scholarly journals The Diagnostic Value of Serum C-Reactive Protein for Identifying Pneumonia in Hospitalized Patients with Acute Respiratory Symptoms

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Agustín Ruiz-González ◽  
Laia Utrillo ◽  
Silvia Bielsa ◽  
Miquel Falguera ◽  
José M. Porcel
Keyword(s):  
Respiratory Symptoms ◽  
Area Under The Curve ◽  
Acute Bronchitis ◽  
Final Diagnosis ◽  
Hospitalized Patients ◽  
Chest Radiographs ◽  
Chronic Obstructive ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Serum Crp

Background. The clinical diagnosis of pneumonia is sometimes difficult since chest radiographs are often indeterminate. In this study, we aimed to assess whether serum C-reactive protein (CRP) could assist in identifying patients with pneumonia. Methods. For one winter, all consecutive patients with acute respiratory symptoms admitted to the emergency ward of a single center were prospectively enrolled. In addition to chest radiographs, basic laboratory tests, and microbiology, serum levels of CRP were measured at entry. Results. A total of 923 (62.3%) of 1473 patients hospitalized for acute respiratory symptoms were included. Subjects with a final diagnosis of pneumonia had higher serum CRP levels (median 187 mg/L) than those with exacerbations of chronic obstructive pulmonary disease (63 mg/L) or acute bronchitis (54 mg/L, p<0.01). CRP was accurate in identifying pneumonia (area under the curve 0.84, 95% CI 0.82–0.87). The multilevel likelihood ratio (LR) for intervals of CRP provided useful information on the posttest probability of having pneumonia. CRP intervals above 200 mg/L were associated with LR+ > 5, for which pneumonia is likely, whereas CRP intervals below 75 mg/L were associated with LR < 0.2, for which pneumonia is unlikely. Conclusion. Serum CRP may be a useful addition for diagnosing pneumonia in hospitalized patients with acute respiratory symptoms.

Study of predictive value of serum C- reactive protein in diagnosis of acute appendicitis

2021 ◽  
Vol 19 (1) ◽  
pp. 31-34
Author(s):  
Pradeep Chandra Sharma ◽  
Keyword(s):  
Acute Appendicitis ◽  
Predictive Value ◽  
Signs And Symptoms ◽  
Final Diagnosis ◽  
Common Finding ◽  
C Reactive Protein ◽  
Diagnostic Efficacy ◽  
Female Ratio ◽  
Reactive Protein ◽  
Serum Crp

Background: Acute appendicitis is a common surgical condition and the most common cause of acute surgical abdomen. Commonly used tests for diagnosis of acute appendicitis were WBC, CRP ESR and procalcitonin (PCT) levels. In present study we correlated the serum levels of CRP with the histopathology of the removed appendix, to study predictive value of serum C- reactive protein in diagnosis of acute appendicitis. Material and Methods:Present study was conducted in patients with possibility of acute appendicitis, underwent appendicectomy. The histopathology report was considered as the final diagnosis. CRP more than 6 mg/dl was considered to be positive. Results: In present study total 88 patients were included. Male to female ratio was 1.4:1, most common age group was 21-30 years (35.23%) followed by 31-40 years (27.27%). Abdominal pain (92.05%), McBurney tenderness (80.68%), vomiting (76.14%), rebound tenderness (67.05%) and fever (55.68%) were common signs and symptoms noted in present study. On histopathology examination, inflammed appendix (51.14%) was most common finding, others were gangrenous appendix (23.86%), perforated appendix (5.68%) and normal appendix (19.32%). In present study diagnostic efficacy of serum CRP was sensitivity (80%), specificity (84.62%), positive predictive value (96.77%), negative predictive value (42.31%), diagnostic accuracy (80.68%). Conclusion. Serum CRP estimation is useful adjunct in diagnosis of acute appendicitis along with clinical diagnosis. Serum CRP value should be interpreted in combination with clinical findings.

Acute Effects of Accumulating Exercise on Postprandial Lipemia and C-Reactive Protein Concentrations in Young Men

2009 ◽  
Vol 19 (6) ◽  
pp. 569-582 ◽  
Author(s):  
Masashi Miyashita ◽  
Stephen F. Burns ◽  
David J. Stensel
Keyword(s):  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Venous Blood ◽  
Postprandial Lipemia ◽  
Area Under The Curve ◽  
Acute Effects ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Serum Crp ◽  
Postprandial Triacylglycerol

