scholarly journals Sleep Spindles as Facilitators of Memory Formation and Learning

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Daniel Ulrich
Keyword(s):  
Recall Performance ◽  
Physiological Role ◽  
Memory Formation ◽  
Sleep Spindles ◽  
The Past ◽  
Learning Tasks ◽  
Close Relationship ◽  
Important Progress ◽  
Made In

Over the past decades important progress has been made in understanding the mechanisms of sleep spindle generation. At the same time a physiological role of sleep spindles is starting to be revealed. Behavioural studies in humans and animals have found significant correlations between the recall performance in different learning tasks and the amount of sleep spindles in the intervening sleep. Concomitant neurophysiological experiments showed a close relationship between sleep spindles and other sleep related EEG rhythms as well as a relationship between sleep spindles and synaptic plasticity. Together, there is growing evidence from several disciplines in neuroscience for a participation of sleep spindles in memory formation and learning.

The Role of Histones and Heparin in Sepsis: A Review

2021 ◽  
pp. 088506662199232
Author(s):  
Xiaojuan Zhang ◽  
Xin Li
Keyword(s):  
Septic Shock ◽  
Multiple Organ ◽  
Clinical Settings ◽  
The Past ◽  
Life Saving ◽  
Extracellular Histones ◽  
Sepsis And Septic Shock ◽  
Development And Management ◽  
Made In

Septic shock with multiple organ failure is a devastating situation in clinical settings. Through the past decades, much progress has been made in the management of sepsis and its underlying pathogenesis, but a highly effective therapeutic has not been developed. Recently, macromolecules such as histones have been targeted in the treatment of sepsis. Histones primarily function as chromosomal organizers to pack DNA and regulate its transcription through epigenetic mechanisms. However, a growing body of research has shown that histone family members can also exert cellular toxicity once they relocate from the nucleus into the extracellular space. Heparin, a commonly used anti-coagulant, has been shown to possess life-saving capabilities for septic patients, but the potential interplay between heparin and extracellular histones has not been investigated. In this review, we summarize the pathogenic roles of extracellular histones and the therapeutic roles of heparin in the development and management of sepsis and septic shock.

Gender, Memory, and Identity in the Roman World

2019 ◽  
Keyword(s):  
Roman Empire ◽  
Late Antiquity ◽  
Roman History ◽  
Public And Private ◽  
Imperial Rome ◽  
The Past ◽  
Roman World ◽  
Material Sources ◽  
Close Relationship

This volume approaches three key concepts in Roman history — gender, memory and identity — and demonstrates the significance of their interaction in all social levels and during all periods of Imperial Rome. When societies, as well as individuals, form their identities, remembrance and references to the past play a significant role. The aim of Gender, Memory, and Identity in the Roman World is to cast light on the constructing and the maintaining of both public and private identities in the Roman Empire through memory, and to highlight, in particular, the role of gender in that process. While approaching this subject, the contributors to this volume scrutinise both the literature and material sources, pointing out how widespread the close relationship between gender, memory and identity was. A major aim of Gender, Memory, and Identity in the Roman World as a whole is to point out the significance of the interaction between these three concepts in both the upper and lower levels of Roman society, and how it remained an important question through the period from Augustus right into Late Antiquity.

Ectomycorrhizae in the Agaricales and Gasteromycetes

1983 ◽  
Vol 61 (3) ◽  
pp. 909-916 ◽  
Author(s):  
Orson K. Miller Jr.
Keyword(s):  
Fruiting Body ◽  
Biological Role ◽  
Spore Morphology ◽  
Generic Level ◽  
Body Form ◽  
Ecological Conditions ◽  
Fungal Succession ◽  
The Past ◽  
Made In

Over the past decade much progress has been made in an effort to determine which fungi are mycorrhizal symbionts. It is now apparent that one ectomycorrhizal or ectendomycorrhizal host is often able to form mycorrhizae with a wide variety of higher fungi. Evidence is presented which supports the hypothesis that fungal succession occurs as the host matures. In addition, fungi which are normally ectomycorrhizal may sometimes form endomycorrhizae on different hosts or under altered ecological conditions. There has also been much evolution in fruiting-body form and mode of spore discharge especially under severe montane or desert conditions. As a result patterns are emerging in the Homobasidiomycetes at the order, family, and generic level in the evolution of the mycorrhizal habit. Spore morphology, habitat, and distribution are listed and discussed in relation to the biological role of the fungi.

scholarly journals Modified Sawhorse Waveform for the Voltammetric Detection of Oxytocin

2022 ◽  
Author(s):  
Favian Liu ◽  
Negar Ghasem Ardabili ◽  
Izaiah Brown ◽  
Harmain Rafi ◽  
Clarice Cook ◽  
...  
Keyword(s):  
Brain Slices ◽  
Physiological Role ◽  
Peptide Hormone ◽  
Protective Effects ◽  
Fast Scan Cyclic Voltammetry ◽  
The Past ◽  
Voltammetric Detection ◽  
Carbon Fiber Microelectrodes

