scholarly journals Synthesis of Monodisperse Iron Oxide Nanoparticles without Surfactants

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Xiao-Chen Yang ◽  
Yun-Long Shang ◽  
Yin-Hua Li ◽  
Jing Zhai ◽  
Neil R. Foster ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Metal Salts ◽  
Precipitation Method ◽  
Oxide Nanoparticles ◽  
Simple Method ◽  
Ph Values ◽  
Monodisperse Nanoparticles ◽  
Average Size ◽  
Tunable Morphology

Monodisperse iron oxide nanoparticles could be successfully synthesized with two kinds of precipitants through a precipitation method. As-prepared nanoparticles in the size around 10 nm with regular spherical-like shape were achieved by adjusting pH values. NaOH and NH3·H2O were used as two precipitants for comparison. The average size of nanoparticles with NH3·H2O precipitant got smaller and represented better dispersibility, while nanoparticles with NaOH precipitant represented better magnetic property. This work provided a simple method without using any organic solvents, organic metal salts, or surfactants which could easily obtain monodisperse nanoparticles with tunable morphology.

scholarly journals Synthesis and Characterization of Dextran coated Iron Oxide Nanoparticles as a T1 Contrast Agent

2021 ◽  
Vol 2114 (1) ◽  
pp. 012037
Author(s):  
Z Ra’ad ◽  
L Q Al-Karam ◽  
N K Abid Alsahib
Keyword(s):  
Iron Oxide ◽  
Contrast Agent ◽  
Contrast Enhancement ◽  
Iron Oxide Nanoparticles ◽  
Precipitation Method ◽  
Oxide Nanoparticles ◽  
Ph Values ◽  
T1 Contrast Agent ◽  
T1 Contrast ◽  
Co Precipitation

Abstract This is a second part of iron oxide nanoparticles synthesis by co-precipitation method with various PH values. This study includes stabilizing iron oxide nanoparticles with dextran of molecular weight 10000 Da by aqueous route, then study its characteristics with AFM, FTIR and VSM also using the stabilized material as a contrast agent in T1-weighted image then compare the contrast enhancement with gadolinium based commercially available contrast agent (MagnevistTM). Ph values were (7,11,14), all samples were injected to mice bodies then imaged with MRI best result of T1 contrast enhancement was obtained from sample with Ph 14 compared with gadolinium-based T1 contrast agent with no toxic effects.

scholarly journals Macrophage-Laden Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Enhanced Dual-Mode CT/MR Imaging of Tumors

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 995
Author(s):  
Yucheng Peng ◽  
Xiaomeng Wang ◽  
Yue Wang ◽  
Yue Gao ◽  
Rui Guo ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Colloidal Stability ◽  
Pamam Dendrimer ◽  
Great Promise ◽  
Oxide Nanoparticles ◽  
Dual Mode ◽  
Gold Nanoflowers ◽  
Average Size

The design of multimodal imaging nanoplatforms with improved tumor accumulation represents a major trend in the current development of precision nanomedicine. To this end, we report herein the preparation of macrophage (MA)-laden gold nanoflowers (NFs) embedded with ultrasmall iron oxide nanoparticles (USIO NPs) for enhanced dual-mode computed tomography (CT) and magnetic resonance (MR) imaging of tumors. In this work, generation 5 poly(amidoamine) (G5 PAMAM) dendrimer-stabilized gold (Au) NPs were conjugated with sodium citrate-stabilized USIO NPs to form hybrid seed particles for the subsequent growth of Au nanoflowers (NFs). Afterwards, the remaining terminal amines of dendrimers were acetylated to form the dendrimer-stabilized Fe3O4/Au NFs (for short, Fe3O4/Au DSNFs). The acquired Fe3O4/Au DSNFs possess an average size around 90 nm, display a high r1 relaxivity (1.22 mM−1 s−1), and exhibit good colloidal stability and cytocompatibility. The created hybrid DSNFs can be loaded within MAs without producing any toxicity to the cells. Through the mediation of MAs with a tumor homing and immune evasion property, the Fe3O4/Au DSNFs can be delivered to tumors more efficiently than those without MAs after intravenous injection, thus significantly improving the MR/CT imaging performance of tumors. The developed MA-mediated delivery system may hold great promise for enhanced tumor delivery of other contrast agents or nanomedicines for precision cancer nanomedicine applications.

scholarly journals Preparation and Characterization of Polyethylene Glycol Coating Iron Oxide Nanoparticles for Curcumin Delivery

2019 ◽  
Vol 31 (8) ◽  
pp. 1719-1723
Author(s):  
Nguyen Thi Thanh Thuy ◽  
Le Duc Anh ◽  
Nguyen Huu Tri ◽  
Cu Van Hoang ◽  
Nguyen Anh Nhut
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Sonication Time ◽  
X Ray Diffraction ◽  
Target Drug Delivery ◽  
Target Drug ◽  
Fe3o4 Nps ◽  
Average Size

The PEG-coated iron oxide nanoparticles (Fe3O4 NPs-PEG) was synthesized by coprecipitation and ultrasonication method. X-ray diffraction results exhibited that the average size of Fe3O4 NPs-PEG was 19.10 nm, which was further confirmed in TEM imaging. In addition, sonication time and curcumin concentration were studied to evaluate the efficiency of loading curcumin onto Fe3O4 NPs-PEG. Further, statistical optimization using response surface methodology (RSM) has shown curcumin concentration (0,01% w/v) and sonication time (21 min) for maximal curcumin loading (0.37 mg/g). Along with the magnetization studies, the immobilization of curcumin onto the Fe3O4 NPs-PEG was characterized by UV, FTIR and SEM. The results showed that the curcumin loaded PEG coated iron oxide nanoparticles could potentially be used for magnetically target drug delivery.

