scholarly journals Efficient and Rapid Detection ofSalmonellaUsing Microfluidic Impedance Based Sensing

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Shibajyoti Ghosh Dastider ◽  
Syed Barizuddin ◽  
Nuh S. Yuksek ◽  
Majed Dweik ◽  
Mahmoud F. Almasri
Keyword(s):  
Salmonella Typhimurium ◽  
Low Cost ◽  
Electrode Array ◽  
Interdigitated Electrode ◽  
Qualitative And Quantitative ◽  
Impedance Response ◽  
Lower Detection ◽  
Microfluidic Biosensor ◽  
Increased Sensitivity ◽  
Quantitative Results

We present a low cost, easy to fabricate biosensor, which can quickly and accurately detectSalmonella typhimurium. This study also compares the advantages of the microfluidic biosensor over a nonmicrofluidic biosensor. High density interdigitated electrode array was used to detectSalmonellacells inside a microfluidic chip. Monoclonal anti-Salmonellaantibodies were allowed to be immobilized on the surface of the electrode array for selective detection ofSalmonella typhimurium. An impedance analyzer was used to measure and record the response signal from the biosensor. The biosensor provides qualitative and quantitative results in 3 hours without any enrichment steps. The microfluidic biosensor’s lower detection limit was found to be3×103 CFU/mL compared to the3×104 CFU/mL of the nonmicrofluidic biosensor, which shows that the microfluidic biosensor has 10-fold increased sensitivity. The impedance response of microfluidic biosensor was also significantly higher (2 to 2.9 times) compared to the nonmicrofluidic biosensor.

The Effects of Therapy with Oestriol Succinate and Ethinyl Oestradiol on the Haemostatic Mechanism in Post-Menopausal Women

1976 ◽  
Vol 35 (02) ◽  
pp. 403-414 ◽  
Author(s):  
Terence Davies ◽  
Gillian Fieldhouse ◽  
George P. McNicol
Keyword(s):  
Coagulation Factors ◽  
Factor Vii ◽  
Oestrogen Therapy ◽  
Qualitative And Quantitative ◽  
Lysis Activity ◽  
Menopausal Women ◽  
Increased Sensitivity ◽  
Post Menopausal ◽  
Incremental Increase ◽  
Ethinyl Oestradiol

SummaryThe effects on the haemostatic mechanism of oestrogen therapy, given to prevent bone loss in post-menopausal women, have been investigated. Oestriol succinate was given orally to 10 women at a level of 2 mg/day for 1 month and for a further 3 months with incremental increase of 2 mg each month. 6 of the 10 women were subsequently treated with 25 μg/day orally of ethinyl oestradiol. Oestriol succinate therapy resulted in a small increase in the level of factor VII, a decrease in factor VIII concentration and increased sensitivity of platelets to aggregating agents. Ethinyl oestradiol treatment resulted in much more widespread changes with marked increases in coagulation factors VII, VIII, IX and X, decreased levels of antithrombin and dramatic increases in circulating plasminogen levels and euglobulin lysis activity. The data suggested that the nature of oestrogens employed therapeutically is important in determining the qualitative and quantitative effect of oestrogen therapy on components of the haemostatic mechanism.

scholarly journals Smart Collaborative Performance-Induced Parameter Identification Algorithms for Synchronous Reluctance Machine Magnetic Model

2021 ◽  
Vol 13 (8) ◽  
pp. 4379
Author(s):  
Linjie Ren ◽  
Guobin Lin ◽  
Yuanzhe Zhao ◽  
Zhiming Liao
Keyword(s):  
Low Cost ◽  
Parameter Extraction ◽  
Synchronous Reluctance Machine ◽  
Fitness Evaluation ◽  
Reluctance Machine ◽  
Candidate Solution ◽  
Collaborative Performance ◽  
Magnetic Model ◽  
Quantitative Results ◽  
Cost Characteristics

In rail transit traction, due to the remarkable energy-saving and low-cost characteristics, synchronous reluctance motors (SynRM) may be a potential substitute for traditional AC motors. However, in the parameter extraction of SynRM nonlinear magnetic model, the accuracy and robustness of the metaheuristic algorithm is restricted by the excessive dependence on fitness evaluation. In this paper, a novel probability-driven smart collaborative performance (SCP) is defined to quantify the comprehensive contribution of candidate solution in current population. With the quantitative results of SCP as feedback in-formation, an algorithm updating mechanism with improved evolutionary quality is established. The allocation of computing resources induced by SCP achieves a good balance between exploration and exploitation. Comprehensive experiment results demonstrate better effectiveness of SCP-induced algorithms to the proposed synchronous reluctance machine magnetic model. Accuracy and robustness of the proposed algorithms are ranked first in the comparison result statistics with other well-known algorithms.

