scholarly journals IVIG Effects on Erythrocyte Sedimentation Rate in Children

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Farhad Salehzadeh ◽  
Ahmadvand Noshin ◽  
Sepideh Jahangiri

Background. Erythrocyte sedimentation rate (ESR) is a valuable laboratory tool in evaluation of infectious, inflammatory, and malignant diseases. Red blood cells in outside from the body precipitate due to their higher density than the plasma. In this study we discuss the IVIG effect on ESR in different diseases and different ages.Methods and Materials. Fifty patients under 12 years old who had indication to receive IVIG enrolled in this study. Total dose of IVIG was 2 gr/kg (400 mg/kg in five days or 2 gr/kg in single dose). ESR before infusion of IVIG and within 24 hours after administration of the last dose of IVIG was checked.Results. 23 (46%) patients were males and 27 (54%) were females. The mean of ESR before IVIG was31.8±29.04and after IVIG it was47.2±36.9; this difference was meaningful(P=0.05). Results of ESR changes in different age groups, 6 patients less than 28 days, 13 patients from 1 month to 1 year, 20 patients from 1 to 6 years old, and 11 patients from 6 to 12 years have been meaningful (P=0.001,P=0.025, andP=0.006, resp.).Conclusion. In patients who are receiving IVIG as a therapy, ESR increased falsely (noninflammatory rising); therefore use of ESR for monitoring of response to treatment may be unreliable. Although these results do not apply to neonatal group, we suggest that, in patients who received IVIG, interpretation of ESR should be used cautiously on followup.

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S80-S80
Author(s):  
Constance Nwadike ◽  
Amarachi Nwakamma ◽  
Harrison Nwanjo ◽  
Denis Nwosu ◽  
Roy Ezekwe

Abstract Objectives The evidence supporting the role of circulating markers of inflammation in the pathogenesis of atria fibrillation remains controversial. This study investigated the levels of serum lipids, C-reactive proteins, erythrocyte sedimentation rate, prothrombin time, and platelet count in subjects with new-onset atria fibrillation (NAF), but with no established cardiac disease, in a Nigerian community. Methods The case control study involved a total of 200 subjects: 110 subjects with NAF and 90 apparently healthy subjects without AF, as control. AF was confirmed by a 12-lead electrocardiogram (ECG), while excluding subjects with high risk. Blood samples from the subjects were analyzed for the following parameters: C-reactive proteins using ELISA method and serum lipids using an enzymatic, colorimetric method; erythrocyte sedimentation rate, by Westergreen method; platelet count using a Midray hematology auto analyzer; and the prothrombin time using a tissue thromboplastin method. Data collected from the result were analyzed using SPSS version 15. Results There was a significant increase in the levels of C-reactive proteins and ESR in subjects with NAF when compared with the control subjects. A significant increase was observed in the mean values of total cholesterol and low-density lipoproteins in subjects with NAF, while that of high-density lipoproteins was lower in NAF than in controls. There was no significant difference in the mean values of triglyceride in NAF and the control. Results also showed significantly reduced prothrombin time, with more platelet count in subjects with NAF. The result demonstrated that females (56.3%) had greater risk of developing AF than males (45.8%), while incidence of AF was observed to increase with age. Conclusion The results of the markers assayed suggest marked dyslipidemia, inflammation, and thrombogenesis in subjects with new-onset AF. Hence dyslipidemia and inflammation play critical roles in the pathogenesis of atria fibrillation.


2020 ◽  
Author(s):  
Zegeye Getaneh ◽  
Fekadu Ayelgn ◽  
Geletaw Asemahegn ◽  
Habtamu Geleta ◽  
Aregawi Yalew ◽  
...  

Abstract Objective: The purpose of this study was comparing the erythrocyte sedimentation rate (ESR) results of trisodium citrate (TSC) and ethylene diamine tetra-acetic acid (EDTA) anticoagulants. A comparative cross-sectional study was conducted at the University of Gondar specialized referral hospital, northwest, Ethiopia. A total of 70 TB presumptive participants were recruited. From each of the 70 participants of the study, 3 and 1.6 ml of blood was collected in EDTA tubes and 0.4 ml of trisodium Citrate anticoagulant containing test tubes, respectively. Results: The mean ± SD values of ESR were 57.9 ± 41.45 mm/hr in EDTA and 50.99 ± 43.5 mm/hr in TSC anticoagulated blood. The mean difference of ESR values between EDTA and TSC blood (6.91 ± 13.66 mm/hr) was statistically significant. The Mean ± SD of ESR values using EDTA and TSC in males were 59.57 ± 42.31 and 53.57 ± 44.61 mm/hr while for females it was 54.71±40.44 and 46.04 ± 41.82 mm/hr, respectively. The study indicated that there was a significant difference between ESR values with EDTA and tri-sodium citrate anticoagulants. Keywords: Erythrocyte sedimentation rate, EDTA, Tri-sodium citrate, Westergren Method, Comparison


