scholarly journals Complex Decongestive Physiotherapy Treats Skin Changes like Hyperkeratosis Caused by Lymphedema

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Hande Kaba ◽  
Yesim Bakar ◽  
Özlem Çinar Özdemir ◽  
Seda Sertel
Keyword(s):  
Radiation Therapy ◽  
Lymphatic System ◽  
Lymphatic Malformation ◽  
Skin Changes ◽  
Secondary Lymphedema ◽  
Complex Decongestive Physiotherapy ◽  
Primary Lymphedema

Lymphedema is a chronic, progressive, and often debilitating condition. Primary lymphedema is a lymphatic malformation developing during the later stage of lymph angiogenesis. Secondary lymphedema is the result of obstruction or disruption of the lymphatic system, which can occur as a consequence of tumors, surgery, trauma, infection, inflammation, and radiation therapy. Here, we report a 64-year-old woman presenting with hyperkeratosis, a lymphedema due to metastatic uterus carcinoma. In this paper, we present the effects of complex decongestive physiotherapy on lymphedema and hyperkeratosis.

scholarly journals Investigating the Lymphatic System by Dual-Color Elemental Mass Spectrometry Imaging

2017 ◽  
Vol 2017 ◽  
pp. 1-8
Author(s):  
Ann-Christin Niehoff ◽  
Tim Klasen ◽  
Rebecca Schmidt ◽  
Daniel Palmes ◽  
Cornelius Faber ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Lymph Nodes ◽  
Contrast Agents ◽  
Inductively Coupled Plasma ◽  
Mass Spectrometry Imaging ◽  
Lymphatic System ◽  
Diagnostic Tools ◽  
Lymphatic Flow ◽  
Secondary Lymphedema ◽  
Inductively Coupled

Secondary lymphedema accompanied with strong restrictions in quality of life is still major side effects in cancer therapy. Therefore, dedicated diagnostic tools and further investigation of the lymphatic system are crucial to improve lymphedema therapy. In this pilot study, a method for quantitative analysis of the lymphatic system in a rat model by laser ablation (LA) with inductively coupled plasma mass spectrometry imaging (ICP-MSI) is presented. As a possible lymph marker, thulium(III)(1R,4R,7R,10R)-α,α′,α′′,α′′′-tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (Tm-DOTMA) is introduced and compared to the clinically used magnetic resonance imaging contrast agent gadolinium(III)2,2′,2′′-(10-((2R,3S)-1,3,4-trihydroxybutan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (Gd-DO3A-butrol). Gadobutrol functioned as standard contrast media in MRI lymphangiography to detect lymphatic flow qualitatively. Thus, Tm-DOTMA was investigated as lymphatic marker to detect lymphatic flow quantitatively. Both contrast agents were successfully used to visualize the lymphatic flow in successive lymph nodes in LA-ICP-MS due to lower limits of detection compared to MRI. Furthermore, the distribution of contrast agents by multicolored imaging showed accumulation in specific areas (sectors) of the lymph nodes after application of contrast agents in different areas.

scholarly journals Aggravated Primary Lymphedema of Contralateral Upper Limb after the Radical Mastectomy: A Case Report

2020 ◽  
Author(s):  
Ying Liu ◽  
Weiren Pan ◽  
Jinghong Guan ◽  
Xiao Long
Keyword(s):  
Breast Cancer ◽  
Upper Limb ◽  
Trauma Surgery ◽  
Radical Mastectomy ◽  
Axillary Lymph ◽  
Contralateral Limb ◽  
Case Presentation ◽  
Secondary Lymphedema ◽  
Primary Lymphedema ◽  
Lymphatic Development

Abstract Background: Breast cancer-related lymphedema is usually characterized by edema of the affected the ipsilateral upper limb and trunk. We report a case of aggravated primary lymphedema in the contralateral limb and trunk after breast cancer resection and axillary lymph node dissection.Case presentation: A 63-year-old female developed right thorax-back and upper limb swelling since childhood. After the modified mastectomy, the swelling of her right chest, back and upper limb increased. While she had no edema of left torso and limb. There was no relevant supplementary examination data because she refused to take lymphoscintigraphy or MRI scan. However, according to her medical history and physical examination, she was preliminarily diagnosed as primary lymphedema, International Society of lymphedema stage 2.Conclusions: Primary lymphedema and secondary lymphedema may be both results of the interaction of multiple factors and can be induced or aggravated by trauma, surgery or other reasons besides the abnormal lymphatic development of individuals.

