Sensory Representation of Temperature in Mosquito Warm and Cold Cells

2005 ◽  
Vol 94 (1) ◽  
pp. 176-185 ◽  
Author(s):  
Ewald Gingl ◽  
Armin Hinterwirth ◽  
Harald Tichy

A pair of antagonistic thermoreceptive cells is associated with each of two peg-in-pit sensilla located on the antennal tip of Aedes aegypti. One, the warm cell, responds to rapid warming with a sudden increase in the rate of discharge. The other, a cold cell, responds to rapid cooling with a sudden increase in the discharge rate. When temperature changes are provided by oscillating changes in the convective heat contained in the stimulating air stream, the oscillating discharge rates of both cell types are in advance of the oscillations in temperature and slightly behind the oscillations in the rate of temperature change. Analysis of these phase relationships shows that both cell types respond not only to the actual temperature at particular instants in time (instantaneous temperature) but also to the rate with which temperature changes. Individual responses are therefore ambiguous and signal tendencies rather than precise instantaneous values. When the temperature oscillations are delivered by changes in radiation power, however, the oscillating discharge rates of the warm and cold cells are in step with the oscillations in temperature. Here, individual responses signal instantaneous values of temperature rather than tendencies. The power of radiant heat required to modulate the discharge rates is relatively high, suggesting that infrared radiation is not a significant cue in distant host location.

2012 ◽  
Vol 127 (1) ◽  
pp. 15-19 ◽  
Author(s):  
A Mirza ◽  
L McClelland ◽  
M Daniel ◽  
N Jones

AbstractBackground:Many ENT conditions can be treated in the emergency clinic on an ambulatory basis. Our clinic traditionally had been run by foundation year two and specialty trainee doctors (period one). However, with perceived increasing inexperience, a dedicated registrar was assigned to support the clinic (period two). This study compared admission and discharge rates for periods one and two to assess if greater registrar input affected discharge rate; an increase in discharge rate was used as a surrogate marker of efficiency.Method:Data was collected prospectively for patients seen in the ENT emergency clinic between 1 August 2009 and 31 July 2011. Time period one included data from patients seen between 1 August 2009 and 31 July 2010, and time period two included data collected between 1 August 2010 and 31 July 2011.Results:The introduction of greater registrar support increased the number of patients that were discharged, and led to a reduction in the number of children requiring the operating theatre.Conclusion:The findings, which were determined using clinic outcomes as markers of the quality of care, highlighted the benefits of increasing senior input within the ENT emergency clinic.


2003 ◽  
Vol 174 (5) ◽  
pp. 441-448 ◽  
Author(s):  
Jean-Christophe Maréchal ◽  
Pierre Perrochet

Abstract The present paper addresses two major problems encountered during tunnel drilling and related to the hydraulic interaction with surrounding groundwater bodies. The first one is the prediction of water discharge into the tunnel, as a function of the geometric and hydrogeological data. The second problem is related to the assessment of the draining effects on surface waters (springs, lakes, wetlands). Surface monitoring campaigns are costly and evaluating their duration is a sensitive question. Both problems are tightly related and depend on aquifer dynamics. It is shown that in a geological context with steeply dipping structures, nearly vertical, inducing series of aquifers and aquicludes such as in the Alps, the drainage of the aquifer by the tunnel can be modelled by the analytical solution of Jacob and Lohman [1952] for artesian wells. First developed for horizontal, confined unsteady flow towards a vertical well with constant drawdown, it is adapted here to a horizontal tunnel by a rotation of π/2. The main difference between this solution and more classical Theis’ solutions is that a constant drawdown condition replaces the constant discharge rate condition. Hence, a relation is obtained for the time-dependent discharge rate Q(t) detected at the tunnel after drilling, as a function of aquifer transmissivity (T), storage coefficient (S), initial drawdown (so) and tunnel radius (ro). This analytical solution is compared to a finite-elements model simulating a draining tunnel in a simplified 2D vertical cross-section. The comparisons show that the decay of the tunnel discharge can be divided into two periods. During the first period, radial drawdown develops around the tunnel and there is excellent match between analytical and numerical results. Tunnel discharge results from the decompression of rock and water (storage effects) as a response to the sudden initial drawdown at the tunnel location. During the second period, the drawdown cone reaches the aquifer limits (lateral and upper) and numerical discharge rates decrease faster than analytical rates because of hydraulic heads decline at the aquifer limits. In the Alps, such trends were observed for the discharge rates into the Simplon and Mont-Blanc tunnels, and the analytical solution of Jacob and Lohman [1952] was applied to the first discharge period to evaluate aquifer transmissivity and storage coefficients. As indicated by the simulations, and corroborated by field observations, the analytical solution is only valid during a first period after tunnel opening, the duration of which scaling with the inverse of the aquifer diffusivity (T/S). In the second part of the paper, dimensionless type-curves are presented to enable rapid evaluation of the time where a given drawdown is observed at a given distance from the tunnel. Accounting for tunnel geometry (radius and depth) and aquifer parametres (T and S), these curves could for instance help in practice to determine when surface waters would start to be affected by a draining tunnel underneath. Although neglecting the boundary effects discussed in the first part of the paper, these type-curves demonstrate the great inertia of mountain aquifers, and could be used to adjust the duration of surface monitoring campaigns according to the specific tunnel/aquifer settings.