Author(s):  
Sruthy Raphel

Erythrocyte sedimentation rate (ESR) is the rate at which RBC sediment in a period of 1 hr. It is a common Haematology test that is a non-specific measure of inflammation and it became a common screening test worldwide for acute phase proteins and chronic diseases. The International Council for Standardization in Haematology (ICSH) recommended the Westergren method as the method of choice for ESR determination. TSC is almost exclusively used as the diluent of choice for setting up ESR, but some contemporary laboratories have resolved to use Normal saline (NS) as the diluent of choice while other set ESR using EDTA anticoagulated Blood (BLD) without any diluent. The objective of this study is to assess the comparison between saline diluted and undiluted EDTA with TSC as an anticoagulant in ESR detection and to find out any gender wise variations by using these anticoagulants. A total of 50 students were participated in this study. From each of the participants 5 ml of BLD was collected and it is then divided into 3 parts. 1.6 ml BLD to 0.4ml 3.8% TSC tube, 1.6 ml EDTA blood to 0.4 ml NS tube. 3rd tube with 2 ml EDTA BLD and set for ESR and obtained result within 1 hour. The Result is the mean +SD value of ESR were 19.48+5.7 mm/hr. in undiluted EDTA, 15.22+4.6 mm/hr. in saline diluted EDTA & 15.36+4.5 mm/hr. in TSC. The mean difference of ESR value between saline diluted EDTA with TSC BLD was 0 and it with undiluted EDTA was 4 mm /hr. The study indicates that there was a significant difference between ESR value with undiluted EDTA and TSC while diluted EDTA and TSC were there is no significant difference. The mean +SD of ESR value using undiluted, diluted EDTA and TSC in males were 16.20+3.3, 11.05+2.8, 11.29+2.6 and while it for females were 21.69+5.2, 17.36+3.8, 17.45+3.8 respectively. In conclusion, TSC is the best diluent to be used in contemporary lab to set ESR as compared to EDTA BLD. But we can use saline diluted EDTA as an alternative to citrate diluted BLD to set ESR and it also showed there is a gender wise variation in ESR using these anticoagulants.


2020 ◽  
Vol 19 (S2) ◽  
pp. 96-102
Author(s):  
E Grabovskaya ◽  
T Lyalina ◽  
N Tarabrina

Aim. The purpose of the article is to study the impact of low-intensity electromagnetic radiation of quantum and micro-vibration effect on nonspecific adaptive reactions and the blood system of wrestlers. Materials and methods. Athletes of the first category or those having master of sport title with at least a five-year experience aged 18–22 years participated in the study. All participants underwent a course of therapy with low-intensity electromagnetic radiation of quantum and micro-vibration effect. The exposure was performed on a daily basis according to the principle ‘one day – one exposure zone’. The course consisted of 10 procedures. Non-specific adaptive reactions of the body, some morphological indicators of red blood, leukogram, erythrocyte sedimentation rate were determined. Mathematical and statistical processing of the data obtained was carried out. Results. It was revealed that low-intensity electromagnetic radiation of quantum and micro-vibration effect improved and stabilized the blood system and nonspecific adaptive reactions of the body. Conclusion. The course treatment with low-intensity electromagnetic radiation of quantum and micro-vibration effect contributes to the redistribution of nonspecific adaptive reactions of the body with an increase in training reactions, calm and increased activation. An increase in the average concentration of hemoglobin in erythrocytes, a slight decrease in hematocrit, a change in the composition of leukogram, and a decrease in the erythrocyte sedimentation rate were registered.


