scholarly journals Assessment of Anticholinesterase Activity ofGelidiella acerosa: Implications for Its Therapeutic Potential against Alzheimer’s Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Arif Nisha Syad ◽  
Karutha Pandian Shunmugiah ◽  
Pandima Devi Kasi
Keyword(s):  
Spectrophotometric Method ◽  
Inhibitory Activity ◽  
Therapeutic Potential ◽  
Phytochemical Analysis ◽  
Phytochemical Screening ◽  
Gelidiella Acerosa ◽  
Cholinesterase Inhibitory Activity ◽  
Inhibitory Activities ◽  
Benzene Extract

The effect of various solvent extracts ofGelidiella acerosaon acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities was investigated. AChE and BuChE inhibitory activities were analyzed by spectrophotometric method. Phytochemical screening of the compounds present in the solvent extracts was done qualitatively. Characterization of the compounds present in the benzene extract ofG. acerosawas done by GC-MS analysis. The results showed that, at 487.80 μg/mL, benzene extract showed significant (P<0.05) inhibitory activity against both AChE and BuChE with the percentage of inhibition54.18±5.65% (IC50 = 434.61±26.53 μg/mL) and78.43±0% (IC50 = 163.01±85.35 μg/mL), respectively. The mode of inhibition exhibited by benzene extract against the AChE and BuChE was found to be competitive and uncompetitive type of inhibition, respectively. Preliminary phytochemical analysis coupled with GC-MS illustrates that the benzene extract possesses high amount of terpenoids, which could be the reason for potential cholinesterase inhibitory activity.

Phytochemical characterization of Caraway (Carum carvi) seed extract and its use as a potent medicinal agent

2021 ◽  
Vol 16 (10) ◽  
pp. 102-110
Author(s):  
Vivek Chauhan ◽  
Sunita Devi ◽  
Sonaxi Sharma ◽  
Shamsher S. Kanwar
Keyword(s):  
Staphylococcus Epidermidis ◽  
Arable Land ◽  
Seed Extract ◽  
Phytochemical Analysis ◽  
Phytochemical Screening ◽  
Food Industries ◽  
Carum Carvi ◽  
Medicinal Properties ◽  
The Village

Carum carvi (Caraway) is a member of Apiaceae family which originated in Asia. Due to its economic importance, it is widely cultivated. Caraway is the only annual species, commonly present in arable land, moist meadows and on low lands to mountains. Caraway has different applications in pharmaceutical and food industries. Phytochemical screening of different medicinal plants is helpful in identifying new sources of industrially and therapeutically important compounds. In this study, Caraway obtained from forest surrounding the village Goherman, Lahaul and Spiti, Himachal Pradesh (India) was used. Seed extract of caraway extracted in methanol (MSE) and distilled water (WSE) was used for phytochemical analysis to determine the constituents of caraway seeds. Further, caraway seeds extract was checked for antibacterial activity [Staphylococcus aureus (ATCC 6538), Salmonella typhimurium (NCTC 74), Escherichia coli (ATCC 25922) and Staphylococcus epidermidis (ATCC 12228)], antioxidant activity and acid neutralizing activity. After analysing the results, it can be said that caraway seeds possess many medicinal properties and it can be used in enhancing human health.

scholarly journals Phytochemical analysis of Viburnum davidii Franch. and cholinesterase inhibitory activity of its dihydrochalcones

2020 ◽  
pp. 1-7
Author(s):  
Lamberto Tomassini ◽  
Antonio Ventrone ◽  
Claudio Frezza ◽  
Anna Maria Fabbri ◽  
Stefano Fortuna ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Phytochemical Analysis ◽  
Cholinesterase Inhibitory Activity

scholarly journals Characterization of the α-Amylase Inhibitory Activity of Oligomeric Proanthocyanidins from Acacia mearnsii Bark Extract

2016 ◽  
Vol 11 (12) ◽  
pp. 1934578X1601101
Author(s):  
Yosuke Matsuo ◽  
Rie Kusano ◽  
Sosuke Ogawa ◽  
Yoshikazu Yazaki ◽  
Takashi Tanaka
Keyword(s):  
Inhibitory Activity ◽  
Complex Mixture ◽  
Bark Extract ◽  
Type B ◽  
Acacia Mearnsii ◽  
Pyrolysis Products ◽  
Oligomeric Proanthocyanidins ◽  
Inhibitory Activities ◽  
C Nmr

Acacia mearnsii (Fabaceae) contains acacia polyphenols, which are a complex mixture of proanthocyanidins that are mainly composed of 5-deoxycatechin units. In this study, an aqueous extract of A. mearnsii bark was fractionated and the α-amylase inhibitory activity of each fraction was evaluated. The 13C NMR and MS data and the pyrolysis products obtained from the active and inactive fractions were compared. The spectroscopic results clearly indicated that fractions with strong inhibitory activity contained proanthocyanidin oligomers with catechol-type B-rings rather than pyrogallol-type B-rings. HPLC analysis of the pyrolysis products showed peaks for pyrocatechol were only observed in the mixtures obtained from the fractions with high inhibitory activities. In addition, (+)-pinitol was isolated as a major polyol of the extract at a level comparable with that of sucrose.

scholarly journals Qualitative Phytochemical Analysis of Incarvillea emodi (Royle ex Lindl.) Chatterjee and Malva neglecta (Wallr.)