Author(s):  
Eduardo Martinez-Valdes ◽  
Francesco Negro ◽  
Michail Arvanitidis ◽  
Dario Farina ◽  
Deborah Falla

At high forces, the discharge rates of lower and higher threshold motor units (MU) are influenced in a different way by muscle pain. These differential effects may be particularly important for performing contractions at different speeds since the proportion of lower and higher threshold MUs recruited varies with contraction velocity. We investigated whether MU discharge and recruitment strategies are differentially affected by pain depending on their recruitment threshold (RT), across a range of contraction speeds. Participants performed ankle dorsiflexion sinusoidal-isometric contractions at two frequencies (0.25Hz and 1Hz) and two modulation amplitudes [5% and 10% of the maximum voluntary contraction (MVC)] with a mean target torque of 20%MVC. High-density surface electromyography recordings from the tibialis anterior muscle were decomposed and the same MUs were tracked across painful (hypertonic saline injection) and non-painful conditions. Torque variability, mean discharge rate (MDR), DR variability (DRvar), RT and the delay between the cumulative spike train and the resultant torque output (neuromechanical delay, NMD) were assessed. The average RT was greater at faster contraction velocities (p=0.01) but was not affected by pain. At the fastest contraction speed, torque variability and DRvar were reduced (p<0.05) and MDR was maintained. Conversely, MDR decreased and DRvar and NMD increased significantly during pain at slow contraction speeds (p<0.05). These results show that reductions in contraction amplitude and increased recruitment of higher threshold MUs at fast contraction speeds appears to compensate for the inhibitory effect of nociceptive inputs on lower threshold MUs, allowing the exertion of fast submaximal contractions during pain.


1987 ◽  
Vol 57 (4) ◽  
pp. 1130-1147 ◽  
Author(s):  
M. N. Semple ◽  
L. M. Kitzes

The central auditory system could encode information about the location of a high-frequency sound source by comparing the sound pressure levels at the ears. Two potential computations are the interaural intensity difference (IID) and the average binaural intensity (ABI). In this study of the central nucleus of the inferior colliculus (ICC) of the anesthetized gerbil, we demonstrate that responses of 85% of the 97 single units in our sample were jointly influenced by IID and ABI. For a given ABI, discharge rate of most units is a sigmoidal function of IID, and peak rates occur at IIDs favoring the contralateral ear. Most commonly, successive increments of ABI cause successive shifts of the IID functions toward IIDs favoring the ipsilateral ear. Neurons displaying this behavior include many that would conventionally be classified EI (receiving predominantly excitatory input arising from one ear and inhibitory input from the other), many that would be classified EE (receiving predominantly excitatory input arising from each ear), and all that are responsive only to contralateral stimulation. The IID sensitivity of a very few EI neurons is unaffected by ABI, except near threshold. Such units could provide directional information that is independent of source intensity. A few EE neurons are very sensitive to ABI, but are minimally sensitive to IID. Nevertheless, our data indicate that responses of most EE units in ICC are strongly dominated by excitation of contralateral origin. For some units, discharge rate is nonmonotonically related to IID and is maximal when the stimuli at the two ears are of comparable sound pressure. This preference for zero IID is common for all binaural levels. Many EI neurons respond nonmonotonically to ABI. Discharge rates are greater for IIDs representative of contralateral space and are maximal at a single best ABI. For a subset of these neurons, the influence arising from the ipsilateral ear is comprised of a mixture of excitation and inhibition. As a consequence, discharge rates are nonmonotonically related not only to ABI but also to IID. This dual nonmonotonicity creates a clear focus of peak response at a particular ABI/IID combination. Because of their mixed monaural influences, such units would be ascribed to different classes of the conventional (EE/EI) binaural classification scheme depending on the binaural level presented. Several response classes were identified in this study, and each might contribute differently to the encoding of spatial information.(ABSTRACT TRUNCATED AT 400 WORDS)


