scholarly journals Adult Lactose Digestion Status and Effects on Disease

2015 ◽  
Vol 29 (3) ◽  
pp. 149-156 ◽  
Author(s):  
Andrew Szilagyi
Keyword(s):  
Lactose Intolerance ◽  
Lactase Persistence ◽  
Dairy Foods ◽  
Microbial Adaptation ◽  
Lactose Maldigestion ◽  
Before And After ◽  
Disease Pattern ◽  
Definition Of ◽  
Detrimental Impact ◽  
Manual Review

BACKGROUND: Adult assimilation of lactose divides humans into dominant lactase-persistent and recessive nonpersistent phenotypes.OBJECTIVES: To review three medical parameters of lactose digestion, namely: the changing concept of lactose intolerance; the possible impact on diseases of microbial adaptation in lactase-nonpersistent populations; and the possibility that the evolution of lactase has influenced some disease pattern distributions.METHODS: A PubMed, Google Scholar and manual review of articles were used to provide a narrative review of the topic.RESULTS: The concept of lactose intolerance is changing and merging with food intolerances. Microbial adaptation to regular lactose consumption in lactase-nonpersistent individuals is supported by limited evidence. There is evidence suggestive of a relationship among geographical distributions of latitude, sunhine exposure and lactase proportional distributions worldwide.DISCUSSION: The definition of lactose intolerance has shifted away from association with lactose maldigestion. Lactose sensitivity is described equally in lactose digesters and maldigesters. The important medical consequence of withholding dairy foods could have a detrimental impact on several diseases; in addition, microbial adaptation in lactase-nonpersistent populations may alter risk for some diseases. There is suggestive evidence that the emergence of lactase persistence, together with human migrations before and after the emergence of lactase persistence, have impacted modern-day diseases.CONCLUSIONS: Lactose maldigestion and lactose intolerance are not synonymous. Withholding dairy foods is a poor method to treat lactose intolerance. Further epidemiological work could shed light on the possible effects of microbial adaptation in lactose maldigesters. The evolutionary impact of lactase may be still ongoing.

scholarly journals Assessment of lactase activity in humans by measurement of galactitol and galactonate in serum and urine after milk intake

2019 ◽  
Vol 109 (2) ◽  
pp. 470-477 ◽  
Author(s):  
Nathalie Vionnet ◽  
Linda H Münger ◽  
Carola Freiburghaus ◽  
Kathryn J Burton ◽  
Grégory Pimentel ◽  
...  
Keyword(s):  
Lactose Intolerance ◽  
Dairy Product ◽  
Primary Objective ◽  
Lactase Persistence ◽  
Common Condition ◽  
Lactase Activity ◽  
Galactose Metabolism ◽  
Lactose Maldigestion ◽  
Genetically Determined ◽  
Serum And Urine

ABSTRACT Background Lactase is an enzyme that hydrolyzes lactose into glucose and galactose in the small intestine, where they are absorbed. Hypolactasia is a common condition, primarily caused by genetic programming, that leads to lactose maldigestion and, in certain cases, lactose intolerance. Galactitol and galactonate are 2 products of hepatic galactose metabolism that are candidate markers for the intake of lactose-containing foods. Objectives The primary objective of the study was to explore the changes in serum and urine metabolomes during postprandial dairy product tests through the association between lactase persistence genotype and the postprandial dynamics of lactose-derived metabolites. Methods We characterized the 6-h postprandial serum kinetics and urinary excretion of lactose, galactose, galactitol, and galactonate in 14 healthy men who had consumed a single dose of acidified milk (800 g) which contained 38.8 g lactose. Genotyping of LCT-13910 C/T (rs4988235) was performed to assess primary lactase persistence. Results There were 2 distinct postprandial responses, classified as high and low metabolite responses, observed for galactose, and its metabolites galactitol and galactonate, in serum and urine. In all but 1 subject, there was a concordance between the high metabolite responses and genetic lactase persistence and between the low metabolite responses and genetic lactase nonpersistence (accuracy 0.92), galactitol and galactonate being more discriminative than galactose. Conclusions Postprandial galactitol and galactonate after lactose overload appear to be good proxies for genetically determined lactase activity. The development of a noninvasive lactose digestion test based on the measurement of these metabolites in urine could be clinically useful. This trial was registered at clinicaltrials.gov as NCT02230345.

scholarly journals Lactose Intolerance, Dairy Avoidance, and Treatment Options

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1994 ◽  
Author(s):  
Andrew Szilagyi ◽  
Norma Ishayek
Keyword(s):  
Lactose Intolerance ◽  
Treatment Options ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Symptoms ◽  
Common Source ◽  
Chromosome 2 ◽  
Dietary Interventions ◽  
Dairy Foods ◽  
Lactose Maldigestion ◽  
Genetically Determined

