scholarly journals Aggressive Angiomyxoma in Pregnancy: A Rare Condition, a Common Misdiagnosis

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
J. Sampaio ◽  
I. Sarmento-Gonçalves ◽  
D. Ramada ◽  
T. Amaro ◽  
P. Tiago-Silva
Keyword(s):  
Early Recognition ◽  
Correct Diagnosis ◽  
Progesterone Receptors ◽  
Rare Condition ◽  
Unknown Origin ◽  
Surgical Excision ◽  
Aggressive Angiomyxoma ◽  
Mesenchymal Neoplasm ◽  
The Impact

Introduction. Aggressive angiomyxoma is a rare mesenchymal neoplasm. Although benign in the majority of the cases, these neoplasms usually present a locally infiltrative nature and high rates of recurrence. Due to its rarity, misdiagnosis is a common problem.Case Presentation. We present one case of aggressive angiomyxoma in a 25-year-old pregnant woman. The patient presented with a large vaginal mass that was interpreted as a vaginal cyst. We performed surgical resection of the neoplasm and the correct diagnosis was only achieved after histological examination. With this case, we highlight the importance of considering this diagnosis in patients with genital and perineal masses of unknown origin and the impact of a correct preoperative diagnosis in patient’s management and follow-up.Conclusion. Although aggressive angiomyxoma is rare, it should be considered in differential diagnosis of pelviperineal masses in young women. Its positivity to estrogen and progesterone receptors can justify enlargement and recurrence during pregnancy, although few cases are reported. Early recognition demands high index of suspicion for both gynaecologists and pathologists. Wide surgical excision with tumor free margins is the basis of curative treatment. Adjuvant therapy may be necessary for residual or recurrent tumors. Long-term follow-up is recommended.

scholarly journals Retroperitoneal Tumours - Treatment and Prognosis of Tumour Recurrence

2019 ◽  
Vol 70 (1) ◽  
pp. 190-184 ◽  
Author(s):  
Ovidiu Gabriel Bratu ◽  
Alexandru Ionut Cherciu ◽  
Adrian Bumbu ◽  
Sorin Lupu ◽  
Dragos Radu Marcu ◽  
...  
Keyword(s):  
Tumor Recurrence ◽  
Treatment Options ◽  
Correct Diagnosis ◽  
Tumor Resection ◽  
Rare Condition ◽  
Unknown Origin ◽  
Surgical Excision ◽  
Tumor Grade ◽  
High Volume ◽  
Retroperitoneal Tumors

Retroperitoneal tumors, once considered uncommon, have been reported in the last years in such numbers that they cannot be considered anymore a rare condition. Tumor recurrence following surgical excision is quite common and a tumor that was considered originally as benign in many cases can recur as a malignant tumor. The purpose of this paper is to underline the difficulties in terms of establishing a correct diagnosis and a proper therapeutic protocol when facing a retroperitoneal mass of unknown origin, as well as to present the available data regarding prognosis, treatment options and tumor recurrence. Retroperitoneal tumors can be classified as benign or malignant; solid, cystic or both; single or multiple, and of varied histological types. A high percentage of patients with retroperitoneal tumors are discovered in advanced stages, usually seeking medical help for symptoms related to nearby organ compression/invasion. This pathology requires a prompt and adequate multidisciplinary management, in order to achieve disease control and to reduce the recurrence rate. Complete surgical resection is the potential curative treatment for retroperitoneal tumors and it is best managed in high-volume centers, by a multidisciplinary team. Complete oncological tumor resection and tumor grade remain the most important predictors for local recurrence and disease-specific survival. Further research is required in order to define the role of radiotherapy, as well as to discover new biological therapies that target various molecular pathways involved in retroperitoneal cancers.