2020 ◽  
Vol 10 (4) ◽  
pp. 93-95
Author(s):  
M. Huzafa ◽  
Z. Jamal ◽  
A. Ahmed
Keyword(s):  
Bioactive Compounds ◽  
Plant Material ◽  
Phytochemical Analysis ◽  
Phytochemical Screening ◽  
Aerial Parts ◽  
Isolation And Characterization ◽  
Confirmatory Tests ◽  
Phytochemical Profile ◽  
Positive Results

The present study was carried out to investigate the phytochemical profile of Incarvillea emodi and Malva neglecta. The two plants were screened for the presence of nine different classes of bioactive compounds. The qualitative tests were performed on the aerial and underground parts of the selected plants to relate the presence of phytochemicals with bioactivities of the plants. The selected plant material was extracted with three different solvents. These extracts were then subjected to phytochemical screening and the presence of various phytochemicals was confirmed by different standard confirmatory tests. Most of the phytochemicals were found to be present. Results showed that the underground parts of Incarvillea emodi contain comparatively greater number of phytochemicals than the aerial parts. Whereas, in case of Malva neglecta the aerial parts showed more positive results than the underground parts. The current study offers proof for the presence of important bioactive compounds in the studied plants and recommends isolation and characterization of these compounds in the future.

Pharmacological Characterization of Orally Active Cholinesterase Inhibitory Activity of Prunus persica L. Batsch in Rats

2006 ◽  
Vol 29 (2) ◽  
pp. 101-108 ◽  
Author(s):  
Seok-Jong Suh ◽  
Byung-Soo Koo ◽  
Un-Ho Jin ◽  
Moon-Je Hwang ◽  
In-Seon Lee ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Prunus Persica ◽  
Pharmacological Characterization ◽  
Cholinesterase Inhibitory Activity ◽  
Orally Active

scholarly journals Physicochemical and Phytochemical Studies on Sphaeranthus indicus Linn. with HPTLC Fingerprinting

2021 ◽  
Vol 11 (2) ◽  
pp. 100-107
Author(s):  
Mohit Garg ◽  
Neelesh Dwivedi
Keyword(s):  
Water Soluble ◽  
Phytochemical Analysis ◽  
Phytochemical Screening ◽  
Ph Values ◽  
Natural Agents ◽  
Sphaeranthus Indicus ◽  
Health And Healing ◽  
Therapeutic Compounds ◽  
Phytochemical Studies

Ayurveda, the oldest paradigm of health and healing known to the world, grew out of the Rishi tradition. The medical and research community is constantly seeking for new natural agents. Sphaeranthus indicus Linn. (Gorakhmundi, Family: Asteraceae), is widely used in Ayurvedic system of medicine to treat various diseases. The present investigation was designed to perform physicochemical and phytochemical analysis with HPTLC fingerprints of Sphaeranthus indicus (leave, flower, and stem) to establish the standard parameters of this herb. Different analytical parameters like extractive values, total ash, acid insoluble ash and water-soluble ash, moisture content, pH values of different parts of the drug were performed. Preliminary phytochemical screening was done to detect and quantify different active constituents such as alkaloids, flavanoids, proteins and total poly phenol using various analytical methods. Our preliminary data of phytochemical screening of the extracts revealed the presence of steroids, carbohydrates, proteins, terpenoid, flavonoid, tannins, alkaloids, resin and saponin. In the current study we established the HPTLC fingerprint of the extract using phytochemical standards. We believe that our study provides a substantial data for identification, purification, standardization, and phytochemical characterization of novel therapeutic compounds that can be used potential drug to combat various diseases for betterment of mankind. Keywords: Sphaeranthus indicus, Ayurveda, physicochemical, UV- Spectrophotometer, HPTLC

scholarly journals PHYTOCHEMICAL SCREENING ON THREE TRADITIONAL MEDICINAL PLANTSAGAINSTPILES

2016 ◽  
Vol 4 (5) ◽  
pp. 99-105
Author(s):  
Ujala Devi ◽  
Inaocha Devi ◽  
Chand Singh
Keyword(s):  
Therapeutic Potential ◽  
Total Phenolic ◽  
Phytochemical Analysis ◽  
Phytochemical Screening ◽  
Steroid Saponin ◽  
High Concentration ◽  
Phenolic Contents ◽  
Total Phenolic Contents ◽  
Soxhlet Apparatus ◽  
Gallic Acid Equivalent