scholarly journals Affective communication: a mixed method investigation into COVID-19 outbreak communication using the Taiwanese government Facebook page

2021 ◽  
pp. 175797592110035
Author(s):  
Chia Yu Lien ◽  
Yun-Hsuan Wu
Keyword(s):  
Social Media ◽  
Mixed Method ◽  
Health Authority ◽  
Disease Outbreak ◽  
Government Agencies ◽  
Affective Communication ◽  
Frontline Workers ◽  
The Public ◽  
Qualitative And Quantitative ◽  
Quantitative Results

The COVID-19 outbreak has created an unprecedented challenge for governments to convey information to the public, and social media has become a critical method of COVID-19 communication in Taiwan. Objectives: This study examines a total of 1128 Facebook posts published by Taiwan’s principal health authority from December 1, 2019 to May 31, 2020. Methods: Using both qualitative and quantitative approaches, this study investigates strategies used by the Taiwan government to communicate the COVID-19 outbreak and public responses toward these strategies. Result: Novel uses of Facebook posts on outbreak communication were identified, including solidarity, reviews of actions, press conferences, and the use of animal and cartoon images. Quantitative results showed that the public responded significantly more frequently to messages generating positive affects, such as posts that reviewed government actions and public efforts; posts that expressed thanks, approval, or comradeship; and posts that paired text with photographs of frontline workers or cute animals. Conclusion: These results suggest that, amid a disease outbreak, the public not only look for updated situations and guidelines but also for affective affirmation from government agencies.

scholarly journals H2S-Sensing Studies Using Interdigitated Electrode with Spin-Coated Carbon Aerogel-Polyaniline Composites

Polymers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1457
Author(s):  
Aamna Bibi ◽  
Yuola Rose M. Rubio ◽  
Karen S. Santiago ◽  
His-Wei Jia ◽  
Mahmoud M. M. Ahmed ◽  
...  
Keyword(s):  
Gas Sensing ◽  
Carbon Aerogel ◽  
Average Response Time ◽  
Interdigitated Electrode ◽  
Gas Sensing Properties ◽  
Increased Sensitivity ◽  
Good Repeatability ◽  
Polyaniline Composites ◽  
Coated Carbon ◽  
Better Than

In this paper, carbon aerogel (CA)-polyaniline (PANI) composites were prepared and first applied in the study of H2S gas sensing. Here, 1 and 3 wt% of as-obtained CA powder were blended with PANI to produce composites, which are denoted by PANI-CA-1 and PANI-CA-3, respectively. For the H2S gas-sensing studies, the interdigitated electrode (IDE) was spin-coated by performing PANI and PANI-CA composite dispersion. The H2S gas-sensing properties were studied in terms of the sensor’s sensitivity, selectivity and repeatability. IDE coated with PANI-CA composites, as compared with pristine PANI, achieved higher sensor sensitivity, higher selectivity and good repeatability. Moreover, composites that contain higher loading of CA (e.g., 3 wt%) perform better than composites with lower loading of CA. At 1 ppm, PANI-CA-3 displayed increased sensitivity of 452% at relative humidity of 60% with a fast average response time of 1 s compared to PANI.

Multidirection Validation of a Finite Element 50th Percentile Male Hybrid III Anthropomorphic Test Device for Spaceflight Applications

2019 ◽  
Vol 141 (3) ◽  
Author(s):  
Derek A. Jones ◽  
James P. Gaewsky ◽  
Mona Saffarzadeh ◽  
Jacob B. Putnam ◽  
Ashley A. Weaver ◽  
...  
Keyword(s):  
Finite Element ◽  
Injury Risk ◽  
Fe Model ◽  
Fe Modeling ◽  
Test Device ◽  
Qualitative And Quantitative ◽  
Hybrid Iii ◽  
Physical Tests ◽  
Quantitative Results ◽  
Male Hybrid

The use of anthropomorphic test devices (ATDs) for calculating injury risk of occupants in spaceflight scenarios is crucial for ensuring the safety of crewmembers. Finite element (FE) modeling of ATDs reduces cost and time in the design process. The objective of this study was to validate a Hybrid III ATD FE model using a multidirection test matrix for future spaceflight configurations. Twenty-five Hybrid III physical tests were simulated using a 50th percentile male Hybrid III FE model. The sled acceleration pulses were approximately half-sine shaped, and can be described as a combination of peak acceleration and time to reach peak (rise time). The range of peak accelerations was 10–20 G, and the rise times were 30–110 ms. Test directions were frontal (−GX), rear (GX), vertical (GZ), and lateral (GY). Simulation responses were compared to physical tests using the correlation and analysis (CORA) method. Correlations were very good to excellent and the order of best average response by direction was −GX (0.916±0.054), GZ (0.841±0.117), GX (0.792±0.145), and finally GY (0.775±0.078). Qualitative and quantitative results demonstrated the model replicated the physical ATD well and can be used for future spaceflight configuration modeling and simulation.