Sonochemical Synthesis of Silica Coated Super Paramagnetic Iron Oxide Nanoparticles

2013 ◽  
Vol 756 ◽  
pp. 74-79 ◽  
Author(s):  
Bashiru Kayode Sodipo ◽  
Azlan Abdul Aziz
Keyword(s):  
Iron Oxide ◽  
Silica Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Ph Value ◽  
Superparamagnetic Iron Oxide ◽  
Silica Nanoparticle ◽  
Precipitation Method ◽  
Oxide Nanoparticles ◽  
Sonochemical Method ◽  
Co Precipitation

Superparamagnetic iron oxide nanoparticles (SPION) of sizes 5 to10 nm were synthesized by the co-precipitation method. They are coated with silica nanoparticles using sonication method. The SPION was produced under the optimum pH of 10, peptized in acidic medium and redispersed in water. The silica nanoparticles were produced through the Stöbermethod. Sonochemical coating of silica nanoparticle on the SPION was successfulat a pH value lower than 5. Otherwise, at higher pH value (but lower than point zero charge (PZC)), the SPION were found to be unstable. Fast hydrolysis of triethoxyvinylsilane(TEVS) shows that silica forms its own particles without coating onto the surfaces of the SPION. Under optimized experimental condition, sonochemical method of coating silica nanoparticles onto the SPION can be considered as an alternative for effective and prompt method that rely mainly on pH of the suspension.

Antibacterial efficacy of Ocimum sanctum leaf extract-treated iron oxide nanoparticles

2017 ◽  
Vol 41 (5) ◽  
pp. 2055-2061 ◽  
Author(s):  
Tokeer Ahmad ◽  
Ruby Phul ◽  
Nafeesa Khatoon ◽  
Meryam Sardar
Keyword(s):  
Antibacterial Activity ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Leaf Extract ◽  
Precipitation Method ◽  
Ocimum Sanctum ◽  
Oxide Nanoparticles ◽  
Antibacterial Efficacy ◽  
Co Precipitation

Iron oxide nanoparticles (IONPs) were preparedviaa co-precipitation method and were then characterized and evaluated for their antibacterial activity after modification withOcimum sanctumleaf extract.

ß-Amido Acid Functionalised Superparamagnetic Iron Oxide Nanoparticles as a Novel Carrier for Efficient Delivery of Doxorubicine

2017 ◽  
Vol 41 (3) ◽  
pp. 129-135
Author(s):  
Fatemeh Ebrahimi ◽  
Maryam Karimi ◽  
Hasan Sereshti ◽  
Mohsen Yousefifar
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Precipitation Method ◽  
Hydrodynamic Diameter ◽  
Oxide Nanoparticles ◽  
Amido Acid

Superparamagnetic iron oxide nanoparticles are increasingly used in medical applications due to their unique physical properties. They are useful carriers for delivering antitumour drugs in targeted cancer treatment. In this study, amido acid-functionalised magnetic nanoparticles (AAFMNs) are used as drug-delivery vehicles for doxorubicine as an efficient tool for the treatment of cancer. Magnetic iron oxide nanoparticles were synthesised using a co-precipitation method. The prepared iron oxide nanoparticles were then functionalised with amido acid functional groups. Finally, the synthesised AAFMNs were used for the delivery of doxorubicine. AAFMNs were characterised by Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis and zeta potential. An in vitro-determined hydrodynamic diameter of ∼80 nm suggested their applicability for this purpose. The findings show that AAFMNs are a promising tool for potential magnetic drug delivery.

The Effect of Oxygen Precursor Concentration to the Iron Oxide Nanoparticles Properties for Lateral Flow Immunoassay Application

2014 ◽  
Vol 1024 ◽  
pp. 277-280
Author(s):  
Mohamad Nor Noorhashimah ◽  
Khairunisak Abdul Razak ◽  
Rahmah Noordin
Keyword(s):  
Growth Rate ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Measurement ◽  
Lateral Flow ◽  
Precipitation Method ◽  
Lateral Flow Immunoassay ◽  
Oxide Nanoparticles ◽  
Polyethelene Glycol ◽  
Effect Of Oxygen

In this study, the influence of hydrogen peroxide (H2O2) concentration to the iron oxide nanoparticles (IONPs) properties prepared using the precipitation method was investigated. The H2O2concentration was varied from 0.85 M to 5.1 M. The concentration of H2O2influenced the crystallinity and the growth rate of the IONPs precipitates. Increasing the concentration of H2O2increased the crystallinity and expedited the growth rate of IONPs. The optimum concentration of H2O2was 1.7 M. From the transmission electron microscopy (TEM) images, the size of IONPs obtained was ~14 nm and the X-ray diffraction (XRD) spectra showed the presence of spinel cubic lattice of maghemite (γ-Fe2O3). The magnetic measurement of IONPs using vibrating sample magnetometer (VSM) was showed that the IONPs exhibited superparamagnetic properties. Furthermore, the electrostatic repulsion using percloric acid (HClO4) and steric stabilization using silane polyethelene glycol (SiPEG) were created surround IONPs in order to obtain a stable colloidal IONPs for the conjugation process. The stable IONPs were then conjugated to the antibody and tested in the lateral flow immunoassay as the labelling agent.

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