The aim of the present study was to determine phytochemical analysis and the total phenol contents of the leaves of Paederiafoetida, Clerodendrumsiphonanthes and Blumeopsisflava. Leave extract were prepared with methanol by Soxhlet apparatus. Total phenolic contents were determined by Folin-Ciocalteus reagent method.  Alkaloid, phenol, flavonoid, terpenoid, glycoside, saponin and steroid were detected in Paederiafoetida but high concentration in terpenoid and steroid.  Saponin was absent inBlumeopsisflava. Steroid was also not found in Blumeopsisflava and Clerodendrumsiphonanthes. The  total  phenolic contents  of  the methanol  e¬xtract  of P. foetida, C. siphonanthes and B. flava  in terms of Gallic acid  equivalent were 138.33 ± 6.41, 131.67 ± 5.77 and 71.25 ± 7.60 mg/g  of  extract   respectively.  Paederiafoetida   exhibited highest total phenolic contents then followed by C. siphonanthes and B. flava. It is evident that Paederiafoetidahas highest therapeutic efficacy. The present study indicates that these plants are of therapeutic potential due to the presence of various phytochemicals.

scholarly journals Alkaloids from the Roots and Leaves of Stichoneuron halabalensis and their Acetylcholinesterase Inhibitory Activities

2013 ◽  
Vol 8 (6) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Rosdayati Alino Ramli ◽  
Wilford Lie ◽  
Stephen G. Pyne
Keyword(s):  
Inhibitory Activity ◽  
Spectroscopic Data ◽  
Electric Eel ◽  
Inhibitory Activities ◽  
Stemona Alkaloids

A study of the hitherto unreported Stichoneuron halabalensis Inthachub led to the characterization of the known compounds (+)-α-tocopherol and ( R)-(+)-goniothalamin; four known Stemona alkaloids, bisdehydoxystemoninine A (1), stemoninine (2), sessilistemonamine C (3) and sessilistemonamine A (4); and three new alkaloids, stichoneurine C (5), D (6) and E (7). The structures of these compounds were determined on the basis of their spectroscopic data. Alkaloid 7 showed significant inhibitory activity against electric eel acetylcholinesterase (AChE) (IC50 5.90±0.084 μM), while goniothalamin and compounds 1 and 2 showed significant inhibitory activities against human AChE (IC50 7.24±0.52, 5.52±0.13 and 3.74±0.09 μM, respectively).

scholarly journals Bioactive Aporphine Alkaloids from the Roots of Artabotrys spinosus: Cholinesterase Inhibitory Activity and Molecular Docking Studies

2018 ◽  
Vol 13 (10) ◽  
pp. 1934578X1801301
Author(s):  
Jirapast Sichaem ◽  
Santi Tip-pyang ◽  
Kiattisak Lugsanangarm
Keyword(s):  
Molecular Docking ◽  
Inhibitory Activity ◽  
Mixed Mode ◽  
Docking Studies ◽  
Experimental Results ◽  
Docking Analysis ◽  
Molecular Docking Studies ◽  
Cholinesterase Inhibitory Activity ◽  
Inhibitory Activities ◽  
Molecular Docking Analysis

Six aporphine alkaloids (1–6) were isolated from Artabotrys spinosus roots based on bioassay-guided fraction and chromatographic methods. All isolated alkaloids were evaluated for their cholinesterase (ChEs) inhibitory activities, in which compounds 4 and 6 exhibited the highest activity toward butyrylcholinesterase (BChE) and acetylcholinesterase (AChE), respectively. The Lineweaver-Burk plots suggested that 4 and 6 were mixed mode inhibitors toward BChE and AChE enzymes, respectively. In addition, the experimental results were also confirmed by molecular docking analysis. This information can help in designing a new inhibitor in the class of aporphine alkaloids in against Alzheimer's disease.

scholarly journals Preliminary phytochemical screening of Iris kashmiriana Baker collected from Budgam, Kashmir, India

2019 ◽  
Vol 9 (1-s) ◽  
pp. 121-124
Author(s):  
Saeema JouFarooqnal ◽  
Roohi Mohi-ud-din ◽  
Zulfiqar Ali Bhat
Keyword(s):  
Secondary Metabolites ◽  
Bioactive Compounds ◽  
Cardiac Glycosides ◽  
Rich Source ◽  
Phytochemical Analysis ◽  
Aqueous Extracts ◽  
Phytochemical Screening ◽  
Isolation And Characterization

The present study was intended to discover the preliminary phytochemicals of Iris kashmiriana Baker collected from Kashmir region, India. The preliminary phytochemical analysis was conducted in methanolic and aqueous extracts which showed the presence of carbohydrates, tannins, flavonoids, phenols, phytosterols, saponins, diterpenes, cardiac glycosides. Among the various phytochemicals studied, alkaloids and proteins were found to be absent in both methanolic and aqueous extracts. From the results, it was noted that the extracts of Iris kashmiriana Baker was found to be a rich source of variety of active secondary metabolites. This report will lead to the further isolation and characterization of these active secondary metabolites for bioefficacy and bioactivity. Keywords: Phytochemical, Bioactive compounds, Iris kashmiriana, Mazar mund, Kashmir.

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