scholarly journals Cognitive Phenotypes, Brain Morphometry and the Detection of Cognitive Decline in Preclinical AD

2009 ◽  
Vol 21 (1-2) ◽  
pp. 29-37 ◽  
Author(s):  
Mark W. Jacobson ◽  
Linda K. McEvoy ◽  
Anders Dale ◽  
Christine Fennema-Notestine
Keyword(s):  
Test Performance ◽  
Neuropsychological Tests ◽  
Healthy Aging ◽  
Structural Changes ◽  
Cognitive Test ◽  
Cognitive Changes ◽  
Brain Morphometry ◽  
Preclinical Phase ◽  
Preclinical Ad ◽  
Cognitive Test Performance

Identifying a preclinical phase of Alzheimer’s Disease (PCAD) that is distinct from cognitive changes in healthy aging continues to be a major research focus. Combining neuropsychological and neuroimaging methodologies should improve our ability to differentiate healthy from pathological aging, although studies that utilize both methods often result in equivocal findings, possibly due to variability in cognitive test performance that may be capturing distinct phenotypes. One method of capturing this cognitive variability is to utilize contrasting neuropsychological tests to identify subgroups representative of distinct cognitive phenotypes, and determine whether differences in brain morphometry support these classifications. We review several approaches to defining cognitive subgroups, and we consider the possibility that cognitive asymmetry might provide one means of identifying both functional and structural changes associated with aging and dementia.

The effects of practice on the cognitive test performance of neurologically normal individuals assessed at brief test–retest intervals

2003 ◽  
Vol 9 (3) ◽  
pp. 419-428 ◽  
Author(s):  
ALEXANDER COLLIE ◽  
PAUL MARUFF ◽  
DAVID G. DARBY ◽  
MICHAEL McSTEPHEN
Keyword(s):  
Test Performance ◽  
Neuropsychological Tests ◽  
Test Battery ◽  
Practice Effects ◽  
Cognitive Test ◽  
Drug Induced ◽  
Cognitive Changes ◽  
Before And After ◽  
Neurologically Normal ◽  
Cognitive Test Performance

Performance on many cognitive and neuropsychological tests may be improved by prior exposure to testing stimuli and procedures. These beneficial practice effects can have a significant impact on test performance when conventional neuropsychological tests are administered at test–retest intervals of weeks, months or years. Many recent investigations have sought to determine changes in cognitive function over periods of minutes or hours (e.g., before and after anesthesia) using computerized tests. However, the effects of practice at such brief test–retest intervals has not been reported. The current study sought to determine the magnitude of practice effects in a group of 113 individuals assessed with an automated cognitive test battery on 4 occasions in 1 day. Practice effects were evident both between and within assessments, and also within individual tests. However, these effects occurred mostly between the 1st and 2nd administration of the test battery, with smaller, nonsignificant improvements observed between the 2nd, 3rd, and 4th administrations. On the basis of these results, methodological and statistical strategies that may aid in the differentiation of practice effects from drug-induced cognitive changes are proposed. (JINS, 2003, 9, 419–428.)

Cognitive Test Performance in a Community-Based Nondemented Elderly Sample in Rural India: The Indo-U.S. Cross-National Dementia Epidemiology Study

1996 ◽  
Vol 8 (4) ◽  
pp. 507-524 ◽  
Author(s):  
Mary Ganguli ◽  
Vijay Chandra ◽  
Joanne E. Gilby ◽  
Graham Ratcliff ◽  
Sujatha D. Sharma ◽  
...  
Keyword(s):  
Test Performance ◽  
Neuropsychological Tests ◽  
Cognitive Test ◽  
Epidemiology Study ◽  
Neuropsychological Battery ◽  
Community Based ◽  
Northern India ◽  
English Speaking ◽  
Cognitive Test Performance ◽  
Cross National

Interpretation of cognitive test performance among individuals from a given population requires an understanding of cognitive norms in that population. Little is known about normative test performance among elderly illiterate non-English-speaking individuals. An age-stratified random sample of men and women, aged 55 years and older, was drawn from a community-based population in the rural area of Ballabgarh in northern India. These Hindi-speaking individuals had little or no education and were largely illiterate. A battery of neuropsychological tests, specially adapted from the CERAD neuropsychological battery, which was adminstered to this sample, is described. Subjects also underwent a protocol diagnostic examination for dementia. Norms for test performance of 374 nondemented subjects on these tests are reported across the sample and also by age, gender, and literacy.

