scholarly journals Correlation between Focal Nodular Low Signal Changes in Hoffa’s Fat Pad Adjacent to Anterior Femoral Cartilage and Focal Cartilage Defect Underlying This Region and Its Possible Implication

Scientifica ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-6
Author(s):  
Chermaine Deepa Antony ◽  
John George ◽  
Wuey Min Ng ◽  
Manimalar Selvi Naicker Subramaniam
Keyword(s):  
Cartilage Damage ◽  
Inflammatory Cells ◽  
Cartilage Defects ◽  
Fat Pad ◽  
Normal Cartilage ◽  
Femoral Cartilage ◽  
Hoffa’S Fat Pad ◽  
Chondral Injury ◽  
High Negative Predictive Value ◽  
Nodular Lesions

Purpose. This study investigates the association between focal nodular mass with low signal in Hoffa’s fat pad adjacent to anterior femoral cartilage of the knee (FNMHF) and focal cartilage abnormality in this region.Method. The magnetic resonance fast imaging employing steady-state acquisition sequence (MR FIESTA) sagittal and axial images of the B1 and C1 region (described later) of 148 patients were independently evaluated by two reviewers and categorized into four categories: normal, FNMHF with underlying focal cartilage abnormality, FNMHF with normal cartilage, and cartilage abnormality with no FNMHF.Results. There was a significant association (p=0.00) between FNMHF and immediate adjacent focal cartilage abnormality with high interobserver agreement. The absence of focal nodular lesions next to the anterior femoral cartilage has a very high negative predictive value for chondral injury (97.8%). Synovial biopsy of focal nodular lesion done during arthroscopy revealed some fibrocollagenous tissue and no inflammatory cells.Conclusion. We postulate that the FNMHF adjacent to the cartilage defects is a form of normal healing response to the cartilage damage. One patient with FHMHF and underlying cartilage abnormality was rescanned six months later. In this patient, the FNMHF disappeared and normal cartilage was observed in the adjacent region which may support this theory.

scholarly journals Infrapatellar fat pad area on knee MRI: does it correlate with the extent of knee osteoarthritis?

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Eman Ragab ◽  
Dena Serag
Keyword(s):  
Large Scale ◽  
Cartilage Damage ◽  
Surrogate Marker ◽  
Joint Space ◽  
Protective Role ◽  
Infrapatellar Fat Pad ◽  
Cartilage Defects ◽  
Fat Pad ◽  
Knee Oa ◽  
Maximal Area

Abstract Background Osteoarthritis (OA) of the knee joint is a common cause of chronic disability in older adults. During the past 10 years, the infrapatellar fat pad (IPFP) has emerged as a new player in the pathogenesis of knee OA. Its exact role in the pathogenesis of knee OA remains uncertain. While many studies focused on the detrimental effect of the chemical mediators released by IPFP and their role in the accentuation of the development of OA, only few studies elucidated the beneficial effect of IPFP maximal area as a local shock absorber protecting the adjacent articular structures from progressive damage. The aim of this study was to evaluate the relation between the IPFP maximal area and the prevalence of OA manifestations. We also studied the relation between the subcutaneous (SC) fat thicknesses on the medial aspect of the knee as a surrogate marker of body obesity and the IPFP area. Results A total of 216 knee scans for 188 adult patients (64 males and 124 females) who met the inclusion criteria were examined. They were between 45 and 66 years (mean 52.5 years). The mean IPFP area for all patients was 6.9 cm2 (± 1.6 SD) (ranged from 4.5 to 11 cm2). After adjustment for potential confounders, there was a significant negative association between IPFP area and radiographic manifestations of OA (osteophites, joint space narrowing, and grade of OA) (P value < 0.001 for each), as well as MRI manifestations of OA (cartilage defects and subchondral bone marrow lesions) (P value < 0.001 and < 0.003, respectively). There was a negative but non-significant association between IPFP area and SC fat thickness. Conclusion In our study, we found supportive evidence that IPFP maximal area is associated with fewer osteoarthritic knee changes and less cartilage damage, suggesting that it plays a protective role against the development and progression of OA. Further large-scale clinical studies are awaited to confirm the obtained results. Based on our findings, it would be recommended to avoid IPFP resection during surgery in order to maintain its protective effect.

scholarly journals The Use of Infrapatellar Fat Pad-Derived Mesenchymal Stem Cells in Articular Cartilage Regeneration: A Review

2021 ◽  
Vol 22 (17) ◽  
pp. 9215
Author(s):  
Parviz Vahedi ◽  
Rana Moghaddamshahabi ◽  
Thomas J. Webster ◽  
Ayse Ceren Calikoglu Koyuncu ◽  
Elham Ahmadian ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Cartilage ◽  
Cartilage Damage ◽  
Treatment Strategies ◽  
Cartilage Regeneration ◽  
Infrapatellar Fat Pad ◽  
Cartilage Defects ◽  
Fat Pad ◽  
Culture Methods

