scholarly journals A Volumetric Approach to Wake Reduction: Design, Optimization, and Experimental Verification

2016 ◽  
Vol 2016 ◽  
pp. 1-15 ◽  
Author(s):  
Dean R. Culver ◽  
Earl Dowell ◽  
David Smith ◽  
Yaroslav Urzhumov ◽  
Abraham Varghese
Keyword(s):  
Computational Models ◽  
Fused Deposition Modeling ◽  
Stationary Flow ◽  
Optimization Methods ◽  
Navier Stokes ◽  
Fused Deposition ◽  
Gradient Based ◽  
Rans Models ◽  
Field Disturbance ◽  
Local Gradient

Wake reduction is a crucial link in the chain leading to undetectable watercraft. Here, we explore a volumetric approach to controlling the wake in a stationary flow past cylindrical and spherical objects. In this approach, these objects are coupled with rigid, fluid-permeable structures prescribed by a macroscopic design approach where all solid boundaries are parameterized and modeled explicitly. Local, gradient-based optimization is employed which permits topological changes in the manifold describing the composite solid component(s) while still allowing the use of adjoint optimization methods. This formalism works below small Reynolds number (Re) turbulent flow (Re≈100–10,000) when simulated using small Reynolds-averaged Navier-Stokes (RANS) models. The output of this topology optimization yields geometries that can be fabricated immediately using fused deposition modeling (FDM). Our prototypes have been verified in an experimental water tunnel facility, where the use of Particle Image Velocimetry (PIV) described the velocity profile. Comparisons with our computational models show excellent agreement for the spherical shapes and reasonable match for cylindrical shapes, with well-understood sources of error. Two important figures of merit are considered: domain-wide wake (DWW) and maximum local wake (MLW), metrics of the flow field disturbance whose definitions are described.

scholarly journals Mimicking the Human Tympanic Membrane: the Significance of Geometry

2020 ◽  
Author(s):  
Shivesh Anand ◽  
Thomas Stoppe ◽  
Mónica Lucena ◽  
Timo Rademakers ◽  
Marcus Neudert ◽  
...  
Keyword(s):  
Tympanic Membrane ◽  
Computational Models ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Dermal Fibroblasts ◽  
Sound Waves ◽  
Fused Deposition ◽  
Biological Studies ◽  
Structural Architecture ◽  
Human Tympanic Membrane

AbstractThe human tympanic membrane (TM) captures sound waves reaching the outer ear from the environment and transforms them into mechanical motion. The successful transmission of these acoustic vibrations in varying frequency ranges is attributed to the structural architecture of the TM. However, a limited knowledge is available on the contribution of its discrete anatomical features, which is important to fabricate functional biomimetic TM replacements. This work synergizes theoretical and experimental approaches toward understanding the significance of geometry in tissue engineered TM scaffolds. Three test designs along with a plain control were chosen to decouple some of the dominant structural attributes, such as, the radial and circumferential alignment of the collagen fibrils. In silico models suggested a geometrical dependency of their mechanical and acoustical responses, where the presence of radially aligned fibers was observed to have a more prominent effect compared to their circumferential counterparts. Following which, a hybrid fabrication strategy combining electrospinning and additive manufacturing was optimized to manufacture hierarchical scaffolds within the dimensions of the native TM. The experimental characterizations conducted using macro-indentation and laser Doppler vibrometry were in line with the computational models. Finally, biological studies performed with human dermal fibroblasts and human mesenchymal stromal cells, revealed a favorable influence of scaffold hierarchy on cellular alignment and subsequent collagen deposition.Abstract FigureGraphical abstract.Schematic diagram illustrating the overall flowchart of the work. 3D: three-dimensional; ES: electrospinning; FDM: fused deposition modeling; TM: tympanic membrane.

Computer Simulations of Airflow Field Around a Cube: Comparisons of LES and RANS Models

2010 ◽  
Author(s):  
Behtash Tavakoli ◽  
Goodarz Ahmadi
Keyword(s):  
Experimental Data ◽  
Computational Models ◽  
Transport Model ◽  
Separated Flow ◽  
Realistic Model ◽  
Navier Stokes ◽  
Reynolds Stress Transport Model ◽  
Rans Models ◽  
Airflow Field ◽  
Computationally Intensive

Simulations of flow field around wall mounted square cylinders have been used extensively for validation of computational models in the literature. In this paper the airflow fields around a square cylinder were simulated using the Reynolds Averaged Navier-Stokes (RANS) models as well as the Large Eddy Simulations (LES). Particular attention was given to the case with Reynolds number of 80,000 for which the experimental data of Hussein and Matinuzzi [1] are available. The nature of the 3D wakes behind the cube as well as the vortices in front and at the back of the cube were investigated. The simulation results were compared with the experimental data and the accuracy of different models were studied. While the LES better captured the features of this separated flow, it is computationally intensive. The Reynolds Stress Transport Model (RSTM) did not properly predict some features of this separated flow, but is comparatively more economical. The accuracy of RSTM for predicting the turbulence features of separated flows was discussed, and its application for the flow around a realistic model of a building was pointed out.