Incidental finding of paratesticular aggressive angiomyxoma in a 72-year-old monorchid male

2019 ◽  
Vol 87 (4) ◽  
pp. 194-198
Author(s):  
Armando Serao ◽  
Donatella Tiranti ◽  
Muriel Ferraro ◽  
Rafaela Malinaric ◽  
Paola Re ◽  
...  
Keyword(s):  
Case Report ◽  
Local Recurrence ◽  
Incidental Finding ◽  
Surgical Excision ◽  
Aggressive Angiomyxoma ◽  
First Line ◽  
Mesenchymal Neoplasm ◽  
The Common ◽  
Line Of Therapy

Aggressive angiomyxoma is an uncommon mesenchymal neoplasm. It arises from soft tissue of pelvis and perineum in fertile females, occurring very rarely in males. Its name emphasizes the common local recurrence and infiltrative tendency, but usually it does not metastasize. Currently, the first line of therapy is surgical excision, achieving R0 surgical margins, and radiological follow-up. This case report describes an uncommon, incidental finding of paratesticular aggressive angiomyxoma in an asymptomatic, cryptorchid 72-year-old male patient.

scholarly journals Subungual Glomus Tumor- Clinical Presentation And Treatment

2014 ◽  
Vol 3 (2) ◽  
pp. 45-48 ◽  
Author(s):  
Shyamal Chandra Debnath ◽  
Suman Kumar Roy ◽  
RR Kairy
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Clinical Presentation ◽  
Glomus Tumor ◽  
Rare Condition ◽  
Surgical Excision ◽  
Tissue Mass ◽  
Delay In Diagnosis ◽  
Nail Deformity

Glomus tumor is a rare condition and constitutes only 1 % of all soft tissue tumor of body. Glomus tumor is familiar for its unusual presentation and long standing symptoms due to delay in diagnosis. Authors have presented the clinical behavior and treatment of 7 patients with subungual soft tissue mass. Following surgical excision, all patients cured of symptoms, at the end of follow up, no recurrence occurred; post operative nail deformity was insignificant. DOI: http://dx.doi.org/10.3329/bdjps.v3i2.18250 Bangladesh Journal of Plastic Surgery July 2012, 3(2): 45-48

Myofibroma of the Gingiva: Report of a Case

2010 ◽  
Vol 34 (3) ◽  
pp. 253-257 ◽  
Author(s):  
Banu Özveri Koyuncu ◽  
Mert Zeytinoğlu ◽  
Taha Ünal ◽  
Bülent Zeytinoğlu
Keyword(s):  
Benign Tumor ◽  
Smooth Muscle Actin ◽  
Correct Diagnosis ◽  
Benign Neoplasm ◽  
Surgical Excision ◽  
Solitary Lesion ◽  
Immunohistochemical Markers ◽  
Mesenchymal Neoplasm ◽  
S 100 ◽  
Histopathologic Evaluation

Myofibroma is a benign mesenchymal neoplasm composed of myofibroblasts which has been described with different synonyms since the first report in 1951. It occurs most commonly as a solitary lesion of soft tissue,skin, or bone in infancy. The prognosis of oral myofibromas is excellent, and surgical excision is curative. Recurrence is rare. Awareness and recognition of this benign tumor is important to establish the correct diagnosis and avoid morbidity of unnecessary aggressive therapy. This report describes a myofibroma of the gingiva in a 14 year old girl and is reported together with the conventional histologic, and immunohistochemical findings. The tumor showed rapid increase in size and clinical features suggestive of malignancy. However, on histopathologic evaluation it was diagnosed as a benign neoplasm, and this diagnosis was supported by immunohistochemical markers. The spindle cells were immunopositive for smooth muscle actin,and vimentin but were negative for desmin and S-100 protein. The patient was treated with surgical excision,and is followed-up for 33 months without any signs of recurrence.

Solitary Fibrous Tumors Arising from Bilateral Ovaries: A Case Report and Review of the literature

2021 ◽  
Vol 17 ◽  
Author(s):  
Tongtong Tian ◽  
Jing Ye ◽  
Jun Sun
Keyword(s):  
Wide Spectrum ◽  
Surgical Excision ◽  
Integrated Approach ◽  
Late Relapse ◽  
Limited Information ◽  
Mesenchymal Neoplasm ◽  
Fibrous Tumor ◽  
Long Term Behavior

Background: A solitary fibrous tumor (SFT) is a distinct mesenchymal neoplasm. It was originally described as a tumor localized to the pleura but was later reported in several other anatomic sites and exhibited a wide spectrum of histological features. Owing to its rarity, the diagnosis of extrapleural SFT is challenging and requires an integrated approach comprising specific clinical, imaging, histological, and immunohistochemical findings. Case presentation: Herein, we report the imaging findings of a rare case of SFT arising from bilateral ovaries confirmed by surgical excision and histological examination. No adjuvant radiotherapy or chemotherapy was given to the patient, and she was disease-free with no evidence of recurrence or metastasis at the 96-month postoperative follow-up. Although it mostly follows a favorable course, SFT is notoriously difficult for prognostication because of its propensity for late relapse or even metastases in 10–39% of cases. Conclusion: Close follow-up is recommended because of the limited information on its long-term behavior.