Cartilage is frequently damaged with a limited capacity for repair. Current treatment strategies are insufficient as they form fibrocartilage as opposed to hyaline cartilage, and do not prevent the progression of degenerative changes. There is increasing interest in the use of autologous mesenchymal stem cells (MSC) for tissue regeneration. MSCs that are used to treat articular cartilage defects must not only present a robust cartilaginous production capacity, but they also must not cause morbidity at the harvest site. In addition, they should be easy to isolate from the tissue and expand in culture without terminal differentiation. The source of MSCs is one of the most important factors that may affect treatment. The infrapatellar fat pad (IPFP) acts as an important reservoir for MSC and is located in the anterior compartment of the knee joint in the extra-synovial area. The IPFP is a rich source of MSCs, and in this review, we discuss studies that demonstrate that these cells have shown many advantages over other tissues in terms of ease of isolation, expansion, and chondrogenic differentiation. Future studies in articular cartilage repair strategies and suitable extraction as well as cell culture methods will extend the therapeutical application of IPFP-derived MSCs into additional orthopedic fields, such as osteoarthritis. This review provides the latest research concerning the use of IPFP-derived MSCs in the treatment of articular cartilage damage, providing critical information for the field to grow.

scholarly journals Effects of Body Mass Index, Infrapatellar Fat Pad Volume and Age on Patellar Cartilage Defect

2014 ◽  
Vol 2 (11_suppl3) ◽  
pp. 2325967114S0015
Author(s):  
Semra Duran ◽  
Ertugrul Akşahin ◽  
Onur Kocadal ◽  
Cem Nuri Aktekin ◽  
Onur Hapa ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Cartilage Defect ◽  
Cartilage Damage ◽  
Infrapatellar Fat Pad ◽  
Cartilage Defects ◽  
Control Group ◽  
Fat Pad ◽  
Patellar Cartilage ◽  
Causative Factors

Objectives: The aim of this study was to evaluate the associations between patellar cartilage defects and body mass index (BMI), infrapatellar fat pad (IPFP) volume and age. Methods: 100 patients who met the inclusion criteria and were aged 18 to 60, were evaluated retrospectively. The BMI’s of the participants were evaluated according to their weight and height. For detecting and measuring patellar cartilage defects, axial sequences were used and sagittal sequences for were used to evaluate IPFP volumes in MRI. Results: 40 patients were found to have patellar cartilage defects. In this group, age and BMI were higher in both sexes when compared with the controls (P<0.05). The IPFP volume was lower in the group with the patellar cartilage defect when compared with the control group (P<0.05). The IPFP volume was statistically significantly lower in women (P<0.05). Conclusion: Patellar cartilage defects were found to be related to age and BMI. In women, the decrease in IPFP volume seems to be one of the causative factors for patellar cartilage defects. The effect of IPFP volume on articular cartilage in healthy people is unknown. Further studies focusing on patellofemoral cartilage damage are needed to reveal this association.

scholarly journals An introduction to Acoustic Emission Analysis (AEA) based medical diagnostic techniques: Screening and Monitoring of cartilage defects in knee joint osteoarthrosis

2020 ◽  
Vol 6 (3) ◽  
pp. 518-521
Author(s):  
Subke Joerg ◽  
Krueger Sabine ◽  
Junker Heinz-Otto ◽  
Schwalbe Hans-Joachim ◽  
Franke Ralf-Peter ◽  
...  
Keyword(s):  
Acoustic Emission ◽  
Load Transfer ◽  
Plane Surface ◽  
Cartilage Damage ◽  
Diagnostic Techniques ◽  
Outer Edge ◽  
Cartilage Defects ◽  
Emission Analysis ◽  
Medical Diagnostic ◽  
Therapeutic Measures

AbstractClinical studies have shown that during standardized movements the Acoustic Emission (AE) from lesions in articular cartilage can be assessed. Specific lesions produce specific acoustic signals, therefore it is possible to evaluate the character of cartilage damage. Consequently it is possible to evaluate the condition of the joint cartilage in order to enhance therapy. Patients performed series of knee bends, first on a plane surface in order to assess the cartilage lesions. Then patients performed knee bends on boards simulating orthopaedic insoles by means of inner and outer edge elevations. Insoles aim at relieving the lesioned areas of cartilage from loads and strain. AEA monitoring reveals the effects of a shift of the zone of load transfer immediately and is an adequate tool for the diagnosis as well as the monitoring of therapeutic measures.

scholarly journals New scoring system in assessment of Hoffa’s fat pad synovitis: A comparative study with established scoring systems

2018 ◽  
Vol 10 (11) ◽  
pp. 162-171 ◽  
Author(s):  
Shigeo Hagiwara ◽  
Albert Yang ◽  
Shoichiro Takao ◽  
Yasuhito Kaneko ◽  
Taiki Nozaki ◽  
...  
Keyword(s):  
Comparative Study ◽  
Scoring System ◽  
Scoring Systems ◽  
Fat Pad ◽  
Hoffa’S Fat Pad ◽  
New Scoring

scholarly journals Is superolateral Hoffa's fat pad hyperintensity a marker of local patellofemoral joint disease? – The MOST study