The current study investigated the acute effects of accumulating short bouts of running on circulating concentrations of postprandial triacylglycerol (TAG) and C-reactive protein (CRP). Ten men, age 21–32 yr, completed two 1-d trials. On 1 occasion participants ran at 70% of maximum oxygen uptake in six 5-min bouts (i.e., 8:30, 10, and 11:30 a.m. and 1, 2:30, and 4 p.m.) with 85 min rest between runs. On another occasion participants rested throughout the day. In both trials, participants consumed test meals at 9 a.m. and 12 p.m. In each trial, venous blood samples were collected at 8:30, 10, and 11:30 a.m. and 1, 2:30, 4, and 5:30 p.m. for plasma TAG measurement and at 8:30 a.m. and 5:30 p.m. for serum CRP measurement. Total area under the curve for plasma TAG concentration versus time was 10% lower on the exercise trial than the control trial (M ± SEM: 13.5 ± 1.8 vs. 15.0 ± 1.9 mmol · 9 hr−1 · L−1; p = .004). Serum CRP concentrations did not differ between trials or over time. This study demonstrates that accumulating short bouts of running reduces postprandial plasma TAG concentrations (a marker for cardiovascular disease risk) but does not alter serum CRP concentrations.

scholarly journals Evaluating serum C-reactive protein level in patients with chronic obstructive pulmonary disease – A cross-sectional study

2019 ◽  
pp. 1-4
Author(s):  
Karthika M ◽  
Prakash Chandra Bhardwaj ◽  
Laimayum Amarnath Sharma ◽  
Laimayum Amarnath Sharma ◽  
W Kanan ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Cross Sectional Study ◽  
Chronic Obstructive ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Reactive Protein ◽  
Copd Patients ◽  
Serum Crp

Abstract Patients with the chronic obstructive pulmonary disease have ongoing systemic inflammation, which can be assessed by measuring serum  C- reactive protein. Objective: To explore whether CRP could be used as an independent predictor of disease outcome in COPD. Methods: A cross-sectional study was conducted among 50 COPD patients attending Respiratory Medicine outpatient services in the Regional Institute of Medical Sciences (RIMS), Imphal from January 2015 to September 2016. Patients aged 18-67 were included in the study after obtaining Ethical approval from the Research Ethics Board, RIMS, Imphal. Computerized Spirometer Helios 401 was the instrument used to measure lung volumes and capacities. BeneSpheraTM CRP Latex Slide test kit was used to estimate serum c-reactive protein. Results and observation: The present study was conducted on fifty COPD patients in which serum CRP level showed positive correlation with COPD (p=0.002) but serum CRP level with spirometric parameters showed significant negative correlation;FEV1 (r=-0.451, p=0.001), FEV1/FVC (r=-0.617, p<0.001) and PEFR (r=-0.398, p=0.004). Conclusion: In our study, we found an association between serum CRP level and severity of COPD and Plasma CRP may be used as a marker of prognosis in COPD as the small increase is associated with poorer prognosis in COPD. Keywords: CRP; Chronic obstructive pulmonary disease (COPD); Imphal.

scholarly journals Combined serum and synovial C-reactive protein tests: a valuable adjunct to the diagnosis of chronic prosthetic joint infection

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Hai Wang ◽  
Leilei Qin ◽  
Jiawei Wang ◽  
Ning Hu ◽  
Wei Huang
Keyword(s):  
Predictive Value ◽  
Joint Infection ◽  
Area Under The Curve ◽  
Diagnostic Value ◽  
C Reactive Protein ◽  
Combined Model ◽  
Diagnostic Efficacy ◽  
Reactive Protein ◽  
Valuable Adjunct ◽  
Serum Crp

Abstract Background Diagnosis of periprosthetic joint infection (PJI), especially chronic PJI, is very confusing and challenging. The value of C-reactive protein (CRP) in infectious diseases has been recognized, but the diagnostic value of CRP in chronic PJI is unknown. Our aim was to investigate the diagnostic value of synovial CRP in chronic PJI and to explore the role of combined serum and synovial CRP in distinguishing chronic PJI from aseptic failure after knee and hip arthroplasties. Methods We prospectively enrolled patients scheduled to have a revision surgery for chronic PJI or aseptic loosening from January 2019 to December 2020, in which synovial CRP was additionally measured along with routine preoperative diagnostic serum ((ESR, CRP) and synovial (PMN%) biomarkers. The receiver operating characteristic (ROC) curves and area under the curve (AUC) were analyzed for each biomarker to determine diagnostic efficacy. Results There were no statistically significant differences between the infection (n = 39) and aseptic (n = 58) groups, including 61 hips and 36 knees. The synovial CRP levels were significantly higher in the infection group than in the aseptic group (median: 9.93 mg/l vs 3.58 mg/l; p < .001). The optimal cut-off value for detecting chronic PJI of Synovial fluid (SF) CRP was of 7.26 mg/l with a sensitivity of 84.62%, a specificity of 93.10%. The combined model I (Serum CRP > 10.2 mg/l OR SF CRP > 7.26 mg/l) had a negative predictive value (NPV) of 96.67%, and a sensitivity of 97.44%. The combined model II (Serum CRP > 10.2 mg/l AND Synovial CRP > 7.26 mg/l) led to a specificity of 1, and a positive predictive value (PPV) of 1. Conclusions The present study demonstrated that the combination of serum and synovial CRP can be used as an adjunct to the diagnosis of chronic PJI.