Chubby Infant – Should One Worry? An Infant with Primary lymphedema – Mini Review and Case Report

2020 ◽  
Author(s):  
Joanna Magdalena Kaczmarek ◽  
Karolina Anna Graczykowska ◽  
Iwona Szymkuć-Bukowska ◽  
Ewa Łoś-Rycharska ◽  
Aneta Krogulska
Keyword(s):  
Case Report ◽  
Lymphatic System ◽  
Subcutaneous Tissue ◽  
Pediatric Population ◽  
Tissue Fluid ◽  
Fat Tissue ◽  
Primary Lymphedema ◽  
Progressive Accumulation ◽  
Secondary Causes ◽  
Localized Form

AbstractLymphedema is a localized form of tissue swelling, characterized by a progressive accumulation of a tissue fluid in the interstitial compartment as a result of the lymphatic system dysfunction. It is a rare disease in the pediatric population and in the majority of cases it is a consequence of an abnormal formation of the lymphatic system, which is called primary lymphedema. Although its epidemiology is not precise, it is assumed that 1:100 000 children suffer from primary lymphedema. The diagnosis can be made by a proper clinical examination after ruling out secondary causes of lymphedema, particularly in cases with a more asymmetric swelling of the extremities. In this very article we present a case report of an 8-months-old infant with primary lymphedema, who had presented swelling of the extremities from birth and yet no pathology was suspected before. The purpose of this article is to draw attention to the fact that a baby with excessive subcutaneous tissue is not always a healthy, chubby infant with considerable amount of fat tissue.

scholarly journals The Role of Protein Kinase Activators and ZFN in Reducing the Harmful Effects of Total Body Irradiation

2020 ◽  
Author(s):  
hana ahmd alahmd ◽  
sawsan madi ◽  
adnan ekhtiar
Keyword(s):  
Flow Cytometry ◽  
Radiation Therapy ◽  
Lymphatic System ◽  
Antiviral Treatment ◽  
Whole Body ◽  
Pathological Changes ◽  
Γ Rays ◽  
Total Body ◽  
Harmful Effects

Abstract ObjectiveAIDS patients are predisposed to develop certain tumors. Radiation therapy is one of the main treatments for cancer. However, exposure to ionizing radiation leads to defects in the lymphatic system. The cells with the highest sensitivity to radiation are the T lymphocytes. We aim to investigate the effect of irradiation on the ratio of CD4 to CD8, and to oppose this effect by using Bryostatin (B) and ZFN and ART (Anti-Retroviral Therapy). So Balb/C mice aged 6-8 weeks were whole-body irradiated with 1.5 Gy of γ-rays, was then mice were treated with ZFN, Bryostatin intraperitoneally. And orally Antiviral treatment. At the end of the study, CD4/CD8 was measured by flow cytometry.Results Irradiation caused significant pathological changes that led to a clear reversal of CD4/CD8 ratio significantly within the normal radiating group. there are no significant differences in CD4/CD8 ratio between all groups treated with ZFN+ X, Z+ B+ X, ART+ X and normal group.So our study suggests the effect of Bryostatin in protecting living organs that were exposed to irradiation in mice. ZFN cuts off both BAX and BAK, and thus decreases apoptotic proteins, reducing cell death.

scholarly journals Lymphatic system and adipose tissue: Crosstalk in health and disease

2021 ◽  
Vol 18 (3) ◽  
pp. 336-344
Author(s):  
V. V. Klimontov ◽  
D. M. Bulumbaeva
Keyword(s):  
Endothelial Cells ◽  
Adipose Tissue ◽  
Molecular Mechanisms ◽  
Lymphatic System ◽  
Lymphatic Vessels ◽  
Inflammatory Cells ◽  
The Body ◽  
Push Button ◽  
Secondary Lymphedema