Lactose intolerance refers to symptoms related to the consumption of lactose-containing dairy foods, which are the most common source for this disaccharide. While four causes are described, the most common is the genetically-determined adult onset lactose maldigestion due to loss of intestinal lactase governed by control of the gene by a 14,000 kb promoter region on chromosome 2. Gastrointestinal symptoms from lactose have expanded to include systemic effects and have also been confounded by other food intolerances or functional gastrointestinal disorders. Partly because lactose maldigestion is often interpreted as lactose intolerance (symptoms), focus of therapy for these symptoms starts with lactose restriction. However, withholding of dairy foods completely is not appropriate due to a more favorable impact on health. Industrial efforts to substitute with plant-based products is not completely successful at this time. This narrative article reviews the complexities of the perception of lactose intolerance, its epidemiology, and pathogenesis. Treatments are discussed, including the inappropriateness of dairy avoidance. In conjunction, effects of dairy products on 19 common diseases are reviewed. Different methods of treatment, lactose-reduced products, plant-based dairy substitutes, adaptation, prebiotics, exogenous lactase, probiotics, and some other dietary interventions are further discussed.

A case for multiple views of function in design based on a common definition

2013 ◽  
Vol 27 (3) ◽  
pp. 271-279 ◽  
Author(s):  
Amaresh Chakrabarti ◽  
V. Srinivasan ◽  
B.S.C. Ranjan ◽  
Udo Lindemann
Keyword(s):  
State Change ◽  
Multiple Views ◽  
System Environment ◽  
Common Definition ◽  
Effect Model ◽  
Before And After ◽  
Definition Of

AbstractFunctions are important in designing. However, several issues hinder progress with the understanding and usage of functions: lack of a clear and overarching definition of function, lack of overall justifications for the inevitability of the multiple views of function, and scarcity of systematic attempts to relate these views with one another. To help resolve these, the objectives of this research are to propose a common definition of function that underlies the multiple views in literature and to identify and validate the views of function that are logically justified to be present in designing. Function is defined as a change intended by designers between two scenarios: before and after the introduction of the design. A framework is proposed that comprises the above definition of function and an empirically validated model of designing, extended generate, evaluate, modify, and select of state-change, and an action, part, phenomenon, input, organ, and effect model of causality (Known as GEMS of SAPPhIRE), comprising the views of activity, outcome, requirement–solution–information, and system–environment. The framework is used to identify the logically possible views of function in the context of designing and is validated by comparing these with the views of function in the literature. Describing the different views of function using the proposed framework should enable comparisons and determine relationships among the various views, leading to better understanding and usage of functions in designing.

The Meaning of Pain and the Pain of Meaning: A Bio-Hermeneutical Inquiry

2021 ◽  
Vol 90 ◽  
pp. 215-234
Author(s):  
Teodora Manea
Keyword(s):  
The Body ◽  
Main Interest ◽  
Main Approach ◽  
Memento Mori ◽  
Finding Meaning ◽  
Pace Of Life ◽  
Before And After ◽  
Definition Of

AbstractMy main interest here is to look at pain as a sign of the body that something is wrong. I will argue that there is a meaning of pain before and after an illness is diagnosed. An illness contains its own semantic paradigm, but the pain before the diagnosis affects the pace of life, not only by limiting our interactions, but also as a struggle with its meaning and a reminder of mortality.My main approach is what I call bio-hermeneutics, an extension of medical hermeneutics branching out from the Continental hermeneutical tradition. As such, I will explore the connection between pain and language, temporality, dialectics, and ontology. Given the centrality of language in constructing the meaning of pain, my analysis is informed by the semantics (looking at pain metaphors), syntax (pain as incoherence), and pragmatics (pain as companion) of expressing pain.The last section explores the meaning of pain in connection with death, as memento mori. Revisiting an old definition of philosophy as melete thanatou, or ‘rehearsal of death’, I will reflect on the difficulty of finding meaning not only for pain, but also for death as cessation of all existential possibilities.

scholarly journals ON CHILD’S RIGHTS BEFORE AND AFTER BIRTH

2021 ◽  
Vol 2 ◽  
pp. 24-28
Author(s):  
Aleksandr V. Fioshin ◽  
Keyword(s):  
Before And After ◽  
Definition Of ◽  
The Right ◽  
Abuse Of Law

The article is devoted to the issues of the unborn child’s rights and the abuse of the rights of children born. Examples of various legal orders protecting the life of a child before birth are given. The issue of the need to protect unborn children in the national doctrine is analyzed. The author’s definition of abuse of law in family legal relations is proposed. The abuse of the right by the child is characterized.