2020 ◽  
Vol 7 (1) ◽  
pp. 34
Author(s):  
Aini Aini Aini ◽  
Nurmawan Nurmawan ◽  
Jumari Ustiawaty

Tuberculosis is a disease caused by rod-shaped bacteria (basil) with another name Mycrobacterium tuberculosis. Mycrobacterium tuberculosis enters the body then causes inflammation, inflammation and bacterial invasion which then induces liver cells to synthesize acute phase C-reactive protein protein (CRP). CRP will increase sharply after inflammation, as well as the formation of aggregates derived from the acute phase protein hormone which causes an increase in the Erythrocyte sedimentation rate (ESR)). The purpose of this study was to determine the relationship Erytrocyte sedimentation rate (ESR) and levels of C-Reactiv protein (CRP) in tuberculosis (TBC) patients. This research is an analytical descriptive study using cross sectional. Data collectors are done using the Non Random Accidental Sampling technique. The number of respondents in this study were 11 people with tuberculosis. Based on the results of this study it is known that TBC patients with smear negative as much as 7 people (63.6%) and TB patients with positive smear as much as 4 people (36.4%), both in TB patients with negative smear and positive smear both have levels of ESR not normal with an average ESR level in positive smear of 101.3 mm / hour and the average ESR level in smear negative is 20.8 mm / hour. All TBC patients with smear positive CRP levels (not normal) with an average mean value of CRP of 36 mg / L or an average CRP level in TBC smear negative patients of 0.9 mg / L. Based on the Pearson test results between levels of erythrocyte sedimentation rate (ESR) with C-Reactive protein (CRP) in tuberculosis (TBC) patients obtained a value of p <0.01 (0.000 <0.01). This shows a strong relationship between LED and CRP levels in TB patients


2019 ◽  
Author(s):  
Zegeye Getaneh ◽  
Fekadu Ayelgn ◽  
Geletaw Asemahegn ◽  
Habtamu Geleta ◽  
Aregawi Yalew ◽  
...  

Abstract Objective: The purpose of this study was comparison of erythrocyte sedimentation rate results of sodium citrate and ethylene diamine tetra-acetic acid anticoagulant. A comparative cross-sectional study was conducted at University of Gondar Referral Hospital, Northwest, Ethiopia. A total of 70 TB suspected study participants were recruited. From each study participants, 3ml blood was collected in to EDTA tube and 1.6ml blood was collected in to a test tube containing 0.4ml Sodium Citrate anticoagulant. Results: The mean ± SD values for ESR were 57.9 ± 41.45 in EDTA and 50.99 ± 43.5 in citrate anticoagulated blood. The mean difference of ESR values between EDTA and citrated blood was 6.91 ± 13.66 mm/hr with a significant difference. The mean ± SD of ESR for EDTA and citrate blood was 59.57 ± 42.31 and 54.71 ± 40.44 mm/hr for males and 53.57 ± 44.61 and 46.04 ± 41.82 mm/hr for females, respectively. This study indicated that there was a significant difference between ESR values with EDTA and tri-sodium citrate anticoagulants.


2020 ◽  
Author(s):  
Zegeye Getaneh ◽  
Fekadu Ayelgn ◽  
Geletaw Asemahegn ◽  
Habtamu Geleta ◽  
Aregawi Yalew ◽  
...  

Abstract Objective: The purpose of this study was comparing the erythrocyte sedimentation rate (ESR) results of trisodium citrate (TSC) and ethylene diamine tetra-acetic acid (EDTA) anticoagulants. A comparative cross-sectional study was conducted at the University of Gondar specialized referral hospital, northwest, Ethiopia. A total of 70 TB presumptive participants were recruited. From each of the 70 participants of the study, 3 and 1.6 ml of blood was collected in EDTA tubes and 0.4 ml of trisodium Citrate anticoagulant containing test tubes, respectively. Results: The mean ± SD values of ESR were 57.9 ± 41.45 mm/hr in EDTA and 50.99 ± 43.5 mm/hr in TSC anticoagulated blood. The mean difference of ESR values between EDTA and TSC blood (6.91 ± 13.66 mm/hr) was statistically significant. The Mean ± SD of ESR values using EDTA and TSC in males were 59.57 ± 42.31 and 53.57 ± 44.61 mm/hr while for females it was 54.71±40.44 and 46.04 ± 41.82 mm/hr, respectively. The study indicated that there was a significant difference between ESR values with EDTA and tri-sodium citrate anticoagulants. Keywords: Erythrocyte sedimentation rate, EDTA, Tri-sodium citrate, Westergren Method, Comparison


2021 ◽  
Vol 12 (7) ◽  
pp. 5-9
Author(s):  
Aslıhan Dilara Demir ◽  
Zeynep Hulya Durmaz