The lymphatic system (LS) is one of the main integrative systems of the body, providing protective and transport functions. In recent years, interactions between LS and adipose tissue (AT) have been of particular interest. Lymphatic vessels play an important role in metabolic and regulatory functions of AT, acting as a collector of lipolysis products and adipokines. In its turn, hormones and adipocytokines that produced in adipocytes (including leptin, adiponectin, IL-6, TNF-α, etc.) affect the function of lymphatic endothelial cells and control the growth of lymphatic vessels. Cooperation between LS and AT becomes pathogenetically and clinically important in lymphedema and obesity. It is known that both primary and secondary lymphedema are characterized by increased fat accumulation which is associated with the severity of lymphostasis and inflammation. Similarly, in obesity, the drainage function of LS is impaired, which is accompanied by perilymphatic mononuclear infiltration in the AT. The development of these changes is facilitated by endocrine dysfunction of adipocytes and impaired production of adipocytokines. The increase in the production of inflammatory mediators and the disruption of the traffic of inflammatory cells causes a further deterioration in the outflow of interstitial fluid and exacerbates the inflammation of the AT, thereby forming a vicious circle. The role of lymphangiogenesis in AT remodeling in obesity needs further research. Another promising area of research is the study of the role of intestinal LS in the development of obesity and related disorders. It has been shown that the transport of chylomicrons from the intestine depends on the expression of a number of molecular mediators (VEGF-C, DLL-4, neuropilin-1, VEGFR-1, CD36/FAT, etc.)in the endotheliocytes of the intestinal lymphatic vessels, as well as the functioning of «push-button» and “zippering” junctions between endothelial cells. New approach to the treatment of obesity based on blockade of lymphatic chylomicrontransport has been experimentally substantiated. Further identification of the molecular mechanisms and signaling pathways that determine the remodeling of AT in lymphedema and obesity are likely to provide new approaches to the treatment of these diseases.

Bodyweight Apparatus Used to Apply Compression Garments for Lymphedema Patients

2011 ◽  
Author(s):  
David DeRoche ◽  
Zachary Sharp
Keyword(s):  
Radiation Therapy ◽  
Cancer Treatment ◽  
Interstitial Fluid ◽  
Lymphatic System ◽  
Medical Condition ◽  
Circulatory System ◽  
Interstitial Tissue ◽  
Compression Garments ◽  
Affected Area ◽  
System 1

Lymphedema is a medical condition caused by an excess of fluid collecting in the interstitial tissue. When the lymphatic system is functioning normally, the interstitial fluid passes into the lymphatic capillaries, thought the lymphatic ducts, and returns to the circulatory system [1]. If this system is disrupted due to congenital reasons, surgery, or radiation therapy associated with cancer treatment, the fluid is unable to properly drain [2]. This collection of fluid leads to swelling of the affected area, usually the legs or arms (Figure 1).

scholarly journals A Re-evaluation of the Importance of the Lymphatic System in the Treatment of Post-mastectomy Lymphoedema

1986 ◽  
Vol 42 (4) ◽  
pp. 116-120
Author(s):  
Aileen Z. Goodenough ◽  
Laetitia A.H.M. Schepers
Keyword(s):  
Patient Education ◽  
Patient Compliance ◽  
Lymphatic System ◽  
Elastic Support ◽  
Good Patient ◽  
Compression Bandaging ◽  
Complex Decongestive Physiotherapy ◽  
Alternative Approach ◽  
Good Patient Compliance ◽  
Hygienic Measures

The physiology and pathophysiology of the lymphatic system are discussed. Complex decongestive physiotherapy is presented as an alternative approach to the treatment of post-mastectomy lymphoedema. This is seen to be an effective method of treatment, but good patient compliance (hygienic measures, wearing elastic support while working, compression bandaging while at rest and remedial exercises), is a prerequisite. This may be achieved by intensive patient education. 

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