Conclusions

2017 ◽  
Author(s):  
Anna K. Hodgkinson
Keyword(s):  
Capital City ◽  
High Status ◽  
Royal Court ◽  
Archaeological Material ◽  
Before And After ◽  
Status Goods ◽  
Royal City ◽  
The One ◽  
Definition Of ◽  
The Individual

This final chapter addresses the individual research questions posed in the Introduction (Chapter 1), in the light of the data and discussion presented in Chapters 2–7. According to the range of settlement types defined by Troy (see Section 1.1), Amarna and Gurob may be regarded as cities, with a less specialized character and the presence of both a royal court and temples. While Amarna was not long-lived, it was specifically founded as a capital city with a large amount of urban planning. Gurob was certainly occupied for a long period, before and after the New Kingdom. Although Malqata can be defined as a royal city, it does not fulfil Troy’s definition of a city in that it was only very short-lived and served the sole purpose of a location for the festivities in honour of Amenhotep III, for which reason it should most likely be regarded a specialized settlement. In conclusion, it can be said that the presence of high-status goods and evidence of their manufacture enhances a settlement’s status. On the one hand, it proves that a strong demand existed for these types of objects, most of which were not for everyday use, and therefore implies the presence of either a consuming elite or royal court. On the other hand, should no royal court be present, it indicates at least the settlement’s dependence on the favours of royal personages acting as recipients of high-status goods. The presence of such personages would also enhance the settlement’s status. Hence, a developed infrastructure, together with a well-managed system of redistribution, as observed in all three case-studies discussed in this book, may very well be a factor determining a high-status settlement, such as a royal city. It can be stated that the analyses of the archaeological material from Amarna, Gurob, and Malqata have been successful in highlighting several areas of intensive industrial activity despite some issues regarding the nature of the data (see Section 1.4.3). In addition, it has been possible to further define the locations in which most of the finished products were found and, probably, used.

Cognitive Effects of Deceptive Advertising

1978 ◽  
Vol 15 (1) ◽  
pp. 29-38 ◽  
Author(s):  
Jerry C. Olson ◽  
Philip A. Dover
Keyword(s):  
Real World ◽  
Cognitive Effects ◽  
Cognitive Variables ◽  
Basic Approach ◽  
Product Trial ◽  
Before And After ◽  
Deceptive Advertising ◽  
Definition Of ◽  
Product Claim

Although much has been written about deception in advertising, no studies have been reported in which a deception and its impact on consumers were demonstrated empirically. The authors present a behavioral definition of deception and illustrate its operationalization in the context of a longitudinal experiment in which the effects of an explicit, deceptive product claim on a variety of cognitive variables were measured both before and after product trial. Issues related to the measurement of deception seriousness are emphasized. The basic approach appears generalizable to nonexperimental studies of real-world deception.

scholarly journals P058: Paramedic recognition and management of anaphylaxis in the prehospital setting

CJEM ◽  
2018 ◽  
Vol 20 (S1) ◽  
pp. S77-S77
Author(s):  
M. Welsford ◽  
R. Gupta ◽  
K. Samoraj ◽  
S. Sandhanwalia ◽  
M. Kerslake ◽  
...  
Keyword(s):  
Educational Intervention ◽  
Prehospital Treatment ◽  
Case Identification ◽  
System Involvement ◽  
Service Areas ◽  
Before And After ◽  
Threatening Condition ◽  
Life Threatening ◽  
Definition Of ◽  
Treatment Priorities

Introduction: Anaphylaxis is a life-threatening condition that paramedics are equipped to treat effectively in the field. Current literature suggests improvements in paramedic recognition and treatment of anaphylaxis could be made. The aim of this study was to compare the proportion of cases of anaphylaxis appropriately treated with epinephrine by paramedics before and after a targeted educational intervention. Methods: This was a retrospective medical records review of patients with anaphylaxis managed by primary or advanced care paramedics in five Emergency Medical Service areas in Ontario, before and after an educational module was introduced. This module included education on anaphylaxis diagnosis, recognition, treatment priorities, and feedback on the recognition and management from the before period. All paramedic call records (PCRs) coded as local allergic reaction or anaphylaxis during 12-month periods before and after the intervention were reviewed by trained data abstractors to determine if patients met an international definition of anaphylaxis. The details of interventions performed by the paramedics were used to determine primary and secondary outcomes. Results: Of the 600 PCRs reviewed, 99/120 PCRs in the before and 300/480 in the after period were included. Of the charts included, 63/99 (63.6%) in the before and 136/300 (45.3%) in the after period met criteria for anaphylaxis (p=0.002). Of the cases meeting anaphylaxis criteria, 41/63 (65.1%) in the before and 88/136 (64.7%) in the after period were correctly identified as anaphylaxis (p=0.96). Epinephrine was administered in 37/63 (58.7%) of anaphylaxis cases in the before period and 76/136 (55.9%) in the after period (p=0.70). Anaphylactic patients with only two-system involvement received epinephrine in 20/40 (50.0%) cases in the before period and 45/93 (48.4%) in the after period (p=0.86). Conclusion: There are gaps in paramedic recognition and management of anaphylaxis, particularly in cases of two-system involvement. These gaps persisted after the implementation of an educational intervention. Other quality interventions and periodic refreshers may be necessary to improve prehospital treatment of anaphylaxis. Limitations include an increase in overall cases and decrease in rate of true anaphylaxis in the after period, which may relate to better case identification after electronic PCR implementation and changes in paramedic recognition.

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