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

Thermal characterization of ABS-Graphene blended three dimensional printed functional prototypes for electro chemical energy storage

2018 ◽  
Vol 1 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Kamaljit Singh Boparai ◽  
Rupinder Singh
Keyword(s):  
Energy Storage ◽  
Structural Changes ◽  
Fused Deposition Modeling ◽  
Morphological Changes ◽  
Three Dimensional ◽  
Thermal Characterization ◽  
Chemical Energy ◽  
Flow Index ◽  
Fused Deposition

This study highlights the thermal characterization of ABS-Graphene blended three dimensional (3D) printed functional prototypes by fused deposition modeling (FDM) process. These functional prototypes have some applications as electro-chemical energy storage devices (EESD). Initially, the suitability of ABS-Graphene composite material for FDM applications has been examined by melt flow index (MFI) test. After establishing MFI, the feedstock filament for FDM has been prepared by an extrusion process. The fabricated filament has been used for printing 3D functional prototypes for printing of in-house EESD. The differential scanning calorimeter (DSC) analysis was conducted to understand the effect on glass transition temperature with the inclusion of Graphene (Gr) particles. It has been observed that the reinforced Gr particles act as a thermal reservoir (sink) and enhances its thermal/electrical conductivity. Also, FT-IR spectra realized the structural changes with the inclusion of Gr in ABS matrix. The results are supported by scanning electron microscopy (SEM) based micrographs for understanding the morphological changes.

An Update on the Use of Alginate in Additive Biofabrication Techniques

2019 ◽  
Vol 25 (11) ◽  
pp. 1249-1264 ◽  
Author(s):  
Amoljit Singh Gill ◽  
Parneet Kaur Deol ◽  
Indu Pal Kaur
Keyword(s):  
Fused Deposition Modeling ◽  
Low Cost ◽  
Selective Laser Sintering ◽  
Layer By Layer ◽  
Three Dimension ◽  
Anionic Polymer ◽  
Fused Deposition ◽  
The Status ◽  
Deposition Modeling ◽  
Extrusion Printing

Background: Solid free forming (SFF) technique also called additive manufacturing process is immensely popular for biofabrication owing to its high accuracy, precision and reproducibility. Method: SFF techniques like stereolithography, selective laser sintering, fused deposition modeling, extrusion printing, and inkjet printing create three dimension (3D) structures by layer by layer processing of the material. To achieve desirable results, selection of the appropriate technique is an important aspect and it is based on the nature of biomaterial or bioink to be processed. Result & Conclusion: Alginate is a commonly employed bioink in biofabrication process, attributable to its nontoxic, biodegradable and biocompatible nature; low cost; and tendency to form hydrogel under mild conditions. Furthermore, control on its rheological properties like viscosity and shear thinning, makes this natural anionic polymer an appropriate candidate for many of the SFF techniques. It is endeavoured in the present review to highlight the status of alginate as bioink in various SFF techniques.

Extrusion-Based 3D Printing for Pharmaceuticals: Contemporary Research and Applications

2019 ◽  
Vol 24 (42) ◽  
pp. 4991-5008 ◽  
Author(s):  
Mohammed S. Algahtani ◽  
Abdul Aleem Mohammed ◽  
Javed Ahmad
Keyword(s):  
Cosmetic Surgery ◽  
Fused Deposition Modeling ◽  
Personalised Medicine ◽  
Organ Transplant ◽  
Three Dimensional ◽  
Dosage Forms ◽  
Release Profile ◽  
Small Scale ◽  
Drug Release Profile ◽  
Fused Deposition

Three-dimensional printing (3DP) has a significant impact on organ transplant, cosmetic surgery, surgical planning, prosthetics and other medical fields. Recently, 3 DP attracted the attention as a promising method for the production of small-scale drug production. The knowledge expansion about the population differences in metabolism and genetics grows the need for personalised medicine substantially. In personalised medicine, the patient receives a tailored dose and the release profile is based on his pharmacokinetics data. 3 DP is expected to be one of the leading solutions for the personalisation of the drug dispensing. This technology can fabricate a drug-device with complicated geometries and fillings to obtain the needed drug release profile. The extrusionbased 3 DP is the most explored method for investigating the feasibility of the technology to produce a novel dosage form with properties that are difficult to achieve using the conventional industrial methods. Extrusionbased 3 DP is divided into two techniques, the semi-solid extrusion (SSE) and the fused deposition modeling (FDM). This review aims to explain the extrusion principles behind the two techniques and discuss their capabilities to fabricate novel dosage forms. The advantages and limitations observed through the application of SSE and FDM for fabrication of drug dosage forms were discussed in this review. Further exploration and development are required to implement this technology in the healthcare frontline for more effective and personalised treatment.

Sign in / Sign up

Export Citation Format

Share Document