Comparison of performance on three neuropsychological tests in healthy Turkish immigrants and Danish elderly

2012 ◽  
Vol 24 (9) ◽  
pp. 1515-1521 ◽  
Author(s):  
T. Rune Nielsen ◽  
Asmus Vogel ◽  
Gunhild Waldemar
Keyword(s):  
Test Performance ◽  
Neuropsychological Tests ◽  
Demographic Variables ◽  
Cross Cultural ◽  
Cognitive Test ◽  
Turkish Immigrants ◽  
Migrant Populations ◽  
Acculturation Level ◽  
Cultural Assessment ◽  
Cognitive Test Performance

ABSTRACTBackground:Appropriate neuropsychological tests for cross-cultural assessment of dementia in elderly ethnic and linguistic minorities are generally lacking in Europe. The aim of this study was to investigate the cross-cultural applicability of the Recall of Pictures Test (RPT), Clock Reading Test (CRT), and supermarket fluency (SF) in samples of Turkish immigrants and Danish elderly.Methods:Samples of Turkish immigrants and Danish elderly were recruited from the Greater Copenhagen area. All participants were screened for factors known to affect cognitive test performance. Those who were included in the study underwent an approximately two-hour assessment, where the RPT, CRT, and SF were applied as a part of a comprehensive battery of neuropsychological tests.Results:A total of 109 elderly participants were included in the study: 73 Turkish and 36 Danish. Significant differences were found between the Turkish and Danish samples in CRT and SF performances, but not in any of the RPT measures. Age and acculturation level were the only demographic variables with significant impact on test performances. Performance data for the three tests are presented as percentiles.Conclusions:Although small differences were observed between the Turkish and Danish samples on the CRT and SF, we consider the three tests to be important neuropsychological tests for assessment of dementia in elderly patients from ethnic minority migrant populations.

scholarly journals Saliva RNA biomarkers predict concussion duration and detect symptom recovery: a comparison with balance and cognitive testing

2021 ◽  
Author(s):  
Gregory Fedorchak ◽  
Aakanksha Rangnekar ◽  
Cayce Onks ◽  
Andrea C. Loeffert ◽  
Jayson Loeffert ◽  
...  
Keyword(s):  
Test Performance ◽  
Area Under The Curve ◽  
Prediction Rule ◽  
Cognitive Testing ◽  
Cognitive Test ◽  
Clinical Tool ◽  
Post Injury ◽  
Symptom Recovery ◽  
Cognitive Test Performance

Abstract Objective The goals of this study were to assess the ability of salivary non-coding RNA (ncRNA) levels to predict post-concussion symptoms lasting ≥ 21 days, and to examine the ability of ncRNAs to identify recovery compared to cognition and balance. Methods RNA sequencing was performed on 505 saliva samples obtained longitudinally from 112 individuals (8–24-years-old) with mild traumatic brain injury (mTBI). Initial samples were obtained ≤ 14 days post-injury, and follow-up samples were obtained ≥ 21 days post-injury. Computerized balance and cognitive test performance were assessed at initial and follow-up time-points. Machine learning was used to define: (1) a model employing initial ncRNA levels to predict persistent post-concussion symptoms (PPCS) ≥ 21 days post-injury; and (2) a model employing follow-up ncRNA levels to identify symptom recovery. Performance of the models was compared against a validated clinical prediction rule, and balance/cognitive test performance, respectively. Results An algorithm using age and 16 ncRNAs predicted PPCS with greater accuracy than the validated clinical tool and demonstrated additive combined utility (area under the curve (AUC) 0.86; 95% CI 0.84–0.88). Initial balance and cognitive test performance did not differ between PPCS and non-PPCS groups (p > 0.05). Follow-up balance and cognitive test performance identified symptom recovery with similar accuracy to a model using 11 ncRNAs and age. A combined model (ncRNAs, balance, cognition) most accurately identified recovery (AUC 0.86; 95% CI 0.83–0.89). Conclusions ncRNA biomarkers show promise for tracking recovery from mTBI, and for predicting who will have prolonged symptoms. They could provide accurate expectations for recovery, stratify need for intervention, and guide safe return-to-activities.