Background: Covid-19 infectious disease becomes a pandemic and later affects the entire world it has various effects in different age groups. Aims and Objective: In our study, we aimed to investigate the distribution of biochemical tests along with age, and the incidence in different age groups under the age of 65 and over the age of 65. Materials and Methods: We planned a retrospective study. Our patients consist of 2 groups. The first group consists of 54 patients aged 18 to 65 years, and the second group consists of 38 patients aged 65 years andolder. Previously analyzed biochemical parameter values (such as lymphocyte, neutrophil, hemoglobin, platelet, CRP, LDH, AST, ALT, D-dimer, BUN, creatinine) of all patients followed up in our hospital were reached retrospectively through the hospital database. Results: There was a strong negative correlation between Alb and CRP, D-Dimer and albumin, neutrophil and albumin in patients under 65 years of age. A positive correlation was observed between other parameters. Negative moderate correlations were found between albumin and CRP, Potassium and age, WBC and albumin, hemoglobin and creatinine, hemoglobin and LDH, platelets and hemoglobin, lymphocytes and age, lymphocytes and prothrombin time, lymphocytes and D-Dimer, neutrophils and albumin, fibrinogen and creatine kinase, erythrocyte sedimentation rate and AST, erythrocyte sedimentation rate and ALT, erythrocyte sedimentation rate and hemoglobin in patients over 65 years of age. Positive correlations were detected between other parameters. Conclusion: ALT, creatinine, CRP, LDH, D-Dimer, WBC, neutrophil, erythrocyte sedimentation rate was significantly higher in patients over 65 years of age than in patients under 65 years of age. Platelet, lymphocytes were statistically significantly higher in patients under 65 than in patients over 65.


2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Serpil Erdogan ◽  
Ridvan Firat ◽  
Gamze Avcioglu ◽  
Gulsen Yilmaz ◽  
Ozcan Erel ◽  
...  

Abstract Objectives As one of the most widely used tests, the erythrocyte sedimentation rate (ESR) is a measurement of sedimentation reaction in blood samples. Although the recommended method for ESR measurement is the Westergren method, this method has some disadvantages in comparison with automated ESR systems. In this cross-sectional study, we aimed to compare Vision c with the Westergren method. Methods The Vision c automated ESR system and the modified Westergren method were compared using K3EDTA-containing tubes and citrated blood tubes from randomly selected 100 patients. Precision, bias, and interference calculations were performed. Results The mean difference between the Vision c (room temperature) and the modified Westergren method was 22.8 ± 26.6 mm/h (95% CI for the mean was 17.50–28.08 mm/h). The mean difference between the Vision c (18 °C) and the modified Westergren method was 27.4 ± 30.6 mm/h (95% CI for the mean was 21.3–33.5 mm/h). The calculated regression analysis equation was “y= 0.263 + 1.053x” and “y= −0.530 + 0.851x” for the Vision c (room temperature) and the Vision c (18 °C), respectively. The imprecision values ranged at 7.55–17.09%. According to our external quality control results, bias was 11.11 and 9.66 for the low- and high-level samples, respectively. Conclusions The Vision c automated ESR system has a comparable analytical performance with the modified Westergren method. The Vision c automated system may be utilized in ESR measurements with quality control evaluations. Nevertheless, temperature correction using Manley’s monogram causes an important negative bias and should be taken into consideration during the evaluation of the Vision c results.


2019 ◽  
Author(s):  
Zegeye Getaneh ◽  
Fekadu Ayelgn ◽  
Geletaw Asemahegn ◽  
Habtamu Geleta ◽  
Aregawi Yalew ◽  
...  

Abstract Objective: The main aim of this study was comparison of erythrocyte sedimentation rate results of sodium citrate and ethylene diamine tetra-acetic acid anticoagulant. A comparative cross-sectional study was conducted at University of Gondar Referral Hospital, Northwest, Ethiopia. A total of 70 TB suspected study participants were recruited. From each study participants, 3ml blood was collected in to EDTA tube and 1.6ml blood was collected in to a test tube containing 0.4ml Sodium Citrate anticoagulant. Results: The mean ± SD values for ESR were 57.9 ± 41.45 in EDTA and 50.99 ± 43.5 in citrate anticoagulated blood. The mean difference of ESR values between EDTA and citrated blood was 6.91 ± 13.66 mm/hr with a significant difference. The mean ± SD of ESR for EDTA and citrate blood was 59.57 ± 42.31 and 54.71 ± 40.44 mm/hr for males and 53.57 ± 44.61 and 46.04 ± 41.82 mm/hr for females, respectively. This study indicated that there was a significant difference between ESR values with EDTA and tri-sodium citrate anticoagulants.


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