scholarly journals Combined Serum and Synovial C-Reactive Protein Tests: An Economical and Efficient Adjunct to the Diagnosis of Chronic Prosthetic Joint Infection

2021 ◽  
Author(s):  
Hai Wang ◽  
Leilei Qin ◽  
Jiawei Wang ◽  
Ning Hu ◽  
Wei Huang
Keyword(s):  
Predictive Value ◽  
Demographic Data ◽  
Joint Infection ◽  
Area Under The Curve ◽  
Diagnostic Value ◽  
C Reactive Protein ◽  
Combined Model ◽  
Diagnostic Efficacy ◽  
Reactive Protein ◽  
Serum Crp

Abstract Background Diagnosis of Periprosthetic joint infection (PJI) is very complex and challenging, especially for chronic PJI. The value of C-reactive protein (CRP) in infectious diseases has been recognized, but the diagnostic value of CRP in chronic PJI is unknown. Our objective was to investigate the effectiveness of synovial CRP in chronic PJI and to determine the optimal combination of serum and synovial CRP in distinguishing chronic PJI from aseptic failure after knee and hip arthroplasties. Methods From January 2018 to December 2019, we prospectively included patients scheduled to have a revision surgery for chronic PJI or aseptic loosening of an implant, in which synovial CRP was additionally measured along with routine preoperative diagnostic serum and synovial biomarkers. The receiver operating characteristic (ROC) curves and area under the curve (AUC) were analyzed for each biomarker to determine diagnostic efficacy. Results There were no statistically significant differences in demographic data among the 97 cases we eventually included. the synovial CRP levels were significantly higher in the infection group than in the aseptic group (median: 19 mg/l vs. 9.25 mg/l; p = .001). The optimal cut-off value for detecting chronic PJI of synovial CRP was of 7.26 mg/l with a sensitivity of 84.62%, a specificity of 93.10%. The combined model I (Serum CRP > 10.2 mg/l OR SF CRP > 7.2 6 mg/l) had a negative predictive value (NPV) of 96.67%, and a sensitivity of 97.44%. The combined model II (Serum CRP > 10.2 mg/l AND Synovial CRP > 7.26 mg/l) led to a specificity of 1, and a positive predictive value (PPV) of 1. Conclusion The present study demonstrated that the combination of serum and synovial CRP can be used as an adjunct to the diagnosis of chronic PJI.

scholarly journals A study of C reactive proteins in patients with stable chronic obstructive pulmonary disease

2019 ◽  
Vol 6 (2) ◽  
pp. 227
Author(s):  
Ashok Kumar Gudagunti ◽  
Sudhir Chaudhri
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Correlation Coefficient ◽  
Chronic Obstructive ◽  
C Reactive Protein ◽  
Obstructive Pulmonary Disease ◽  
Baseline Serum ◽  
Protein Levels ◽  
Reactive Protein ◽  
Serum Crp

Background: Whenever there is damage to the tissue or inflammatory process, the hepatocytes synthesize a protein which is an acute phase reactant, and this is the C reactive protein. Studies have shown that serum C reactive protein levels are usually elevated during acute exacerbations of COPD. The objective of this study was studying the baseline serum C reactive protein levels in patients with stable chronic obstructive pulmonary disease.Methods: During the study period, 90 subjects were studied. Out of them, 47 had stable COPD and 43 were without COPD. The subjects were either admitted in indoor wards or were attending OPD of department of tuberculosis and respiratory diseases, Dr. Murari Lal Chest Hospital, G.S.V.M Medical College, Kanpur, Uttar Pradesh, and were recruited if they fulfilled the criteria for inclusion. Informed consent was taken from all study subjects and the study protocol was approved by the board of faculty of medicine.Results: Of the 47 patients in the stable COPD group, 23 were found to be active smokers. Pearson’s correlation coefficient showed that lower limit of serum CRP levels were significantly negatively correlating with 6 MWD (r= -0.707; p=0.0001), FEV1% (r=-0.635; p=0.0001), PaO2 (r=-0.592; p=0.0001), and BMI (r= -0.534; p=0.0001). Pearson’s correlation coefficient showed that upper limit of serum CRP levels were significantly negatively correlating with 6 MWD (r= -0.707; p=0.0001), FEV1% (r= -0.633; p=0.0001), PaO2 (r= -0.61; p=0.001) and BMI (r= -0.520; p=0.0001).Conclusions: The circulating levels of inflammatory marker, baseline serum CRP are significantly elevated in patients with stable chronic obstructive pulmonary disease.