Abstract Carbon fiber microelectrodes (CFMEs) have been used to detect neurotransmitters and other biomolecules using fast-scan cyclic voltammetry (FSCV) for the past few decades. This technique measures neurotransmitters such as dopamine and, more recently, physiologically relevant neuropeptides. Oxytocin, a pleiotropic peptide hormone, is physiologically important for adaptation, development, reproduction, and social behavior. This neuropeptide functions as a stress-coping molecule, an anti-inflammatory agent, and serves as an antioxidant with protective effects especially during adversity or trauma. Here, we measure tyrosine using the Modified Sawhorse Waveform (MSW), enabling enhanced electrode sensitivity for the amino acid and oxytocin peptide. Applying the MSW, decreased surface fouling and enabled codetection with other monoamines. As oxytocin contains tyrosine, the MSW was also used to detect oxytocin. The sensitivity of oxytocin detection was found to be 3.99 ± 0.49 nA/µM, (n=5). Additionally, we demonstrate that applying the MSW on CFMEs allows for real time measurements of exogenously applied oxytocin on rat brain slices. These studies may serve as novel assays for oxytocin detection in a fast, sub-second timescale with possible implications for in vivo measurements and further understanding of the physiological role of oxytocin.

The Role of Biography in Writing the History of Archaeology (1992)

2008 ◽  
Author(s):  
Douglas R. Givens
Keyword(s):  
No Value ◽  
History Of Archaeology ◽  
History Of Anthropology ◽  
Historical Evidence ◽  
Past Work ◽  
The Past ◽  
Institutional Influences ◽  
History Of ◽  
Made In

The history of any discipline involves the explanation of its past and how the past has influenced its development through time. Its ‘objects are events which have finished happening, and conditions no longer in existence. Only when they are no longer perceptible do they become objects of historical thought’ (Collingwood 1946: 233). Writing the history of archaeology involves the analysis of past events and of the contributions that individual archaeologists have made to its development through time. The roles of individuals in archaeology are best seen in biographical accounts of their labours and in the contributions to the discipline that they have made. In general, historians of archaeological science, who are interested in explaining the roles of the individuals in its development, must focus their attention on three important items. First, the most important item is evidence that something has occurred. If individuals’ contributions have no basis in truth and cannot be justified, then they are of no value to the historian of archaeology. Second, the historical picture of individuals’ lives and work must have defined boundaries in space and time. These provide the area of focus for study and description of individuals’ activities. Third, the efforts of individual practitioners must be couched within the intellectual climate in which they are made. Individuals’ contributions are not made in an intellectual vacuum, apart from collegial or institutional influences. Biography, as a tool for writing the history of archaeology, must embrace all of these requisites. For those engaged in explaining archaeology’s past, historical evidence of event and period provide the foundation upon which we can trace our science’s development. Studying and evaluating past work can be helpful in separating useful and outdated methodologies of the field and laboratory. Moreover, the study of the history of anthropology may give the anthropologist needed ‘distance from their own theoretical and methodological preoccupations’ (Darnell 1974: 2). What we see anthropology today as being is certainly not what the ultimate science of humankind will be in the future.

scholarly journals Sciences and audiences along the last century: the impact of Astronomy Education

2018 ◽  
Vol 13 (S349) ◽  
pp. 474-478
Author(s):  
Rosa M. Ros ◽  
Beatriz Garca
Keyword(s):  
Secondary Teachers ◽  
Astronomy Education ◽  
Interest In Science ◽  
The Past ◽  
The World ◽  
History Of ◽  
The Impact ◽  
Made In ◽  
Science Activities

AbstractJust as in the past, the development of the natural sciences and in particular of astronomy has changed the history of humanity. If we think about the role of our discipline into the future, it shows its enormous power in the field of education, owing to the possibility of awakening interest in science in very varied audiences. Within the framework of the enormous progress made in the technologies related to astronomy, many of them of daily use, the role of the astronomer in the era of Communications acquires fundamental importance.In this presentation, we will try to make a journey through the different ways of presenting astronomical topics for different audiences over the last 100 years. In turn, we will show some specific achievements, associated with education programmes of the discipline. We discuss the impact produced by proposals that are both rigorous in terms of content, and also appeal to the development of the human being in an integral manner, within the framework of citizen science activities.For this research, we have taken into account the uninterrupted development of the NASE programme, which has performed 112 courses in 24 countries throughout the world and in different languages. NASE has involved 4966 secondary teachers in the last eight years.