2020 ◽  
Vol 13 (3) ◽  
pp. 22-31
Author(s):  
Shakil A. Masum ◽  
Md. Sultanul Islam

Significant amounts of heavy metals in the directly discharged wastewater released from the newly built tannery industrial site in Dhaka, Bangladesh are reported. Despite their detrimental impacts on public health and natural ecosystem, no environmental impact study is yet conducted. Therefore, information on safe discharge rates are not available. In this study, the extent of pollution around the industrial site is investigated for four representative trace metals. Temporal and spatial distributions of chromium (Cr), lead (Pb), cadmium (Cd) and arsenic (As) have been predicted using a numerical model with the aim to estimate safe discharge of these metal contaminants. From multiple simulation runs it has been estimated that a discharge of0.026 m3 of wastewater per day can lead to high levels of Cr and Pb accumulation, exceeding the regulatory standard limits, in the study area. Whilst As and Cd concentrations remain below the advised limits in most cases at this rate. However, an order of magnitude reduction in the total discharge rate, i.e.,0.0026 m3 per day, results into the metal accumulation below the recommended guidelines in all cases. Elevated concentration of Pb is found to be limited to the top 0.5 m of the soil as compared to Cr, As and Cd, which exhibit larger spread along the depth of the soil. The relative dominance of the metal contamination follows the sequence: Pb>Cr>As>Cd as sorbed concentration in soil aggregates and Cr>Pb>As>Cd as aqueous concentration in soil porewater. Further investigations that are essential for a comprehensive environmental impact assessment have been highlighted.


PEDIATRICS ◽  
1987 ◽  
Vol 80 (4) ◽  
pp. 481-490 ◽  
Author(s):  
Lola Jean Kozak ◽  
Catherine Norton ◽  
Margaret McManus ◽  
Eileen McCarthy

The hospital discharge rate of children less than 15 years of age in the United States declined 12% from 1983 to 1984. This was the first time in the 20-year history of the National Hospital Discharge Survey that there was a statistically significant decrease in children's hospital discharge rates in a 1-year period. The change occurred during a period when prospective hospital payment systems were introduced and when prepaid group health plans and alternative systems of providing health care were expanding. The unprecedented decrease in children's hospital use was evaluated using data from the National Hospital Discharge Survey. This is a continuous survey in which data from a national sample of medical records of discharged patients are collected. Children's hospital use rates were reviewed by age, sex, region, and expected principal source of payment. Significant decreases in discharge rates were found for the age group 1 to 4 years and for all children with private insurance. The patterns and changes in hospital use by diagnostic category were also investigated. The major finding was a 19% decrease in children's discharge rate for diseases of the respiratory system. Mortality statistics and data from the National Health Interview Survey were evaluated for indications of changes in children's health status or use of physician services accompanying the decline in hospital use. Although there were fewer deaths due to respiratory diseases for children less than 5 years of age in 1984 than in 1983, most measures of health status were unchanged. The only significant change in physician use was a decrease in the percentage of acute conditions that were medically attended, also among children less than 5 years of age. It is important to continue monitoring children's hospital use patterns, as well as their health status and use of alternative health services, to further assess the impact of changes in the organization and financing of health services.


Dose-Response ◽  
2020 ◽  
Vol 18 (3) ◽  
pp. 155932582094974
Author(s):  
Xingsheng Hu ◽  
Chunhong Hu ◽  
Ping Zhong ◽  
Yajing Wen ◽  
Yong Yang ◽  
...  