Aggressive Angiomyxoma

2012 ◽  
Vol 136 (2) ◽  
pp. 217-221 ◽  
Author(s):  
Brian J. Sutton ◽  
Jennifer Laudadio
Keyword(s):  
Local Recurrence ◽  
Progesterone Receptors ◽  
Chromosomal Translocation ◽  
Surgical Excision ◽  
Vascular Tumor ◽  
Gonadotropin Releasing Hormone ◽  
Aggressive Angiomyxoma ◽  
Estrogen And Progesterone Receptors ◽  
Myxoid Stroma ◽  
Emerging Therapy

Aggressive angiomyxoma is a rare mesenchymal tumor that most commonly arises in the vulvovaginal region, perineum, and pelvis of women. The term aggressive emphasizes the often infiltrative nature of the tumor and its frequent association with local recurrence. Patients often present with nonspecific symptoms which are frequently misdiagnosed with more common entities, such as a Bartholin cyst, lipoma, or hernia. Histologic examination reveals a hypocellular and highly vascular tumor with a myxoid stroma containing cytologically bland stellate or spindled cells. The tumor cells are characteristically positive for estrogen and progesterone receptors, suggesting a hormonal role in the development of the tumor. Chromosomal translocation of the 12q13-15 band involving the HMGA2 gene has been described. Surgical excision is the treatment of choice, although treatment with gonadotropin-releasing hormone agonists is an emerging therapy. Metastases are exceedingly rare, and overall, the prognosis is good.

scholarly journals Juvenile Xanthogranuloma Presenting as Bilateral Non-Infiltrative Extraconal Superior Orbital Tumour in a 27 Year Old Nigerian Woman: Features, Management and Outcome

2012 ◽  
Vol 5 ◽  
pp. CCRep.S10138 ◽  
Author(s):  
Okosa Michael Chuka ◽  
Anyiam Daniel Chukwuemeka Darlinton
Keyword(s):  
Systemic Disease ◽  
Rare Condition ◽  
Surgical Excision ◽  
Juvenile Xanthogranuloma ◽  
Case Presentation ◽  
Nigerian Woman ◽  
Upper Lid ◽  
Systemic Manifestations ◽  
Systemic Symptoms

Introduction Orbital masses in adults are often caused by systemic diseases or are associated with systemic manifestations. Juvenile xanthogranuloma as a cause is rare and unreported in Africa. We present clinical features, management, and outcomes of bilateral orbital adult onset juvenile xanthogranuloma. Case Presentation A 27 year old Nigerian woman presented with bilateral upper-lid lumps having lasted 5 months. These increased in size for about 1 month and stopped. Lid swelling was preceded by itchy eyes, redness of conjunctiva, and occasional mild pain. There were no visual or systemic symptoms. The lumps were firm, slightly mobile, not tender, and not attached to skin but rather to deeper structures. There was restriction on up-gaze but no proptosis or diplopia. Hematological, biochemical, and X-ray investigations were normal. Prednisolone tablets 10 mg daily for two weeks were not useful. Tissue biopsy was invaluable in diagnosis of this rare condition and disclosed juvenile xanthogranuloma. Partial surgical excision was done under lidocaine infiltration. No recurrence has occurred in 40 months of follow-up. No systemic disease has manifested. Conclusion Juvenile xanthogranuloma can present as bilateral superior orbital tumor in adults; functional and cosmetic aims were achieved by sub-total excision.

Tonsillar leiomyoma

1987 ◽  
Vol 101 (6) ◽  
pp. 619-623 ◽  
Author(s):  
E. Greenberg ◽  
A. Shupak ◽  
Judith Kelner ◽  
W. S. Meyer
Keyword(s):  
Smooth Muscle ◽  
Spindle Cell ◽  
Correct Diagnosis ◽  
Surgical Excision ◽  
Mitotic Figure ◽  
First Case ◽  
Spindle Cell Tumours ◽  
Benign Leiomyoma ◽  
Histologic Types