Patterns of Cognitive Test Performance As Functions of the Lateral Localization of Cerebral Abnormalities in the Temporal Lobe

1957 ◽  
Vol 103 (433) ◽  
pp. 758-772 ◽  
Author(s):  
Victor Meyer ◽  
H. Gwynne Jones
Keyword(s):  
Test Performance ◽  
Right Hemisphere ◽  
Cognitive Test ◽  
Temporal Relationships ◽  
Verbal Tasks ◽  
Specific Locus ◽  
Left And Right ◽  
Spatio Temporal ◽  
Cognitive Test Performance ◽  
Lateral Localization

Various investigations into the effects of brain injury on psychological test performance (Weisenburg and McBride, 1935; Patterson and Zangwill, 1944; Anderson, 1951; McFie and Piercy, 1952; Bauer and Becka, 1954; Milner, 1954) suggest the overall conclusion that patients with left hemisphere lesions are relatively poor at verbal tasks, while those with right-sided lesions do worst at practical tasks, particularly the manipulation of spatial or spatio-temporal relationships. Heilbfun's (1956) study confirmed that verbal deficits result from left-sided lesions but his left and right hemisphere groups produced almost identical scores on spatial tests. In so far as these workers paid attention to the specific sites of the lesions, their findings indicate that the pattern of test performance is a function of the hemisphere in which the lesion occurs rather than of its specific locus.

Improvement of cognitive test performance in patients undergoing primary CABG and other CPB-assisted cardiac procedures

Perfusion ◽  
2008 ◽  
Vol 23 (5) ◽  
pp. 267-273 ◽  
Author(s):  
JM van den Goor ◽  
BK Saxby ◽  
JG Tijssen ◽  
KA Wesnes ◽  
BA de Mol ◽  
...  
Keyword(s):  
Cognitive Functions ◽  
Test Performance ◽  
Artery Bypass ◽  
Cardiac Surgical Procedures ◽  
Cognitive Test ◽  
Cardiac Procedures ◽  
Patient Groups ◽  
Cognitive Test Performance ◽  
Composite Scores ◽  
Cabg Patients

Cardiac surgical procedures assisted by cardiopulmonary bypass (CPB) impair cognitive functions. Several studies, however, showed that cognitive functions were unaffected in patients undergoing either primary coronary artery bypass grafting (CABG) or more complex surgery assisted by CPB. Therefore, we conducted a straightforward study to compare patient groups who differed significantly in terms of risk factors such as prolonged CPB times. Consecutive patients (n = 54) were included, undergoing either non-primary CABG, e.g. valve and/or CABG, (n = 30) or primary CABG (n = 24), assisted by CPB. Cognitive function was determined pre-operatively on the day of hospital admission, and post-operatively after one and six months using the Cognitive Drug Research computerized assessment battery. Data from the fourteen individual task variables were summarized in four composite scores: Power of Attention (PoA), Continuity of Attention (CoA), Quality of Episodic Memory (QoEM), and Speed of Memory (SoM). In the non-primary CABG patients, both CoA and QoEM improved after 1 month (p = 0.001 and p = 0.016, respectively), whereas, after 6 months, CoA (p = 0.002), QoEM (p = 0.002) and SoM (p < 0.001) were improved. In primary CABG patients, CoA improved at one month after surgery (p = 0.002) and, after six months, not only CoA (p = 0.003), but also QoEM and SoM were improved (p = 0.001 and p = 0.030, respectively). The test performance was similar in non-primary and primary CABG patients after surgery. Our present study shows a post-operative improvement of cognitive composite scores after cardiac surgery assisted by CPB in both non-primary CABG and in primary CABG patients.

scholarly journals An Evaluation of Visual Perception Visual Memory Cognitive Functions and Emotional Status among Genders in Elderly Subjects

2021 ◽  
pp. 330-336
Author(s):  
A. Ruhina ◽  
G. Sridevi
Keyword(s):  
Gender Differences ◽  
Visual Perception ◽  
Depth Perception ◽  
Cognitive Functions ◽  
Test Performance ◽  
Visual Memory ◽  
Cognitive Test ◽  
Emotional Status ◽  
Cognitive Test Performance ◽  
Picture Identification

Background: Gender differences in visual memory and perception and cognitive test performance have been significantly influenced by factors like sex Objective: The current study aimed to evaluate the gender differences in patterns of cognitive test performance and visual perception in healthy elderly individuals. Methods: Cognitive functions and visual perception was analyzed using clock drawing test and picture identification test in 20 elderly men and women (10 each) and their emotional status was assessed using depression scale Results: The results revealed that females had a better visual memory and depth perception compared to men and the value was statistically significant at p<0.05. Females performed better than men on tests of Picture identification and were better in phonemic verbal skills compared to male men and the value was statistically significant at p<0.05 Conclusion: The present study concluded an innovative finding that women were better in their performance related to visual depth perception and cognitive functions.

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