Objective: To compare the efficacy of 3/4-drugs’ group with 1-drug’s or 2-drugs’ groups in coronavirus disease 2019 (COVID-19). Methods: We included 207 patients confirmed with COVID-19. We compared the viral clearance rate and discharge rate at day 7, 14, 21 and 28, and median time of viral clearance and length of hospitalization in patients treated with 3/4, 1 or 2 drugs. Results: The viral clearance rates of the 3/4-drugs group at day 7, 14 and 21 were significantly lower than those in the 1-drug’s or 2-drugs’ groups (P < 0.05). The median viral clearance days in 3/4-drugs group (13.5 days) were longer than 1-drug’s or 2-drugs’ groups (both were 9 days) (P < 0.001). The patients’ discharge rates in the 3/4-drugs group at day 14 and 21 were significantly lower than that in the 1-drug’s or 2 drugs’ group (P < 0.05). The median length of hospitalization in the 3/4-drugs group was 17 days, which was significantly longer than 11 days in the 1-drug group and 13 days in the 2-drug group (P < 0.05). Conclusion: The efficacy of 1 or 2 antiviral drugs was similar in COVID-19, and 3/4-drug regimens were not associated with clinical improvement. Corticosteroid treatment and more serious disease were also risk factors for viral clearance and patients’discharge.


1991 ◽  
Vol 261 (1) ◽  
pp. R64-R69 ◽  
Author(s):  
G. J. Schwartz ◽  
P. R. McHugh ◽  
T. H. Moran

The neurophysiological responses to 2-ml intragastric saline loads and 100-pmol celiac artery infusions of cholecystokinin (CCK) were obtained from 20 vagal afferent fibers in 14 rats. Two groups of fibers were identified. Discharge rates of group I fibers (n = 16) were significantly increased by gastric loading, adapted slowly to maintained gastric volume, and were inhibited by load withdrawal. CCK elicited a significant increase in the discharge rate of these group I fibers. Prior exposure to CCK nearly doubled the response of these fibers to a subsequent gastric load. In contrast, group II fibers (n = 4) increased firing rate only during infusion of a gastric load and showed rapid adaptation and no response to CCK. CCK failed to alter subsequent responses to gastric loads in these fibers. These results 1) demonstrate an integration of signals elicited by exogenous CCK and gastric loads at the level of vagal afferent fibers and 2) imply that aspects of CCK's inhibition of food intake may derive from CCK's ability to mimic and amplify vagal afferent activity provoked by meal-related gastric events.


2006 ◽  
Vol 96 (3) ◽  
pp. 989-997 ◽  
Author(s):  
E. Gingl ◽  
H. Tichy

The warm cells of the spider tarsal organ respond very sensitively to low-amplitude changes in temperature and discharge continuously as the rate of change in temperature reaches zero. To test whether the continuous tonic discharge remains without sensory input, we blocked the warm cell's receptive region by Epoxy glue. The activity continued in this situation, but its dependence on temperature changes was strongly reduced. We interpret this to mean that the warm cells exhibit specific intrinsic properties that underlie the generation of the tonic discharge. Experiments with electrical stimulation confirmed the observation that the warm cells persist in activity without an external drive. In warm cells with blocked receptive region, the response curves describing the relationship between the tonic discharge and the level of depolarization is the same for different temperatures. In warm cells with intact receptive region, the curves are shifted upward with rising temperature, as if the injected current is simply added to the receptor current. This indicates a modulating effect of the receptor current on the tonic discharge. Stimulation causes a change in the tonic discharge rate and thereby enables individual warm cells to signal the direction in addition to the magnitude of temperature changes.


1996 ◽  
Vol 9 (4) ◽  
pp. 238-242 ◽  
Author(s):  
F. Dexter ◽  
K. Pearson ◽  
D. L. Griffiths ◽  
P. Jebson

An SICU must have sufficient capacity to handle peak weekly demand to prevent re-admission and/or poor quality of care. Excess capacity may, however, encourage unnecessary SICU utilization. The goal of this study was to assess the influence of availability of SICU beds on patient discharge and re-admission rates. The case series included 1,492 days, 36,816 patient days, 8,821 discharges, and 186 re-admissions within 3 days from a 24-bed multidisciplinary SICU at a tertiary care center. Census was defined to equal the total number of patients in the SICU each day. We found low census levels were not associated with significantly lower discharge rates. Decreasing the census from 19–24 to 13–18 patients per day decreased discharge rates from 31% to 30%. Odds ratio that a decrease in census by five from 24 decreased discharge rate equaled 1.01 (95% confidence interval 0.96 to 1.06). We conclude that when hospital managers choose an appropriate SICU capacity they need not be concerned that intermittent excess capacity will prompt physicians to significantly decrease their discharge rates.


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