fibroblasts. However, mRNA expression for extracellular matrix–associated genes, including procollagen I and III and elastin, and hyaluronic acid synthase I was elevated only by addition of testosterone to fibroblasts from the vocal fold. These results indicate that each steroid hormone exerts region-specific effects on cervicothoracic fibroblasts with different properties through binding to specific receptors.

Characteristics of steroid hormone receptors in cultured MC3T3-E1 osteoblastic cells and effect of steroid hormones on cell proliferation

1992 ◽  
Vol 51 (5) ◽  
pp. 376-381 ◽  
Author(s):  
Akihiro Masuyama ◽  
Yasuyoshi Ouchi ◽  
Fumiyasu Sato ◽  
Takyauki Hosoi ◽  
Tetsuro Nakamura ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Steroid Hormones ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors ◽  
Osteoblastic Cells
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