2017 ◽  
Vol 25 (9) ◽  
pp. 1459-1467 ◽  
Author(s):  
M. Jarraya ◽  
A. Guermazi ◽  
D.T. Felson ◽  
F.W. Roemer ◽  
M.C. Nevitt ◽  
...  
Keyword(s):  
Patellofemoral Joint ◽  
Joint Disease ◽  
Fat Pad ◽  
Hoffa’S Fat Pad

scholarly journals Simple geometry tribological study of osteochondral graft implantation in the knee

2018 ◽  
Vol 232 (3) ◽  
pp. 249-256 ◽  
Author(s):  
Philippa Bowland ◽  
Eileen Ingham ◽  
John Fisher ◽  
Louise M Jennings
Keyword(s):  
Knee Joint ◽  
Articular Surface ◽  
Cartilage Damage ◽  
Surface Damage ◽  
Negative Control ◽  
Osteochondral Allograft ◽  
Cartilage Defects ◽  
Osteochondral Grafts ◽  
Osteochondral Repair ◽  
Simple Geometry

Robust preclinical test methods involving tribological simulations are required to investigate and understand the tribological function of osteochondral repair interventions in natural knee tissues. The aim of this study was to investigate the effects of osteochondral allograft implantation on the local tribology (friction, surface damage, wear and deformation) of the tissues in the natural knee joint using a simple geometry, reciprocating pin-on-plate friction simulator. In addition, the study aimed to assess the ability of osteochondral grafts to restore a low surface damage, deformation and wear articulation when compared to the native state. A method was developed to characterise and quantify surface damage wear and deformation of the opposing cartilage-bone pin surface using a non-contacting optical profiler (Alicona Infinite Focus). Porcine 12 mm diameter cartilage-bone pins were reciprocated against bovine cartilage-bone plates that had 6 mm diameter osteochondral allografts, cartilage defects or stainless steel pins (positive controls) inserted centrally. Increased levels of surface damage with changes in geometry were not associated with significant increases in the coefficient of dynamic friction. Significant damage to the opposing cartilage surface was observed in the positive control groups. Cartilage damage, deformation and wear (as measured by change in geometry) in the xenograft (2.4 mm3) and cartilage defect (0.99 mm3) groups were low and not significantly different (p > 0.05) compared to the negative control in either group. The study demonstrated the potential of osteochondral grafts to restore the congruent articular surface and biphasic tribology of the natural joint. An optical method has been developed to characterise cartilage wear, damage and deformation that can be applied to the tribological assessment of osteochondral grafts in a whole natural knee joint simulation model.

Quantitative DCE-MRI Demonstrates Increased Blood Perfusion in Hoffa’s Fat Pad Signal Abnormalities in Knee Osteoarthritis

2020 ◽  
Author(s):  
B. A. de Vries ◽  
R. V.D. van der Heijden ◽  
D. Poot ◽  
M. van Middelkoop ◽  
D. Meufels ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Blood Perfusion ◽  
Fat Pad ◽  
Dce Mri ◽  
Hoffa’S Fat Pad

scholarly journals Phosphorus Concentration in Knee Joint Structures of Patients Following Replacement Surgery

2019 ◽  
Vol 16 (4) ◽  
pp. 525 ◽  
Author(s):  
Ciosek Żaneta ◽  
Kosik-Bogacka Danuta ◽  
Łanocha-Arendarczyk Natalia ◽  
Kot Karolina ◽  
Karaczun Maciej ◽  
...  
Keyword(s):  
Knee Joint ◽  
Cruciate Ligament ◽  
The Body ◽  
Infrapatellar Fat Pad ◽  
Emission Spectrometry ◽  
Phosphorus Concentration ◽  
Spongy Bone ◽  
Fat Pad ◽  
Hoffa’S Fat Pad ◽  
P Concentration

The aim of the study was to assess phosphorus (P) concentration in structures of the knee joint—including the tibial spongy bone, articular cartilage, meniscus, anterior cruciate ligament, and infrapatellar fat pad (Hoffa’s fat pad)—of patients following knee joint replacement. The study also aimed to assess the influence of selected biological and environmental factors on P concentration in studied parts of the knee joint. Phosphorus concentration was determined using inductively coupled plasma-atomic emission spectrometry (ICP-AES). Statistically significant differences in P concentration were found between different elements of the knee joint. The highest P concentration was measured in the spongy bone (72,746.68 mg kg−1 dw) and the lowest in the Hoffa’s fat pad (1203.19 mg kg−1 dw). P levels were unaffected by gender, age, BMI, place of residence, smoking, or alcohol consumption. Data on P concentration in the osteoarticular elements of the knee may be useful in the interpretation and evaluation of biochemical, morphological, and mechanical changes occurring in the body.

Sign in / Sign up

Export Citation Format

Share Document