scholarly journals Correlation of BMI and serum albumin with c-reactive protein in male patients with stable chronic obstructive pulmonary disease

2018 ◽  
Vol 6 (9) ◽  
pp. 3147
Author(s):  
Pranab Mandal ◽  
Niranjan Sit ◽  
Abinash Agarwala ◽  
Aloke Gopal Ghoshal ◽  
Debasmita Bandyopadhyay
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Serum Albumin ◽  
Systemic Inflammation ◽  
Chronic Obstructive ◽  
P Value ◽  
C Reactive Protein ◽  
Obstructive Pulmonary Disease ◽  
Reactive Protein ◽  
Copd Patients ◽  
Serum Crp

Background: There is growing consensus that chronic obstructive pulmonary disease (COPD), a chronic inflammatory disease of the airways and lung parenchyma is associated with low grade systemic inflammation even in stable COPD, which increases during acute exacerbation. It is still debated whether the inflammation is a spill-over from the lung or the lung bears the share of systemic inflammation in COPD. There is systemic manifestation in COPD which is responsible for its severity in individual cases, but it is not clearly known whether the systemic inflammation give rise to systemic manifestations.Methods: In this background we measured serum C-reactive protein (CRP) level in 53 stable COPD patients and 32 age/sex matched control without known ischemic heart disease (IHD)/ diabetes mellitus (DM)/ peripheral arterial disease and normal chest X-ray and tried to find out any correlation of serum CRP level (marker of systemic inflammation) with BMI and serum albumin (marker of nutritional abnormality).Results: The study found that serum CRP level was significantly higher in stable COPD patient in comparison to healthy control. (6.226±3.9 vs 1.31±0.53).Though serum CRP level did not significantly increase with increasing severity of the disease, but serum CRP level was significantly increased in COPD patients with low BMI and low serum albumin (9.10±3.14 vs 4.01±2.90 p value <0.001 and 8.51±3.5 vs 3.59±2.5 with p value <0.001 respectively for BMI and serum albumin).Conclusions: So, the study concluded that stable COPD is associated with increased systemic inflammatory markers than normal control, correlates significantly with nutritional parameters in COPD like BMI and serum albumin level and may be an indicator of malnutrition regardless of lung function impairment.

scholarly journals Serum C-Reactive Protein Is Negatively Associated With Olfactory Identification Ability in Older Adults

i-Perception ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 204166952110099
Author(s):  
Ingrid Ekström ◽  
Davide Liborio Vetrano ◽  
Goran Papenberg ◽  
Erika J. Laukka
Keyword(s):  
Statistical Significance ◽  
Population Based ◽  
Rate Of Change ◽  
Odor Identification ◽  
Sensitivity Analyses ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Olfactory Identification ◽  
Olfactory Ability ◽  
Serum Crp

Importance Olfactory deficits are common in aging and associated with several conditions linked to inflammation. A few studies suggest that increased concentration of pro-inflammatory biomarkers may be related to olfactory deficits, but these associations are understudied in population-based samples. Objective To investigate the association between serum concentrations of C-reactive protein (CRP) and olfactory identification level as well as rate of change in aging. Methods We included 1,721 participants (mean age 70.5 years; 61.9% female) with at least two olfactory assessments across the 12-year follow-up. Baseline level and change in odor identification were estimated with linear mixed models as a function of CRP levels, derived from blood plasma at baseline. Results Results indicated a negative dose–response association between CRP level and odor identification scores at baseline, after adjustment for demographic, cognitive, health, and lifestyle factors. CRP levels ranging between 11 and 20 mg/L were significantly related to lower olfactory ability (β = −0.811, 95% confidence interval [CI] [−1.503 to −0.118]; p = .022). Likewise, CRP values above 20 mg/L were related to lower olfactory scores, an association that approached statistical significance (β = −0.996, 95% CI [−2.045 to 0.054]; p = .063). We found no associations between CRP and olfactory change ( ps > .368). Sensitivity analyses showed that associations between CRP and olfaction were confined to younger participants (age ≤72 years) and men ( ps < .034). Conclusions Our findings suggest a negative association between serum CRP levels and olfactory identification ability in aging that may be dependent on age and sex.

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