Nonlinear Analysis of a Rigid Rotor on Magnetic Bearings

1995 ◽  
Author(s):  
C. Nataraj
Keyword(s):  
Nonlinear Analysis ◽  
Equations Of Motion ◽  
Forced Response ◽  
Magnetic Bearings ◽  
Rigid Rotor ◽  
Stability Criteria ◽  
Safe Operation ◽  
Qualitative And Quantitative ◽  
Quantitative Results ◽  
Nonlinear Equations Of Motion

A simple model of a rigid rotor supported on magnetic bearings is considered. A proportional control architecture is assumed, the nonlinear equations of motion are derived and some essential nondimensional parameters are identified. The free and forced response of the system is analyzed using techniques of nonlinear analysis. Both qualitative and quantitative results are obtained and stability criteria are derived for safe operation of the system.

scholarly journals An ultra-low-cost electroporator with microneedle electrodes (ePatch) for SARS-CoV-2 vaccination

2021 ◽  
Vol 118 (45) ◽  
pp. e2110817118
Author(s):  
Dengning Xia ◽  
Rui Jin ◽  
Gaurav Byagathvalli ◽  
Huan Yu ◽  
Ling Ye ◽  
...  
Keyword(s):  
Immune Responses ◽  
Large Scale ◽  
Low Cost ◽  
Electrode Array ◽  
Dna Vaccination ◽  
Intradermal Injection ◽  
Antibody Responses ◽  
Transient Effects ◽  
Electric Pulses ◽  
High Electric Field Strength

Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other pathogens with pandemic potential requires safe, protective, inexpensive, and easily accessible vaccines that can be developed and manufactured rapidly at a large scale. DNA vaccines can achieve these criteria, but induction of strong immune responses has often required bulky, expensive electroporation devices. Here, we report an ultra-low-cost (<1 USD), handheld (<50 g) electroporation system utilizing a microneedle electrode array (“ePatch”) for DNA vaccination against SARS-CoV-2. The low cost and small size are achieved by combining a thumb-operated piezoelectric pulser derived from a common household stove lighter that emits microsecond, bipolar, oscillatory electric pulses and a microneedle electrode array that targets delivery of high electric field strength pulses to the skin’s epidermis. Antibody responses against SARS-CoV-2 induced by this electroporation system in mice were strong and enabled at least 10-fold dose sparing compared to conventional intramuscular or intradermal injection of the DNA vaccine. Vaccination was well tolerated with mild, transient effects on the skin. This ePatch system is easily portable, without any battery or other power source supply, offering an attractive, inexpensive approach for rapid and accessible DNA vaccination to combat COVID-19, as well as other epidemics.

scholarly journals UCAN: A Learning-based Model to Enhance Poorly Exposed Images

2020 ◽  
Author(s):  
Lucas R. V. Messias ◽  
Cristiano R. Steffens ◽  
Paulo L. J. Drews-Jr ◽  
Silvia S. C. Botelho
Keyword(s):  
Image Quality ◽  
Image Enhancement ◽  
Dynamic Range ◽  
Low Contrast ◽  
Qualitative And Quantitative ◽  
Fast Learning ◽  
Proposed Model ◽  
Quantitative Results ◽  
Critical Process ◽  
Poor Lighting

Image enhancement is a critical process in imagebased systems. In these systems, image quality is a crucial factor to achieve a good performance. Scenes with a dynamic range above the capability of the camera or poor lighting are challenging conditions, which usually result in low contrast images, and, with that, we can have the underexposure and/or overexposure problem. In this work, our aim is to restore illexposed images. For this purpose, we present UCAN, a small and fast learning-based model capable to restore and enhance poorly exposed images. The obtained results are evaluated using image quality indicators which show that the proposed network is able to improve images damaged by real and simulated exposure. Qualitative and quantitative results show that the proposed model outperforms the existing models for this objective.

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