AbstractTumors of smooth muscle origin are rare in the oral cavity. To date, only eighty-three cases of oral leiomyomas have been reported. A first case of tonsillar leiomyoma in a 73-year-old male is presented. The theories of origin and the various histologic types of oral leiomyomas are discussed. Leiomyoma can easily be confused with other spindle-cell tumours. Special stains are necessary to reach a correct diagnosis. It is sometimes difficult to differentiate benign leiomyoma from malignant leiomyosarcoma. The use of mitotic figure count to indicate malignant behaviour is not always reliable. The need for wide surgical excision of the tumour, complete sectioning and examination of the specimen and meticulous follow-up of the patient for evidence of recurrence are emphasized.

scholarly journals Radical excision of a massive vulvo: Vaginal mass

2016 ◽  
Author(s):  
J. Meena ◽  
A. Parthasarathy ◽  
R. Vatsa ◽  
N. Singh ◽  
S. Kumar ◽  
...  
Keyword(s):  
Condylomata Acuminata ◽  
Surgical Excision ◽  
Posterior Wall ◽  
Reproductive Age ◽  
Ischiorectal Fossa ◽  
Radical Excision ◽  
Aggressive Angiomyxoma ◽  
Diagnostic Features ◽  
Vaginal Mass

Background: Vulvo-vaginal masses has a varied presentation and causes. The most common differential diagnosis are Condylomata acuminata, Vulvular abscess, Vulvular/vaginal cysts, Vulval carcinoma, Vulval lipoma, Angiomyofibroblastoma and Aggressive Angiomyxoma. Surgical excision of the mass is the main method of treatment and the outcome differs with the histological diagnosis. We present a video of excision of a massive Vulvo vaginal mass in toto. Case: A 45 year old P3 L3 female, presented with complaint of mass in perineal area & discharge per vaginum for 2 years. The mass was growing progressively and reached the present size. On examination there was a 9 X 8 cm irregular firm to cystic mass, arising from posterior wall of vagina and protruding out of introitus with bossellated surface. The mass also extended into right ischiorectal fossa, 10 X 10 cm mass with cystic, smooth surface that was irreducible with no cough impulse. CECT abdomen and pelvis revealed a well-defined 12 X 10 X 8 cm mass in right perineum arising from right lower lateral vaginal wall with ischiorectal fossa extension. There was no extension into cervix, bladder or rectum. Biopsy taken from the mass was inconclusive. A wide local excision was done under general anesthesia wherein an ischiorectal and vaginal mass of size 30 X 10 cm with irregular margin was excised in toto. Histopathology was suggestive of Aggressive Angiomyxoma. The patient is under follow up. Discussion: Aggressive Angiomyxoma is a rare slow growing locally invasive mesenchymal tumor and has a substantial potential for recurrence. It is often misdiagnosed. Pre-operative diagnosis is difficult due to rarity of this entity and absence of diagnostic features, but it should be considered in case of masses in genital, perianal and pelvic region in a woman of reproductive age. Radical surgical excision is the first line of management. A long term follow up of the case is necessary and MRI is preferred method for detecting recurrences.

scholarly journals IoT-Based Skin Monitoring System

2020 ◽  
Vol 8 (5) ◽  
pp. 4258-4264
Keyword(s):  
Skin Diseases ◽  
Correct Diagnosis ◽  
Delayed Diagnosis ◽  
Environmental Sensors ◽  
Technological Advances ◽  
Common Skin ◽  
Treatment Facilities ◽  
The Many ◽  
The Impact

The numbers of patients with skin diseases reported a dramatic increase which is a major concern and must be dealt with. The method of diagnosis is always based on physician’s observations and experiences. Many common symptoms such as side effects, allergies and even risks of skin cancer can be seen in someone following misdiagnosis, delayed diagnosis and failure to diagnose. The evaluation of skin changes is crucial to the correct diagnosis during follow-up. Through technological advances and partnerships, skin disorders can be identified and predicted and medical diagnosis outside physical limits are made. The article proposed an IoT-based skin surveillance system that facilitates the monitoring of skin patients in remote locations. In a diagnostic device for real-time skin monitoring and analysis, the proposed system architecture can be applied. A sensor fitted medical carriage is proposed in a remote location to treat individuals suffering from a common skin disorder. The system is also designed to research the impact of climate change on the disease through environmental sensors and provide pre-alertfor prevention. This addresses the many problems that people in remote areas without restricted treatment facilities face.

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