Role of autophagy in cancer prevention, development and therapy

2013 ◽  
Vol 55 ◽  
pp. 133-151 ◽  
Author(s):  
G. Vignir Helgason ◽  
Tessa L. Holyoake ◽  
Kevin M. Ryan
Keyword(s):  
Quality Control ◽  
Clinical Trials ◽  
Cancer Prevention ◽  
Mammalian Cells ◽  
Physiological Role ◽  
Anticancer Therapy ◽  
Substantial Progress ◽  
Health And Disease ◽  
Made In

Autophagy is a process that takes place in all mammalian cells and ensures homoeostasis and quality control. The term autophagy [self (auto)-eating (phagy)] was first introduced in 1963 by Christian de Duve, who discovered the involvement of lysosomes in the autophagy process. Since then, substantial progress has been made in understanding the molecular mechanism and signalling regulation of autophagy and several reviews have been published that comprehensively summarize these findings. The role of autophagy in cancer has received a lot of attention in the last few years and autophagy modulators are now being tested in several clinical trials. In the present chapter we aim to give a brief overview of recent findings regarding the mechanism and key regulators of autophagy and discuss the important physiological role of mammalian autophagy in health and disease. Particular focus is given to the role of autophagy in cancer prevention, development and in response to anticancer therapy. In this regard, we also give an updated list and discuss current clinical trials that aim to modulate autophagy, alone or in combination with radio-, chemo- or targeted therapy, for enhanced anticancer intervention.

Role of different aberrant cell signalling pathways prevalent in acute lymphoblastic leukemia

Biologia ◽  
2014 ◽  
Vol 69 (9) ◽  
Author(s):  
Priya Gopal ◽  
Mausumi Paul ◽  
Santanu Paul
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Treatment Options ◽  
Cell Signalling ◽  
Signalling Pathways ◽  
Survival Ratio ◽  
Functional Abnormality ◽  
Important Progress ◽  
Made In

AbstractAcute lymphoblastic leukemia (ALL) is one of the major forms of leukemia that affects mostly adolescent individuals. The main cause of the development of ALL is not known though several important signal transduction pathways have been reported with functional abnormality in all the cases. Crucial signalling pathways reported in ALL include PI3K/Akt, Notch, Wnt, mTOR, JaK/Stat, etc. Over the past several decades important progress has been made in the management of ALL, however, relapses and post therapy survival ratio has not improved much. This brings the need for understanding the biology and mechanism involved in ALL occurrences and find new molecular targets for better treatment options and risk-adapted therapies to improve the outcome of ALL patients.

Evolutionary Approaches to Innovation, the Firm, and the Dynamics of Industries

2021 ◽  
Vol 6 (4) ◽  
pp. 265-289
Author(s):  
Gino Cattani ◽  
Franco Malerba
Keyword(s):  
Dynamic Capabilities ◽  
Evolutionary Strategies ◽  
Industry Dynamics ◽  
The Road ◽  
Evolutionary Trajectories ◽  
Quantitative Analyses ◽  
Important Progress ◽  
Made In

We examine the progress of the evolutionary research on innovation, the firm, and the dynamics of industries in the last four decades. The paper acknowledges that the themes related to knowledge and technological regimes, the evolutionary processes leading to innovation, and the long-term dynamics of technologies have generated, and still remain, relevant research trajectories. The same can be said for the research trajectories on organizational and dynamic capabilities, evolutionary strategies, vertical integration, diversification, niche construction, and authority and power in organizations. Important progress has also been made in understanding the evolutionary trajectories of industries, the link between industry architecture and industry dynamics, the types of knowledge of entrants, the role of focal and vertical spinouts, the relevance of institutions and sectoral innovation systems in industry dynamics, and the catch-up process by firms from latecomer countries. We argue that future developments in the evolutionary camp should continue to be characterized by eclecticism and multidisciplinarity, as well as by the integration of different methodologies from cases to stylized facts, quantitative analyses, appreciative theorizing, and formal modelling. We conclude with an analysis of the main methodologies used by evolutionary scholars and a discussion of the road ahead.

Pharmacology of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels

2020 ◽  
Vol 60 (1) ◽  
pp. 219-240 ◽  
Author(s):  
Brandon M. Brown ◽  
Heesung Shim ◽  
Palle Christophersen ◽  
Heike Wulff
Keyword(s):  
Small Molecule ◽  
Binding Sites ◽  
Physiological Role ◽  
Membrane Hyperpolarization ◽  
Multiple Binding Sites ◽  
Multiple Binding ◽  
Calcium Activated Potassium Channels ◽  
Small Conductance ◽  
Made In

The three small-conductance calcium-activated potassium (KCa2) channels and the related intermediate-conductance KCa3.1 channel are voltage-independent K+ channels that mediate calcium-induced membrane hyperpolarization. When intracellular calcium increases in the channel vicinity, it calcifies the flexible N lobe of the channel-bound calmodulin, which then swings over to the S4-S5 linker and opens the channel. KCa2 and KCa3.1 channels are highly druggable and offer multiple binding sites for venom peptides and small-molecule blockers as well as for positive- and negative-gating modulators. In this review, we briefly summarize the physiological role of KCa channels and then discuss the pharmacophores and the mechanism of action of the most commonly used peptidic and small-molecule KCa2 and KCa3.1 modulators. Finally, we describe the progress that has been made in advancing KCa3.1 blockers and KCa2.2 negative- and positive-gating modulators toward the clinic for neurological and cardiovascular diseases and discuss the remaining challenges.

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